| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Macarena Lorena Herrera, Leandro Gabriel Champarini, Osvaldo Mart\\xc3\\xadn Basmadjian, Mar\\xc3\\xada Jos\\xc3\\xa9 Bellini, Claudia Beatriz Here\\xc3\\xb1\\xc3\\xb. IGF-1 gene therapy prevents spatial memory deficits and modulates dopaminergic neurodegeneration and inflammation in a parkinsonism model. Brain, behavior, and immunity. vol 119. 2024-05-17. PMID:38750702.' |
in addition, the therapy resulted in significant changes in several parameters (area, perimeter, roundness, ramification, and skeleton ́s analyses) related to microglia and astrocyte phenotypes, particularly in the cpu and dorsal hippocampal areas. |
2024-05-17 |
2024-05-27 |
rat |
| Haili He, Xiaomei Zhang, Hui He, Chenghong Xiao, Gaojie Xu, Liangyuan Li, Yu-E Liu, Chengyan Yang, Tao Zhou, Zili You, Jinqiang Zhan. Priming of hippocampal microglia by IFN-γ/STAT1 pathway impairs social memory in mice. International immunopharmacology. vol 134. 2024-05-17. PMID:38759369. |
priming of hippocampal microglia by ifn-γ/stat1 pathway impairs social memory in mice. |
2024-05-17 |
2024-05-27 |
mouse |
| Haili He, Xiaomei Zhang, Hui He, Chenghong Xiao, Gaojie Xu, Liangyuan Li, Yu-E Liu, Chengyan Yang, Tao Zhou, Zili You, Jinqiang Zhan. Priming of hippocampal microglia by IFN-γ/STAT1 pathway impairs social memory in mice. International immunopharmacology. vol 134. 2024-05-17. PMID:38759369. |
the morphology of microglia in the hippocampus, prelimbic cortex and amygdala was examined using immunohistochemistry, and the phenotype of microglia were examined using immunohistochemistry and enzyme-linked immunosorbent assays. |
2024-05-17 |
2024-05-27 |
mouse |
| Haili He, Xiaomei Zhang, Hui He, Chenghong Xiao, Gaojie Xu, Liangyuan Li, Yu-E Liu, Chengyan Yang, Tao Zhou, Zili You, Jinqiang Zhan. Priming of hippocampal microglia by IFN-γ/STAT1 pathway impairs social memory in mice. International immunopharmacology. vol 134. 2024-05-17. PMID:38759369. |
ifn-γ upregulated pstat1 and stat1 and promoted the nuclear translocation of stat1 in the hippocampal microglia and in the primary microglia. |
2024-05-17 |
2024-05-27 |
mouse |
| Haili He, Xiaomei Zhang, Hui He, Chenghong Xiao, Gaojie Xu, Liangyuan Li, Yu-E Liu, Chengyan Yang, Tao Zhou, Zili You, Jinqiang Zhan. Priming of hippocampal microglia by IFN-γ/STAT1 pathway impairs social memory in mice. International immunopharmacology. vol 134. 2024-05-17. PMID:38759369. |
giving minocycline or stat1 inhibitor fludarabin blocked the priming of hippocampal microglia induced by ifn-γ, ameliorated the dysfunction in hippocampal microglia-neuron interactions and synapse pruning by microglia, thereby improving social memory deficits in ifn-γ injected mice. |
2024-05-17 |
2024-05-27 |
mouse |
| Haili He, Xiaomei Zhang, Hui He, Chenghong Xiao, Gaojie Xu, Liangyuan Li, Yu-E Liu, Chengyan Yang, Tao Zhou, Zili You, Jinqiang Zhan. Priming of hippocampal microglia by IFN-γ/STAT1 pathway impairs social memory in mice. International immunopharmacology. vol 134. 2024-05-17. PMID:38759369. |
ifn-γ initiates stat1 pathway to induce priming of hippocampal microglia, thereby disrupts hippocampal microglia-neuron interactions and neural circuit link to social memory. |
2024-05-17 |
2024-05-27 |
mouse |
| Solal Chauquet, Emily F Willis, Laura Grice, Samuel B R Harley, Joseph E Powell, Naomi R Wray, Quan Nguyen, Marc J Ruitenberg, Sonia Shah, Jana Vukovi. Exercise rejuvenates microglia and reverses T cell accumulation in the aged female mouse brain. Aging cell. 2024-05-15. PMID:38747044. |
pharmacologic depletion of microglia further demonstrated that these cells are required for the stimulatory effects of exercise on hippocampal neurogenesis but not cognition. |
2024-05-15 |
2024-05-27 |
mouse |
| Manon Moreau, Rodolphe Dard, Amélia Madani, Janany Kandiah, Nadim Kassis, Jessica Ziga, Héloïse Castiglione, Solenn Day, Thomas Bourgeois, Boris Matrot, François Vialard, Nathalie Jane. Prenatal treatment with preimplantation factor improves early postnatal neurogenesis and cognitive impairments in a mouse model of Down syndrome. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-05-13. PMID:38739166. |
treatment with spif restored early postnatal hippocampal neurogenesis, with beneficial effects on astrocytes, microglia, inflammation, and cell cycle markers. |
2024-05-13 |
2024-05-27 |
mouse |
| Chunlan Zhang, Ruxin Tan, Xiaoqing Zhou, Ruru Wang, Xin Wang, Ren Ma, Fangxuan Chu, Ying Li, Tao Yin, Zhipeng Li. Transcranial Magneto-Acoustic Stimulation Protects Synaptic Rehabilitation from Amyloid-Beta Plaques via Regulation of Microglial Functions. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38731870. |
overall, our study highlights that stimulation of hippocampal microglia by tmas treatment can induce anti-cognitive impairment effects via pi3k-akt signaling, providing hope for the development of new strategies for an adjuvant therapy for alzheimer's disease. |
2024-05-11 |
2024-05-27 |
mouse |
| Jiao Cheng, Lin Yuan, Shuwen Yu, Bing Gu, Qian Luo, Xixi Wang, Yijing Zhao, Chengcheng Gai, Tingting Li, Weiyang Liu, Zhen Wang, Dexiang Liu, Roger C M Ho, Cyrus S H H. Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression. Behavioural brain research. vol 468. 2024-05-11. PMID:38723677. |
the results of immunohistochemical staining and sholl analysis showed that the number of microglia in the hippocampus of "two-hit" stress mice significantly increased, with morphological changes, shortened branches, and decreased numbers. |
2024-05-11 |
2024-05-27 |
mouse |
| Xu Zhao, Jiancong Lu, Jingyi Zhang, Ce Liu, Huijun Wang, Yan Wang, Qingfeng D. Sleep restriction promotes brain oxidative stress and inflammation, and aggravates cognitive impairment in insulin-resistant mice. Psychoneuroendocrinology. vol 166. 2024-05-08. PMID:38718616. |
compared with control group, ir mice showed impaired cognitive capacity, meanwhile, sr not only promoted bax/bcl2-induced hippocampal neuronal cell apoptosis and nrf2/ho1- induced oxidative stress, but also increased microglia activation and inflammatory factor levels and bbb permeability, thus aggravating the cognitive impairment in ir mice. |
2024-05-08 |
2024-05-27 |
mouse |
| Jingshu Hong, Yue Li, Lei Chen, Dengyang Han, Yitong Li, Xinning Mi, Kaixi Liu, Qian Wang, Yanan Song, Taotao Liu, Ning Yang, Yajie Liu, Zhengqian Li, Xiangyang Gu. A53T α-synuclein mutation increases susceptibility to postoperative delayed neurocognitive recovery via hippocampal Ang-(1-7)/MasR axis. Biochemical pharmacology. 2024-05-05. PMID:38705534. |
we respectively examined molecular changes at 6 h, 1 day, and 2 days after partial hepatectomy and observed that cognitive changes were accompanied by weakened angiotensin-(1-7)/mas receptor [ang-(1-7)/masr] axis, increased alpha-synuclein (α-syn) expression and phosphorylation, decreased methylated protein phosphatase-2a (me-pp2a), and prompted microglia m1 polarization and neuronal apoptosis in the hippocampus at 1 day after surgery. |
2024-05-05 |
2024-05-08 |
mouse |
| Valeria Cogut, Maaike Goris, Aukje Jansma, Marrit van der Staaij, Robert H Hennin. Hippocampal neuroimmune response in mice undergoing serial daily torpor induced by calorie restriction. Frontiers in neuroanatomy. vol 18. 2024-05-01. PMID:38686173. |
concurrently, the ca1 region of the hippocampus showed persistent morphological changes in microglia, characterized by reduced cell branching, decreased cell complexity and altered shape. |
2024-05-01 |
2024-05-03 |
mouse |
| Pablo Berríos-Cárcamo, Sarah Núñez, Justine Castañeda, Javiera Gallardo, María Rosa Bono, Fernando Ezque. Two-Month Voluntary Ethanol Consumption Promotes Mild Neuroinflammation in the Cerebellum but Not in the Prefrontal Cortex, Hippocampus, or Striatum of Mice. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673763. |
we found a significant increase in mcp1 mrna levels in the cerebellum of mice that consumed ethanol compared to controls, whereas no significant changes were observed in the prefrontal cortex, hippocampus, or striatum or in microglia isolated from the hippocampus and striatum. |
2024-04-27 |
2024-04-29 |
mouse |
| Bilal El-Mansoury, Kamal Smimih, Abdelaati El Khiat, Ahmed Draoui, Abdelmohcine Aimrane, Redouane Chatoui, Abdesslam Ferssiwi, Abdelali Bitar, Halima Gamrani, Arumugam R Jayakumar, Omar El Hib. Short Working Memory Impairment Associated with Hippocampal Microglia Activation in Chronic Hepatic Encephalopathy. Metabolites. vol 14. issue 4. 2024-04-26. PMID:38668321. |
short working memory impairment associated with hippocampal microglia activation in chronic hepatic encephalopathy. |
2024-04-26 |
2024-04-28 |
rat |
| Bilal El-Mansoury, Kamal Smimih, Abdelaati El Khiat, Ahmed Draoui, Abdelmohcine Aimrane, Redouane Chatoui, Abdesslam Ferssiwi, Abdelali Bitar, Halima Gamrani, Arumugam R Jayakumar, Omar El Hib. Short Working Memory Impairment Associated with Hippocampal Microglia Activation in Chronic Hepatic Encephalopathy. Metabolites. vol 14. issue 4. 2024-04-26. PMID:38668321. |
swm function was assessed through y-maze, t-maze, and novel object recognition (nor) tests, together with an immunofluorescence study of microglia activation within the hippocampal areas. |
2024-04-26 |
2024-04-28 |
rat |
| Feng Liu, Yaping Wang, Dongbo Li, Tao Yan. Atractylodin ameliorates lipopolysaccharide-induced depressive-like behaviors in mice through reducing neuroinflammation and neuronal damage. Journal of neuroimmunology. vol 390. 2024-04-26. PMID:38669915. |
further study showed atractylodin reduced the oxidative stress and the activation of microglia in mouse hippocampus, also inhibited the level of cytokine release, especially il-1β. |
2024-04-26 |
2024-04-29 |
mouse |
| Josephin Wagner, Lauren M Park, Partha Mukhopadhyay, Csaba Matyas, Eszter Trojnar, Ruslan Damadzic, Jeesun Jung, Andrew S Bell, Lucas A Mavromatis, Ali M Hamandi, Daniel B Rosoff, Leandro F Vendruscolo, George F Koob, Pal Pacher, Falk W Lohof. PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury. Brain, behavior, and immunity. vol 119. 2024-04-25. PMID:38657842. |
alirocumab also mitigated ethanol-induced microglia recruitment in the cortex and hippocampus (iba1). |
2024-04-25 |
2024-04-28 |
rat |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
we also observe abnormal activation of microglia characterized by enhanced release of the nlrp3 inflammasome, casepase-1 and pro-inflammatory cytokines il-1β, in the hippocampus of mice and bv2 cells. |
2024-04-24 |
2024-04-28 |
mouse |
| Jeremy M Shea, Saul A Villed. Microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38645176. |
microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline. |
2024-04-22 |
2024-04-24 |
mouse |