| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi-Cheng Lin, Jiao Wang, Xin-Lin Wang, Chi Pan, Shao-Wu Jin, Steven Char, Yuan-Xiang Tao, Hong Cao, Jun L. Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice. Biochimica et biophysica acta. Molecular basis of disease. 2024-03-25. PMID:38527593. |
hippocampal hdac6 promotes pocd by regulating nlrp3-induced microglia pyroptosis via hsp90/hsp70 in aged mice. |
2024-03-25 |
2024-03-28 |
mouse |
| Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Egge. Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. Journal of neuroscience research. vol 102. issue 3. 2024-03-22. PMID:38515329. |
here, to determine early changes in microglia gene expression, hippocampal microglia from male appswe/ps1de9 (app/ps1) mice and wild-type littermates were isolated and analyzed by rna sequencing (rna-seq). |
2024-03-22 |
2024-03-24 |
mouse |
| Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Egge. Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. Journal of neuroscience research. vol 102. issue 3. 2024-03-22. PMID:38515329. |
by bulk rna-seq, transcriptomic changes were detected in hippocampal microglia from 6-months-old app/ps1 mice. |
2024-03-22 |
2024-03-24 |
mouse |
| Heng-Cai Wang, Wei Yang, Ling Xu, Yong-Hui Han, Yi Lin, Cui-Tao Lu, Kwonseop Kim, Ying-Zheng Zhao, Xi-Chong Y. BV2 Membrane-coated PEGylated-liposomes Delivered hFGF21 to Cortical and Hippocampal Microglia for Alzheimer's Disease Therapy. Advanced healthcare materials. 2024-03-21. PMID:38513154. |
bv2 membrane-coated pegylated-liposomes delivered hfgf21 to cortical and hippocampal microglia for alzheimer's disease therapy. |
2024-03-21 |
2024-03-24 |
Not clear |
| Elena Di Martino, Anoop Ambikan, Daniel Ramsköld, Takashi Umekawa, Sarantis Giatrellis, Davide Vacondio, Alejandro Lastra Romero, Marta Gómez Galán, Rickard Sandberg, Ulrika Ådén, Volker M Lauschke, Ujjwal Neogi, Klas Blomgren, Julianna Kel. Inflammatory, metabolic, and sex-dependent gene-regulatory dynamics of microglia and macrophages in neonatal hippocampus after hypoxia-ischemia. iScience. vol 27. issue 4. 2024-03-19. PMID:38500830. |
inflammatory, metabolic, and sex-dependent gene-regulatory dynamics of microglia and macrophages in neonatal hippocampus after hypoxia-ischemia. |
2024-03-19 |
2024-03-21 |
Not clear |
| Seyedeh Naghmeh Nourirad, Amhr-Hossein Bayat, Moitaba Sani, Amirreza Beirami, Maral Hasanzadeh, Susan Roustaee, Mobina Fathi, Kimia Vakili, Siavash Parvardeh, Gholam Hossein Meftahi, Nahid Sarahian, Fariba Khodagholi, Abbas Aliaghaei, Hojjat-Allah Abbaszadeh, Meysam Hassani Moghadda. Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study. Behavioural brain research. 2024-03-18. PMID:38499158. |
also, in addition to an increase in expression of caspase-3 in the hippocampus, which indicates the susceptibility to apoptosis in ldx-treated rats, the number of microglia and astrocytes went up significantly in the ldx group. |
2024-03-18 |
2024-03-21 |
rat |
| Seyedeh Naghmeh Nourirad, Amhr-Hossein Bayat, Moitaba Sani, Amirreza Beirami, Maral Hasanzadeh, Susan Roustaee, Mobina Fathi, Kimia Vakili, Siavash Parvardeh, Gholam Hossein Meftahi, Nahid Sarahian, Fariba Khodagholi, Abbas Aliaghaei, Hojjat-Allah Abbaszadeh, Meysam Hassani Moghadda. Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study. Behavioural brain research. 2024-03-18. PMID:38499158. |
moreover, sholl's analysis showed an increase in the soma size and total process length in both hippocampal astrocytes and microglia. |
2024-03-18 |
2024-03-21 |
rat |
| Alifiya Kapasi, Lei Yu, Sue E Leurgans, Sonal Agrawal, Patricia A Boyle, David A Bennett, Julie A Schneide. Association between hippocampal microglia, AD and LATE-NC, and cognitive decline in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-03-18. PMID:38494787. |
association between hippocampal microglia, ad and late-nc, and cognitive decline in older adults. |
2024-03-18 |
2024-03-20 |
Not clear |
| Alifiya Kapasi, Lei Yu, Sue E Leurgans, Sonal Agrawal, Patricia A Boyle, David A Bennett, Julie A Schneide. Association between hippocampal microglia, AD and LATE-NC, and cognitive decline in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-03-18. PMID:38494787. |
this study investigates the relationship between microglia inflammation in the hippocampus, brain pathologies, and cognitive decline. |
2024-03-18 |
2024-03-20 |
Not clear |
| Zheng Liang, Xiaokang Gong, Yang Zhao, Yanna Zhao, Jing Yu, Tiantian Huang, Chaoqing Yang, Liangwei Wu, Mengbing Huang, Xiaochuan Wang, Xiji Shu, Jian Ba. Long-Term High-Fat Diet Consumption Aggravates β-Amyloid Deposition and Tau Pathology Accompanied by Microglial Activation in an Alzheimer's Disease Model. Molecular nutrition & food research. 2024-03-16. PMID:38491393. |
within the hippocampus, microglia exhibit aberrant morphology and lipid accretion in response to the hfd, evidenced by conspicuously enlarged microglial cell bodies and accumulation of lipid droplets. |
2024-03-16 |
2024-03-19 |
mouse |
| Kohei Takahashi, Minoru Tsuji, Osamu Nakagawasai, Soh Katsuyama, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Hiroshi Takeda, Takeshi Tadan. Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction. Neurochemistry international. 2024-03-15. PMID:38490486. |
polarization to m1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction. |
2024-03-15 |
2024-03-18 |
mouse |
| Deyue Li, Qiao Zhang, Xia Yang, Guoqing Zhang, Jinping Wang, Rong Zhang, Yong Li. Microglial AT1R conditional knockout ameliorates hypoperfusive cognitive impairment by reducing microglial inflammatory responses. Neuroscience. 2024-03-14. PMID:38484837. |
the levels of at1r were increased in the hippocampus and the hippocampal microglia after cch induction. |
2024-03-14 |
2024-03-17 |
Not clear |
| Khaled S Abd-Elrahman, Tash-Lynn L Colson, Shaarika Sarasija, Stephen S G Ferguso. A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer's mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 173. 2024-03-09. PMID:38460371. |
we find that vu0486846 reduces the presence of iba1-positive microglia and gfap-positive astrocytes in the hippocampus of female app/ps1 mice and limits the recruitment of these cells to remaining aβ plaques. |
2024-03-09 |
2024-03-12 |
mouse |
| Shunta Goto, Natsuki Kojima, Miyu Komori, Noe Kawade, Kenzi Oshima, Daita Nadano, Nobumitsu Sasaki, Fumihiko Horio, Tsukasa Matsuda, Shinji Miyat. Vitamin C deficiency alters the transcriptome of the rat brain in a glucocorticoid-dependent manner, leading to microglial activation and reduced neurogenesis. The Journal of nutritional biochemistry. 2024-03-08. PMID:38458474. |
the morphological activation of microglia was accompanied by increased expression of proinflammatory cytokines such as interleukin-6 in the hippocampus. |
2024-03-08 |
2024-03-11 |
rat |
| Ethan J Goodman, Rebecca G Biltz, Jonathan M Packer, Damon J DiSabato, Samuel P Swanson, Braeden Oliver, Ning Quan, John F Sheridan, Jonathan P Godbou. Enhanced fear memory after social defeat in mice is dependent on interleukin-1 receptor signaling in glutamatergic neurons. Molecular psychiatry. 2024-03-08. PMID:38459193. |
because il-1β rna was prominent in the hippocampus after rsd even with microglia depletion, il-1r1 mediated signaling in glutamatergic neurons was assessed using neuronal vglut2 |
2024-03-08 |
2024-03-11 |
mouse |
| Danira Toral-Rios, Justin M Long, Jason D Ulrich, Jinsheng Yu, Michael R Strickland, Xianlin Han, David M Holtzman, Anil G Cashikar, Steven M Pau. Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. The Journal of experimental medicine. vol 221. issue 4. 2024-03-05. PMID:38442267. |
transcriptomic analyses of bulk hippocampal tissue and single nuclei revealed that ch25h deficiency in ps19 mice strongly suppressed proinflammatory signaling in microglia. |
2024-03-05 |
2024-03-08 |
mouse |
| Shanshan Tang, Wen Hu, Helin Zou, Qingyang Luo, Wenwen Deng, Song Ca. The complement system: a potential target for the comorbidity of chronic pain and depression. The Korean journal of pain. 2024-03-04. PMID:38433474. |
the primary potential mechanisms encompass the involvement of the complement cascade c1q/c3-cr3 in the activation of microglia and synaptic pruning in the amygdala and hippocampus, the role of complement cascade c3/c3a-c3ar in the interaction between astrocytes and microglia, leading to synaptic pruning, and the c3a-c3ar axis and c5a-c5ar axis to trigger inflammation within the central nervous system. |
2024-03-04 |
2024-03-06 |
Not clear |
| Irena Majkutewicz, Ewelina Kurowska-Rucińska, Jan Ruciński, Dorota Myślińska, Beata Grembecka, Jagoda Mantej, Katarzyna P Dzi. Diverse Efficacy of Dimethyl Fumarate in Alleviating the Late Streptozotocin-Induced Cognitive Impairment and Neuropathological Features in Rat. Molecular neurobiology. 2024-03-02. PMID:38430351. |
spatial memory was assessed with morris water maze (mwm), general brain level of amyloid β (aβ) and p-tau was measured by western blot, immunofluorescent labelling of active microglia (iba1), aβ and p-tau and histological assay of neurodegeneration (fluoro-jade c) were performed in hippocampus and cortex. |
2024-03-02 |
2024-03-04 |
human |
| Janna B Hart, Robert K Poon, Robert E Ward, Korry J Hintze, Sara M Freema. Effects of Dietary Fiber on Short Chain Fatty Acid Receptor mRNA in Microglia and Serotonergic Neurons in the Mouse Brain. Neuroscience. 2024-03-02. PMID:38431042. |
we found high colocalization of scfa receptors in both microglia and serotonergic neurons and discovered that scfa receptor expression in the dorsal raphe is driven by fiber solubility, while scfa receptor expression in the hippocampus is driven by fiber amount. |
2024-03-02 |
2024-03-06 |
mouse |
| Rademene S Oria, Godson E Anyanwu, Johnson N Nto, James O Ikp. Curcumin abrogates cobalt-induced neuroinflammation by suppressing proinflammatory cytokines release, inhibiting microgliosis and modulation of ERK/MAPK signaling pathway. Journal of chemical neuroanatomy. 2024-03-01. PMID:38428651. |
results revealed a significant (p<0.05) elevation in the tissue level of tnfα and il-1β, an increase in the number of iba1-positive microglia, and upregulation of erk protein in the hippocampal subfields of the rats after exposure to cobalt-only. |
2024-03-01 |
2024-03-04 |
rat |