| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiuxia Wan, Lufeng Xu, Yulong B. Effects of Dexmedetomidine combined with Dezocine on cognition function and hippocampal microglia activation of rats. International journal of clinical and experimental medicine. vol 7. issue 9. 2014-10-30. PMID:25356140. |
effects of dexmedetomidine combined with dezocine on cognition function and hippocampal microglia activation of rats. |
2014-10-30 |
2023-08-13 |
rat |
| Qiuxia Wan, Lufeng Xu, Yulong B. Effects of Dexmedetomidine combined with Dezocine on cognition function and hippocampal microglia activation of rats. International journal of clinical and experimental medicine. vol 7. issue 9. 2014-10-30. PMID:25356140. |
this study aimed to investigate the effects of dexmedetomidine combined with dezocine on the cognition and hippocampal microglia activation of rats. |
2014-10-30 |
2023-08-13 |
rat |
| Miklós Sárvári, Imre Kalló, Erik Hrabovszky, Norbert Solymosi, Zsolt Liposit. Ovariectomy and subsequent treatment with estrogen receptor agonists tune the innate immune system of the hippocampus in middle-aged female rats. PloS one. vol 9. issue 2. 2014-10-14. PMID:24551115. |
the innate immune system including microglia has a major contribution to maintenance of the physiological functions of the hippocampus by permanent monitoring of the neural milieu and elimination of tissue-damaging threats. |
2014-10-14 |
2023-08-12 |
rat |
| Miklós Sárvári, Imre Kalló, Erik Hrabovszky, Norbert Solymosi, Zsolt Liposit. Ovariectomy and subsequent treatment with estrogen receptor agonists tune the innate immune system of the hippocampus in middle-aged female rats. PloS one. vol 9. issue 2. 2014-10-14. PMID:24551115. |
in ovariectomized female rats, estradiol replacement exerts potent immunomodulatory effects including attenuation of microglia sensitization, initiation of m2-like activation and modulation of complement expression by targeting hippocampal neurons and glial cells through erα and erβ. |
2014-10-14 |
2023-08-12 |
rat |
| Tzu-Yu Lin, Wei-Jan Huang, Chia-Chan Wu, Cheng-Wei Lu, Su-Jane Wan. Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats. PloS one. vol 9. issue 2. 2014-10-13. PMID:24520409. |
in a kainic acid (ka) rat model, an animal model used for excitotoxic neurodegeneration experiments, acacetin (10 or 50 mg/kg) was administrated intraperitoneally to the rats 30 min before the ka (15 mg/kg) intraperitoneal injection, and subsequently induced the attenuation of ka-induced neuronal cell death and microglia activation in the ca3 region of the hippocampus. |
2014-10-13 |
2023-08-12 |
rat |
| Matthew G Frank, Sarah A Hershman, Michael D Weber, Linda R Watkins, Steven F Maie. Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus. Psychoneuroendocrinology. vol 40. 2014-10-09. PMID:24485491. |
chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces nlrp3 mrna in the hippocampus. |
2014-10-09 |
2023-08-12 |
rat |
| Matthew G Frank, Sarah A Hershman, Michael D Weber, Linda R Watkins, Steven F Maie. Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus. Psychoneuroendocrinology. vol 40. 2014-10-09. PMID:24485491. |
after 10 days of cort exposure, whole hippocampus was collected and expression of glial activation markers measured or hippocampal microglia were isolated and challenged with lps to probe for cort-induced sensitization of pro-inflammatory responses. |
2014-10-09 |
2023-08-12 |
rat |
| Amanda Sierra, Sol Beccari, Irune Diaz-Aparicio, Juan M Encinas, Samuel Comeau, Marie-Ève Trembla. Surveillance, phagocytosis, and inflammation: how never-resting microglia influence adult hippocampal neurogenesis. Neural plasticity. vol 2014. 2014-10-06. PMID:24772353. |
surveillance, phagocytosis, and inflammation: how never-resting microglia influence adult hippocampal neurogenesis. |
2014-10-06 |
2023-08-13 |
Not clear |
| Amanda Sierra, Sol Beccari, Irune Diaz-Aparicio, Juan M Encinas, Samuel Comeau, Marie-Ève Trembla. Surveillance, phagocytosis, and inflammation: how never-resting microglia influence adult hippocampal neurogenesis. Neural plasticity. vol 2014. 2014-10-06. PMID:24772353. |
here, we will review the roles of microglia in adult hippocampal neurogenesis and their regulation by inflammation during chronic stress, aging, and neurodegenerative diseases, with a particular emphasis on their underlying molecular mechanisms and their functional consequences for learning and memory. |
2014-10-06 |
2023-08-13 |
Not clear |
| Lasse Dissing-Olesen, Jeffrey M LeDue, Ravi L Rungta, Jasmin K Hefendehl, Hyun B Choi, Brian A MacVica. Activation of neuronal NMDA receptors triggers transient ATP-mediated microglial process outgrowth. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 32. 2014-10-03. PMID:25100586. |
we used acute mouse hippocampal brain slices and two-photon laser scanning microscopy to study microglial dynamics and developed a novel protocol for fixation and immunolabeling of microglia processes. |
2014-10-03 |
2023-08-13 |
mouse |
| Tuo Ma, Kai Gong, Qiang Ao, Yufang Yan, Bo Song, Hongyun Huang, Xiufang Zhang, Yandao Gon. Intracerebral transplantation of adipose-derived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in Alzheimer's disease mice. Cell transplantation. vol 22 Suppl 1. 2014-10-02. PMID:24070198. |
it was observed that in both regions of the hippocampus and the cortex there were more activated microglia, which preferentially surrounded and infiltrated into plaques after adsc transplantation. |
2014-10-02 |
2023-08-12 |
mouse |
| Nuria Vázquez-Villoldo, María Domercq, Abraham Martín, Jordi Llop, Vanessa Gómez-Vallejo, Carlos Matut. P2X4 receptors control the fate and survival of activated microglia. Glia. vol 62. issue 2. 2014-09-26. PMID:24254916. |
within the brain, microglia in the hippocampal dentate gyrus showed particular vulnerability to lps-induced neuroinflammation. |
2014-09-26 |
2023-08-12 |
rat |
| Yoshinori Hayashi, Hiroshi Nakanish. [Synaptic plasticity and synaptic reorganization regulated by microglia]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 33. issue 5-6. 2014-09-25. PMID:25069260. |
importantly, microglia secret glycine to enhance nmda receptor-mediated responses and hippocampal long-term potentiation, a cellular basis of learning and memory. |
2014-09-25 |
2023-08-13 |
Not clear |
| Xiaoxiao Wang, Di Hu, Lijia Zhang, Guoning Lian, Siqi Zhao, Chunming Wang, Jun Yin, Chunfu Wu, Jingyu Yan. Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 63. 2014-09-22. PMID:24211520. |
additionally, gomisin a alleviated the cell death of sh-sy5y neuroblastoma, rat primary cortical and hippocampal neurons induced by the conditioned-media from activated microglia. |
2014-09-22 |
2023-08-12 |
rat |
| Sung-Woon Hong, Hwon Heo, Jeong-hwa Yang, Maeum Han, Dong-Hyun Kim, Yunhee Kim Kwo. Soyasaponin I improved neuroprotection and regeneration in memory deficient model rats. PloS one. vol 8. issue 12. 2014-09-11. PMID:24324703. |
soya-Ι also increased brdu incorporation into the dentate gyrus and the number of cell types (gad67, chat, and vglut1) in the hippocampal region of memory-deficient rats, whereas the number of reactive microglia (ox42) decreased. |
2014-09-11 |
2023-08-12 |
rat |
| Ulrika Beitnere, Thomas van Groen, Ashish Kumar, Baiba Jansone, Vija Klusa, Inga Kadis. Mildronate improves cognition and reduces amyloid-β pathology in transgenic Alzheimer's disease mice. Journal of neuroscience research. vol 92. issue 3. 2014-09-10. PMID:24273007. |
the data show that mildronate treatment significantly improved animal performance in water maze and social recognition tests, lowered amyloid-β deposition in the hippocampus, increased expression of the microglia marker iba-1, and decreased ache staining, although it did not alter expression of proteins involved in synaptic plasticity (gap-43, synaptophysin, and gad67). |
2014-09-10 |
2023-08-12 |
mouse |
| Huaibo Wang, Weitao Guo, Hongliang Liu, Rong Zeng, Mingnan Lu, Ziqiu Chen, Qixian Xia. Inhibition of inflammatory mediator release from microglia can treat ischemic/hypoxic brain injury. Neural regeneration research. vol 8. issue 13. 2014-09-10. PMID:25206410. |
immunofluorescence staining revealed that during ischemia/hypoxia, the p2x4 receptor, p2x7 receptor, interleukin-1α and interleukin-1β expression was detectable in rat hippocampal microglia, but only p2x4 receptor and p2x7 receptor expression was detected in astrocytes. |
2014-09-10 |
2023-08-13 |
rat |
| Huaibo Wang, Weitao Guo, Hongliang Liu, Rong Zeng, Mingnan Lu, Ziqiu Chen, Qixian Xia. Inhibition of inflammatory mediator release from microglia can treat ischemic/hypoxic brain injury. Neural regeneration research. vol 8. issue 13. 2014-09-10. PMID:25206410. |
results suggested that the p2x4 receptor and p2x7 receptor, respectively, mediated interleukin-1α and interleukin-1β released by microglia, resulting in hippocampal ischemic/hypoxic injury. |
2014-09-10 |
2023-08-13 |
rat |
| Sung Min Nam, Yo Na Kim, Dae Young Yoo, Sun Shin Yi, Jung Hoon Choi, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoo. Hypothyroidism affects astrocyte and microglial morphology in type 2 diabetes. Neural regeneration research. vol 8. issue 26. 2014-09-10. PMID:25206556. |
in the present study, we investigated the effects of hypothyroidism on the morphology of astrocytes and microglia in the hippocampus of zucker diabetic fatty rats and zucker lean control rats. |
2014-09-10 |
2023-08-13 |
rat |
| Lei Song, Yue Gu, Jing Jie, Xiaoxue Bai, Ying Yang, Chaoying Liu, Qun Li. Dab2 attenuates brain injury in APP/PS1 mice via targeting transforming growth factor-beta/SMAD signaling. Neural regeneration research. vol 9. issue 1. 2014-09-10. PMID:25206742. |
after dab2 expression, hippocampal tβrii and p-smad2/3 levels were significantly increased, while amyloid-beta deposition, microglia activation, tumor necrosis factor-α and interleulin-6 levels and neuronal loss were significantly attenuated in app/ps1 mouse brain tissue. |
2014-09-10 |
2023-08-13 |
mouse |