| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyo Geun Kim, Ji-Young Kim, Wei-Wan Whang, Myung Sook O. Neuroprotective effect of Chunghyuldan from amyloid beta oligomer induced neuroinflammation in vitro and in vivo. Canadian journal of physiology and pharmacology. vol 92. issue 6. 2015-08-31. PMID:24820962. |
in an in-vivo ad model, administration of chd (50 mg·(kg body mass)(-1), for 5 days, per oral) inhibited the activation of astrocytes and microglia in the dentate gyrus and neuronal damage in the ca1 of the ipsilateral hippocampus. |
2015-08-31 |
2023-08-13 |
rat |
| Silke Smolders, Sophie M T Smolders, Nina Swinnen, Annette Gärtner, Jean-Michel Rigo, Pascal Legendre, Bert Brôn. Maternal immune activation evoked by polyinosinic:polycytidylic acid does not evoke microglial cell activation in the embryo. Frontiers in cellular neuroscience. vol 9. 2015-08-24. PMID:26300736. |
microglial cell density and activation level in the fetal cortex and hippocampus were determined. |
2015-08-24 |
2023-08-13 |
mouse |
| Caroline I Schnegg, Dana Greene-Schloesser, Mitra Kooshki, Valerie S Payne, Fang-Chi Hsu, Mike E Robbin. The PPARδ agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation. Free radical biology & medicine. vol 61. 2015-08-21. PMID:23499837. |
dietary gw0742 prevented the acute increase in il-1β mrna and erk phosphorylation measured at 3h after a single 10-gy dose of wbi; it also prevented the increase in the number of activated hippocampal microglia 1 week after wbi. |
2015-08-21 |
2023-08-12 |
mouse |
| Caroline I Schnegg, Dana Greene-Schloesser, Mitra Kooshki, Valerie S Payne, Fang-Chi Hsu, Mike E Robbin. The PPARδ agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation. Free radical biology & medicine. vol 61. 2015-08-21. PMID:23499837. |
pparδ ko mice exhibited defects including decreased numbers of astrocytes in the dentate gyrus/hilus of the hippocampus and a failure to exhibit a radiation-induced increase in activated hippocampal microglia. |
2015-08-21 |
2023-08-12 |
mouse |
| Juhwan Kim, Miyoung Yang, Yeonghoon Son, Hyosun Jang, Dongwoo Kim, Jong-Choon Kim, Sung-Ho Kim, Man-Jong Kang, Heh-In Im, Taekyun Shin, Changjong Moo. Glial activation with concurrent up-regulation of inflammatory mediators in trimethyltin-induced neurotoxicity in mice. Acta histochemica. vol 116. issue 8. 2015-08-20. PMID:25265880. |
the present study assessed tmt-induced glial cell activation and inflammatory cytokine alterations in the mouse hippocampus, bv-2 microglia, and primary cultured astrocytes. |
2015-08-20 |
2023-08-13 |
mouse |
| Yu-Wen Hung, Shao-Wen Hung, Yi-Chen Wu, Lin-King Wong, Ming-Tsong Lai, Yang-Hsin Shih, Tzong-Shyuan Lee, Yung-Yang Li. Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. Brain, behavior, and immunity. vol 43. 2015-08-07. PMID:25135858. |
in the hippocampus of wt mice, seh was mainly expressed in astrocytes (gfap(+)), neurons (neun(+)) and scattered microglia (iba-1(+)) in the regions of ca1, ca3 and dentate gyrus. |
2015-08-07 |
2023-08-13 |
mouse |
| Gisele Agustini Lovatel, Karine Bertoldi, Viviane Rostirola Elsnerb, Francele Valente Piazza, Carla Giovana Basso, Felipe Dos Santos Moysés, Paulo Valdeci Worm, Carlos Alexandre Netto, Simone Marcuzzo, Ionara Rodrigues Siqueir. Long-term effects of pre and post-ischemic exercise following global cerebral ischemia on astrocyte and microglia functions in hippocampus from Wistar rats. Brain research. vol 1587. 2015-07-17. PMID:25192647. |
long-term effects of pre and post-ischemic exercise following global cerebral ischemia on astrocyte and microglia functions in hippocampus from wistar rats. |
2015-07-17 |
2023-08-13 |
rat |
| Gisele Agustini Lovatel, Karine Bertoldi, Viviane Rostirola Elsnerb, Francele Valente Piazza, Carla Giovana Basso, Felipe Dos Santos Moysés, Paulo Valdeci Worm, Carlos Alexandre Netto, Simone Marcuzzo, Ionara Rodrigues Siqueir. Long-term effects of pre and post-ischemic exercise following global cerebral ischemia on astrocyte and microglia functions in hippocampus from Wistar rats. Brain research. vol 1587. 2015-07-17. PMID:25192647. |
in conclusion, postischemic exercise distinctly modulates astrocyte and microglia immunostaining in the hippocampal dentate gyrus following global cerebral ischemia in wistar rats. |
2015-07-17 |
2023-08-13 |
rat |
| Isabel Vieira de Assis Lima, Alline Cristina Campos, Aline Silva Miranda, Érica Leandro Marciano Vieira, Flávia Amaral-Martins, Juliana Priscila Vago, Rebeca Priscila de Melo Santos, Lirlândia Pires Sousa, Luciene Bruno Vieira, Mauro Martins Teixeira, Bernd L Fiebich, Márcio Flávio Dutra Moraes, Antonio Lucio Teixeira, Antonio Carlos Pinheiro de Oliveir. PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine. Experimental neurology. vol 267. 2015-07-06. PMID:25749189. |
we investigated the role of pi3kγ on seizures, production of neurotrophic and inflammatory mediators, expression of a marker for microglia, neuronal death and hippocampal neurogenesis in mice (wt and pi3kγ(-/-)) subjected to intrahippocampal microinjection of pilocarpine. |
2015-07-06 |
2023-08-13 |
mouse |
| Kyoung Hoon Jeong, Un Ju Jung, Sang Ryong Ki. Naringin Attenuates Autophagic Stress and Neuroinflammation in Kainic Acid-Treated Hippocampus In Vivo. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-06-30. PMID:26124853. |
moreover, naringin treatment protected hippocampal ca1 neurons in the ka-treated hippocampus, ameliorated ka-induced autophagic stress, confirmed by the expression of microtubule-associated protein light chain 3 (lc3), and attenuated an increase in tumor necrosis factor-α (tnfα) in activated microglia. |
2015-06-30 |
2023-08-13 |
mouse |
| Feng Xiao, Jun-Mei Xu, Xing-Hua Jian. CX3 chemokine receptor 1 deficiency leads to reduced dendritic complexity and delayed maturation of newborn neurons in the adult mouse hippocampus. Neural regeneration research. vol 10. issue 5. 2015-06-25. PMID:26109952. |
previous studies have shown that microglia impact the proliferation and differentiation of neurons during hippocampal neurogenesis via the fractalkine/cx3 chemokine receptor 1 (cx3cr1) signaling pathway. |
2015-06-25 |
2023-08-13 |
mouse |
| Feng Xiao, Jun-Mei Xu, Xing-Hua Jian. CX3 chemokine receptor 1 deficiency leads to reduced dendritic complexity and delayed maturation of newborn neurons in the adult mouse hippocampus. Neural regeneration research. vol 10. issue 5. 2015-06-25. PMID:26109952. |
however, whether microglia can influence the maturation and dendritic growth of newborn neurons during hippocampal neurogenesis remains unclear. |
2015-06-25 |
2023-08-13 |
mouse |
| Matthew J Kan, Jennifer E Lee, Joan G Wilson, Angela L Everhart, Candice M Brown, Andrew N Hoofnagle, Marilyn Jansen, Michael P Vitek, Michael D Gunn, Carol A Colto. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 15. 2015-06-18. PMID:25878270. |
areas of hippocampal neuronal death are associated with the presence of immunosuppressive cd11c(+) microglia and extracellular arginase, resulting in arginine catabolism and reduced levels of total brain arginine. |
2015-06-18 |
2023-08-13 |
mouse |
| Dennis Y Chuang, Jiankun Cui, Agnes Simonyi, Victoria A Engel, Shanyan Chen, Kevin L Fritsche, Andrew L Thomas, Wendy L Applequist, William R Folk, Dennis B Lubahn, Albert Y Sun, Grace Y Sun, Zezong G. Dietary Sutherlandia and elderberry mitigate cerebral ischemia-induced neuronal damage and attenuate p47phox and phospho-ERK1/2 expression in microglial cells. ASN neuro. vol 6. issue 6. 2015-06-12. PMID:25324465. |
immunohistochemical staining for ionized calcium-binding adapter molecule-1 demonstrated pronounced activation of microglia in the hippocampus and striatum in the ischemic brains 3 days after i/r, and microglial activation was significantly reduced in animals fed supplemented diets. |
2015-06-12 |
2023-08-13 |
mouse |
| Patrizia Ambrogini, Andrea Minelli, Claudia Galati, Michele Betti, Davide Lattanzi, Silvia Ciffolilli, Marta Piroddi, Francesco Galli, Riccardo Cuppin. Post-seizure α-tocopherol treatment decreases neuroinflammation and neuronal degeneration induced by status epilepticus in rat hippocampus. Molecular neurobiology. vol 50. issue 1. 2015-06-10. PMID:24488645. |
post-seizure α-t administration significantly reduced astrocytosis and microglia activation, and decreased neuron degeneration and spine loss; these effects were associated with the presence of a lowered lipid peroxidation in hippocampus. |
2015-06-10 |
2023-08-12 |
rat |
| Wai-Yu Li, Yi-Chun Chang, L Jyuhn-Hsiarn Lee, Li-Jen Le. Prenatal infection affects the neuronal architecture and cognitive function in adult mice. Developmental neuroscience. vol 36. issue 5. 2015-06-10. PMID:24942872. |
neonates born to these poly i:c-treated dams showed an increase of microglia in the hippocampus, indicating an activation of the immune system in the brains. |
2015-06-10 |
2023-08-13 |
mouse |
| Ronen Reshef, Tirzah Kreisel, Dorsa Beroukhim Kay, Raz Yirmiy. Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24933434. |
we report that the cx3cr1-deficient mice displayed better hippocampal-dependent memory functioning and olfactory recognition, along with increased number and soma size of hippocampal microglia, suggestive of mild activation status, but no changes in ob microglia. |
2015-06-09 |
2023-08-13 |
mouse |
| Ronen Reshef, Tirzah Kreisel, Dorsa Beroukhim Kay, Raz Yirmiy. Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24933434. |
in control mice, ee improved hippocampal-dependent memory and neurogenesis, and increased hippocampal microglia number and soma size, whereas odor enrichment (oe) improved olfactory recognition and ob neurogenesis without changing ob microglia status. |
2015-06-09 |
2023-08-13 |
mouse |
| Ronen Reshef, Tirzah Kreisel, Dorsa Beroukhim Kay, Raz Yirmiy. Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis. Brain, behavior, and immunity. vol 41. 2015-06-09. PMID:24933434. |
these results support the notion that in the hippocampus microglia and their interactions with neurons via the cx3cr1 play an important role in memory functioning and neurogenesis, whereas in the ob microglia do not seem to be involved in these processes. |
2015-06-09 |
2023-08-13 |
mouse |
| Karlijn J Doorn, Tim Moors, Benjamin Drukarch, Wilma Dj van de Berg, Paul J Lucassen, Anne-Marie van Da. Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients. Acta neuropathologica communications. vol 2. 2015-05-29. PMID:25099483. |
little is known, however, about the different phenotypes of microglia and how they change during disease progression, in the sn or in another brain region, like the hippocampus (hc), which is implicated in dementia and depression, important non-motor symptoms in pd. |
2015-05-29 |
2023-08-13 |
Not clear |