| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catrinel Girbovan, Hélène Plamondo. Resveratrol downregulates type-1 glutamate transporter expression and microglia activation in the hippocampus following cerebral ischemia reperfusion in rats. Brain research. vol 1608. 2015-12-24. PMID:25727173. |
on microglia and astrocyte activation and characterized glt-1 expression in the dentate gyrus (dg), ca1 and ca3 layers of the hippocampus 7 days following 10min global ischemia. |
2015-12-24 |
2023-08-13 |
rat |
| M Banerjee, V A Sasse, Y Wang, M Maulik, S Ka. Increased levels and activity of cathepsins B and D in kainate-induced toxicity. Neuroscience. vol 284. 2015-12-22. PMID:25307300. |
our results showed that systemic administration of kainic acid evoked severe loss of neurons along with hypertrophy of astrocytes and microglia in the hippocampus of the adult rat brain. |
2015-12-22 |
2023-08-13 |
human |
| Marie Lou Camara, Frances Corrigan, Emily J Jaehne, Magdalene C Jawahar, Helen Anscomb, Bernhard T Baun. Effects of centrally administered etanercept on behavior, microglia, and astrocytes in mice following a peripheral immune challenge. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 2. 2015-12-18. PMID:25103178. |
mice underwent behavioral analyses for locomotion, memory, and anxiety-like behavior 24 h post-etanercept/acsf treatment, and tissue was collected to estimate the numbers of hippocampal microglia and astrocytes. |
2015-12-18 |
2023-08-13 |
mouse |
| Marie Lou Camara, Frances Corrigan, Emily J Jaehne, Magdalene C Jawahar, Helen Anscomb, Bernhard T Baun. Effects of centrally administered etanercept on behavior, microglia, and astrocytes in mice following a peripheral immune challenge. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 2. 2015-12-18. PMID:25103178. |
a significant reduction in the number of microglia within the hippocampus of these mice was noted (two-way anova: interaction: f(1,15)=11.41, p=0.0041; saline/lps challenge: f(1,15)=50.13, p<0.0001, etanercept vs acsf: f(1,15)=3.36, p=0.08). |
2015-12-18 |
2023-08-13 |
mouse |
| Marie Lou Camara, Frances Corrigan, Emily J Jaehne, Magdalene C Jawahar, Helen Anscomb, Bernhard T Baun. Effects of centrally administered etanercept on behavior, microglia, and astrocytes in mice following a peripheral immune challenge. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 2. 2015-12-18. PMID:25103178. |
centrally administered etanercept improved anxiety-like behavior but not spatial memory under a peripheral immune challenge and was associated with a decrease in the hippocampal microglia numbers. |
2015-12-18 |
2023-08-13 |
mouse |
| J Y Xiong, S C Li, Y X Sun, X S Zhang, Z Z Dong, P Zhong, X R Su. Long-term treadmill exercise improves spatial memory of male APPswe/PS1dE9 mice by regulation of BDNF expression and microglia activation. Biology of sport. vol 32. issue 4. 2015-12-18. PMID:26681831. |
meanwhile, treadmill exercise significantly increased the number of bdnf-positive cells and decreased the ratios of activated microglia in both the cerebral cortex and the hippocampus. |
2015-12-18 |
2023-08-13 |
mouse |
| Tania Campos-Ordonez, David Zarate-Lopez, Alma Y Galvez-Contreras, Norma Moy-Lopez, Jorge Guzman-Muniz, Oscar Gonzalez-Pere. Cyclohexane produces behavioral deficits associated with astrogliosis and microglial reactivity in the adult hippocampus mouse brain. Cellular and molecular neurobiology. vol 35. issue 4. 2015-12-15. PMID:25433657. |
in summary, cyclohexane exposure produces functional deficits that are associated with an important increase in the ape1 expression as well as the number of astrocytes and microglia cells and their cytoplasmic complexity in the ca1 and ca3 regions of the adult hippocampus. |
2015-12-15 |
2023-08-13 |
mouse |
| S Q Cui, Q Wang, Y Zheng, B Xiao, H W Sun, X L Gu, Y C Zhang, C H Fu, P X Dong, X M Wan. Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 48. issue 6. 2015-12-15. PMID:25831201. |
six weeks after treatment, the morris water maze and tru scan behavioral tests and immunofluorescence staining of cerebral cortex and hippocampal neurons (by neu-n) and microglia (by ib1) were conducted. |
2015-12-15 |
2023-08-13 |
mouse |
| S Q Cui, Q Wang, Y Zheng, B Xiao, H W Sun, X L Gu, Y C Zhang, C H Fu, P X Dong, X M Wan. Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 48. issue 6. 2015-12-15. PMID:25831201. |
the number of microglia was increased in both the cortex and hippocampal dentate gyrus (p<0.01), and neurons were reduced only in the hippocampal dentate gyrus (p<0.01) in puerarin-treated mice. |
2015-12-15 |
2023-08-13 |
mouse |
| Suman K Guha, Rucha Tillu, Ankit Sood, Mandar Patgaonkar, Ishira N Nanavaty, Arjun Sengupta, Shobhona Sharma, Vidita A Vaidya, Sulabha Patha. Single episode of mild murine malaria induces neuroinflammation, alters microglial profile, impairs adult neurogenesis, and causes deficits in social and anxiety-like behavior. Brain, behavior, and immunity. vol 42. 2015-12-14. PMID:24953429. |
hippocampal microglia numbers were enhanced, and we noted a shift to an activated profile at this time point, accompanied by a striking redistribution of the microglia to the subgranular zone adjacent to hippocampal neuronal progenitors. |
2015-12-14 |
2023-08-13 |
mouse |
| Junjun Ni, Zhou Wu, Christoph Peterts, Kenji Yamamoto, Hong Qing, Hiroshi Nakanish. The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 36. 2015-12-14. PMID:26354916. |
ca-074me, a specific catb inhibitor, significantly inhibited the neuronal death of primary cultured hippocampal neurons induced by the conditioned medium from cultured microglia polarized in the neurotoxic phenotype. |
2015-12-14 |
2023-08-13 |
mouse |
| Verónica Abudara, Lisa Roux, Glenn Dallérac, Isabelle Matias, Jérôme Dulong, Jean Pierre Mothet, Nathalie Rouach, Christian Giaum. Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes. Glia. vol 63. issue 5. 2015-12-07. PMID:25643695. |
activated microglia impairs neuroglial interaction by opening cx43 hemichannels in hippocampal astrocytes. |
2015-12-07 |
2023-08-13 |
Not clear |
| Harold A Silverman, Meghan Dancho, Angelique Regnier-Golanov, Mansoor Nasim, Mahendar Ochani, Peder S Olofsson, Mohamed Ahmed, Edmund J Miller, Sangeeta S Chavan, Eugene Golanov, Christine N Metz, Kevin J Tracey, Valentin A Pavlo. Brain region-specific alterations in the gene expression of cytokines, immune cell markers and cholinergic system components during peripheral endotoxin-induced inflammation. Molecular medicine (Cambridge, Mass.). vol 20. 2015-12-01. PMID:25299421. |
however, iba1 (microglia marker) mrna expression was decreased in the cortex, hippocampus and other brain regions in parallel with morphological changes, indicating microglia activation. |
2015-12-01 |
2023-08-13 |
mouse |
| Judith M van der Harg, Leslie Eggels, Silvie R Ruigrok, Jeroen J M Hoozemans, Susanne E la Fleur, Wiep Schepe. Neuroinflammation is not a Prerequisite for Diabetes-induced Tau Phosphorylation. Frontiers in neuroscience. vol 9. 2015-11-30. PMID:26617484. |
remarkably, neither of the diabetic animal models showed reactive microglia or increased gfap and cox-2 levels in the cortex or hippocampus. |
2015-11-30 |
2023-08-13 |
rat |
| Ruth M Barrientos, Vanessa M Thompson, Meagan M Kitt, Jose Amat, Matthew W Hale, Matthew G Frank, Nicole Y Crysdale, Christopher E Stamper, Patrick A Hennessey, Linda R Watkins, Robert L Spencer, Christopher A Lowry, Steven F Maie. Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. Neurobiology of aging. vol 36. issue 3. 2015-11-24. PMID:25559333. |
greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. |
2015-11-24 |
2023-08-13 |
rat |
| Ruth M Barrientos, Vanessa M Thompson, Meagan M Kitt, Jose Amat, Matthew W Hale, Matthew G Frank, Nicole Y Crysdale, Christopher E Stamper, Patrick A Hennessey, Linda R Watkins, Robert L Spencer, Christopher A Lowry, Steven F Maie. Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. Neurobiology of aging. vol 36. issue 3. 2015-11-24. PMID:25559333. |
intracisternal administration of mifepristone, a gr antagonist, effectively reduced immune-activated proinflammatory responses, specifically from hippocampal microglia and prevented escherichia coli-induced memory impairments in aged rats. |
2015-11-24 |
2023-08-13 |
rat |
| Ruth M Barrientos, Vanessa M Thompson, Meagan M Kitt, Jose Amat, Matthew W Hale, Matthew G Frank, Nicole Y Crysdale, Christopher E Stamper, Patrick A Hennessey, Linda R Watkins, Robert L Spencer, Christopher A Lowry, Steven F Maie. Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. Neurobiology of aging. vol 36. issue 3. 2015-11-24. PMID:25559333. |
these data strongly suggest that increased gr activation in the aged hippocampus plays a critical role in sensitizing microglia. |
2015-11-24 |
2023-08-13 |
rat |
| Laura K Fonken, Matthew G Frank, Meagan M Kitt, Ruth M Barrientos, Linda R Watkins, Steven F Maie. Microglia inflammatory responses are controlled by an intrinsic circadian clock. Brain, behavior, and immunity. vol 45. 2015-11-17. PMID:25433170. |
hippocampal microglia isolated from adult rats rhythmically expressed inflammatory factors and circadian clock genes. |
2015-11-17 |
2023-08-13 |
rat |
| Beatriz Almolda, Carmen de Labra, Iliana Barrera, Agnès Gruart, Jose M Delgado-Garcia, Nàdia Villacampa, Antonietta Vilella, Markus J Hofer, Juan Hidalgo, Iain L Campbell, Berta González, Bernardo Castellan. Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10. Brain, behavior, and immunity. vol 45. 2015-11-17. PMID:25449577. |
our results showed that, in gfap-il10tg animals, microglia displayed an increase in density and a specific activated phenotype characterised by morphological changes in specific areas of the brain including the hippocampus, cortex and cerebellum that correlated with the level of transgene expressed il-10 mrna. |
2015-11-17 |
2023-08-13 |
mouse |
| Siriporn Chamniansawat, Sukumal Chongthammaku. Inhibition of hippocampal estrogen synthesis by reactive microglia leads to down-regulation of synaptic protein expression. Neurotoxicology. vol 46. 2015-11-12. PMID:25447322. |
inhibition of hippocampal estrogen synthesis by reactive microglia leads to down-regulation of synaptic protein expression. |
2015-11-12 |
2023-08-13 |
Not clear |