| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathleen Grabert, Tom Michoel, Michail H Karavolos, Sara Clohisey, J Kenneth Baillie, Mark P Stevens, Tom C Freeman, Kim M Summers, Barry W McCol. Microglial brain region-dependent diversity and selective regional sensitivities to aging. Nature neuroscience. vol 19. issue 3. 2016-07-07. PMID:26780511. |
in the young adult brain, differences in bioenergetic and immunoregulatory pathways were the major sources of heterogeneity and suggested that cerebellar and hippocampal microglia exist in a more immune-vigilant state. |
2016-07-07 |
2023-08-13 |
mouse |
| Sydney A Rowson, Constance S Harrell, Mandakh Bekhbat, Apoorva Gangavelli, Matthew J Wu, Sean D Kelly, Renuka Reddy, Gretchen N Neig. Neuroinflammation and Behavior in HIV-1 Transgenic Rats Exposed to Chronic Adolescent Stress. Frontiers in psychiatry. vol 7. 2016-07-06. PMID:27378953. |
microglia in female hiv-1 tg rats exhibited a hyper-ramified structure, and gene expression of complement factor b was increased in the hippocampus. |
2016-07-06 |
2023-08-13 |
rat |
| Markel Olabarria, Maria Putilina, Ellen C Riemer, James E Goldma. Astrocyte pathology in Alexander disease causes a marked inflammatory environment. Acta neuropathologica. vol 130. issue 4. 2016-06-28. PMID:26296699. |
we have studied the inflammatory response in the hippocampus and spinal cord of these mice and have found marked microglial activation, which follows that of astrocytes in a spatial pathological progression, as shown by increased levels of iba1 and microglial cell (iba1+) density. |
2016-06-28 |
2023-08-13 |
mouse |
| Feng Wang, Na Cui, Lijun Yang, Lin Shi, Qian Li, Gengshen Zhang, Jianliang Wu, Jun Zheng, Baohua Jia. Resveratrol Rescues the Impairments of Hippocampal Neurons Stimulated by Microglial Over-Activation In Vitro. Cellular and molecular neurobiology. vol 35. issue 7. 2016-06-24. PMID:25898934. |
conditioned medium (cm) from activated microglia treated by resveratrol directly protected primary cultured hippocampal neurons against lps-cm-induced neuronal death, and restored the inhibitory effects of lps-cm on dendrite sprouting and outgrowth. |
2016-06-24 |
2023-08-13 |
Not clear |
| Dusica Maysinger, Dominic Gröger, Andrew Lake, Kai Licha, Marie Weinhart, Philip K-Y Chang, Rose Mulvey, Rainer Haag, R Anne McKinne. Dendritic Polyglycerol Sulfate Inhibits Microglial Activation and Reduces Hippocampal CA1 Dendritic Spine Morphology Deficits. Biomacromolecules. vol 16. issue 9. 2016-06-10. PMID:26218295. |
herein, we investigate the response of microglia and changes in hippocampal dendritic postsynaptic spines by dendritic polyglycerol sulfate (dpgs) treatment. |
2016-06-10 |
2023-08-13 |
mouse |
| Dusica Maysinger, Dominic Gröger, Andrew Lake, Kai Licha, Marie Weinhart, Philip K-Y Chang, Rose Mulvey, Rainer Haag, R Anne McKinne. Dendritic Polyglycerol Sulfate Inhibits Microglial Activation and Reduces Hippocampal CA1 Dendritic Spine Morphology Deficits. Biomacromolecules. vol 16. issue 9. 2016-06-10. PMID:26218295. |
mouse microglia and organotypic hippocampal slices were exposed to dpgs and an inflammogen (lipopolysaccharides). |
2016-06-10 |
2023-08-13 |
mouse |
| Matthew J Bellizzi, Jasmine S Geathers, Kevin C Allan, Harris A Gelbar. Platelet-Activating Factor Receptors Mediate Excitatory Postsynaptic Hippocampal Injury in Experimental Autoimmune Encephalomyelitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 4. 2016-06-01. PMID:26818520. |
loss of postsynaptic structures was accompanied by appearance of psd95-positive debris that colocalized with the processes of activated microglia at 25 d after immunization, and clearance of debris was followed by persistently reduced synaptic density at 55 d. in vitro, addition of activated bv2 microglial cells to hippocampal cultures increased neuronal vulnerability to excitotoxic dendritic damage following a burst of synaptic activity in a manner dependent on platelet-activating factor receptor (pafr) signaling. |
2016-06-01 |
2023-08-13 |
mouse |
| Irena Baranowska-Bosiacka, Joanna Listos, Izabela Gutowska, Anna Machoy-Mokrzyńska, Agnieszka Kolasa-Wołosiuk, Maciej Tarnowski, Kamila Puchałowicz, Adam Prokopowicz, Sylwia Talarek, Piotr Listos, Agnieszka Wąsik, Dariusz Chlube. Effects of perinatal exposure to lead (Pb) on purine receptor expression in the brain and gliosis in rats tolerant to morphine analgesia. Toxicology. vol 339. 2016-05-23. PMID:26478469. |
the aim of the present study was to investigate the molecular effects of perinatal exposure to lead (pb) on protein and mrna expression of purine receptors: p2x4, p2x7, adenosine receptor a1; and astrocytes (gfap mrna expression) and on microglia activation (iba1 mrna expression) in several structures of the mesolimbic system (striatum, hippocampus, prefrontal cortex) in rats expressing tolerance to the antinociceptive effect of morphine. |
2016-05-23 |
2023-08-13 |
rat |
| Irena Baranowska-Bosiacka, Joanna Listos, Izabela Gutowska, Anna Machoy-Mokrzyńska, Agnieszka Kolasa-Wołosiuk, Maciej Tarnowski, Kamila Puchałowicz, Adam Prokopowicz, Sylwia Talarek, Piotr Listos, Agnieszka Wąsik, Dariusz Chlube. Effects of perinatal exposure to lead (Pb) on purine receptor expression in the brain and gliosis in rats tolerant to morphine analgesia. Toxicology. vol 339. 2016-05-23. PMID:26478469. |
strong expressions of p2x4, p2x7, a1 receptors, astrocytes and microglia activation were observed in the hippocampus in pb and/or morphine treated rats. |
2016-05-23 |
2023-08-13 |
rat |
| Ai-Guo Xuan, Yan Chen, Da-Hong Long, Meng Zhang, Wei-Dong Ji, Wen-Juan Zhang, Ji-Hong Liu, Le-Peng Hong, Xiao-Song He, Wen-Liang Che. PPARα Agonist Fenofibrate Ameliorates Learning and Memory Deficits in Rats Following Global Cerebral Ischemia. Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25241646. |
fenofibrate administration also inhibited gci/r-induced over-activation of microglia but not astrocytes and prevented up-regulations of pro-inflammatory mediators in hippocampus. |
2016-05-17 |
2023-08-13 |
rat |
| Jenni Neubert, Susanne Wagner, Jürgen Kiwit, Anja U Bräuer, Jana Glum. New findings about iron oxide nanoparticles and their different effects on murine primary brain cells. International journal of nanomedicine. vol 10. 2016-05-10. PMID:25792834. |
we exposed primary cell cultures of microglia and hippocampal neurons, as well as neuron-glia cocultures to varying concentrations of spios for 6 and/or 24 hours, respectively. |
2016-05-10 |
2023-08-13 |
Not clear |
| Abbie Chapman Johnson, Keith J Nagle, Sarah M Tremble, Marilyn J Cipoll. The Contribution of Normal Pregnancy to Eclampsia. PloS one. vol 10. issue 7. 2016-05-06. PMID:26218425. |
further, activation of microglia, a measure of neuroinflammation (n = 6-8/group), and gabaar δ- and γ2-subunit protein expression in the cerebral cortex and hippocampus (n = 6/group) was determined. |
2016-05-06 |
2023-08-13 |
rat |
| Abbie Chapman Johnson, Keith J Nagle, Sarah M Tremble, Marilyn J Cipoll. The Contribution of Normal Pregnancy to Eclampsia. PloS one. vol 10. issue 7. 2016-05-06. PMID:26218425. |
the % of active microglia was similar between groups; however, pregnancy was associated with downregulation of cortical gabaar-δ and hippocampal gabaar-γ2 expression. |
2016-05-06 |
2023-08-13 |
rat |
| V Porrini, A Lanzillotta, C Branca, M Benarese, E Parrella, L Lorenzini, L Calzà, R Flaibani, P F Spano, B P Imbimbo, M Pizz. CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid. Neuroscience. vol 302. 2016-04-26. PMID:25450955. |
these data show that chf5074 specifically drives the expression of microglia m2 markers either in young tg2576 hippocampus or in primary astrocyte-microglia cultures, suggesting its potential therapeutic efficacy as microglial modulator in the early phase of ad. |
2016-04-26 |
2023-08-13 |
mouse |
| Michael M Zeineh, Yuanxin Chen, Hagen H Kitzler, Robert Hammond, Hannes Vogel, Brian K Rut. Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease. Neurobiology of aging. vol 36. issue 9. 2016-04-25. PMID:26190634. |
activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in alzheimer disease. |
2016-04-25 |
2023-08-13 |
human |
| Barbara Rinaldi, Francesca Guida, Anna Furiano, Maria Donniacuo, Livio Luongo, Giulia Gritti, Konrad Urbanek, Giovanni Messina, Sabatino Maione, Francesco Rossi, Vito de Novelli. Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction. Neural plasticity. vol 2015. 2016-04-19. PMID:26266053. |
in this study we analyzed in sedentary and trained rats the microglia and astrocytes 48 hours after mi in pvn, thalamus, prefrontal cortex, and hippocampus through immunofluorescence approach. |
2016-04-19 |
2023-08-13 |
rat |
| Barbara Rinaldi, Francesca Guida, Anna Furiano, Maria Donniacuo, Livio Luongo, Giulia Gritti, Konrad Urbanek, Giovanni Messina, Sabatino Maione, Francesco Rossi, Vito de Novelli. Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction. Neural plasticity. vol 2015. 2016-04-19. PMID:26266053. |
prolonged exercise normalized these morphological changes of microglia and astrocytes in the prefrontal cortex, hippocampus, and thalamus but not in the pvn. |
2016-04-19 |
2023-08-13 |
rat |
| Shankar Sadasivan, Mark Zanin, Kevin O'Brien, Stacey Schultz-Cherry, Richard J Smeyn. Induction of microglia activation after infection with the non-neurotropic A/CA/04/2009 H1N1 influenza virus. PloS one. vol 10. issue 4. 2016-04-18. PMID:25861024. |
we did, however, observe a robust increase in microglial activity in the brain characterized by an increase in the number of activated iba-1-positive microglia in the substantia nigra (sn) and the hippocampus, despite the absence of virus in the brain. |
2016-04-18 |
2023-08-13 |
mouse |
| Lars Klapal, Birte A Igelhorst, Irmgard D Dietzel-Meye. Changes in Neuronal Excitability by Activated Microglia: Differential Na(+) Current Upregulation in Pyramid-Shaped and Bipolar Neurons by TNF-α and IL-18. Frontiers in neurology. vol 7. 2016-04-12. PMID:27065940. |
here, we demonstrate that the addition of 5% microglia activated by 1 μg/ml lipopolysaccharides (lps) to hippocampal cultures upregulates na(+) current densities (inavd) of bipolar as well as pyramid-shaped neurons, thereby increasing their excitability. |
2016-04-12 |
2023-08-13 |
Not clear |
| Lars Klapal, Birte A Igelhorst, Irmgard D Dietzel-Meye. Changes in Neuronal Excitability by Activated Microglia: Differential Na(+) Current Upregulation in Pyramid-Shaped and Bipolar Neurons by TNF-α and IL-18. Frontiers in neurology. vol 7. 2016-04-12. PMID:27065940. |
preincubation of hippocampal cultures with 10 ng/ml tumor necrosis factor-α (tnf-α), a major cytokine released by activated microglia, upregulated inavd significantly by ~30% in bipolar cells, whereas in pyramid-shaped cells, the upregulation only reached an increase of ~14%. |
2016-04-12 |
2023-08-13 |
Not clear |