| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siriporn Chamniansawat, Sukumal Chongthammaku. Inhibition of hippocampal estrogen synthesis by reactive microglia leads to down-regulation of synaptic protein expression. Neurotoxicology. vol 46. 2015-11-12. PMID:25447322. |
we hypothesize that activated microglia may inhibit de novo hippocampal estrogen synthesis and in turn suppress hippocampal synaptic protein expression. |
2015-11-12 |
2023-08-13 |
Not clear |
| Siriporn Chamniansawat, Sukumal Chongthammaku. Inhibition of hippocampal estrogen synthesis by reactive microglia leads to down-regulation of synaptic protein expression. Neurotoxicology. vol 46. 2015-11-12. PMID:25447322. |
exposure to either lps-activated microglia or il-6, significantly suppressed the expression of synaptic proteins and the secretion of de novo hippocampal estrogen in h19-7 hippocampal neurons. |
2015-11-12 |
2023-08-13 |
Not clear |
| Siriporn Chamniansawat, Sukumal Chongthammaku. Inhibition of hippocampal estrogen synthesis by reactive microglia leads to down-regulation of synaptic protein expression. Neurotoxicology. vol 46. 2015-11-12. PMID:25447322. |
in addition, lps-activated microglia also decreased the expression of estrogen receptors (erα and erβ) in h19-7 hippocampal neurons. |
2015-11-12 |
2023-08-13 |
Not clear |
| Siriporn Chamniansawat, Sukumal Chongthammaku. Inhibition of hippocampal estrogen synthesis by reactive microglia leads to down-regulation of synaptic protein expression. Neurotoxicology. vol 46. 2015-11-12. PMID:25447322. |
our findings demonstrate a potential mechanism of microglia activation underlying the reduction in estrogen-mediated signaling on synaptic proteins in hippocampal neurons, which may be involved in hippocampal-dependent memory formation. |
2015-11-12 |
2023-08-13 |
Not clear |
| Iris B Hovens, Barbara L van Leeuwen, Csaba Nyakas, Erik Heineman, Eddy A van der Zee, Regien G Schoemake. Postoperative cognitive dysfunction and microglial activation in associated brain regions in old rats. Neurobiology of learning and memory. vol 118. 2015-11-10. PMID:25460037. |
the number and morphology of microglia were analyzed in the hippocampus, prefrontal cortex, striatum and amygdala on postoperative day 14. |
2015-11-10 |
2023-08-13 |
rat |
| J R Perez-Polo, H C Rea, K M Johnson, M A Parsley, G C Unabia, G-Y Xu, D Prough, D S DeWitt, H Spratt, C E Hulsebosc. A rodent model of mild traumatic brain blast injury. Journal of neuroscience research. vol 93. issue 4. 2015-10-30. PMID:25410497. |
there were significant inflammatory responses in the cortex, hippocampus, thalamus, and amygdala 6 hr after mbbi, as evidenced by increased levels of the inflammatory markers associated with activation of microglia and macrophages, ionized calcium binding adaptor 1 (iba1), impairment of the blood-brain barrier, and significant neuronal losses. |
2015-10-30 |
2023-08-13 |
human |
| Vasiliki Kyrargyri, Germán Vega-Flores, Agnès Gruart, José M Delgado-García, Lesley Prober. Differential contributions of microglial and neuronal IKKβ to synaptic plasticity and associative learning in alert behaving mice. Glia. vol 63. issue 4. 2015-10-29. PMID:25297800. |
our results show that microglia, through ikkβ and therefore nf-κb activity, regulate hippocampal synaptic plasticity and that both microglia and neurons, through ikkβ, are necessary for animals to modify hippocampus-driven behavior during associative learning. |
2015-10-29 |
2023-08-13 |
mouse |
| Kangning Xu, Yufen Zhang, Yan Wang, Peng Ling, Xin Xie, Chenyao Jiang, Zhizhen Zhang, Xiao-Yuan Lia. Ginseng Rb fraction protects glia, neurons and cognitive function in a rat model of neurodegeneration. PloS one. vol 9. issue 6. 2015-10-28. PMID:24971630. |
ka injection produced significant acute hippocampal injuries, including gad67-positive gabaergic interneuron loss in ca1, paralbumin (pv)-positive gabaergic interneuron loss, pyramidal neuron degeneration and astrocyte damage accompanied with reactive microglia in both ca1 and ca3 regions of the hippocampus. |
2015-10-28 |
2023-08-13 |
rat |
| Ji Xu, Hua Chai, Konstantin Ehinger, Terrance M Egan, Rahul Srinivasan, Manfred Frick, Baljit S Khak. Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin. The Journal of general physiology. vol 144. issue 1. 2015-10-19. PMID:24935743. |
p2x4-phluorin123 identified cell surface and intracellular fractions of receptors in hek-293 cells, hippocampal neurons, c8-b4 microglia, and alveolar type ii (atii) cells. |
2015-10-19 |
2023-08-13 |
mouse |
| Aarti Nagayach, Nisha Patro, Ishan Patr. Astrocytic and microglial response in experimentally induced diabetic rat brain. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24833555. |
such caspase 3 mediated cellular damage with a concomitant activation of the astrocytes and microglia suggests that diabetes linked cell death activates the astrocytes and microglia in hippocampus which further underpin the progression and severity of brain disorders resulting in cognitive and behavioural impairments. |
2015-10-16 |
2023-08-13 |
rat |
| Shohei Fukushima, Eriko Furube, Masanobu Itoh, Toshihiro Nakashima, Seiji Miyat. Robust increase of microglia proliferation in the fornix of hippocampal axonal pathway after a single LPS stimulation. Journal of neuroimmunology. vol 285. 2015-10-16. PMID:26198916. |
robust increase of microglia proliferation in the fornix of hippocampal axonal pathway after a single lps stimulation. |
2015-10-16 |
2023-08-13 |
mouse |
| Kyung-Il Park, Volodymyr Dzhala, Yero Saponjian, Kevin J Stale. What Elements of the Inflammatory System Are Necessary for Epileptogenesis In Vitro? eNeuro. vol 2. issue 2. 2015-10-14. PMID:26464976. |
here, we found that rodent hippocampal organotypic slice cultures depleted of t lymphocytes and microglia developed epileptic activity at essentially the same rate and to similar degrees of severity as matched control slice cultures. |
2015-10-14 |
2023-08-13 |
Not clear |
| Sooyong Kim, Il-Hwan Kang, Jung-Bum Nam, Yoonchul Cho, Doo-Young Chung, Seung-Hwan Kim, Jeong-Soo Kim, Yong-Deok Cho, Eun-Ki Hong, Nak-Won Sohn, Jung-Won Shi. Ameliorating the effect of astragaloside IV on learning and memory deficit after chronic cerebral hypoperfusion in rats. Molecules (Basel, Switzerland). vol 20. issue 2. 2015-10-13. PMID:25625683. |
as-iv also significantly reduced 8-hydroxy-2'-deoxyguanosine expression, a maker of oxidative dna damage, while significantly inhibited the astrocyte and microglia activation in the hippocampus. |
2015-10-13 |
2023-08-13 |
rat |
| Katja Horling, Gudrun Schlegel, Sarah Schulz, Ricardo Vierk, Kurt Ullrich, René Santer, Gabriele M Run. Hippocampal synaptic connectivity in phenylketonuria. Human molecular genetics. vol 24. issue 4. 2015-09-22. PMID:25296915. |
most importantly, in the hippocampus of pah(enu2)/c57bl6 mice, we found a significant reduction in microglia activity. |
2015-09-22 |
2023-08-13 |
mouse |
| Katja Horling, Gudrun Schlegel, Sarah Schulz, Ricardo Vierk, Kurt Ullrich, René Santer, Gabriele M Run. Hippocampal synaptic connectivity in phenylketonuria. Human molecular genetics. vol 24. issue 4. 2015-09-22. PMID:25296915. |
reorganization of hippocampal circuitry after birth, namely synaptic pruning, relies on elimination of weak synapses by activated microglia in response to neuronal activity. |
2015-09-22 |
2023-08-13 |
mouse |
| Rachel A Rice, Elizabeth E Spangenberg, Hana Yamate-Morgan, Rafael J Lee, Rajan P S Arora, Michael X Hernandez, Andrea J Tenner, Brian L West, Kim N Gree. Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 27. 2015-09-22. PMID:26156998. |
elimination of microglia improves functional outcomes following extensive neuronal loss in the hippocampus. |
2015-09-22 |
2023-08-13 |
mouse |
| Hui-Lin Wang, Rui-Hua Ma, Hao Fang, Zhang-Gang Xue, Qing-Wu Lia. Impaired Spatial Learning Memory after Isoflurane Anesthesia or Appendectomy in Aged Mice is Associated with Microglia Activation. Journal of cell death. vol 8. 2015-09-18. PMID:26380557. |
hippocampal microglia activation and il-1β, tnf-α, and ifn-γ expression were also evaluated at day 3, day 14 and day 28 after iso exposure or appendectomy. |
2015-09-18 |
2023-08-13 |
mouse |
| Hui-Lin Wang, Rui-Hua Ma, Hao Fang, Zhang-Gang Xue, Qing-Wu Lia. Impaired Spatial Learning Memory after Isoflurane Anesthesia or Appendectomy in Aged Mice is Associated with Microglia Activation. Journal of cell death. vol 8. 2015-09-18. PMID:26380557. |
results showed that spatial learning memory of aged, but not adult, mice was impaired after iso exposure or appendectomy, accompanied with more hippocampal microglia activation and il-1β, tnf-α, and ifn-γ overexpression. |
2015-09-18 |
2023-08-13 |
mouse |
| Hui-Lin Wang, Rui-Hua Ma, Hao Fang, Zhang-Gang Xue, Qing-Wu Lia. Impaired Spatial Learning Memory after Isoflurane Anesthesia or Appendectomy in Aged Mice is Associated with Microglia Activation. Journal of cell death. vol 8. 2015-09-18. PMID:26380557. |
these findings suggest that the cognitive deficits of elderly patients who have undergone surgeries are quite possibly caused by hippocampal microglia overactivation and the subsequent inflammation. |
2015-09-18 |
2023-08-13 |
mouse |
| Maya E Woodbury, Robert W Freilich, Christopher J Cheng, Hirohide Asai, Seiko Ikezu, Jonathan D Boucher, Frank Slack, Tsuneya Ikez. miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 26. 2015-09-15. PMID:26134658. |
moreover, mice with transgenic elevated expression of mir-155 in nestin-positive neural and hematopoietic stem cells, including microglia, show increased cell proliferation and ectopically localized doublecortin-positive immature neurons and radial glia-like cells in the hippocampal dentate gyrus (dg) granular cell layer. |
2015-09-15 |
2023-08-13 |
mouse |