| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Le, Shuli Liu, Mingchao Peng, Chang Tan, Qin Liao, Kaiming Duan, Wen Ouyang, Jianbin Ton. Aging differentially affects the loss of neuronal dendritic spine, neuroinflammation and memory impairment at rats after surgery. PloS one. vol 9. issue 9. 2015-05-28. PMID:25198176. |
we found that (1) in young adult rats, the memory was not significantly affected (p>0.05) 1d, 3d and 7d after partial hepatectomy, but was significantly impaired (p<0.001) in aged rats 1d and 3d post-surgery; (2) in young adult rats, the surgery did not significantly affect the densities of dendritic spines of neurons at ca1, dentate gyrus (dg) and cingulate cortex (p>0.05, respectively) 1d and 3d post-surgery, but the spine densities at ca1 and dg of aged rats were significant reduced 1d and 3d post-surgery (p<0.001, respectively), however this didn't happen at cingulate cortex (p>0.05); (3) in young adult rats, surgery didn't affect the activation of microglia and levels of tnf-α and il-1β at hippocampus (p>0.05), but significantly activated microglia and increased levels of tnf-α and il-1β at hippocampus of aged rats (p<0.05). |
2015-05-28 |
2023-08-13 |
rat |
| Hui-Bin Chen, Fei Li, Shuai Wu, Shu-Cheng A. [Hippocampus quinolinic acid modulates glutamate and NMDAR/mGluR1 in chronic unpredictable mild stress-induced depression]. Sheng li xue bao : [Acta physiologica Sinica]. vol 65. issue 6. 2015-05-16. PMID:24343714. |
the results suggest that cums may contribute to the production and release of quin in hippocampal microglia. |
2015-05-16 |
2023-08-12 |
rat |
| Karlijn J Doorn, Benjamin Drukarch, Anne-Marie van Dam, Paul J Lucasse. Hippocampal proliferation is increased in presymptomatic Parkinson's disease and due to microglia. Neural plasticity. vol 2014. 2015-05-11. PMID:25197578. |
hippocampal proliferation is increased in presymptomatic parkinson's disease and due to microglia. |
2015-05-11 |
2023-08-13 |
human |
| Michael W Marlatt, Jan Bauer, Eleonora Aronica, Elise S van Haastert, Jeroen J M Hoozemans, Marian Joels, Paul J Lucasse. Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural plasticity. vol 2014. 2015-05-11. PMID:25215243. |
proliferation in the alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. |
2015-05-11 |
2023-08-13 |
Not clear |
| Michael W Marlatt, Jan Bauer, Eleonora Aronica, Elise S van Haastert, Jeroen J M Hoozemans, Marian Joels, Paul J Lucasse. Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural plasticity. vol 2014. 2015-05-11. PMID:25215243. |
thus, consistent with animal studies, proliferation in the ad hippocampus is due to microglia, occurs in close proximity of plaque pathology, and may contribute to the neuroinflammation common in ad. |
2015-05-11 |
2023-08-13 |
Not clear |
| So-Hee Lim, Eunha Park, Boram You, Youngseob Jung, A-Reum Park, Sung Goo Park, Jae-Ran Le. Neuronal synapse formation induced by microglia and interleukin 10. PloS one. vol 8. issue 11. 2015-05-08. PMID:24278397. |
when the developing microglia were applied to cultured hippocampal neurons without direct contact, the numbers of dendritic spines and excitatory and inhibitory synapses significantly increased. |
2015-05-08 |
2023-08-12 |
Not clear |
| So-Hee Lim, Eunha Park, Boram You, Youngseob Jung, A-Reum Park, Sung Goo Park, Jae-Ran Le. Neuronal synapse formation induced by microglia and interleukin 10. PloS one. vol 8. issue 11. 2015-05-08. PMID:24278397. |
when interleukin 10 receptors on the hippocampal neurons were knocked down with specific shrna, the induction of synaptic formation by microglia and interleukin 10 disappeared. |
2015-05-08 |
2023-08-12 |
Not clear |
| So-Hee Lim, Eunha Park, Boram You, Youngseob Jung, A-Reum Park, Sung Goo Park, Jae-Ran Le. Neuronal synapse formation induced by microglia and interleukin 10. PloS one. vol 8. issue 11. 2015-05-08. PMID:24278397. |
in conclusion, the developing microglia regulated synaptic functions and neuronal development through the interactions of the interleukin 10 released from the microglia with interleukin 10 receptors expressed on the hippocampal neurons. |
2015-05-08 |
2023-08-12 |
Not clear |
| Kuo-Mao Lan, Lu-Tai Tien, Yi Pang, Abhay J Bhatt, Lir-Wan Fa. IL-1 receptor antagonist attenuates neonatal lipopolysaccharide-induced long-lasting learning impairment and hippocampal injury in adult rats. Toxicology letters. vol 234. issue 1. 2015-04-24. PMID:25665855. |
those neuropathological and neurobehavioral alterations by lps exposure were associated with a sustained inflammatory response in the p71 rat hippocampus, indicated by increased number of activated microglia as well as elevated levels of il-1β. |
2015-04-24 |
2023-08-13 |
rat |
| Juan A Orellana, Rodrigo Moraga-Amaro, Raúl Díaz-Galarce, Sebastián Rojas, Carola J Maturana, Jimmy Stehberg, Juan C Sáe. Restraint stress increases hemichannel activity in hippocampal glial cells and neurons. Frontiers in cellular neuroscience. vol 9. 2015-04-17. PMID:25883550. |
dye uptake experiments in hippocampal slices revealed that acute stress induces opening of both cx43 and panx1 hemichannels in astrocytes, which were further increased by chronic stress; whereas enhanced panx1 hemichannel activity was detected in microglia and neurons after acute/chronic and chronic stress, respectively. |
2015-04-17 |
2023-08-13 |
mouse |
| Patricia Rivera, Laura Bindila, Antoni Pastor, Margarita Pérez-Martín, Francisco J Pavón, Antonia Serrano, Rafael de la Torre, Beat Lutz, Fernando Rodríguez de Fonseca, Juan Suáre. Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context. Frontiers in cellular neuroscience. vol 9. 2015-04-14. PMID:25870539. |
cell proliferation (phospho-h3(+) or brdu(+) cells) of the main adult neurogenic zones as well as apoptosis (cleaved caspase-3(+)), astroglia (gfap(+)), and microglia (iba1(+) cells) were analyzed in the hippocampus, hypothalamus and striatum of rats intraperitoneally treated with urb597 (0.3 mg/kg/day) at one dose/4-days resting or 5 doses (1 dose/day). |
2015-04-14 |
2023-08-13 |
rat |
| Alison Spilsbury, Satomi Miwa, Johannes Attems, Gabriele Saretzk. The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 4. 2015-04-07. PMID:25632141. |
our data reveal that tert is expressed in vitro in mouse neurons and microglia, and in vivo in the cytoplasm of mature human hippocampal neurons and activated microglia, but is absent from astrocytes. |
2015-04-07 |
2023-08-13 |
mouse |
| In Koo Hwang, Jung Hoon Choi, Sung Min Nam, Ok Kyu Park, Dae Young Yoo, Woosuk Kim, Sun Shin Yi, Moo-Ho Won, Je Kyung Seong, Yeo Sung Yoo. Activation of microglia and induction of pro-inflammatory cytokines in the hippocampus of type 2 diabetic rats. Neurological research. vol 36. issue 9. 2015-03-30. PMID:24571083. |
activation of microglia and induction of pro-inflammatory cytokines in the hippocampus of type 2 diabetic rats. |
2015-03-30 |
2023-08-12 |
rat |
| Bartholomeus C M Benno Haarman, Rixt F Riemersma-Van der Lek, Jan Cees de Groot, Henricus G Eric Ruhé, Hans C Klein, Tjitske E Zandstra, Huibert Burger, Robert A Schoevers, Erik F J de Vries, Hemmo A Drexhage, Willem A Nolen, Janine Doordui. Neuroinflammation in bipolar disorder - A [(11)C]-(R)-PK11195 positron emission tomography study. Brain, behavior, and immunity. vol 40. 2015-03-30. PMID:24703991. |
we aim to determine if there is increased [(11)c]-(r)-pk11195 binding to activated microglia in the hippocampus of patients with bipolar i disorder when compared to healthy controls. |
2015-03-30 |
2023-08-13 |
Not clear |
| YuHong Fu, Zoltán Rusznák, John B J Kwok, Woojin Scott Kim, George Paxino. Age-dependent alterations of the hippocampal cell composition and proliferative potential in the hAβPPSwInd-J20 mouse. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787919. |
accordingly, early signs of ad include reduced cell proliferation, impaired neurogenesis, and increased activity of microglia in the hippocampus. |
2015-03-30 |
2023-08-13 |
mouse |
| Renée Marie Bogdanović, Stina Syvänen, Christina Michler, Vera Russmann, Jonas Eriksson, Albert D Windhorst, Adriaan A Lammertsma, Elisabeth C de Lange, Rob A Voskuyl, Heidrun Potschk. (R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model. Neuropharmacology. vol 85. 2015-03-30. PMID:24880085. |
in hippocampal sections, ed1 immunostaining argued against a general difference in microglia activation between both groups. |
2015-03-30 |
2023-08-13 |
rat |
| Hui Jin, Weixi Wang, Shanshan Zhao, Weina Yang, Yihua Qian, Ning Jia, Gaifeng Fen. Aβ-HBc virus-like particles immunization without additional adjuvant ameliorates the learning and memory and reduces Aβ deposit in PDAPP mice. Vaccine. vol 32. issue 35. 2015-03-30. PMID:24962758. |
immunohistochemistry results showed that aβ-hbc vlps immunized mice had less amyloid deposit with less microglia in cortex and hippocampus. |
2015-03-30 |
2023-08-13 |
mouse |
| Li Tao, Fali Zhang, Lili Hao, Jing Wu, Jia Jia, Jiang-yun Liu, Long Tai Zheng, Xuechu Zhe. 1-O-tigloyl-1-O-deacetyl-nimbolinin B inhibits LPS-stimulated inflammatory responses by suppressing NF-κB and JNK activation in microglia cells. Journal of pharmacological sciences. vol 125. issue 4. 2015-03-30. PMID:25018136. |
furthermore, tnb reduced cytotoxicity of activated microglia toward ht-22 hippocampal cells in a co-culture system. |
2015-03-30 |
2023-08-13 |
Not clear |
| Shao-Huai Shi, Xu Zhao, Bing Liu, Huan Li, Ai-Jing Liu, Bo Wu, Kai-Shun Bi, Ying Ji. The effects of sesquiterpenes-rich extract of Alpinia oxyphylla Miq. on amyloid-β-induced cognitive impairment and neuronal abnormalities in the cortex and hippocampus of mice. Oxidative medicine and cellular longevity. vol 2014. 2015-03-30. PMID:25180067. |
the results showed that the long-term treatment of cf enhanced the cognitive performances in behavior tests, increased activities of glutathione peroxidase (gsh-px) and decreased the level of malondialdehyde (mda), acetylcholinesterase (ache), and amyloid-β (aβ), and reversed the activation of microglia, degeneration of neuronal acidophilia, and nuclear condensation in the cortex and hippocampus. |
2015-03-30 |
2023-08-13 |
mouse |
| Michael D Weber, Matthew G Frank, Kevin J Tracey, Linda R Watkins, Steven F Maie. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568124. |
stress induces the danger-associated molecular pattern hmgb-1 in the hippocampus of male sprague dawley rats: a priming stimulus of microglia and the nlrp3 inflammasome. |
2015-03-20 |
2023-08-13 |
rat |