| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuka Kasahara, Ryuta Koyama, Yuji Ikegay. Depth and time-dependent heterogeneity of microglia in mouse hippocampal slice cultures. Neuroscience research. vol 111. 2016-12-29. PMID:27211829. |
here, we performed a detailed investigation of microglial properties in mouse hippocampal slice cultures, focusing on the changes in morphology in the activated state, finding a depth and time-dependent localization of in vivo-like microglia in slice cultures. |
2016-12-29 |
2023-08-13 |
mouse |
| Massimiliano Di Filippo, Antonio de Iure, Carmela Giampà, Davide Chiasserini, Alessandro Tozzi, Pier Luigi Orvietani, Veronica Ghiglieri, Michela Tantucci, Valentina Durante, Ana Quiroga-Varela, Andrea Mancini, Cinzia Costa, Paola Sarchielli, Francesca Romana Fusco, Paolo Calabres. Persistent activation of microglia and NADPH oxidase [corrected] drive hippocampal dysfunction in experimental multiple sclerosis. Scientific reports. vol 6. 2016-12-23. PMID:26887636. |
persistent activation of microglia and nadph oxidase [corrected] drive hippocampal dysfunction in experimental multiple sclerosis. |
2016-12-23 |
2023-08-13 |
Not clear |
| Massimiliano Di Filippo, Antonio de Iure, Carmela Giampà, Davide Chiasserini, Alessandro Tozzi, Pier Luigi Orvietani, Veronica Ghiglieri, Michela Tantucci, Valentina Durante, Ana Quiroga-Varela, Andrea Mancini, Cinzia Costa, Paola Sarchielli, Francesca Romana Fusco, Paolo Calabres. Persistent activation of microglia and NADPH oxidase [corrected] drive hippocampal dysfunction in experimental multiple sclerosis. Scientific reports. vol 6. 2016-12-23. PMID:26887636. |
the activation of hippocampal microglia mediated synaptic and cognitive/behavioural alterations during eae. |
2016-12-23 |
2023-08-13 |
Not clear |
| Kuan Ming Chiu, Cheng Wei Lu, Ming Yi Lee, Ming Jiuh Wang, Tzu Yu Lin, Su Jane Wan. Neuroprotective and anti-inflammatory effects of lidocaine in kainic acid-injected rats. Neuroreport. vol 27. issue 7. 2016-12-20. PMID:26999361. |
moreover, ka-induced microglia activation and gene expression of proinflammatory cytokines, namely, interleukin-1β, interleukin-6, and tumor necrosis factor-α, in the hippocampus were reduced by the lidocaine pretreatment. |
2016-12-20 |
2023-08-13 |
rat |
| Da-ming Sui, Qun Xie, Wen-jing Yi, Sahil Gupta, Xi-ya Yu, Jin-bao Li, Jun Wang, Jia-feng Wang, Xiao-ming Den. Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1β Axis in Microglia. Mediators of inflammation. vol 2016. 2016-12-19. PMID:26924896. |
the tunel assay demonstrated significantly attenuated rates of apoptosis, in resveratrol treated mice, while decreasing the number of iba-1 positive microglia in the hippocampus region. |
2016-12-19 |
2023-08-13 |
mouse |
| Dong-Cheol Kim, Kwang-Ho Cho, Wonmin Ko, Chi-Su Yoon, Jae Hak Sohn, Joung Han Yim, Youn-Chul Kim, Hyuncheol O. Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines. International journal of molecular sciences. vol 17. issue 4. 2016-12-15. PMID:27070586. |
sf-6354 via up-regulation of heme oxygenase-1 in murine hippocampal and microglial cell lines. |
2016-12-15 |
2023-08-13 |
mouse |
| Joo-Hee Park, Ha-Jin Pak, Tae-Ryong Riew, Yoo-Jin Shin, Mun-Yong Le. Increased expression of Slit2 and its receptors Robo1 and Robo4 in reactive astrocytes of the rat hippocampus after transient forebrain ischemia. Brain research. vol 1634. 2016-12-13. PMID:26764532. |
the ligand and receptors were constitutively expressed in hippocampal neurons in control animals; however, in animals with ischemic injury, their upregulation was detected in reactive astrocytes, but not in neurons or activated microglia, in the ca1 region. |
2016-12-13 |
2023-08-13 |
rat |
| Y-H Shih, S-F Tsai, S-H Huang, Y-T Chiang, M W Hughes, S-Y Wu, C-W Lee, T-T Yang, Y-M Ku. Hypertension impairs hippocampus-related adult neurogenesis, CA1 neuron dendritic arborization and long-term memory. Neuroscience. vol 322. 2016-12-13. PMID:26921651. |
furthermore, 2k1c decreased the levels of hippocampal brain-derived neurotrophic factor, while blood vessel density and activation status of astrocytes and microglia were not affected. |
2016-12-13 |
2023-08-13 |
mouse |
| Weei Lo, Martha O'Donnell, Daniel Tancredi, Myra Orgain, Nicole Glase. Diabetic ketoacidosis in juvenile rats is associated with reactive gliosis and activation of microglia in the hippocampus. Pediatric diabetes. vol 17. issue 2. 2016-11-11. PMID:25594864. |
diabetic ketoacidosis in juvenile rats is associated with reactive gliosis and activation of microglia in the hippocampus. |
2016-11-11 |
2023-08-13 |
rat |
| Kuo-Mao Lan, Lu-Tai Tien, Zhengwei Cai, Shuying Lin, Yi Pang, Sachiko Tanaka, Philip G Rhodes, Abhay J Bhatt, Renate D Savich, Lir-Wan Fa. Erythropoietin Ameliorates Neonatal Hypoxia-Ischemia-Induced Neurobehavioral Deficits, Neuroinflammation, and Hippocampal Injury in the Juvenile Rat. International journal of molecular sciences. vol 17. issue 3. 2016-11-04. PMID:26927081. |
hi insult also resulted in brain inflammation (as indicated by microglia activation) and neuronal death (as indicated by jade b positive staining) in the white matter, striatum, cortex, and hippocampal areas of the p21 rat. |
2016-11-04 |
2023-08-13 |
human |
| Kuo-Mao Lan, Lu-Tai Tien, Zhengwei Cai, Shuying Lin, Yi Pang, Sachiko Tanaka, Philip G Rhodes, Abhay J Bhatt, Renate D Savich, Lir-Wan Fa. Erythropoietin Ameliorates Neonatal Hypoxia-Ischemia-Induced Neurobehavioral Deficits, Neuroinflammation, and Hippocampal Injury in the Juvenile Rat. International journal of molecular sciences. vol 17. issue 3. 2016-11-04. PMID:26927081. |
both pre- and post-treatment with repo significantly improved neurobehavioral performance and protected against the hi-induced neuronal death, microglia activation (ox42+) as well as loss of mature oligodendrocytes (apc-cc1+) and hippocampal neurons (nissl+). |
2016-11-04 |
2023-08-13 |
human |
| E Murawska-Cialowicz, J Wojna, J Zuwala-Jagiell. Crossfit training changes brain-derived neurotrophic factor and irisin levels at rest, after wingate and progressive tests, and improves aerobic capacity and body composition of young physically active men and women. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 66. issue 6. 2016-10-24. PMID:26769830. |
brain-derived neurotrophic factor (bdnf) is a protein that stimulates processes of neurogenesis, the survival of neurons and microglia, stimulates neuroplasticity, and takes part in the differentiation of cells developed in the hippocampus. |
2016-10-24 |
2023-08-13 |
human |
| Annette Masuch, Chu-Hsin Shieh, Nico van Rooijen, Dietrich van Calker, Knut Bibe. Mechanism of microglia neuroprotection: Involvement of P2X7, TNFα, and valproic acid. Glia. vol 64. issue 1. 2016-10-20. PMID:26295445. |
recently, we have demonstrated that ramified microglia are neuroprotective in n-methyl-d-aspartate (nmda)-induced excitotoxicity in organotypic hippocampal slice cultures (ohscs). |
2016-10-20 |
2023-08-13 |
mouse |
| Iris Kim, Lauren M Mlsna, Stella Yoon, Brandy Le, Songtao Yu, Dan Xu, Sookyong Ko. A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers. Brain and behavior. vol 5. issue 12. 2016-10-20. PMID:26807334. |
to determine the temporal correlation between microglial development and age-dependent susceptibility and response to seizures, we quantified developmental changes in basal microglia levels and seizure-induced microglial activation in the hippocampus of cx3cr1(gfp /+) transgenic mice. |
2016-10-20 |
2023-08-13 |
mouse |
| Vikas Mishra, Bing Shuai, Maheedhar Kodali, Geetha A Shetty, Bharathi Hattiangady, Xiaolan Rao, Ashok K Shett. Resveratrol Treatment after Status Epilepticus Restrains Neurodegeneration and Abnormal Neurogenesis with Suppression of Oxidative Stress and Inflammation. Scientific reports. vol 5. 2016-10-10. PMID:26639668. |
in contrast to the vehicle-treated group, the hippocampus of animals receiving resv during and after se presented no loss of glutamatergic neurons in hippocampal cell layers, diminished loss of inhibitory interneurons expressing parvalbumin, somatostatin and neuropeptide y in the dentate gyrus, reduced aberrant neurogenesis with preservation of reelin + interneurons, lowered concentration of oxidative stress byproduct malondialdehyde and pro-inflammatory cytokine tumor necrosis factor-alpha, normalized expression of oxidative stress responsive genes and diminished numbers of activated microglia. |
2016-10-10 |
2023-08-13 |
rat |
| Gongliang Zhang, Bing-Xue Zhao, Rong Hua, Jie Kang, Bo-Ming Shao, Theresa M Carbonaro, Yong-Mei Zhan. Hippocampal microglial activation and glucocorticoid receptor down-regulation precipitate visceral hypersensitivity induced by colorectal distension in rats. Neuropharmacology. vol 102. 2016-10-07. PMID:26656865. |
these results suggest that neonatal crd can increase the vulnerability of hippocampal microglia, and adult crd challenge facilitates the hippocampal cytokine release from the sensitized microglia, which down-regulates hippocampal gr protein expression and, subsequently, precipitates visceral hypersensitivity. |
2016-10-07 |
2023-08-13 |
rat |
| Jin Hee Kim, Bo Young Choi, Hyun Jung Kim, In Yeol Kim, Bo Eun Lee, Min Sohn, Hyoung Jin Park, Sang Won Su. A Water-Ethanol Extract from the Willow Bracket Mushroom, Phellinus igniarius (Higher Basidiomycetes), Reduces Transient Cerebral Ischemia-Induced Neuronal Death. International journal of medicinal mushrooms. vol 17. issue 9. 2016-10-05. PMID:26756300. |
piwep injection lead to decreased hippocampal neuronal death, suppression of oxidative injury, activation of microglia, and disruption of the blood-brain barrier. |
2016-10-05 |
2023-08-13 |
human |
| Vicente Hernández-Rabaza, Andrea Cabrera-Pastor, Lucas Taoro-González, Michele Malaguarnera, Ana Agustí, Marta Llansola, Vicente Felip. Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane. Journal of neuroinflammation. vol 13. 2016-10-05. PMID:26883214. |
two main aims of this work were: (1) to assess whether chronic hyperammonemia increases inflammatory factors in the hippocampus and if this is associated with microglia and/or astrocytes activation and (2) to assess whether hyperammonemia-induced neuroinflammation in the hippocampus is associated with altered membrane expression of glutamate and gaba receptors and spatial learning impairment. |
2016-10-05 |
2023-08-13 |
rat |
| Junhua Yang, Fangfang Qi, Huaiyu Gu, Juntao Zou, Yang Yang, Qunfang Yuan, Zhibin Ya. Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life. Brain research bulletin. vol 120. 2016-09-30. PMID:26536170. |
the mice were also subjected to tests at 2 and 6 w to examine bcg's effects on neurogenesis, the hippocampal microglia phenotype and number, and the expression of hippocampal neuroimmune molecules and peripheral cytokines. |
2016-09-30 |
2023-08-13 |
mouse |
| R Seigers, M Loos, O Van Tellingen, W Boogerd, A B Smit, S B Schage. Neurobiological changes by cytotoxic agents in mice. Behavioural brain research. vol 299. 2016-09-27. PMID:26602283. |
animals were sacrificed 3 weeks after treatment and no notable effect was seen in hippocampal cell differentiation (dcx), microglia activation, or blood vessel density. |
2016-09-27 |
2023-08-13 |
mouse |