| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meghan E Rebuli, Paul Gibson, Cassie L Rhodes, Bruce S Cushing, Heather B Patisau. Sex differences in microglial colonization and vulnerabilities to endocrine disruption in the social brain. General and comparative endocrinology. vol 238. 2017-09-11. PMID:27102938. |
through a comparison of the promiscuous wistar rat (rattus norvegicus) and the socially monogamous prairie vole (microtus ochrogaster), we are the first to observe that developmental exposure to the synthetic estrogen ethinyl estradiol (ee) or bpa alters the sex-specific colonization of the hippocampus and amygdala by microglia. |
2017-09-11 |
2023-08-13 |
rat |
| Dai-Shi Tian, Jiyun Peng, Madhuvika Murugan, Li-Jie Feng, Jun-Li Liu, Ukpong B Eyo, Li-Jun Zhou, Rochelle Mogilevsky, Wei Wang, Long-Jun W. Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 33. 2017-09-11. PMID:28716963. |
in this study, we found that the upregulated ccl2 was mainly expressed in hippocampal neurons and activated microglia from mice 1 d after kainic acid (ka)-induced seizures. |
2017-09-11 |
2023-08-13 |
mouse |
| Masaaki Iwata, Hisahito Ishida, Koichi Kaneko, Yukihiko Shirayam. Learned helplessness activates hippocampal microglia in rats: A potential target for the antidepressant imipramine. Pharmacology, biochemistry, and behavior. vol 150-151. 2017-08-31. PMID:27769904. |
learned helplessness activates hippocampal microglia in rats: a potential target for the antidepressant imipramine. |
2017-08-31 |
2023-08-13 |
rat |
| Masaaki Iwata, Hisahito Ishida, Koichi Kaneko, Yukihiko Shirayam. Learned helplessness activates hippocampal microglia in rats: A potential target for the antidepressant imipramine. Pharmacology, biochemistry, and behavior. vol 150-151. 2017-08-31. PMID:27769904. |
microglia, the resident macrophages in the brain, play a central role in the innate immune system and express inflammasomes; thus, we hypothesized that hippocampal microglia would be key mediators in the development of depression via stress-induced inflammation. |
2017-08-31 |
2023-08-13 |
rat |
| Masaaki Iwata, Hisahito Ishida, Koichi Kaneko, Yukihiko Shirayam. Learned helplessness activates hippocampal microglia in rats: A potential target for the antidepressant imipramine. Pharmacology, biochemistry, and behavior. vol 150-151. 2017-08-31. PMID:27769904. |
to test this hypothesis and to determine how antidepressants modulate microglial function, we used immunohistochemistry to examine the morphological changes that occur in the hippocampal microglia of rats exposed to the learned helplessness (lh) paradigm. |
2017-08-31 |
2023-08-13 |
rat |
| Masaaki Iwata, Hisahito Ishida, Koichi Kaneko, Yukihiko Shirayam. Learned helplessness activates hippocampal microglia in rats: A potential target for the antidepressant imipramine. Pharmacology, biochemistry, and behavior. vol 150-151. 2017-08-31. PMID:27769904. |
these data suggest that stress activates hippocampal microglia, while certain antidepressants decrease the number of activated microglia in the hilus, but not in other hippocampal regions. |
2017-08-31 |
2023-08-13 |
rat |
| Mary K Holder, Jeffrey D Blaustei. Developmental time course and effects of immunostressors that alter hormone-responsive behavior on microglia in the peripubertal and adult female mouse brain. PloS one. vol 12. issue 2. 2017-08-28. PMID:28158270. |
peripubertal mice have more microglia with long, thick processes in the hippocampus, amygdala and hypothalamus as compared with adult mice in the absence of an immune challenge. |
2017-08-28 |
2023-08-13 |
mouse |
| Naserddine Hamadi, Azimullah Sheikh, Nather Madjid, Loai Lubbad, Naheed Amir, Safa Al-Deen Saudi Shehab, Fatima Khelifi-Touhami, Abdu Ade. Increased pro-inflammatory cytokines, glial activation and oxidative stress in the hippocampus after short-term bilateral adrenalectomy. BMC neuroscience. vol 17. issue 1. 2017-08-23. PMID:27586269. |
in the present study we aimed to investigate the effects of short-term bilateral adrenalectomy on the levels of pro-inflammatory cytokines il-1β, il-6 and tnf-α; the response of microglia and astrocytes to neuronal cell death as well as oxidative stress markers gsh, sod and mda over the course of time (4 h, 24 h, 3 days, 1 week and 2 weeks) in the hippocampus of wistar rats. |
2017-08-23 |
2023-08-13 |
rat |
| Qing-Peng Hu, Ding-An Ma. Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation. BMC neuroscience. vol 17. issue 1. 2017-08-21. PMID:27193049. |
histone deacetylase inhibitor saha attenuates post-seizure hippocampal microglia tlr4/myd88 signaling and inhibits tlr4 gene expression via histone acetylation. |
2017-08-21 |
2023-08-13 |
rat |
| Debbie A E Hendrickx, Corbert G van Eden, Karianne G Schuurman, Jörg Hamann, Inge Huiting. Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology. Journal of neuroimmunology. vol 309. 2017-08-21. PMID:28601280. |
dense core ad plaques in the hippocampus were mostly associated with microglia expressing hla-dr. diffuse ad plaques were not specifically associated with microglia at all. |
2017-08-21 |
2023-08-13 |
human |
| Xing-Wen Fan, Huan-Huan Liu, Hong-Bing Wang, Fu Chen, Yu Yang, Yan Chen, Shi-Kuo Guan, Kai-Liang W. Electroacupuncture Improves Cognitive Function and Hippocampal Neurogenesis after Brain Irradiation. Radiation research. vol 187. issue 6. 2017-08-18. PMID:28375680. |
electroacupuncture decreased the amount of activated microglia and increased resting microglia in the hippocampus after irradiation. |
2017-08-18 |
2023-08-13 |
rat |
| Xing-Wen Fan, Huan-Huan Liu, Hong-Bing Wang, Fu Chen, Yu Yang, Yan Chen, Shi-Kuo Guan, Kai-Liang W. Electroacupuncture Improves Cognitive Function and Hippocampal Neurogenesis after Brain Irradiation. Radiation research. vol 187. issue 6. 2017-08-18. PMID:28375680. |
in conclusion, electroacupuncture could improve cognitive function and hippocampal neurogenesis after irradiation, and the protective effect of electroacupuncture was associated with the modulation of microglia and upregulation of bdnf in the hippocampus. |
2017-08-18 |
2023-08-13 |
rat |
| Hui Shi, Kuang Zheng, Zulu Su, Hai Su, Ming Zhong, Xuenong He, Changlong Zhou, Hao Chen, Qijiang Xiong, Yi Zhan. Sinomenine enhances microglia M2 polarization and attenuates inflammatory injury in intracerebral hemorrhage. Journal of neuroimmunology. vol 299. 2017-08-14. PMID:27725118. |
sinomenine also protected hippocampal neurons from indirect toxicity mediated by ich-treated microglia. |
2017-08-14 |
2023-08-13 |
mouse |
| Sandra Oliveira Braz, Andrea Cruz, Andrea Lobo, Joana Bravo, Joana Moreira-Ribeiro, Isabel Pereira-Castro, Jaime Freitas, Joao B Relvas, Teresa Summavielle, Alexandra Moreir. Expression of Rac1 alternative 3' UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons. Biochimica et biophysica acta. Gene regulatory mechanisms. vol 1860. issue 6. 2017-08-14. PMID:28274785. |
here we used different brain cell types and tissues, including oligodendrocytes, microglia, astrocytes, cortical and hippocampal neurons, and optical nerve, to show that classical rho gtpases express mrnas with alternative 3' utrs differently, by gene- and cell- specific mechanisms. |
2017-08-14 |
2023-08-13 |
Not clear |
| Colleen A Mangold, Dustin R Masser, David R Stanford, Georgina V Bixler, Aditya Pisupati, Cory B Giles, Jonathan D Wren, Matthew M Ford, William E Sonntag, Willard M Freema. CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 72. issue 1. 2017-08-07. PMID:26786204. |
in the mouse, mhci is expressed by neurons and microglia, and mhci components and receptors (h2-k1, h2-d1, β2m, lilrb3, klra2, cd247) display markedly different expression profiles across the hippocampus, cortex, cerebellum, brainstem, and retina. |
2017-08-07 |
2023-08-13 |
mouse |
| Yong Liu, Li-Jun Zhou, Jun Wang, Dai Li, Wen-Jie Ren, Jiyun Peng, Xiao Wei, Ting Xu, Wen-Jun Xin, Rui-Ping Pang, Yong-Yong Li, Zhi-Hai Qin, Madhuvika Murugan, Mark P Mattson, Long-Jun Wu, Xian-Guo Li. TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 4. 2017-08-01. PMID:28123022. |
furthermore, sni activated microglia in both spinal dorsal horn and hippocampus; pharmacological inhibition or genetic ablation of microglia prevented the region-dependent synaptic changes, neuropathic pain, and memory deficits induced by sni. |
2017-08-01 |
2023-08-13 |
mouse |
| Kouichi Itoh, Yasuhiro Ishihara, Rie Komori, Hiromi Nochi, Ruri Taniguchi, Yoichi Chiba, Masaki Ueno, Fuyuko Takata-Tsuji, Shinya Dohgu, Yasufumi Kataok. Levetiracetam treatment influences blood-brain barrier failure associated with angiogenesis and inflammatory responses in the acute phase of epileptogenesis in post-status epilepticus mice. Brain research. vol 1652. 2017-07-28. PMID:27693413. |
furthermore, in the acute phase of the latent period, pro-inflammatory responses for epileptogenic targets in microglia and astrocytes of the hippocampus activated, and these upregulations of pro-inflammatory-related molecules were inhibited by lev treatment. |
2017-07-28 |
2023-08-13 |
mouse |
| Mónica Tramullas, Beate C Finger, Timothy G Dinan, John F Crya. Obesity Takes Its Toll on Visceral Pain: High-Fat Diet Induces Toll-Like Receptor 4-Dependent Visceral Hypersensitivity. PloS one. vol 11. issue 5. 2017-07-26. PMID:27159520. |
in the present study we investigated the impact of long-term exposure to high-fat diet on visceral pain perception and on the levels of tlr4 and cd11b (a microglial cell marker) protein expression in the prefrontal cortex (pfc) and hippocampus. |
2017-07-26 |
2023-08-13 |
mouse |
| Mónica Tramullas, Beate C Finger, Timothy G Dinan, John F Crya. Obesity Takes Its Toll on Visceral Pain: High-Fat Diet Induces Toll-Like Receptor 4-Dependent Visceral Hypersensitivity. PloS one. vol 11. issue 5. 2017-07-26. PMID:27159520. |
in parallel, enhanced tlr4 expression and microglia activation were found in brain areas related to visceral pain, the pfc and the hippocampus. |
2017-07-26 |
2023-08-13 |
mouse |
| Ting Yang, Shaomin Li, Huixin Xu, Dominic M Walsh, Dennis J Selko. Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053038. |
however, incubation of hmw oaβ in mildly alkaline buffer led to their quantitative dissociation into low molecular weight oligomers (∼8-70 kda), and these were now far more bioactive: they impaired hippocampal ltp, decreased neuronal levels of β2-adrenergic receptors, and activated microglia in wt mice in vivo thus, most soluble aβ assemblies in ad cortex are large and inactive but under certain circumstances can dissociate into smaller, highly bioactive species. |
2017-07-24 |
2023-08-13 |
mouse |