| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jimmy George, Rodrigo A Cunha, Christophe Mulle, Thierry Amédé. Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors. The European journal of neuroscience. vol 43. issue 10. 2017-11-16. PMID:27199162. |
here, we used a simple model of adding immune-challenged microglia to mouse hippocampal slices to investigate their impact on synaptic transmission and plasticity at hippocampal mossy fibre (mf) synapses onto ca3 pyramidal neurons. |
2017-11-16 |
2023-08-13 |
mouse |
| Adam D Bachstetter, Eseosa T Ighodaro, Yasmin Hassoun, Danah Aldeiri, Janna H Neltner, Ela Patel, Erin L Abner, Peter T Nelso. Rod-shaped microglia morphology is associated with aging in 2 human autopsy series. Neurobiology of aging. vol 52. 2017-11-16. PMID:28131016. |
rod-shaped microglia were shown recently to account for a substantial proportion of the microglia cells in the hippocampus of both demented and cognitively intact aged individuals. |
2017-11-16 |
2023-08-13 |
human |
| Adam D Bachstetter, Eseosa T Ighodaro, Yasmin Hassoun, Danah Aldeiri, Janna H Neltner, Ela Patel, Erin L Abner, Peter T Nelso. Rod-shaped microglia morphology is associated with aging in 2 human autopsy series. Neurobiology of aging. vol 52. 2017-11-16. PMID:28131016. |
the presence or absence of rod-shaped microglia was scored on iba1 immunohistochemically stained slides for the hippocampus and cortex. |
2017-11-16 |
2023-08-13 |
human |
| Adam D Bachstetter, Eseosa T Ighodaro, Yasmin Hassoun, Danah Aldeiri, Janna H Neltner, Ela Patel, Erin L Abner, Peter T Nelso. Rod-shaped microglia morphology is associated with aging in 2 human autopsy series. Neurobiology of aging. vol 52. 2017-11-16. PMID:28131016. |
we found that age was one of the strongest determinants for the presence of rod-shaped microglia in the hippocampus and the cortex. |
2017-11-16 |
2023-08-13 |
human |
| Adam D Bachstetter, Eseosa T Ighodaro, Yasmin Hassoun, Danah Aldeiri, Janna H Neltner, Ela Patel, Erin L Abner, Peter T Nelso. Rod-shaped microglia morphology is associated with aging in 2 human autopsy series. Neurobiology of aging. vol 52. 2017-11-16. PMID:28131016. |
alzheimer's disease-related pathology was found to influence the presence of rod-shaped microglia, but only in the parietal cortex and not in the hippocampus or temporal cortex. |
2017-11-16 |
2023-08-13 |
human |
| Emile Wogram, Stefan Wendt, Marina Matyash, Tatyana Pivneva, Andreas Draguhn, Helmut Kettenman. Satellite microglia show spontaneous electrical activity that is uncorrelated with activity of the attached neuron. The European journal of neuroscience. vol 43. issue 11. 2017-11-13. PMID:27060918. |
likewise, evoked local field potentials or action potentials and postsynaptic potentials of the associated neuron did not lead to any transmembrane currents or non-capacitive changes in the membrane potential of the satellite microglia in the cortex and hippocampus. |
2017-11-13 |
2023-08-13 |
Not clear |
| Risa Takamura, Naoto Watamura, Miyu Nikkuni, Toshio Ohshim. All-trans retinoic acid improved impaired proliferation of neural stem cells and suppressed microglial activation in the hippocampus in an Alzheimer's mouse model. Journal of neuroscience research. vol 95. issue 3. 2017-11-13. PMID:27448243. |
we found that atra has effects on the recovery of proliferative cells along with suppression of activated microglia in the hippocampus. |
2017-11-13 |
2023-08-13 |
mouse |
| Yafeng Wang, Kai Zhou, Tao Li, Yiran Xu, Cuicui Xie, Yanyan Sun, Yaodong Zhang, Juan Rodriguez, Klas Blomgren, Changlian Zh. Inhibition of autophagy prevents irradiation-induced neural stem and progenitor cell death in the juvenile mouse brain. Cell death & disease. vol 8. issue 3. 2017-11-13. PMID:28333139. |
cell death and proliferation as well as microglia activation and inflammation were evaluated in the dentate gyrus of the hippocampus and in the cerebellum at 6 h after irradiation. |
2017-11-13 |
2023-08-13 |
mouse |
| Alyssa Littlefield, Rachel A Kohma. Differential response to intrahippocampal interleukin-4/interleukin-13 in aged and exercise mice. Neuroscience. vol 343. 2017-11-08. PMID:27916728. |
twenty-four hours later hippocampal samples were collected and analyzed for expression of genes associated with the m1 (inflammatory) and m2 microglia phenotypes. |
2017-11-08 |
2023-08-13 |
mouse |
| Qinwen Mao, Dongyang Wang, Yanqing Li, Missia Kohler, Jayson Wilson, Zachary Parton, Bella Shmaltsuyeva, Demirkan Gursel, Rosa Rademakers, Sandra Weintraub, Marek-Marsel Mesulam, Haibin Xia, Eileen H Bigi. Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration. Journal of neuropathology and experimental neurology. vol 76. issue 11. 2017-10-27. PMID:29044416. |
in the hippocampus, grn immunopositivity in the ca1 and ca2 regions showed disease-specific changes in both neurons and microglia. |
2017-10-27 |
2023-08-13 |
Not clear |
| Elise C Cope, Brandy A Briones, Adam T Brockett, Susana Martinez, Pierre-Antoine Vigneron, Maya Opendak, Samuel S-H Wang, Elizabeth Goul. Immature Neurons and Radial Glia, But Not Astrocytes or Microglia, Are Altered in Adult Cntnap2 and Shank3 Mice, Models of Autism. eNeuro. vol 3. issue 5. 2017-10-26. PMID:27785461. |
here, we examined adult neurogenesis in the hippocampus, as well as astroglia and microglia in the hippocampus, mpfc, and striatum of two models that display autism-like phenotypes, cntnap2 |
2017-10-26 |
2023-08-13 |
mouse |
| Laura K Fonken, Meagan M Kitt, Andrew D Gaudet, Ruth M Barrientos, Linda R Watkins, Steven F Maie. Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization. Neurobiology of aging. vol 47. 2017-10-17. PMID:27568094. |
diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization. |
2017-10-17 |
2023-08-13 |
rat |
| Laura K Fonken, Meagan M Kitt, Andrew D Gaudet, Ruth M Barrientos, Linda R Watkins, Steven F Maie. Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization. Neurobiology of aging. vol 47. 2017-10-17. PMID:27568094. |
first, hippocampal microglia isolated from young rats (4 months f344xbn) rhythmically expressed circadian clock genes, whereas microglia isolated from the hippocampus of aged rats (25 months) had aberrant per1 and per2 rhythms. |
2017-10-17 |
2023-08-13 |
rat |
| Hong-Tao Wang, Fu-Lian Huang, Zhao-Lan Hu, Wen-Juan Zhang, Xiao-Qing Qiao, Yan-Qing Huang, Ru-Ping Dai, Fang Li, Chang-Qi L. Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline. Neurotoxicity research. vol 31. issue 4. 2017-10-02. PMID:28092020. |
here, we used the early-life social isolation (esi) model of early-life stress in rats to characterize development of depressive-like behavior, the role of microglia, levels of histone methylation, as well as expression of glutamate receptor subunits in the hippocampus. |
2017-10-02 |
2023-08-13 |
rat |
| Hong-Tao Wang, Fu-Lian Huang, Zhao-Lan Hu, Wen-Juan Zhang, Xiao-Qing Qiao, Yan-Qing Huang, Ru-Ping Dai, Fang Li, Chang-Qi L. Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline. Neurotoxicity research. vol 31. issue 4. 2017-10-02. PMID:28092020. |
interestingly, treatment with minocycline to block microglial activation induced by esi inhibited increases in hippocampal microglia and prevented esi-induced depressive-like behavior as well as increases in il-1β, il-6, and tnf-α. |
2017-10-02 |
2023-08-13 |
rat |
| Aitzkoa Lopez de Lapuente, Ana Feliú, Nerea Ugidos, Miriam Mecha, Jorge Mena, Ianire Astobiza, José Riera, Francisco J. Carrillo-Salinas, Manuel Comabella, Xavier Montalban, Iraide Alloza, Carmen Guaza, Koen Vandenbroec. Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55. Journal of immunology (Baltimore, Md. : 1950). vol 196. issue 11. 2017-09-28. PMID:27183579. |
ankrd55 was produced by primary cultures of murine hippocampal neurons and microglia, as well as by the murine microglial cell line bv2, and it was induced by inflammatory stimuli. |
2017-09-28 |
2023-08-13 |
mouse |
| Diego Mastroeni, Shobana Sekar, Jennifer Nolz, Elaine Delvaux, Katie Lunnon, Jonathan Mill, Winnie S Liang, Paul D Colema. ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PloS one. vol 12. issue 7. 2017-09-26. PMID:28700589. |
using this unique rnaseq data set, we show that in the hippocampus, ank1 is significantly (p<0.0001) up-regulated 4-fold in ad microglia, but not in neurons or astrocytes from the same individuals. |
2017-09-26 |
2023-08-13 |
Not clear |
| Jennifer N Jernberg, Caitlyn E Bowman, Michael J Wolfgang, Susanna Scafid. Developmental regulation and localization of carnitine palmitoyltransferases (CPTs) in rat brain. Journal of neurochemistry. vol 142. issue 3. 2017-09-21. PMID:28512781. |
the cpt system is highly enriched in vivo in hippocampus and cerebellum, relative to cortex and midbrain, and is exclusively present in astrocytes and neural progenitor cells, while absent in neurons, microglia, and oligodendrocytes. |
2017-09-21 |
2023-08-13 |
rat |
| Diana Varol, Alexander Mildner, Thomas Blank, Anat Shemer, Neta Barashi, Simon Yona, Eyal David, Sigalit Boura-Halfon, Yifat Segal-Hayoun, Louise Chappell-Maor, Hadas Keren-Shaul, Dena Leshkowitz, Eran Hornstein, Martin Fuhrmann, Ido Amit, Nicola Maggio, Marco Prinz, Steffen Jun. Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain. Immunity. vol 46. issue 6. 2017-09-15. PMID:28636953. |
after peripheral endotoxin exposure, dicer-deficient microglia expressed more pro-inflammatory cytokines than wild-type microglia and thereby compromised hippocampal neuronal functions. |
2017-09-15 |
2023-08-13 |
mouse |
| Yu Zhang, Ruinan Gu, Jia Jia, Tingjun Hou, Long Tai Zheng, Xuechu Zhe. Inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity suppresses microglia-mediated inflammatory responses. Clinical and experimental pharmacology & physiology. vol 43. issue 11. 2017-09-12. PMID:27543936. |
furthermore, z-590 reduced cytotoxicity of activated microglia toward ht-22 hippocampal cells in a microglia-conditioned medium system. |
2017-09-12 |
2023-08-13 |
Not clear |