| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joon Ha Park, Jin-A Park, Ji Hyeon Ahn, Yang Hee Kim, Il Jun Kang, Moo-Ho Won, Choong-Hyun Le. Transient cerebral ischemia induces albumin expression in microglia only in the CA1 region of the gerbil hippocampus. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28586018. |
albumin immunoreactivity was observed in microglia of the ca1 hippocampal region 2 days post‑ischemic insult, and it was significantly increased at 4 days following ischemia-reperfusion. |
2018-03-26 |
2023-08-13 |
Not clear |
| Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Yolanda Marin-Zambrana, Maria Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Monica Garcia-Alloz. Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model. Brain pathology (Zurich, Switzerland). vol 27. issue 4. 2018-03-16. PMID:27537110. |
mgf reduced central inflammation by lowering microglia burden, both in the cortex and the hippocampus. |
2018-03-16 |
2023-08-13 |
mouse |
| Olalekan M Ogundele, Philip J Ebenezer, Charles C Lee, Joseph Franci. Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy. Neuroscience. vol 353. 2018-03-14. PMID:28438613. |
in addition to a decrease in igf-1/igf-1r, an increase in activated hippocampal and cortical microglia was seen in stress (p<0.05) and after a pet (stress-pet; p<0.001). |
2018-03-14 |
2023-08-13 |
rat |
| Fabiano B Carvalho, Jessié M Gutierres, Andressa Bueno, Paula Agostinho, Adriana M Zago, Juliano Vieira, Pâmela Frühauf, José L Cechella, Cristina Wayne Nogueira, Sara M Oliveira, Caroline Rizzi, Roselia M Spanevello, Marta M F Duarte, Thiago Duarte, Odir A Dellagostin, Cinthia M Andrad. Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27167130. |
in parallel, lps increased the activity of myeloperoxidase in cortex and hippocampus, and ant prevented this effect, also reducing microglia (iba-1) and astrocyte (gfap) immunoreactivity. |
2018-03-09 |
2023-08-13 |
mouse |
| Yanbo Ma, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihar. Progranulin Protects Hippocampal Neurogenesis via Suppression of Neuroinflammatory Responses Under Acute Immune Stress. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27215202. |
treatment of mice with lps significantly increased the expression of pgrn in activated microglia and decreased neurogenesis in the dentate gyrus of the hippocampus. |
2018-03-09 |
2023-08-13 |
mouse |
| Anna Posod, Karina Wechselberger, Ruslan Iljitsch Stanika, Gerald J Obermair, Karina Wegleiter, Eva Huber, Martina Urbanek, Ursula Kiechl-Kohlendorfer, Elke Griesmaie. Administration of secretoneurin is protective in hypoxic-ischemic neonatal brain injury predominantly in the hypoxic-only hemisphere. Neuroscience. vol 352. 2018-03-05. PMID:28391015. |
in the hypoxic-only hemisphere administration of sn significantly reduced the number of caspase-3-positive cells (in cortex, white matter, hippocampus, thalamus and striatum) and inhibited microglial cell activation in the thalamus. |
2018-03-05 |
2023-08-13 |
mouse |
| Jingjing Tai, Weizhen Liu, Yanwei Li, Lin Li, Christian Hölsche. Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease. Brain research. vol 1678. 2018-03-02. PMID:29050859. |
furthermore, ta treatment reduced the total amount of β-amyloid, reduced neuroinflammation (activated microglia and astrocytes), and oxidative stress in the cortex and hippocampus. |
2018-03-02 |
2023-08-13 |
mouse |
| Yujiao Lu, Yan Dong, Donovan Tucker, Ruimin Wang, Mohammad Ejaz Ahmed, Darrell Brann, Quanguang Zhan. Treadmill Exercise Exerts Neuroprotection and Regulates Microglial Polarization and Oxidative Stress in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 56. issue 4. 2018-02-23. PMID:28157094. |
intriguingly, treadmill exercise remarkably inhibited reactive gliosis following stz insult and effectively shifted activated microglia from a pro-inflammatory m1 to an anti-inflammatory m2 phenotype, which was correlated with a significantly reduced expression of pro-inflammatory mediators and a corresponding enhancement of anti-inflammatory cytokine expression in the hippocampus. |
2018-02-23 |
2023-08-13 |
rat |
| Stefan J Kempf, Dirk Janik, Zarko Barjaktarovic, Ignacia Braga-Tanaka, Satoshi Tanaka, Frauke Neff, Anna Saran, Martin R Larsen, Soile Tapi. Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE-/- Alzheimer's mouse model. Oncotarget. vol 7. issue 44. 2018-02-21. PMID:27708245. |
similarly, the reduction in the number of activated microglia in the molecular layer of hippocampus that paralleled with reduced levels of tnfα expression and lipid peroxidation was significant only at the lower dose rate. |
2018-02-21 |
2023-08-13 |
mouse |
| Wei Han, Takashi Umekawa, Kai Zhou, Xing-Mei Zhang, Makiko Ohshima, Cecilia A Dominguez, Robert A Harris, Changlian Zhu, Klas Blomgre. Cranial irradiation induces transient microglia accumulation, followed by long-lasting inflammation and loss of microglia. Oncotarget. vol 7. issue 50. 2018-02-21. PMID:27793054. |
microglia accumulated in the subgranular zone of the hippocampal granule cell layer, where progenitor cell death was prominent. |
2018-02-21 |
2023-08-13 |
mouse |
| Wei Han, Takashi Umekawa, Kai Zhou, Xing-Mei Zhang, Makiko Ohshima, Cecilia A Dominguez, Robert A Harris, Changlian Zhu, Klas Blomgre. Cranial irradiation induces transient microglia accumulation, followed by long-lasting inflammation and loss of microglia. Oncotarget. vol 7. issue 50. 2018-02-21. PMID:27793054. |
isolated hippocampal microglia revealed reduced cd206 and increased il1-beta expression after irradiation, more pronounced in juvenile brains. |
2018-02-21 |
2023-08-13 |
mouse |
| Mari Falck, Damjan Osredkar, Elke Maes, Torun Flatebø, Thomas Ragnar Wood, Hemmen Sabir, Marianne Thorese. Hypothermic Neuronal Rescue from Infection-Sensitised Hypoxic-Ischaemic Brain Injury Is Pathogen Dependent. Developmental neuroscience. vol 39. issue 1-4. 2018-02-13. PMID:28407632. |
brains were harvested after 7 days' survival for hemispheric and hippocampal area loss analyses and immunolabelling of microglia (iba1) and hippocampal neurons (neun). |
2018-02-13 |
2023-08-13 |
rat |
| Marc J Ruitenberg, Julia Wells, Perry F Bartlett, Alan R Harvey, Jana Vukovi. Enrichment increases hippocampal neurogenesis independent of blood monocyte-derived microglia presence following high-dose total body irradiation. Brain research bulletin. vol 132. 2018-02-09. PMID:28552674. |
enrichment increases hippocampal neurogenesis independent of blood monocyte-derived microglia presence following high-dose total body irradiation. |
2018-02-09 |
2023-08-13 |
mouse |
| Marc J Ruitenberg, Julia Wells, Perry F Bartlett, Alan R Harvey, Jana Vukovi. Enrichment increases hippocampal neurogenesis independent of blood monocyte-derived microglia presence following high-dose total body irradiation. Brain research bulletin. vol 132. 2018-02-09. PMID:28552674. |
exposure to voluntary exercise, but not enriched environment, did lead to significant increases in microglia density in the granule cell layer of the hippocampus; our study shows that these changes result from local microglia proliferation rather than recruitment and infiltration of circulating cx |
2018-02-09 |
2023-08-13 |
mouse |
| Rao Sun, Zuoxia Zhang, Yishan Lei, Yue Liu, Cui'e Lu, Hui Rong, Yu'e Sun, Wei Zhang, Zhengliang Ma, Xiaoping G. Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain. Molecular pain. vol 12. 2018-02-08. PMID:27852966. |
hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain. |
2018-02-08 |
2023-08-13 |
rat |
| Rao Sun, Zuoxia Zhang, Yishan Lei, Yue Liu, Cui'e Lu, Hui Rong, Yu'e Sun, Wei Zhang, Zhengliang Ma, Xiaoping G. Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain. Molecular pain. vol 12. 2018-02-08. PMID:27852966. |
considering that microglia are substrates underlying the initiation and propagation of the neuroimmune response, we hypothesized that stress-induced activation of hippocampal microglia may contribute to the pathogenesis of posttraumatic stress disorder-pain comorbidity. |
2018-02-08 |
2023-08-13 |
rat |
| Rao Sun, Zuoxia Zhang, Yishan Lei, Yue Liu, Cui'e Lu, Hui Rong, Yu'e Sun, Wei Zhang, Zhengliang Ma, Xiaoping G. Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain. Molecular pain. vol 12. 2018-02-08. PMID:27852966. |
we showed that rats exposed to single prolonged stress, an established posttraumatic stress disorder model, exhibited persistent mechanical allodynia and anxiety-like behavior, which were accompanied by increased activation of microglia and secretion of pro-inflammatory cytokines in the hippocampus. |
2018-02-08 |
2023-08-13 |
rat |
| Rao Sun, Zuoxia Zhang, Yishan Lei, Yue Liu, Cui'e Lu, Hui Rong, Yu'e Sun, Wei Zhang, Zhengliang Ma, Xiaoping G. Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain. Molecular pain. vol 12. 2018-02-08. PMID:27852966. |
correlation analyses showed that hippocampal activation of microglia was significantly correlated with mechanical allodynia and anxiety-like behavior. |
2018-02-08 |
2023-08-13 |
rat |
| Rao Sun, Zuoxia Zhang, Yishan Lei, Yue Liu, Cui'e Lu, Hui Rong, Yu'e Sun, Wei Zhang, Zhengliang Ma, Xiaoping G. Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain. Molecular pain. vol 12. 2018-02-08. PMID:27852966. |
our data also showed that both intraperitoneal and intra-hippocampal injection of minocycline suppressed single prolonged stress-induced microglia activation and inflammatory cytokines accumulation in the hippocampus, and attenuated both single prolonged stress-induced mechanical allodynia and anxiety-like behavior. |
2018-02-08 |
2023-08-13 |
rat |
| Rao Sun, Zuoxia Zhang, Yishan Lei, Yue Liu, Cui'e Lu, Hui Rong, Yu'e Sun, Wei Zhang, Zhengliang Ma, Xiaoping G. Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain. Molecular pain. vol 12. 2018-02-08. PMID:27852966. |
taken together, the present study suggests that stress-induced microglia activation in the hippocampus may serve as a critical mechanistic link in the comorbid relationship between posttraumatic stress disorder and chronic pain. |
2018-02-08 |
2023-08-13 |
rat |