| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Tang, Wenbo Yu, Sheng Chen, Zidan Gao, Baoguo Xia. Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse. Neurochemical research. vol 43. issue 5. 2018-09-27. PMID:29574669. |
and it was observed in the hippocampus of csds induced depression mice that increased activated microglia was merged with inos instead of arginase by immunofluorescence staining. |
2018-09-27 |
2023-08-13 |
mouse |
| Zhao-Hui Yao, Xiao-Li Yao, Yong Zhang, Shao-Feng Zhang, Ji-Chang H. Luteolin Could Improve Cognitive Dysfunction by Inhibiting Neuroinflammation. Neurochemical research. vol 43. issue 4. 2018-09-24. PMID:29392519. |
specifically, luteolin prevented the increase of tnf-α and il-1β, il-6, and mda, improved the activity of sod and gpx, inhibited microglia over-activation and astrogliosis (particularly in the hippocampus and cortex), and ameliorated learning and short-term memory dysfunction, and ltp deficit. |
2018-09-24 |
2023-08-13 |
rat |
| Inssaf Berkiks, S Boulbaroud, L M Garcia-Segura, A Mesfioui, A Ouichou, S Mouden, H Benmhammed, A El Hasnaoui, R Nakache, Y Bahbiti, A El Hessn. Thymelaea lythroides extract attenuates microglial activation and depressive-like behavior in LPS-induced inflammation in adult male rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 99. 2018-09-17. PMID:29710462. |
the levels of proinflammatory cytokines, oxidative damage, and activation of microglia were determined in the hippocampus (hp) of male rats on (pnd90-97). |
2018-09-17 |
2023-08-13 |
rat |
| Harsharan S Bhatia, Nora Roelofs, Eduardo Muñoz, Bernd L Fiebic. Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE Scientific reports. vol 7. issue 1. 2018-09-04. PMID:28273917. |
here we have investigated the hitherto unknown effects of capsaicin (cap) - a transient receptor potential vanilloid 1 (trpv1) agonist- in murine primary microglia, organotypic hippocampal slice cultures (ohscs) and human primary monocytes. |
2018-09-04 |
2023-08-13 |
human |
| Lauren D Claypoole, Betty Zimmerberg, Lauren L Williamso. Neonatal lipopolysaccharide treatment alters hippocampal neuroinflammation, microglia morphology and anxiety-like behavior in rats selectively bred for an infantile trait. Brain, behavior, and immunity. vol 59. 2018-08-23. PMID:27591170. |
neonatal lipopolysaccharide treatment alters hippocampal neuroinflammation, microglia morphology and anxiety-like behavior in rats selectively bred for an infantile trait. |
2018-08-23 |
2023-08-13 |
rat |
| Achikam Haim, Dominic Julian, Christopher Albin-Brooks, Holly M Brothers, Kathryn M Lenz, Benedetta Leune. A survey of neuroimmune changes in pregnant and postpartum female rats. Brain, behavior, and immunity. vol 59. 2018-08-23. PMID:27686844. |
the peripartum decrease in microglia may be a consequence of reduced proliferation as there were fewer numbers of proliferating microglia, and no changes in apoptotic microglia, in the postpartum hippocampus. |
2018-08-23 |
2023-08-13 |
rat |
| Yosuke Yamawaki, Norika Yoshioka, Kanako Nozaki, Hikaru Ito, Keisuke Oda, Kana Harada, Satomi Shirawachi, Satoshi Asano, Hidenori Aizawa, Shigeto Yamawaki, Takashi Kanematsu, Hiroyuki Akag. Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice. Brain research. vol 1680. 2018-08-14. PMID:29229502. |
in addition, we demonstrated the effect of sb on gene information in hippocampal microglia under neuroinflammatory conditions. |
2018-08-14 |
2023-08-13 |
mouse |
| Lijuan Tong, Yu Gong, Peng Wang, Wenfeng Hu, Jili Wang, Zhuo Chen, Wei Zhang, Chao Huan. Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28434164. |
recently, the loss and dystrophy of hippocampal microglia induced by chronic unpredictable stress (cus) has been reported to mediate the development of major depression in mice whose microglial cells were labeled with enhanced green fluorescent protein-conjuncted-cx3c receptor type 1. |
2018-08-07 |
2023-08-13 |
mouse |
| Lijuan Tong, Yu Gong, Peng Wang, Wenfeng Hu, Jili Wang, Zhuo Chen, Wei Zhang, Chao Huan. Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28434164. |
results showed that the cellular numbers, process lengths, soma areas and activation markers of endogenous hippocampal but not cortical microglia, were markedly reduced by cus, crs and csds treatment. |
2018-08-07 |
2023-08-13 |
mouse |
| Lijuan Tong, Yu Gong, Peng Wang, Wenfeng Hu, Jili Wang, Zhuo Chen, Wei Zhang, Chao Huan. Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28434164. |
administration of mice with two classical stimulators of microglia, lipopolysaccharide (lps) or macrophage colony-stimulating factor (m-csf), reversed the cus-, crs- and csds-induced reductions in endogenous hippocampal microglial numbers, and also improved the cus-, crs- or csds-induced behavioral abnormalities, including the increases in the immobile time in the forced swimming test and tail suspension test, the inhibition of sucrose preference, and the decrease in the time spent in the center of open field. |
2018-08-07 |
2023-08-13 |
mouse |
| Lijuan Tong, Yu Gong, Peng Wang, Wenfeng Hu, Jili Wang, Zhuo Chen, Wei Zhang, Chao Huan. Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28434164. |
furthermore, inhibition of the initial activation of hippocampal microglia by minocycline pretreatment also reversed the reduction in hippocampal microglial numbers as well as the behavioral abnormalities induced by cus, crs and csds treatment. |
2018-08-07 |
2023-08-13 |
mouse |
| Lijuan Tong, Yu Gong, Peng Wang, Wenfeng Hu, Jili Wang, Zhuo Chen, Wei Zhang, Chao Huan. Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28434164. |
these results provide compelling evidences to show that different types of chronic stresses can trigger the loss of endogenous hippocampal microglia and restoration of microglial numbers may have therapeutic values in major depression. |
2018-08-07 |
2023-08-13 |
mouse |
| Fang-Xue Zhang, Ren-Shi X. Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson's disease and cell culture via inactivating TLR4/NF-κB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-03. PMID:29136779. |
furthermore, lps induced neuroinflammation through the acceleration of various pro-inflammatory cytokines, including interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), interleukin-18 (il-18) and cyclooxygenase-2 (cox-2), via activating tlr4/nuclear factor (nf)-κb pathway in hippocampus of mice and microglia cells. |
2018-08-03 |
2023-08-13 |
mouse |
| Meetu Wadhwa, Amit Prabhakar, Koushik Ray, Koustav Roy, Punita Kumari, Prabhash Kumar Jha, Krishna Kishore, Sanjeev Kumar, Usha Panjwan. Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation. Journal of neuroinflammation. vol 14. issue 1. 2018-07-24. PMID:29141671. |
inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation. |
2018-07-24 |
2023-08-13 |
rat |
| Andre R C Barreto-Vianna, Marcia B Aguila, Carlos A Mandarim-de-Lacerd. Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation. Metabolic brain disease. vol 32. issue 5. 2018-07-23. PMID:28681199. |
the hippocampal dentate gyrus and ca1 regions were analyzed (morphology and inflammation-related proteins in microglia and astrocyte by confocal microscopy). |
2018-07-23 |
2023-08-13 |
mouse |
| Andre R C Barreto-Vianna, Marcia B Aguila, Carlos A Mandarim-de-Lacerd. Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation. Metabolic brain disease. vol 32. issue 5. 2018-07-23. PMID:28681199. |
palmitate icv infusion resulted in pronounced inflammation response in the hippocampus, reactive microgliosis, and astrogliosis, with hypertrophied iba1 immunoreactive microglia, increased microglial density with ameboid shape, decreased in the number of branches and junctions and increased the major histocompatibility complex (mhc) ii expression. |
2018-07-23 |
2023-08-13 |
mouse |
| Weijia Gu, Yi Wang, Zhenmin Qiu, Jing Dong, Yuan Wang, Jie Che. Maternal exposure to nonylphenol during pregnancy and lactation induces microglial cell activation and pro-inflammatory cytokine production in offspring hippocampus. The Science of the total environment. vol 634. 2018-07-18. PMID:29635194. |
maternal exposure to nonylphenol during pregnancy and lactation induces microglial cell activation and pro-inflammatory cytokine production in offspring hippocampus. |
2018-07-18 |
2023-08-13 |
Not clear |
| Zhang Mengying, Xu Yiyue, Pan Tong, Hu Yue, Yanin Limpanont, Huang Ping, Kamolnetr Okanurak, Wu Yanqi, Paron Dekumyoy, Zhou Hongli, Dorn Watthanakulpanich, Wu Zhongdao, Wang Zhi, Lv Zhiyu. Apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by Angiostrongylus cantonensis infection. Parasites & vectors. vol 10. issue 1. 2018-07-16. PMID:29258580. |
apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by angiostrongylus cantonensis infection. |
2018-07-16 |
2023-08-13 |
mouse |
| S N De Luca, I Ziko, K Dhuna, L Sominsky, M Tolcos, L Stokes, S J Spence. Neonatal overfeeding by small-litter rearing sensitises hippocampal microglial responses to immune challenge: Reversal with neonatal repeated injections of saline or minocycline. Journal of neuroendocrinology. vol 29. issue 11. 2018-07-12. PMID:28983991. |
we have previously demonstrated that adult rats overfed as neonates have hypothalamic microglia that are hyper-responsive to an immune challenge, as well as hippocampal microglia that respond less efficiently to learning. |
2018-07-12 |
2023-08-13 |
rat |
| S N De Luca, I Ziko, K Dhuna, L Sominsky, M Tolcos, L Stokes, S J Spence. Neonatal overfeeding by small-litter rearing sensitises hippocampal microglial responses to immune challenge: Reversal with neonatal repeated injections of saline or minocycline. Journal of neuroendocrinology. vol 29. issue 11. 2018-07-12. PMID:28983991. |
we therefore hypothesised that neonatal overfeeding would alter the ability of hippocampal microglia to respond to an immune challenge with lipopolysaccharide (lps) and that concomitant minocycline, a tetracycline antibiotic that suppresses microglial activity, could restore these responses. |
2018-07-12 |
2023-08-13 |
rat |