| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chuan Qin, Shan-Qiu Wu, Bao-Sheng Chen, Xiao-Xian Wu, Kun-Yao Qu, Jun-Min Liu, Gui-Fang Zhang, Yan-Feng Xu, Shunli Shu, Lihua Sun, Yan-Yong Li, Hua Zhu, Lan Huang, Chun-Mei Ma, Yu-Huan Xu, Yun-Lin Han, Yao-Zeng L. Pathological Changes in APP/PS-1 Transgenic Mouse Models of Alzheimer's Disease Treated with Ganoderma Lucidum Preparation. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 39. issue 4. 2019-02-11. PMID:28877835. |
results the senile plaques and neurofibrillar tangles in the cerebrum and cerebellum were dissolved or disappeared in lz-h and lz-m groups.decrease of amyloid angiopathy was found in lz-h and lz-m groups.the immature neurons appeared more in hippocampus and dentate nucleus of lz-h and lz-m groups than those in ad model and donepezil hydrochloride groups(hippcampus:f=1.738,p=0.016;dentate nucleus:f=1.924,p=0.026),and these immature neurons differentiated to be neurons.more purkinje cells loss occurred in ad model mice than that in lz-h and lz-m groups(f=9.46,p=0.007;f=9.46,p=0.010).the lz-h and lz-m groups had more new neuron stem cells grown up in cerebellum.electromicroscopic examination showed the hippocampal neurons in lz-h and lz-m group were integrated,the nuclear membrane was intact,and the mitochondria in the cytoplasm,endoplasmic reticulum,golgi bodies,microtubules,and synapses were also complete.the microglial cell showed no abnormality.no toxicity appeared in the pathological specimens of mice treated with ganoderma lucidum preparation.conclusion the ganoderma lucidum preparation can dissolve and decline or dismiss the senile plaques and neurofibrillar tangles in the brain of ad mice and also reduce the amyloid angiopathy. |
2019-02-11 |
2023-08-13 |
mouse |
| Judith T Zelikoff, Nancy L Parmalee, Kevin Corbett, Terry Gordon, Catherine B Klein, Michael Aschne. Microglia Activation and Gene Expression Alteration of Neurotrophins in the Hippocampus Following Early-Life Exposure to E-Cigarette Aerosols in a Murine Model. Toxicological sciences : an official journal of the Society of Toxicology. vol 162. issue 1. 2019-02-07. PMID:29161446. |
microglia activation and gene expression alteration of neurotrophins in the hippocampus following early-life exposure to e-cigarette aerosols in a murine model. |
2019-02-07 |
2023-08-13 |
mouse |
| Judith T Zelikoff, Nancy L Parmalee, Kevin Corbett, Terry Gordon, Catherine B Klein, Michael Aschne. Microglia Activation and Gene Expression Alteration of Neurotrophins in the Hippocampus Following Early-Life Exposure to E-Cigarette Aerosols in a Murine Model. Toxicological sciences : an official journal of the Society of Toxicology. vol 162. issue 1. 2019-02-07. PMID:29161446. |
exposure to e-cigarette aerosols without nicotine enhanced expression of iba-1, a specific marker of microglia, in the cornus ammonis 1 region of the hippocampus. |
2019-02-07 |
2023-08-13 |
mouse |
| Shahnawaz Ali Bhat, Ruby Goel, Shubha Shukla, Rakesh Shukla, Kashif Hani. Angiotensin Receptor Blockade by Inhibiting Glial Activation Promotes Hippocampal Neurogenesis Via Activation of Wnt/β-Catenin Signaling in Hypertension. Molecular neurobiology. vol 55. issue 6. 2019-02-04. PMID:28884281. |
therefore, in the present study, we examined the effect of hypertension and ras on glial (astrocytes and microglia) activation and hippocampal neurogenesis in a rat model of chronic hypertension. |
2019-02-04 |
2023-08-13 |
rat |
| Federica Frigerio, Corey Flynn, Ye Han, Kyle Lyman, Joaquin N Lugo, Teresa Ravizza, Antoine Ghestem, Julika Pitsch, Albert Becker, Anne E Anderson, Annamaria Vezzani, Dane Chetkovich, Christophe Bernar. Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells. Molecular neurobiology. vol 55. issue 9. 2019-02-04. PMID:29427087. |
here, we report that intracerebroventricular injection of the prototypical inflammatory molecule lipopolysaccharide (lps) in rats triggered a strong and long-lasting inflammatory response in hippocampal microglia associated with a concomitant upregulation of toll-like receptor (tlr4) in pyramidal and hilar neurons. |
2019-02-04 |
2023-08-13 |
rat |
| Yu Gong, Lijuan Tong, Rongrong Yang, Wenfeng Hu, Xingguo Xu, Wenjing Wang, Peng Wang, Xu Lu, Minhui Gao, Yue Wu, Xing Xu, Yaru Zhang, Zhuo Chen, Chao Huan. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. vol 135. 2019-02-04. PMID:29574097. |
dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. |
2019-02-04 |
2023-08-13 |
mouse |
| Yu Gong, Lijuan Tong, Rongrong Yang, Wenfeng Hu, Xingguo Xu, Wenjing Wang, Peng Wang, Xu Lu, Minhui Gao, Yue Wu, Xing Xu, Yaru Zhang, Zhuo Chen, Chao Huan. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. vol 135. 2019-02-04. PMID:29574097. |
recently, we and others reported that different types of chronic stress induce a significant loss of hippocampal microglia, which is mediated by an initial activation of these microglia. |
2019-02-04 |
2023-08-13 |
mouse |
| Yu Gong, Lijuan Tong, Rongrong Yang, Wenfeng Hu, Xingguo Xu, Wenjing Wang, Peng Wang, Xu Lu, Minhui Gao, Yue Wu, Xing Xu, Yaru Zhang, Zhuo Chen, Chao Huan. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. vol 135. 2019-02-04. PMID:29574097. |
since early-life stress also promotes microglial activation, we investigated the dynamic changes in hippocampal microglia in mice suffering from depression induced by early social isolation (esi). |
2019-02-04 |
2023-08-13 |
mouse |
| Yu Gong, Lijuan Tong, Rongrong Yang, Wenfeng Hu, Xingguo Xu, Wenjing Wang, Peng Wang, Xu Lu, Minhui Gao, Yue Wu, Xing Xu, Yaru Zhang, Zhuo Chen, Chao Huan. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. vol 135. 2019-02-04. PMID:29574097. |
results showed that 8 days of esi induced depressive-like behaviors in a tail suspension test, forced swim test, sucrose preference test, and open field test, and it also induced a loss and dystrophy of hippocampal microglia. |
2019-02-04 |
2023-08-13 |
mouse |
| Yu Gong, Lijuan Tong, Rongrong Yang, Wenfeng Hu, Xingguo Xu, Wenjing Wang, Peng Wang, Xu Lu, Minhui Gao, Yue Wu, Xing Xu, Yaru Zhang, Zhuo Chen, Chao Huan. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. vol 135. 2019-02-04. PMID:29574097. |
we found that this esi-induced loss of hippocampal microglia was mediated by both microglial activation and apoptosis. |
2019-02-04 |
2023-08-13 |
mouse |
| Yu Gong, Lijuan Tong, Rongrong Yang, Wenfeng Hu, Xingguo Xu, Wenjing Wang, Peng Wang, Xu Lu, Minhui Gao, Yue Wu, Xing Xu, Yaru Zhang, Zhuo Chen, Chao Huan. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. vol 135. 2019-02-04. PMID:29574097. |
this was demonstrated by the following results: (i) 1 day of esi induced an obvious activation of hippocampal microglia followed by their apoptosis, and (ii) the blockade of the initial activation of hippocampal microglia by minocycline pretreatment suppressed the esi-induced apoptosis and loss as well as esi-induced depressive-like behavior. |
2019-02-04 |
2023-08-13 |
mouse |
| Yu Gong, Lijuan Tong, Rongrong Yang, Wenfeng Hu, Xingguo Xu, Wenjing Wang, Peng Wang, Xu Lu, Minhui Gao, Yue Wu, Xing Xu, Yaru Zhang, Zhuo Chen, Chao Huan. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. vol 135. 2019-02-04. PMID:29574097. |
lipopolysaccharide (lps) and macrophage colony-stimulating factor (m-csf), two activators of microglia, almost completely reversed esi-induced depressive-like behavior by promoting microglial proliferation in the hippocampus. |
2019-02-04 |
2023-08-13 |
mouse |
| Dong-Cheol Kim, Dong-Sung Lee, Wonmin Ko, Kwan-Woo Kim, Hye Jin Kim, Chi-Su Yoon, Hyuncheol Oh, Youn-Chul Ki. Heme Oxygenase-1-Inducing Activity of 4-Methoxydalbergione and 4'-Hydroxy-4-methoxydalbergione from Dalbergia odorifera and Their Anti-inflammatory and Cytoprotective Effects in Murine Hippocampal and BV2 Microglial Cell Line and Primary Rat Microglial Cells. Neurotoxicity research. vol 33. issue 2. 2019-01-31. PMID:28836188. |
heme oxygenase-1-inducing activity of 4-methoxydalbergione and 4'-hydroxy-4-methoxydalbergione from dalbergia odorifera and their anti-inflammatory and cytoprotective effects in murine hippocampal and bv2 microglial cell line and primary rat microglial cells. |
2019-01-31 |
2023-08-13 |
rat |
| Siriporn Chamniansawat, Chattraporn Sawatdiyaphano. Age-Related Memory Impairment Associated With Decreased Endogenous Estradiol in the Hippocampus of Female Rats. International journal of toxicology. vol 37. issue 3. 2019-01-29. PMID:29554823. |
we also investigated the effect of microglia activation on e2 synthesis in hippocampal neurons. |
2019-01-29 |
2023-08-13 |
rat |
| Siriporn Chamniansawat, Chattraporn Sawatdiyaphano. Age-Related Memory Impairment Associated With Decreased Endogenous Estradiol in the Hippocampus of Female Rats. International journal of toxicology. vol 37. issue 3. 2019-01-29. PMID:29554823. |
in addition, we found that the microglia of aged brain highly expressed interleukin 6 (il-6), which directly inhibited e2 synthesis in hippocampal neurons via suppression of p450 synthesis. |
2019-01-29 |
2023-08-13 |
rat |
| Gabriela Meneses, Marcos Rosetti, Alejandro Espinosa, Alejandra Florentino, Marcel Bautista, Georgina Díaz, Guillermo Olvera, Brandon Bárcena, Agnes Fleury, Laura Adalid-Peralta, Edmundo Lamoyi, Gladis Fragoso, Edda Sciutt. Recovery from an acute systemic and central LPS-inflammation challenge is affected by mouse sex and genetic background. PloS one. vol 13. issue 8. 2019-01-23. PMID:30133465. |
percentage of microglia and astrocytes was determined in the cortex and hippocampus. |
2019-01-23 |
2023-08-13 |
mouse |
| Yunlong Wang, Mengshi Wang, Mengjie Xu, Tongde Li, Kaiyue Fan, Tingxu Yan, Feng Xiao, Kaishun Bi, Ying Ji. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. International immunopharmacology. vol 62. 2019-01-02. PMID:29990697. |
the results of histopathological examination and immunohistochemical analysis showed that lps induced degeneration of neurons and activation of microglia particularly in hippocampus and nkt (10 mg/kg) reversed these changes. |
2019-01-02 |
2023-08-13 |
mouse |
| Prasant Kumar Jena, Lili Sheng, Jacopo Di Lucente, Lee-Way Jin, Izumi Maezawa, Yu-Jui Yvonne Wa. Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 5. 2018-12-31. PMID:29401580. |
the results showed that long-term wd intake reduced hippocampal synaptic plasticity and the level of brain-derived neurotrophic factor mrna in the brain and isolated microglia. |
2018-12-31 |
2023-08-13 |
mouse |
| Ravikanth Velagapudi, Abdelmeneim El-Bakoush, Olumayokun A Olajid. Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside. Molecular neurobiology. vol 55. issue 10. 2018-12-18. PMID:29508282. |
the effects of tiliroside on nrf2 and sirt1 activities in bv2 microglia and ht22 hippocampal neurons were investigated using immunoblotting and dna binding assays. |
2018-12-18 |
2023-08-13 |
mouse |
| Weike Chen, Tingting Liang, Wenwen Zuo, Xin Wu, Zibo Shen, Fang Wang, Cunyu Li, Yunfeng Zheng, Guoping Pen. Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:29957471. |
compared to senescence-accelerated-resistant mouse 1 (samr1) mice, samp8 mice exhibited conspicuous declines in spatial memory abilities and brain-derived neurotrophic factor (bdnf) and tyrosine kinase receptors (trkb) level in hippocampus; increased aβ deposition, β-secretase (bace1) level, microglia activation and inflammatory factors, including interleukin-1β (il-1β), interleukin-6 (il-6) and tumor necrosis factor α (tnf-α) in the brain. |
2018-12-18 |
2023-08-13 |
mouse |