| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongxiang Yang, Yuqin Ye, Chuiguang Kong, Xinhong Su, Xin Zhang, Wei Bai, Xiaosheng H. MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway. Neurochemical research. vol 44. issue 4. 2019-04-26. PMID:30628018. |
mir-124 enriched exosomes promoted the m2 polarization of microglia and enhanced hippocampus neurogenesis after traumatic brain injury by inhibiting tlr4 pathway. |
2019-04-26 |
2023-08-13 |
rat |
| Yongxiang Yang, Yuqin Ye, Chuiguang Kong, Xinhong Su, Xin Zhang, Wei Bai, Xiaosheng H. MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway. Neurochemical research. vol 44. issue 4. 2019-04-26. PMID:30628018. |
however, whether mir-124 enriched exosomes (exo-mir-124) can regulate the polarization of microglia and affect hippocampus neurogenesis after traumatic brain injury (tbi) is unknown. |
2019-04-26 |
2023-08-13 |
rat |
| Zhenri Ou, Xuejian Kong, Xiangdong Sun, Xiaosong He, Le Zhang, Zhuo Gong, Jingyi Huang, Biao Xu, Dahong Long, Jianhua Li, Qingqing Li, Liping Xu, Aiguo Xua. Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice. Brain, behavior, and immunity. vol 69. 2019-04-23. PMID:29253574. |
in addition, metformin administration decreased amyloid-β (aβ)plaque load and chronic inflammation (activated microglia and astrocytes as well as pro-inflammatory mediators) in the hippocampus and cortex. |
2019-04-23 |
2023-08-13 |
mouse |
| M Kodali, B Hattiangady, G A Shetty, A Bates, B Shuai, A K Shett. Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and mitochondrial dysfunction in the hippocampus. Brain, behavior, and immunity. vol 69. 2019-04-23. PMID:29454881. |
these rats also displayed enhanced neurogenesis and diminished inflammation typified by reduced astrocyte hypertrophy and activated microglia in the hippocampus. |
2019-04-23 |
2023-08-13 |
rat |
| Charise Garber, Michael J Vasek, Lauren L Vollmer, Tony Sun, Xiaoping Jiang, Robyn S Klei. Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1. Nature immunology. vol 19. issue 2. 2019-04-22. PMID:29292385. |
mice that had recovered from wnnd exhibited fewer neuroblasts and increased astrogenesis without recovery of hippocampal neurogenesis at 30 d. analysis of cytokine production in microglia and astrocytes isolated ex vivo revealed that the latter were the predominant source of il-1. |
2019-04-22 |
2023-08-13 |
mouse |
| Michael S Hester, Natalia Tulina, Amy Brown, Guillermo Barila, Michal A Elovit. Intrauterine inflammation reduces postnatal neurogenesis in the hippocampal subgranular zone and leads to accumulation of hilar ectopic granule cells. Brain research. vol 1685. 2019-04-19. PMID:29448014. |
intrauterine inflammation had no effect on hippocampal astrocyte or microglia density or on apoptosis rate at the postnatal time points examined. |
2019-04-19 |
2023-08-13 |
mouse |
| Irena Majkutewicz, Ewelina Kurowska, Magdalena Podlacha, Dorota Myślińska, Beata Grembecka, Jan Ruciński, Karolina Pierzynowska, Danuta Wron. Age-dependent effects of dimethyl fumarate on cognitive and neuropathological features in the streptozotocin-induced rat model of Alzheimer's disease. Brain research. vol 1686. 2019-04-19. PMID:29453958. |
hippocampal samples from young (4-month-old, n = 36, collected previously) and aged rats were assessed for presence of activated (cd68-positive) microglia, il-10 and oxidative/nitrative stress marker nitrotyrosine. |
2019-04-19 |
2023-08-13 |
rat |
| Irena Majkutewicz, Ewelina Kurowska, Magdalena Podlacha, Dorota Myślińska, Beata Grembecka, Jan Ruciński, Karolina Pierzynowska, Danuta Wron. Age-dependent effects of dimethyl fumarate on cognitive and neuropathological features in the streptozotocin-induced rat model of Alzheimer's disease. Brain research. vol 1686. 2019-04-19. PMID:29453958. |
notably, within aged stz-injected rats, dmf treatment was associated with improved performance in mwm, reduced neurodegeneration in all hippocampal areas, reduced dg microglia activation, and reduced ca1 nitrotyrosine labeling compared to age-matched rats without dmf treatment. |
2019-04-19 |
2023-08-13 |
rat |
| Pan Jiang, Lei Chen, Jing Sun, Jingsong Li, Jian Xu, Wenyuan Liu, Feng Feng, Wei Q. Chotosan ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia via activating the Nrf2-mediated antioxidant pathway. Journal of pharmacological sciences. vol 139. issue 2. 2019-04-17. PMID:30642751. |
furthermore, chotosan could significantly reverse reactive oxygen species production, neuronal apoptosis and microglia over-activation in hippocampus. |
2019-04-17 |
2023-08-13 |
Not clear |
| Frances K Johnson, Arie Kaffma. Early life stress perturbs the function of microglia in the developing rodent brain: New insights and future challenges. Brain, behavior, and immunity. vol 69. 2019-04-15. PMID:28625767. |
here, we highlight recent work demonstrating that exposure to bds alters microglial cell number, morphology, phagocytic activity, and gene expression in the developing hippocampus in a manner that extends into the juvenile period. |
2019-04-15 |
2023-08-13 |
mouse |
| Matthew G Frank, Laura K Fonken, Jessica L Annis, Linda R Watkins, Steven F Maie. Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming. Brain, behavior, and immunity. vol 69. 2019-04-15. PMID:29104062. |
here, we found that exposure to an acute stressor reduced cd200r expression across sub-regions of the hippocampus, amygdala as well as in isolated hippocampal microglia. |
2019-04-15 |
2023-08-13 |
Not clear |
| Matthew G Frank, Laura K Fonken, Jessica L Annis, Linda R Watkins, Steven F Maie. Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming. Brain, behavior, and immunity. vol 69. 2019-04-15. PMID:29104062. |
we previously found that stress increases the alarmin high mobility group box-1 (hmgb1) in hippocampus, and that hmgb1 mediates stress-induced priming of microglia. |
2019-04-15 |
2023-08-13 |
Not clear |
| Brahim Gargouri, Nizar M Yousif, Michèle Bouchard, Hamadi Fetoui, Bernd L Fiebic. Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29793499. |
inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures. |
2019-04-08 |
2023-08-13 |
human |
| Junming Fan, Hui Guang, Haizeng Zhang, Danyang Chen, Lu Ding, Xiaofang Fan, Feng Xue, Zhuohui Gan, Yongyu Wang, Sunzhong Mao, Lianggang Hu, Yongsheng Gon. SIRT1 Mediates Apelin-13 in Ameliorating Chronic Normobaric Hypoxia-induced Anxiety-like Behavior by Suppressing NF-κB Pathway in Mice Hippocampus. Neuroscience. vol 381. 2019-04-05. PMID:29680708. |
we also showed that resveratrol treatment decreased il-1β, il-6, tnf-ɑ, pcna, bcl-2, and acetyl-p65 levels, but increased bax and caspase 3 levels in hippocampus, suggesting a suppressive effect of resveratrol on cellular neuroinflammation and proliferation while a promotive effect on apoptosis of microglia in hippocampus. |
2019-04-05 |
2023-08-13 |
mouse |
| Nicholas A DaSilva, Pragati P Nahar, Hang Ma, Aseel Eid, Zhengxi Wei, Susan Meschwitz, Nasser H Zawia, Angela L Slitt, Navindra P Seera. Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro. Nutritional neuroscience. vol 22. issue 3. 2019-03-26. PMID:28784051. |
herein, we: (1) evaluated whether urolithins (urolithins a and b and their methylated derivatives) attenuate neuroinflammation in murine bv-2 microglia and human sh-sy5y neurons, and (2) evaluated hippocampus of transgenic ad (r1.40) mice administered a pomegranate extract (pe; 100 or 200 mg/kg/day for 3 weeks) for inflammatory biomarkers. |
2019-03-26 |
2023-08-13 |
mouse |
| Nathan T Fiore, Paul J Austi. Glial-cytokine-neuronal Adaptations in the Ventral Hippocampus of Rats with Affective Behavioral Changes Following Peripheral Nerve Injury. Neuroscience. vol 390. 2019-03-21. PMID:30125685. |
the withdrawal from pellet-seeking was found to be concomitant with distinct glial-cytokine-neuronal adaptations within the contralateral ventral hippocampus, including; increased expression of il-1β and mcp-1; astrocyte atrophy and decreased area in the dentate gyrus; reactive microglia and increased fosb/Δfosb expression in the cornu ammonis subfield. |
2019-03-21 |
2023-08-13 |
rat |
| Lina Feng, Jing Gao, Yuexiang Wang, Yuen-Ki Cheong, Guogang Ren, Zhuo Yan. Etidronate-zinc Complex Ameliorated Cognitive and Synaptic Plasticity Impairments in 2-Vessel Occlusion Model Rats by Reducing Neuroinflammation. Neuroscience. vol 390. 2019-03-21. PMID:30176319. |
moreover, eti-zn treatment reduced both the over-activation of microglia and the expressions of neuroinflammatory cytokines (tnf-α, il-1β and il-6) in the hippocampus. |
2019-03-21 |
2023-08-13 |
rat |
| Matthew J Bellizzi, Jennetta W Hammond, Herman Li, Mary A Gantz Marker, Daniel F Marker, Robert S Freeman, Harris A Gelbar. The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis. eNeuro. vol 5. issue 6. 2019-03-19. PMID:30627663. |
we tested whether inhibiting mixed-lineage kinases (mlks), which can drive inflammatory microglial activation and neuronal degeneration, could protect hippocampal synapses in c57bl/6 mice with experimental autoimmune encephalomyelitis (eae), a disease model that recapitulates the excitatory synaptic injury that occurs widely within the gray matter in ms. urmc-099, a broad spectrum mlk inhibitor with additional activity against leucine-rich repeat kinase 2 (lrrk2) and other kinases, prevented loss of psd95-positive postsynaptic structures, shifted activated microglia toward a less inflammatory phenotype, and reversed deficits in hippocampal-dependent contextual fear conditioning in eae mice when administered after the onset of motor symptoms. |
2019-03-19 |
2023-08-13 |
mouse |
| Xian Wu, Yang-Ge Lv, Yi-Feng Du, Mei Hu, Miranda N Reed, Yan Long, Vishnu Suppiramaniam, Hao Hong, Su-Su Tan. Inhibitory effect of INT-777 on lipopolysaccharide-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 88. 2019-03-18. PMID:30144494. |
importantly, int-777 treatment reversed lps-induced tgr5 down-regulation, suppressed the increase of nuclear nf-κb p65, and mitigated neuroinflammation, evidenced by lower proinflammatory cytokines, less activation of microglia, and increased the ratio of p-creb/creb or mbdnf/probdnf in the hippocampus and frontal cortex. |
2019-03-18 |
2023-08-13 |
mouse |
| Lorenz Fülle, Nina Offermann, Jan Niklas Hansen, Björn Breithausen, Anna Belen Erazo, Oliver Schanz, Luca Radau, Fabian Gondorf, Konrad Knöpper, Judith Alferink, Zeinab Abdullah, Harald Neumann, Heike Weighardt, Christian Henneberger, Annett Halle, Irmgard Förste. CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons. Glia. vol 66. issue 10. 2019-03-18. PMID:30277599. |
taken together, our data identify ccl17 as a homeostatic and inducible neuromodulatory chemokine affecting the presence and morphology of microglia and synaptic transmission in the hippocampus. |
2019-03-18 |
2023-08-13 |
mouse |