| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Youichirou Higashi, Takaaki Aratake, Shogo Shimizu, Takahiro Shimizu, Kumiko Nakamura, Masayuki Tsuda, Toshio Yawata, Tetuya Ueba, Motoaki Sait. Influence of extracellular zinc on M1 microglial activation. Scientific reports. vol 7. 2018-11-26. PMID:28240322. |
extracellular zinc, which is released from hippocampal neurons in response to brain ischaemia, triggers morphological changes in microglia. |
2018-11-26 |
2023-08-13 |
Not clear |
| Efrat Shavit Stein, Marina Ben Shimon, Avital Artan Furman, Valery Golderman, Joab Chapman, Nicola Maggi. Thrombin Inhibition Reduces the Expression of Brain Inflammation Markers upon Systemic LPS Treatment. Neural plasticity. vol 2018. 2018-11-26. PMID:30018633. |
a panel of coagulation factors and effectors (such as thrombin, fx, par1, epcr, and pc) was tested in the hippocampus, isolated microglia, and n9 microglia cell by western blot and real-time pcr and found to be modulated by lps. |
2018-11-26 |
2023-08-13 |
Not clear |
| Efrat Shavit Stein, Marina Ben Shimon, Avital Artan Furman, Valery Golderman, Joab Chapman, Nicola Maggi. Thrombin Inhibition Reduces the Expression of Brain Inflammation Markers upon Systemic LPS Treatment. Neural plasticity. vol 2018. 2018-11-26. PMID:30018633. |
one central finding is a significant increase in fx expression level following lps induction both in vivo in the hippocampus and in vitro in n9 microglia cell line (5.5 ± 0.6- and 2.3 ± 0.1-fold of increase, resp.). |
2018-11-26 |
2023-08-13 |
Not clear |
| Shu-Qi Dong, Qiu-Ping Zhang, Ji-Xiao Zhu, Min Chen, Cheng-Fu Li, Qing Liu, Di Geng, Li-Tao Y. Gypenosides reverses depressive behavior via inhibiting hippocampal neuroinflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-11-26. PMID:30119182. |
in conclusion, this study demonstrates that gypenosides exhibits the antidepressant-like effects in mice, which may be mediated by the inhibition of microglia and nf-κb signaling in the hippocampus. |
2018-11-26 |
2023-08-13 |
mouse |
| Ping Dong, Jian Zhao, Ning Li, Lingling Lu, Liang Li, Xiyan Zhang, Bo Yang, Li Zhang, Dongliang L. Sevoflurane exaggerates cognitive decline in a rat model of chronic intermittent hypoxia by aggravating microglia-mediated neuroinflammation via downregulation of PPAR-γ in the hippocampus. Behavioural brain research. vol 347. 2018-11-13. PMID:29574103. |
molecular studies revealed that pro-inflammatory cytokine expression and activated microglia in the hippocampus were increased in both groups of cih rats, with greater increases in cih + sevoflurane rats. |
2018-11-13 |
2023-08-13 |
rat |
| Adrienne M Antonson, Bindu Balakrishnan, Emily C Radlowski, Geraldine Petr, Rodney W Johnso. Altered Hippocampal Gene Expression and Morphology in Fetal Piglets following Maternal Respiratory Viral Infection. Developmental neuroscience. vol 40. issue 2. 2018-11-09. PMID:29539630. |
mhcii protein, a classic monocyte activation marker, was reduced in microglia, while expression of the mhcii gene was decreased in hippocampal tissue of the fetuses from prrsv-infected gilts. |
2018-11-09 |
2023-08-13 |
Not clear |
| Laetitia Weinhard, Urte Neniskyte, Auguste Vadisiute, Giulia di Bartolomei, Nil Aygün, Laurie Riviere, Francesca Zonfrillo, Susan Dymecki, Cornelius Gros. Sexual dimorphism of microglia and synapses during mouse postnatal development. Developmental neurobiology. vol 78. issue 6. 2018-11-08. PMID:29239126. |
microglia participate in synapse remodeling in the cortex and hippocampus during mouse postnatal development. |
2018-11-08 |
2023-08-13 |
mouse |
| Laetitia Weinhard, Urte Neniskyte, Auguste Vadisiute, Giulia di Bartolomei, Nil Aygün, Laurie Riviere, Francesca Zonfrillo, Susan Dymecki, Cornelius Gros. Sexual dimorphism of microglia and synapses during mouse postnatal development. Developmental neurobiology. vol 78. issue 6. 2018-11-08. PMID:29239126. |
here, we investigated morphological and functional features of microglia across early postnatal development as well as morphological features of both pre- and postsynaptic neuronal compartments in the mouse hippocampus. |
2018-11-08 |
2023-08-13 |
mouse |
| Jun Go, Tae-Shin Park, Geun-Hee Han, Hye-Yeon Park, Young-Kyoung Ryu, Yong-Hoon Kim, Jung Hwan Hwang, Dong-Hee Choi, Jung-Ran Noh, Dae Youn Hwang, Sanghee Kim, Won Keun Oh, Chul-Ho Lee, Kyoung-Shim Ki. Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice. International journal of molecular medicine. vol 42. issue 4. 2018-11-08. PMID:30066827. |
although neither the percentage area occupied by astrocytes and microglia nor the level of 4‑hydroxynonenal protein, a specific marker of lipid peroxidation, were altered by pl treatment, the phosphorylation levels of n‑methyl‑d‑aspartate receptor subtype 2b (nr2b), calmodulin‑dependent protein kinase ii alpha (camkiiα) and extracellular signal‑regulated kinase 1/2 (erk1/2) were markedly increased in the hippocampus of aged mice following the administration of pl. |
2018-11-08 |
2023-08-13 |
mouse |
| Mandy Busse, Vanessa Hettler, Victoria Fischer, Christian Mawrin, Roland Hartig, Henrik Dobrowolny, Bernhard Bogerts, Thomas Frodl, Stefan Buss. Increased quinolinic acid in peripheral mononuclear cells in Alzheimer's dementia. European archives of psychiatry and clinical neuroscience. vol 268. issue 5. 2018-10-26. PMID:28386767. |
although only little is known about the function of activated macrophages and microglia in ad, one important mechanism involves the expression of quinolinic acid (quin), an endogenous n-methyl-d-aspartate glutamate receptor (nmda-r) agonist which mediates excitotoxicity especially in the hippocampus. |
2018-10-26 |
2023-08-13 |
human |
| Anna A Tyrtyshnaia, Igor V Manzhulo, Ruslan M Sultanov, Ekaterina V Ermolenk. Adult hippocampal neurogenesis in neuropathic pain and alkyl glycerol ethers treatment. Acta histochemica. vol 119. issue 8. 2018-10-25. PMID:29107326. |
in addition, we observed a decrease in hippocampal pro-inflammatory microglia marker cd86 immunostaining on day 28 after surgery in alkyl glycerol ethers-treated mice with sciatic nerve ligation. |
2018-10-25 |
2023-08-13 |
mouse |
| Yu Jin Kim, Soo-Jin Jeong, Chang-Seob Seo, Hye-Sun Lim, Eunjin Sohn, Jiyeon Yun, Bu-Yeo Ki. Simultaneous Determination of the Traditional Herbal Formula Ukgansan and the In Vitro Antioxidant Activity of Ferulic Acid as an Active Compound. Molecules (Basel, Switzerland). vol 23. issue 7. 2018-10-24. PMID:29986512. |
furthermore, ugs extract exerted the neuroprotective effect and blocked the inflammatory response in neuronal hippocampal cells and microglia, respectively. |
2018-10-24 |
2023-08-13 |
Not clear |
| Dale B Bosco, Jiaying Zheng, Zhiyan Xu, Jiyun Peng, Ukpong B Eyo, Ke Tang, Cheng Yan, Jun Huang, Lijie Feng, Gongxiong Wu, Jason R Richardson, Hui Wang, Long-Jun W. RNAseq analysis of hippocampal microglia after kainic acid-induced seizures. Molecular brain. vol 11. issue 1. 2018-10-22. PMID:29925434. |
rnaseq analysis of hippocampal microglia after kainic acid-induced seizures. |
2018-10-22 |
2023-08-13 |
Not clear |
| Dale B Bosco, Jiaying Zheng, Zhiyan Xu, Jiyun Peng, Ukpong B Eyo, Ke Tang, Cheng Yan, Jun Huang, Lijie Feng, Gongxiong Wu, Jason R Richardson, Hui Wang, Long-Jun W. RNAseq analysis of hippocampal microglia after kainic acid-induced seizures. Molecular brain. vol 11. issue 1. 2018-10-22. PMID:29925434. |
as such, we utilized rnaseq analysis upon microglia isolated from the hippocampus to determine expression pattern alterations following kainic acid induced seizure. |
2018-10-22 |
2023-08-13 |
Not clear |
| Jian Han, Qi-Hua Yin, Yang Fang, Wei-Qing Shou, Cong-Cong Zhang, Fu-Qiang Gu. Atorvastatin protects BV‑2 mouse microglia and hippocampal neurons against oxygen‑glucose deprivation‑induced neuronal inflammatory injury by suppressing the TLR4/TRAF6/NF‑κB pathway. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29845194. |
atorvastatin protects bv‑2 mouse microglia and hippocampal neurons against oxygen‑glucose deprivation‑induced neuronal inflammatory injury by suppressing the tlr4/traf6/nf‑κb pathway. |
2018-10-19 |
2023-08-13 |
mouse |
| Jian Han, Qi-Hua Yin, Yang Fang, Wei-Qing Shou, Cong-Cong Zhang, Fu-Qiang Gu. Atorvastatin protects BV‑2 mouse microglia and hippocampal neurons against oxygen‑glucose deprivation‑induced neuronal inflammatory injury by suppressing the TLR4/TRAF6/NF‑κB pathway. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29845194. |
the aim of the present study was to assess whether atorvastatin may protect bv‑2 microglia and hippocampal neurons against oxygen‑glucose deprivation (ogd)‑induced neuronal inflammatory injury and to determine the underlying mechanisms by which its effects are produced. |
2018-10-19 |
2023-08-13 |
mouse |
| Jian Han, Qi-Hua Yin, Yang Fang, Wei-Qing Shou, Cong-Cong Zhang, Fu-Qiang Gu. Atorvastatin protects BV‑2 mouse microglia and hippocampal neurons against oxygen‑glucose deprivation‑induced neuronal inflammatory injury by suppressing the TLR4/TRAF6/NF‑κB pathway. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29845194. |
the results of the current study revealed that atorvastatin treatment suppressed the viability of ogd bv‑2 microglia and hippocampal neurons. |
2018-10-19 |
2023-08-13 |
mouse |
| Jian Han, Qi-Hua Yin, Yang Fang, Wei-Qing Shou, Cong-Cong Zhang, Fu-Qiang Gu. Atorvastatin protects BV‑2 mouse microglia and hippocampal neurons against oxygen‑glucose deprivation‑induced neuronal inflammatory injury by suppressing the TLR4/TRAF6/NF‑κB pathway. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29845194. |
it was concluded that atorvastatin treatment may protect bv‑2 microglia and hippocampal neurons from ogd‑induced neuronal inflammatory injury by suppressing the tlr4/traf6/nf‑κb pathway. |
2018-10-19 |
2023-08-13 |
mouse |
| Bingxu Huang, Dewei He, Guangxin Chen, Xin Ran, Wenjin Guo, Xingchi Kan, Wei Wang, Dianfeng Liu, Shoupeng Fu, Juxiong Li. α-Cyperone inhibits LPS-induced inflammation in BV-2 cells through activation of Akt/Nrf2/HO-1 and suppression of the NF-κB pathway. Food & function. vol 9. issue 5. 2018-10-03. PMID:29667667. |
moreover, the toxicities of conditioned medium from activated microglia toward dopaminergic neuronal sh-sy5y cells and hippocampal neuronal ht22 cells were significantly inhibited by pretreatment with α-cyperone. |
2018-10-03 |
2023-08-13 |
Not clear |
| Satoshi Okuyama, Kana Yamamoto, Hirotomo Mori, Atsushi Sawamoto, Yoshiaki Amakura, Morio Yoshimura, Arisa Tamanaha, Yuu Ohkubo, Kuniaki Sugawara, Masahiko Sudo, Mitsunari Nakajima, Yoshiko Furukaw. Neuroprotective effect of Citrus kawachiensis (Kawachi Bankan) peels, a rich source of naringin, against global cerebral ischemia/reperfusion injury in mice. Bioscience, biotechnology, and biochemistry. vol 82. issue 7. 2018-09-28. PMID:29618282. |
administered dried peel powder of c. kawachiensis to mice of a transient global ischemia model and found in the hippocampus region that it 1) suppressed neuronal cell death, 2) reversed the reduction in the level of phosphorylated calcium-calmodulin-dependent protein kinase ii, 3) had the tendency to reverse the reduction in the level of glutathione, and 4) blocked excessive activation of microglia and astrocytes. |
2018-09-28 |
2023-08-13 |
mouse |