| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fa-Xiang Wang, Xiao-Lin Yang, Yuan-Shi Ma, Yu-Jia Wei, Mei-Hua Yang, Xin Chen, Bing Chen, Qian He, Qing-Wu Yang, Hui Yang, Shi-Yong Li. TRIF contributes to epileptogenesis in temporal lobe epilepsy during TLR4 activation. Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28867282. |
meanwhile, in ka-induced trif-deficient mouse models, microglia activation was significantly suppressed; pro-inflammatory factors including il-1β, tnf-α, inos, hmgb1 and ifn-β were reduced; and the survival of the neurons in the hippocampus increased compared with wt mice. |
2018-07-11 |
2023-08-13 |
mouse |
| Radhika Patnala, Thiruma V Arumugam, Neelima Gupta, S Thameem Dhee. HDAC Inhibitor Sodium Butyrate-Mediated Epigenetic Regulation Enhances Neuroprotective Function of Microglia During Ischemic Stroke. Molecular neurobiology. vol 54. issue 8. 2018-07-09. PMID:27722928. |
interestingly, h3k9ac levels were found to be upregulated in activated microglia distributed in the cortex, striatum, and hippocampus of mcao mice. |
2018-07-09 |
2023-08-13 |
mouse |
| Franziska Menzel, Nicole Kaiser, Susann Haehnel, Felicitas Rapp, Ina Patties, Nina Schöneberg, Zhana Haimon, Kerstin Immig, Ingo Bechman. Impact of X-irradiation on microglia. Glia. vol 66. issue 1. 2018-07-02. PMID:29024033. |
furthermore, we investigated long-term effects of x-irradiation on microglia using organotypic hippocampal slice cultures (ohscs). |
2018-07-02 |
2023-08-13 |
Not clear |
| Zhongke Wang, Xie He, Xiaotang Fa. Postnatal administration of memantine rescues TNF-α-induced decreased hippocampal precursor proliferation. Neuroscience letters. vol 662. 2018-06-29. PMID:29042205. |
we further confirmed that mem treatment reversed the tnf-α-induced microglia activation and up-regulation of hippocampal nf-κb, mcp-1 and il-6 mrna levels, which may be related to the proliferation and maintenance of npcs. |
2018-06-29 |
2023-08-13 |
mouse |
| Min-Hee Yi, Enji Zhang, Jwa-Jin Kim, Hyunjung Baek, Nara Shin, Sena Kim, Sang Ryong Kim, Hang-Rae Kim, Sung Joong Lee, Jin Bong Park, Yonghyun Kim, O-Yu Kwon, Young Ho Lee, Sang-Ha Oh, Dong Woon Ki. CD200R/Foxp3-mediated signalling regulates microglial activation. Scientific reports. vol 6. 2018-06-25. PMID:27731341. |
foxp3 expression was up-regulated in microglia activated by excitotoxicity-induced hippocampal neuroinflammation. |
2018-06-25 |
2023-08-13 |
Not clear |
| Hansruedi Mathys, Chinnakkaruppan Adaikkan, Fan Gao, Jennie Z Young, Elodie Manet, Martin Hemberg, Philip L De Jager, Richard M Ransohoff, Aviv Regev, Li-Huei Tsa. Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution. Cell reports. vol 21. issue 2. 2018-06-13. PMID:29020624. |
here, using single-cell rna sequencing, we determined the transcriptome of more than 1,600 individual microglia cells isolated from the hippocampus of a mouse model of severe neurodegeneration with ad-like phenotypes and of control mice at multiple time points during progression of neurodegeneration. |
2018-06-13 |
2023-08-13 |
mouse |
| Patricia B de la Tremblaye, Simon M Benoit, Sarah Schock, Hélène Plamondo. CRHR1 exacerbates the glial inflammatory response and alters BDNF/TrkB/pCREB signaling in a rat model of global cerebral ischemia: implications for neuroprotection and cognitive recovery. Progress in neuro-psychopharmacology & biological psychiatry. vol 79. issue Pt B. 2018-06-12. PMID:28647536. |
thirty days post ischemia, brain derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) receptor expression, hippocampal neuronal death and inflammation were determined by analyzing immunoreactivity (ir) of neuron-specific nuclear protein (neun), microglia (iba1, ionized calcium binding adaptor molecule 1), astrocytes (gfap, glial fibrillary acidic protein) and tnfα (tumor necrosis factor alpha) a pro-inflammatory cytokine. |
2018-06-12 |
2023-08-13 |
rat |
| Yun Zhang, Mao-Lin H. Deferoxamine enhances alternative activation of microglia and inhibits amyloid beta deposits in APP/PS1 mice. Brain research. vol 1677. 2018-06-11. PMID:28963052. |
consistent with these observations, dfx induced m2 activation of microglia and inhibited m1 activation of microglia in the hippocampus of app/ps1 mice. |
2018-06-11 |
2023-08-13 |
mouse |
| Yong Li, Jimok Ki. Distinct roles of neuronal and microglial CB2 cannabinoid receptors in the mouse hippocampus. Neuroscience. vol 363. 2018-06-08. PMID:28888955. |
the targeted manipulation of cb2r expression in pyramidal neurons and microglia suggests that cb2rs in different types of cells in the mature hippocampus play distinct roles in the regulation of memory and anxiety. |
2018-06-08 |
2023-08-13 |
mouse |
| Claudia Espinosa-Garcia, Iqbal Sayeed, Seema Yousuf, Fahim Atif, Elena G Sergeeva, Gretchen N Neigh, Donald G Stei. Stress primes microglial polarization after global ischemia: Therapeutic potential of progesterone. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28648389. |
treatment with progesterone significantly attenuated stress-induced microglia priming by modulating polarized microglia and the inflammatory environment in the hippocampus, the area most vulnerable to ischemic injury. |
2018-06-06 |
2023-08-13 |
rat |
| Geoffroy Laumet, Wenjun Zhou, Robert Dantzer, Jules D Edralin, XiaoJiao Huo, David P Budac, Jason C O'Connor, Anna W Lee, Cobi J Heijnen, Annemieke Kavelaar. Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28709913. |
the increase in kmo-protein in response to sni mostly took place in hippocampal neun-positive neurons rather than microglia. |
2018-06-06 |
2023-08-13 |
mouse |
| Lianne Hoeijmakers, Gideon F Meerhoff, Janneke W de Vries, Silvie R Ruigrok, Anne-Marie van Dam, Fred van Leuven, Aniko Korosi, Paul J Lucasse. The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis. Neurobiology of aging. vol 61. 2018-06-04. PMID:29059594. |
the age-related slow increase in amyloid pathology in app.v717i mice activates microglia, but does not alter hippocampal neurogenesis. |
2018-06-04 |
2023-08-13 |
mouse |
| Alexandra Turano, Jennifer H Lawrence, Jaclyn M Schwar. Activation of neonatal microglia can be influenced by other neural cells. Neuroscience letters. vol 657. 2018-05-28. PMID:28774571. |
thus, we treated freshly isolated, sex-specific microglia from the rat hippocampus with lipopolysaccharide (lps) on p4, in either the presence or absence of other neural cells. |
2018-05-28 |
2023-08-13 |
rat |
| Setayesh R Tasbihgou, Mina Netkova, Alain F Kalmar, Janine Doorduin, Michel M R F Struys, Regien G Schoemaker, Anthony R Absalo. Brain changes due to hypoxia during light anaesthesia can be prevented by deepening anaesthesia; a study in rats. PloS one. vol 13. issue 2. 2018-05-23. PMID:29451906. |
although reduced hippocampal neurogenesis may be considered unfavourable, higher bdnf expression, associated with microglia hyper-ramification may suggest activation of repair mechanisms. |
2018-05-23 |
2023-08-13 |
rat |
| Thomas Pfeiffer, Elena Avignone, U Valentin Näger. Induction of hippocampal long-term potentiation increases the morphological dynamics of microglial processes and prolongs their contacts with dendritic spines. Scientific reports. vol 6. 2018-05-18. PMID:27604518. |
to this end, we characterized the morphological dynamics of microglia and their interactions with synapses before and after the induction of synaptic plasticity (ltp) in the hippocampus by time-lapse two-photon imaging and electrophysiological recordings in acute brain slices. |
2018-05-18 |
2023-08-13 |
Not clear |
| Thomas Pfeiffer, Elena Avignone, U Valentin Näger. Induction of hippocampal long-term potentiation increases the morphological dynamics of microglial processes and prolongs their contacts with dendritic spines. Scientific reports. vol 6. 2018-05-18. PMID:27604518. |
we demonstrate that during hippocampal ltp microglia alter their morphological dynamics by increasing the number of their processes and by prolonging their physical contacts with dendritic spines. |
2018-05-18 |
2023-08-13 |
Not clear |
| Yanbo Ma, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihar. Involvement of progranulin in modulating neuroinflammatory responses but not neurogenesis in the hippocampus of aged mice. Experimental gerontology. vol 95. 2018-05-16. PMID:28479389. |
the number of cd68-positive activated microglia and the expression of lysosomal genes in the hippocampus were significantly increased with age, and pgrn deficiency further increased them. |
2018-05-16 |
2023-08-13 |
mouse |
| Yanbo Ma, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihar. Involvement of progranulin in modulating neuroinflammatory responses but not neurogenesis in the hippocampus of aged mice. Experimental gerontology. vol 95. 2018-05-16. PMID:28479389. |
these results suggest that pgrn deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while pgrn may not counteract the decline of hippocampal neurogenesis with age. |
2018-05-16 |
2023-08-13 |
mouse |
| Wandert Schaafsma, Laura Bozal Basterra, Sabrina Jacobs, Nieske Brouwer, Peter Meerlo, Anne Schaafsma, Erik W G M Boddeke, Bart J L Egge. Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood. Neurobiology of disease. vol 106. 2018-05-15. PMID:28751257. |
in contrast, hippocampal microglia of these mice displayed an increased inflammatory response to an lps re-challenge. |
2018-05-15 |
2023-08-13 |
mouse |
| Wandert Schaafsma, Laura Bozal Basterra, Sabrina Jacobs, Nieske Brouwer, Peter Meerlo, Anne Schaafsma, Erik W G M Boddeke, Bart J L Egge. Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood. Neurobiology of disease. vol 106. 2018-05-15. PMID:28751257. |
in addition, a reduced expression of brain-derived neurotrophic factor (bdnf) was observed in hippocampal microglia of lps-offspring. |
2018-05-15 |
2023-08-13 |
mouse |