| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingrui Pan, Lei He, Xiangpen Li, Mei Li, Xiaoni Zhang, Jacob Venesky, Yi Li, Ying Pen. Activating Autophagy in Hippocampal Cells Alleviates the Morphine-Induced Memory Impairment. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26873855. |
autophagy inhibition by 3-methyladenine obviously aggravates this morphine-induced memory impairment, accompanied with increased cell deaths in stratum pyramidale of hippocampal ca1, ca3, and dg regions and the activation of microglia to induce inflammation in hippocampus, such as upregulated expression of tnf-α, il-1β, il-6, and inos, as well as nf-κb' s activation, while morphine alone promoted microglial immunosuppression in hippocampus with autophagy activation which was also confirmed in primary microglia. |
2018-02-07 |
2023-08-13 |
mouse |
| Jingrui Pan, Lei He, Xiangpen Li, Mei Li, Xiaoni Zhang, Jacob Venesky, Yi Li, Ying Pen. Activating Autophagy in Hippocampal Cells Alleviates the Morphine-Induced Memory Impairment. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26873855. |
taken together, our data indicates that autophagy activating in hippocampal cells can alleviate the memory impairment caused by morphine, by decreasing neuronal deaths in hippocampus and suppressing inflammation in hippocampal microglia, implying that modulating the activation of autophagy might be a promising method to prevent or treat the memory impairment caused by morphine. |
2018-02-07 |
2023-08-13 |
mouse |
| Xuelai Fan, Elizabeth G Wheatley, Saul A Villed. Mechanisms of Hippocampal Aging and the Potential for Rejuvenation. Annual review of neuroscience. vol 40. 2018-02-07. PMID:28441118. |
we discuss the functional changes in synaptic plasticity and regenerative potential of the aged hippocampus, followed by mechanisms of microglia aging, and assess the cross talk between these proaging processes. |
2018-02-07 |
2023-08-13 |
Not clear |
| Ravit Hadar, Le Dong, Lucia Del-Valle-Anton, Dilansu Guneykaya, Mareike Voget, Henriette Edemann-Callesen, Regina Schweibold, Anais Djodari-Irani, Thomas Goetz, Samuel Ewing, Helmut Kettenmann, Susanne A Wolf, Christine Winte. Deep brain stimulation during early adolescence prevents microglial alterations in a model of maternal immune activation. Brain, behavior, and immunity. vol 63. 2018-01-30. PMID:27939248. |
stimulation of either the medial prefrontal cortex or the nucleus accumbens normalized microglia density and soma size in main projection areas including the hippocampus and in the area around the electrode implantation. |
2018-01-30 |
2023-08-13 |
rat |
| Lianne Hoeijmakers, Silvie R Ruigrok, Anna Amelianchik, Daniela Ivan, Anne-Marie van Dam, Paul J Lucassen, Aniko Koros. Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model. Brain, behavior, and immunity. vol 63. 2018-01-30. PMID:28027926. |
in wt mice, immediately following es exposure (p9), iba1-immunopositive microglia exhibited reduced complexity and hippocampal interleukin (il)-1β expression was increased. |
2018-01-30 |
2023-08-13 |
mouse |
| Nicole D Schartz, Seth A Herr, Lauren Madsen, Sarah J Butts, Ceidy Torres, Loyda B Mendez, Amy L Brewste. Spatiotemporal profile of Map2 and microglial changes in the hippocampal CA1 region following pilocarpine-induced status epilepticus. Scientific reports. vol 6. 2018-01-18. PMID:27143585. |
recently, we reported a substantial decline in map2 that coincided with robust microglia accumulation in the ca1 hippocampal region after an episode of se. |
2018-01-18 |
2023-08-13 |
human |
| Nicole D Schartz, Seth A Herr, Lauren Madsen, Sarah J Butts, Ceidy Torres, Loyda B Mendez, Amy L Brewste. Spatiotemporal profile of Map2 and microglial changes in the hippocampal CA1 region following pilocarpine-induced status epilepticus. Scientific reports. vol 6. 2018-01-18. PMID:27143585. |
we used immunohistochemistry to determine the distribution of map2 and the microglia marker iba1 in the hippocampus after pilocarpine-induced se from 4 hrs to 35 days. |
2018-01-18 |
2023-08-13 |
human |
| Min-Xuan Xu, Rong Yu, Li-Fei Shao, Yan-Xiu Zhang, Chen-Xu Ge, Xin-Meng Liu, Wen-Yuan Wu, Jian-Mei Li, Ling-Dong Kon. Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin. Brain, behavior, and immunity. vol 58. 2018-01-17. PMID:26765996. |
fructose feeding was found to induce hippocampal microglia activation with neuroinflammation through the activation of the toll-like receptor 4 (tlr4)/nuclear transcription factor κb (nf-κb) signaling, resulting in the reduction of neurogenesis in the dentate gyrus (dg) of mice. |
2018-01-17 |
2023-08-13 |
mouse |
| Min-Xuan Xu, Rong Yu, Li-Fei Shao, Yan-Xiu Zhang, Chen-Xu Ge, Xin-Meng Liu, Wen-Yuan Wu, Jian-Mei Li, Ling-Dong Kon. Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin. Brain, behavior, and immunity. vol 58. 2018-01-17. PMID:26765996. |
curcumin protected against neuronal damage in hippocampal dg of fructose-fed mice by inhibiting microglia activation and suppressed fkn/cx3cr1 up-regulation in the neuronal network. |
2018-01-17 |
2023-08-13 |
mouse |
| Silvia Alboni, Silvia Poggini, Stefano Garofalo, Giampaolo Milior, Hassan El Hajj, Cynthia Lecours, Isabelle Girard, Steven Gagnon, Samuel Boisjoly-Villeneuve, Nicoletta Brunello, David P Wolfer, Cristina Limatola, Marie-Ève Tremblay, Laura Maggi, Igor Branch. Fluoxetine treatment affects the inflammatory response and microglial function according to the quality of the living environment. Brain, behavior, and immunity. vol 58. 2018-01-17. PMID:27474084. |
at the end of treatment, we measured the expression levels of several anti- and pro-inflammatory cytokines and inflammatory mediators in the whole hippocampus and in isolated microglia. |
2018-01-17 |
2023-08-13 |
mouse |
| Junfang Wu, Zaorui Zhao, Alok Kumar, Marta M Lipinski, David J Loane, Bogdan A Stoica, Alan I Fade. Endoplasmic Reticulum Stress and Disrupted Neurogenesis in the Brain Are Associated with Cognitive Impairment and Depressive-Like Behavior after Spinal Cord Injury. Journal of neurotrauma. vol 33. issue 21. 2018-01-12. PMID:27050417. |
stereological analysis demonstrated that moderate/severe sci reduced neuronal survival and increased the number of activated microglia chronically in the cerebral cortex and hippocampus. |
2018-01-12 |
2023-08-13 |
mouse |
| Jean-Christophe Delpech, Lan Wei, Jin Hao, Xiaoqing Yu, Charlotte Madore, Oleg Butovsky, Arie Kaffma. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27301858. |
early life stress perturbs the maturation of microglia in the developing hippocampus. |
2018-01-11 |
2023-08-13 |
mouse |
| Jean-Christophe Delpech, Lan Wei, Jin Hao, Xiaoqing Yu, Charlotte Madore, Oleg Butovsky, Arie Kaffma. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27301858. |
given that microglia are involved in these developmental processes, we tested whether bds impairs microglial activity in the hippocampus of 14 (during bds) and 28-day old mice (one week after bds). |
2018-01-11 |
2023-08-13 |
mouse |
| Jean-Christophe Delpech, Lan Wei, Jin Hao, Xiaoqing Yu, Charlotte Madore, Oleg Butovsky, Arie Kaffma. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27301858. |
we found that bds increased the density and altered the morphology of microglia in the hippocampus of 14-day old pups, effects that were no longer present on postnatal day (pnd) 28. |
2018-01-11 |
2023-08-13 |
mouse |
| Jean-Christophe Delpech, Lan Wei, Jin Hao, Xiaoqing Yu, Charlotte Madore, Oleg Butovsky, Arie Kaffma. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27301858. |
despite the normal cell number and morphology seen at pnd28, the molecular signature of hippocampal microglia, assessed using the nanostring immune panel, was altered at both ages. |
2018-01-11 |
2023-08-13 |
mouse |
| Jean-Christophe Delpech, Lan Wei, Jin Hao, Xiaoqing Yu, Charlotte Madore, Oleg Butovsky, Arie Kaffma. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27301858. |
we showed that during normal hippocampal development, microglia undergo significant changes between pnd14 and pnd28, including reduced cell density, decreased ex vivo phagocytic activity, and an increase in the expression of genes involved in inflammation and cell migration. |
2018-01-11 |
2023-08-13 |
mouse |
| Jean-Christophe Delpech, Lan Wei, Jin Hao, Xiaoqing Yu, Charlotte Madore, Oleg Butovsky, Arie Kaffma. Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27301858. |
however, microglia harvested from the hippocampus of 28-day old bds mice showed an increase in phagocytic activity and reduced expression of genes that normally increase across development. |
2018-01-11 |
2023-08-13 |
mouse |
| Nan Yan, Yan Liu, Shengnan Liu, Siqi Cao, Fei Wang, Zhengdong Wang, Shuhua X. Fluoride-Induced Neuron Apoptosis and Expressions of Inflammatory Factors by Activating Microglia in Rat Brain. Molecular neurobiology. vol 53. issue 7. 2018-01-08. PMID:26253724. |
the microglia in the hippocampus and cortex of fluoride-treated rats were activated by immunostaining with ox-42, a marker of activated microglia, and ox-42-positive microglia cells were more abundant in the hippocampus than in the cortex. |
2018-01-08 |
2023-08-13 |
rat |
| Alita Soch, Steven Bradburn, Luba Sominsky, Simone N De Luca, Christopher Murgatroyd, Sarah J Spence. Effects of exercise on adolescent and adult hypothalamic and hippocampal neuroinflammation. Hippocampus. vol 26. issue 11. 2018-01-08. PMID:27438996. |
together these data suggest that adolescent hippocampal microglia are more sensitive to the effects of exercise than those of adults, but this leads to no apparent improvement in recognition memory. |
2018-01-08 |
2023-08-13 |
rat |
| E-B Kang, J-H Koo, Y-C Jang, C-H Yang, Y Lee, L M Cosio-Lima, J-Y Ch. Neuroprotective Effects of Endurance Exercise Against High-Fat Diet-Induced Hippocampal Neuroinflammation. Journal of neuroendocrinology. vol 28. issue 5. 2018-01-04. PMID:26991447. |
moreover, te reduced an indicator of microglia activation, ionised calcium-binding adapter molecule-1, and also decreased glial fibrillary acidic protein, an indicator of gliosis formed by activated astrocytes in the cerebral cortex and the hippocampal dentate gyrus, compared to hfd-fed sedentary rats. |
2018-01-04 |
2023-08-13 |
rat |