| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yosuke Yamawaki, Norika Yoshioka, Kanako Nozaki, Hikaru Ito, Keisuke Oda, Kana Harada, Satomi Shirawachi, Satoshi Asano, Hidenori Aizawa, Shigeto Yamawaki, Takashi Kanematsu, Hiroyuki Akag. Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice. Brain research. vol 1680. 2018-08-14. PMID:29229502. |
in addition, we demonstrated the effect of sb on gene information in hippocampal microglia under neuroinflammatory conditions. |
2018-08-14 |
2023-08-13 |
mouse |
| Lijuan Tong, Yu Gong, Peng Wang, Wenfeng Hu, Jili Wang, Zhuo Chen, Wei Zhang, Chao Huan. Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28434164. |
recently, the loss and dystrophy of hippocampal microglia induced by chronic unpredictable stress (cus) has been reported to mediate the development of major depression in mice whose microglial cells were labeled with enhanced green fluorescent protein-conjuncted-cx3c receptor type 1. |
2018-08-07 |
2023-08-13 |
mouse |
| Lijuan Tong, Yu Gong, Peng Wang, Wenfeng Hu, Jili Wang, Zhuo Chen, Wei Zhang, Chao Huan. Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28434164. |
results showed that the cellular numbers, process lengths, soma areas and activation markers of endogenous hippocampal but not cortical microglia, were markedly reduced by cus, crs and csds treatment. |
2018-08-07 |
2023-08-13 |
mouse |
| Lijuan Tong, Yu Gong, Peng Wang, Wenfeng Hu, Jili Wang, Zhuo Chen, Wei Zhang, Chao Huan. Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28434164. |
administration of mice with two classical stimulators of microglia, lipopolysaccharide (lps) or macrophage colony-stimulating factor (m-csf), reversed the cus-, crs- and csds-induced reductions in endogenous hippocampal microglial numbers, and also improved the cus-, crs- or csds-induced behavioral abnormalities, including the increases in the immobile time in the forced swimming test and tail suspension test, the inhibition of sucrose preference, and the decrease in the time spent in the center of open field. |
2018-08-07 |
2023-08-13 |
mouse |
| Lijuan Tong, Yu Gong, Peng Wang, Wenfeng Hu, Jili Wang, Zhuo Chen, Wei Zhang, Chao Huan. Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28434164. |
furthermore, inhibition of the initial activation of hippocampal microglia by minocycline pretreatment also reversed the reduction in hippocampal microglial numbers as well as the behavioral abnormalities induced by cus, crs and csds treatment. |
2018-08-07 |
2023-08-13 |
mouse |
| Lijuan Tong, Yu Gong, Peng Wang, Wenfeng Hu, Jili Wang, Zhuo Chen, Wei Zhang, Chao Huan. Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28434164. |
these results provide compelling evidences to show that different types of chronic stresses can trigger the loss of endogenous hippocampal microglia and restoration of microglial numbers may have therapeutic values in major depression. |
2018-08-07 |
2023-08-13 |
mouse |
| Fang-Xue Zhang, Ren-Shi X. Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson's disease and cell culture via inactivating TLR4/NF-κB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-03. PMID:29136779. |
furthermore, lps induced neuroinflammation through the acceleration of various pro-inflammatory cytokines, including interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), interleukin-18 (il-18) and cyclooxygenase-2 (cox-2), via activating tlr4/nuclear factor (nf)-κb pathway in hippocampus of mice and microglia cells. |
2018-08-03 |
2023-08-13 |
mouse |
| Meetu Wadhwa, Amit Prabhakar, Koushik Ray, Koustav Roy, Punita Kumari, Prabhash Kumar Jha, Krishna Kishore, Sanjeev Kumar, Usha Panjwan. Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation. Journal of neuroinflammation. vol 14. issue 1. 2018-07-24. PMID:29141671. |
inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation. |
2018-07-24 |
2023-08-13 |
rat |
| Andre R C Barreto-Vianna, Marcia B Aguila, Carlos A Mandarim-de-Lacerd. Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation. Metabolic brain disease. vol 32. issue 5. 2018-07-23. PMID:28681199. |
the hippocampal dentate gyrus and ca1 regions were analyzed (morphology and inflammation-related proteins in microglia and astrocyte by confocal microscopy). |
2018-07-23 |
2023-08-13 |
mouse |
| Andre R C Barreto-Vianna, Marcia B Aguila, Carlos A Mandarim-de-Lacerd. Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation. Metabolic brain disease. vol 32. issue 5. 2018-07-23. PMID:28681199. |
palmitate icv infusion resulted in pronounced inflammation response in the hippocampus, reactive microgliosis, and astrogliosis, with hypertrophied iba1 immunoreactive microglia, increased microglial density with ameboid shape, decreased in the number of branches and junctions and increased the major histocompatibility complex (mhc) ii expression. |
2018-07-23 |
2023-08-13 |
mouse |
| Weijia Gu, Yi Wang, Zhenmin Qiu, Jing Dong, Yuan Wang, Jie Che. Maternal exposure to nonylphenol during pregnancy and lactation induces microglial cell activation and pro-inflammatory cytokine production in offspring hippocampus. The Science of the total environment. vol 634. 2018-07-18. PMID:29635194. |
maternal exposure to nonylphenol during pregnancy and lactation induces microglial cell activation and pro-inflammatory cytokine production in offspring hippocampus. |
2018-07-18 |
2023-08-13 |
Not clear |
| Zhang Mengying, Xu Yiyue, Pan Tong, Hu Yue, Yanin Limpanont, Huang Ping, Kamolnetr Okanurak, Wu Yanqi, Paron Dekumyoy, Zhou Hongli, Dorn Watthanakulpanich, Wu Zhongdao, Wang Zhi, Lv Zhiyu. Apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by Angiostrongylus cantonensis infection. Parasites & vectors. vol 10. issue 1. 2018-07-16. PMID:29258580. |
apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by angiostrongylus cantonensis infection. |
2018-07-16 |
2023-08-13 |
mouse |
| S N De Luca, I Ziko, K Dhuna, L Sominsky, M Tolcos, L Stokes, S J Spence. Neonatal overfeeding by small-litter rearing sensitises hippocampal microglial responses to immune challenge: Reversal with neonatal repeated injections of saline or minocycline. Journal of neuroendocrinology. vol 29. issue 11. 2018-07-12. PMID:28983991. |
we have previously demonstrated that adult rats overfed as neonates have hypothalamic microglia that are hyper-responsive to an immune challenge, as well as hippocampal microglia that respond less efficiently to learning. |
2018-07-12 |
2023-08-13 |
rat |
| S N De Luca, I Ziko, K Dhuna, L Sominsky, M Tolcos, L Stokes, S J Spence. Neonatal overfeeding by small-litter rearing sensitises hippocampal microglial responses to immune challenge: Reversal with neonatal repeated injections of saline or minocycline. Journal of neuroendocrinology. vol 29. issue 11. 2018-07-12. PMID:28983991. |
we therefore hypothesised that neonatal overfeeding would alter the ability of hippocampal microglia to respond to an immune challenge with lipopolysaccharide (lps) and that concomitant minocycline, a tetracycline antibiotic that suppresses microglial activity, could restore these responses. |
2018-07-12 |
2023-08-13 |
rat |
| Fa-Xiang Wang, Xiao-Lin Yang, Yuan-Shi Ma, Yu-Jia Wei, Mei-Hua Yang, Xin Chen, Bing Chen, Qian He, Qing-Wu Yang, Hui Yang, Shi-Yong Li. TRIF contributes to epileptogenesis in temporal lobe epilepsy during TLR4 activation. Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28867282. |
meanwhile, in ka-induced trif-deficient mouse models, microglia activation was significantly suppressed; pro-inflammatory factors including il-1β, tnf-α, inos, hmgb1 and ifn-β were reduced; and the survival of the neurons in the hippocampus increased compared with wt mice. |
2018-07-11 |
2023-08-13 |
mouse |
| Radhika Patnala, Thiruma V Arumugam, Neelima Gupta, S Thameem Dhee. HDAC Inhibitor Sodium Butyrate-Mediated Epigenetic Regulation Enhances Neuroprotective Function of Microglia During Ischemic Stroke. Molecular neurobiology. vol 54. issue 8. 2018-07-09. PMID:27722928. |
interestingly, h3k9ac levels were found to be upregulated in activated microglia distributed in the cortex, striatum, and hippocampus of mcao mice. |
2018-07-09 |
2023-08-13 |
mouse |
| Franziska Menzel, Nicole Kaiser, Susann Haehnel, Felicitas Rapp, Ina Patties, Nina Schöneberg, Zhana Haimon, Kerstin Immig, Ingo Bechman. Impact of X-irradiation on microglia. Glia. vol 66. issue 1. 2018-07-02. PMID:29024033. |
furthermore, we investigated long-term effects of x-irradiation on microglia using organotypic hippocampal slice cultures (ohscs). |
2018-07-02 |
2023-08-13 |
Not clear |
| Zhongke Wang, Xie He, Xiaotang Fa. Postnatal administration of memantine rescues TNF-α-induced decreased hippocampal precursor proliferation. Neuroscience letters. vol 662. 2018-06-29. PMID:29042205. |
we further confirmed that mem treatment reversed the tnf-α-induced microglia activation and up-regulation of hippocampal nf-κb, mcp-1 and il-6 mrna levels, which may be related to the proliferation and maintenance of npcs. |
2018-06-29 |
2023-08-13 |
mouse |
| Min-Hee Yi, Enji Zhang, Jwa-Jin Kim, Hyunjung Baek, Nara Shin, Sena Kim, Sang Ryong Kim, Hang-Rae Kim, Sung Joong Lee, Jin Bong Park, Yonghyun Kim, O-Yu Kwon, Young Ho Lee, Sang-Ha Oh, Dong Woon Ki. CD200R/Foxp3-mediated signalling regulates microglial activation. Scientific reports. vol 6. 2018-06-25. PMID:27731341. |
foxp3 expression was up-regulated in microglia activated by excitotoxicity-induced hippocampal neuroinflammation. |
2018-06-25 |
2023-08-13 |
Not clear |
| Hansruedi Mathys, Chinnakkaruppan Adaikkan, Fan Gao, Jennie Z Young, Elodie Manet, Martin Hemberg, Philip L De Jager, Richard M Ransohoff, Aviv Regev, Li-Huei Tsa. Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution. Cell reports. vol 21. issue 2. 2018-06-13. PMID:29020624. |
here, using single-cell rna sequencing, we determined the transcriptome of more than 1,600 individual microglia cells isolated from the hippocampus of a mouse model of severe neurodegeneration with ad-like phenotypes and of control mice at multiple time points during progression of neurodegeneration. |
2018-06-13 |
2023-08-13 |
mouse |