| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lynn van Olst, Pascal Bielefeld, Carlos P Fitzsimons, Helga E de Vries, Marijn Schoute. Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia. Aging cell. vol 17. issue 4. 2019-10-07. PMID:29882317. |
these data suggest that gcs increase ramification of hippocampal microglia and may modulate age-associated changes in microglial morphology. |
2019-10-07 |
2023-08-13 |
mouse |
| Elise C Cope, Elizabeth A LaMarca, Patrick K Monari, Lyra B Olson, Susana Martinez, Anna D Zych, Nicole J Katchur, Elizabeth Goul. Microglia Play an Active Role in Obesity-Associated Cognitive Decline. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 41. 2019-10-07. PMID:30201764. |
to investigate the cellular mechanisms that underlie obesity-associated cognitive decline, we used diet-induced obesity in male mice and found memory impairments along with reductions in dendritic spines, sites of excitatory synapses, increases in the activation of microglia, the brain's resident immune cells, and increases in synaptic profiles within microglia, in the hippocampus, a brain region linked to cognition. |
2019-10-07 |
2023-08-13 |
mouse |
| Clarissa von Haefen, Marco Sifringer, Stefanie Endesfelder, Alexander Kalb, Adrián González-López, Annalena Tegethoff, Nadine Paeschke, Claudia D Spie. Physostigmine Restores Impaired Autophagy in the Rat Hippocampus after Surgery Stress and LPS Treatment. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 3. 2019-10-02. PMID:29790105. |
activated microglia, apoptosis-, autophagy-, and anti-inflammatory-related genes and -proteins in the hippocampus were determined by real-time pcr, western blot and fluorescence microscopy after 1 h, 24 h and 3 d. surgery combined with lps-treatment led to microglia activation after 1 h and 24 h which was accompanied by apoptotic cell death after 24 h in the hippocampus. |
2019-10-02 |
2023-08-13 |
rat |
| Jinling Zhang, Liu Yang, Zeman Fang, Jiming Kong, Qingjun Huang, Haiyun X. Adenosine Promotes the Recovery of Mice from the Cuprizone-Induced Behavioral and Morphological Changes while Effecting on Microglia and Inflammatory Cytokines in the Brain. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 3. 2019-10-02. PMID:30069711. |
in addition, the effective dose (10 mg/kg) of adenosine inhibited microglia activation and suppressed abnormal elevation of the pro-inflammatory cytokines il-1β and tnf-α in ctx and hippocampus, but increased levels of the anti-inflammatory cytokines il-4 or il-10 in the same brain regions during the remyelinating process. |
2019-10-02 |
2023-08-13 |
mouse |
| Hamid Gholami Pourbadie, Mohammad Sayyah, Baharak Khoshkholgh-Sima, Samira Choopani, Mohsen Nategh, Fereshteh Motamedi, Mohammad Ali Shokrgoza. Early minor stimulation of microglial TLR2 and TLR4 receptors attenuates Alzheimer's disease-related cognitive deficit in rats: behavioral, molecular, and electrophysiological evidence. Neurobiology of aging. vol 70. 2019-09-27. PMID:30031930. |
finally, the following factors were measured: memory performance by morris water maze, postsynaptic potentials of dentate gyrus following perforant pathway stimulation, hippocampal inflammatory cytokines interleukin 1 (il-1)β and tnf-α, anti-inflammatory cytokines il-10 and tgf-1β, microglia marker arginase 1, aβ deposits, and the receptor involved in aβ clearance, formyl peptide receptor 2 (fpr2). |
2019-09-27 |
2023-08-13 |
rat |
| Hamid Gholami Pourbadie, Mohammad Sayyah, Baharak Khoshkholgh-Sima, Samira Choopani, Mohsen Nategh, Fereshteh Motamedi, Mohammad Ali Shokrgoza. Early minor stimulation of microglial TLR2 and TLR4 receptors attenuates Alzheimer's disease-related cognitive deficit in rats: behavioral, molecular, and electrophysiological evidence. Neurobiology of aging. vol 70. 2019-09-27. PMID:30031930. |
low-dose tlrs ligands improved the disturbance in spatial and working memory; restored the impaired long-term potentiation induced by aβ; decreased tnf-α, and aβ deposits; enhanced tgf-1β, il-10, and arginase 1 in the hippocampus of aβ-treated rats; and increased polarization of hippocampal microglia to the anti-inflammatory phenotype. |
2019-09-27 |
2023-08-13 |
rat |
| Fengling Li, Lei Li. Comparison of kainate-induced seizures, cognitive impairment and hippocampal damage in male and female mice. Life sciences. vol 232. 2019-09-27. PMID:31269415. |
ka-induced neurodegeneration in the whole hippocampus, particularly in ca1 and ca3 subregions, along with the deteriorative reactive gliosis in astrocytes and microglia, was more severe in males than that in females. |
2019-09-27 |
2023-08-13 |
mouse |
| Carlos Guevara, Gonzalo Farias, Carlos Silva-Rosas, Pablo Alarcon, Gabriel Abudinen, Julio Espinoza, Andrés Caro, Heather Angus-Leppan, Jose de Grazi. Encephalitis Associated to Metabotropic Glutamate Receptor 5 (mGluR5) Antibodies in Cerebrospinal Fluid. Frontiers in immunology. vol 9. 2019-09-26. PMID:30455705. |
mglur5 is found on post-synaptic terminals of neurons and microglia and is expressed primarily in the hippocampus and amygdala. |
2019-09-26 |
2023-08-13 |
Not clear |
| Yuan Gao, En-Jie Liu, Wei-Jin Wang, Ya-Li Wang, Xiao-Guang Li, Xin Wang, Shi-Hong Li, Shu-Juan Zhang, Meng-Zhu Li, Qiu-Zhi Zhou, Xiao-Bing Long, Hua-Qiu Zhang, Jian-Zhi Wan. Microglia CREB-Phosphorylation Mediates Amyloid-β-Induced Neuronal Toxicity. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-19. PMID:30282353. |
aβ treatment for 24 h increased ps133-creb level in microglia of the hippocampal non-granular cell layers with remarkably decreased ps133-creb immunoreactivity in neurons of the hippocampal granular cell layers, including ca1, ca3, and dg subsets. |
2019-09-19 |
2023-08-13 |
mouse |
| Yuan Gao, En-Jie Liu, Wei-Jin Wang, Ya-Li Wang, Xiao-Guang Li, Xin Wang, Shi-Hong Li, Shu-Juan Zhang, Meng-Zhu Li, Qiu-Zhi Zhou, Xiao-Bing Long, Hua-Qiu Zhang, Jian-Zhi Wan. Microglia CREB-Phosphorylation Mediates Amyloid-β-Induced Neuronal Toxicity. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-19. PMID:30282353. |
finally, treatment of the primary hippocampal neurons with aβ-potentiated microglia media decreased neuronal glun1 and glua2 levels, while simultaneous inhibition of pka restored the levels. |
2019-09-19 |
2023-08-13 |
mouse |
| Weiwei Ma, Mengnan Wu, Siyan Zhou, Ye Tao, Zuolei Xie, Yi Zhon. Reduced Smoothened level rescues Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. Journal of genetics and genomics = Yi chuan xue bao. vol 45. issue 5. 2019-09-17. PMID:29807798. |
furthermore, pharmaceutical administration of a smo antagonist lde rescued aβ-induced upregulation of smo in astrocytes of mouse hippocampus, improved memory in morris water maze (mwm), and reduced expression of astrocyte secreting pro-inflammatory factors il-1β, tnfα and the microglia marker iba-1 in an app/ps1 transgenic mouse model. |
2019-09-17 |
2023-08-13 |
mouse |
| Anastasia Noël, Libin Zhou, Bénédicte Foveau, P Jesper Sjöström, Andréa C LeBlan. Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6. Cell death and differentiation. vol 25. issue 7. 2019-09-16. PMID:29352267. |
microglia and astrocytes were increased in the hippocampal stratum lacunosum molecular and in the cortex, but not in the striatum. |
2019-09-16 |
2023-08-13 |
mouse |
| Mayra Gisel Flores-Montoya, Colin A Bill, Charlotte M Vines, Christina Sobi. Early chronic low-level lead exposure reduced C-C chemokine receptor 7 in hippocampal microglia. Toxicology letters. vol 314. 2019-09-16. PMID:31306743. |
early chronic low-level lead exposure reduced c-c chemokine receptor 7 in hippocampal microglia. |
2019-09-16 |
2023-08-13 |
mouse |
| Mayra Gisel Flores-Montoya, Colin A Bill, Charlotte M Vines, Christina Sobi. Early chronic low-level lead exposure reduced C-C chemokine receptor 7 in hippocampal microglia. Toxicology letters. vol 314. 2019-09-16. PMID:31306743. |
flow cytometry was used to quantify cell types and cell surface expression of mhc ii and ccr7 in hippocampal and whole brain microglia. |
2019-09-16 |
2023-08-13 |
mouse |
| Mayra Gisel Flores-Montoya, Colin A Bill, Charlotte M Vines, Christina Sobi. Early chronic low-level lead exposure reduced C-C chemokine receptor 7 in hippocampal microglia. Toxicology letters. vol 314. 2019-09-16. PMID:31306743. |
as compared to controls, ccr7 in hippocampal microglia was decreased in the low-dose group, measured as geometric mean fluorescence intensity (gmfi); in the higher-dose group ccr7 |
2019-09-16 |
2023-08-13 |
mouse |
| T M Brombacher, K S De Gouveia, L Cruywagen, N Makena, F Booley, O Tamgue, F Brombache. Nippostrongylus brasiliensis infection leads to impaired reference memory and myeloid cell interference. Scientific reports. vol 8. issue 1. 2019-09-12. PMID:29440657. |
of further interest, an increase in the number of hippocampal macrophages and microglia with training and/or infection suggested a significant role of these cell types during spatial learning. |
2019-09-12 |
2023-08-13 |
mouse |
| Laura K Fonken, Matthew G Frank, Heather M D'Angelo, Jared D Heinze, Linda R Watkins, Christopher A Lowry, Steven F Maie. Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction. Neurobiology of aging. vol 71. 2019-09-11. PMID:30118926. |
furthermore, m. vaccae immunization reduced age-related hyperinflammatory responses in isolated hippocampal microglia. |
2019-09-11 |
2023-08-13 |
rat |
| Karen Krukowski, Katherine Grue, Elma S Frias, John Pietrykowski, Tamako Jones, Gregory Nelson, Susanna Ros. Female mice are protected from space radiation-induced maladaptive responses. Brain, behavior, and immunity. vol 74. 2019-09-10. PMID:30107198. |
mechanistically, the maladaptive behavioral responses observed only in the male cohorts correspond with microglia activation and synaptic loss in the hippocampus, a brain region involved in the cognitive domains reported here. |
2019-09-10 |
2023-08-13 |
mouse |
| Inken Waltl, Christopher Käufer, Ingo Gerhauser, Chintan Chhatbar, Luca Ghita, Ulrich Kalinke, Wolfgang Lösche. Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage. Brain, behavior, and immunity. vol 74. 2019-09-10. PMID:30217535. |
microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage. |
2019-09-10 |
2023-08-13 |
mouse |
| Inken Waltl, Christopher Käufer, Ingo Gerhauser, Chintan Chhatbar, Luca Ghita, Ulrich Kalinke, Wolfgang Lösche. Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage. Brain, behavior, and immunity. vol 74. 2019-09-10. PMID:30217535. |
microglia depletion accelerated the occurrence of seizures, exacerbated hippocampal damage, and led to neurodegeneration in the spinal cord, which is normally not observed in this mouse strain. |
2019-09-10 |
2023-08-13 |
mouse |