| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiqu Xu, Hui Gao, Li Zhang, Shuang Rong, Wei Yang, Congcong Ma, Meng Chen, Qingde Huang, Qianchun Deng, Fenghong Huan. Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. Journal of pineal research. vol 67. issue 2. 2020-01-09. PMID:31050371. |
activated microglia and astrocytes and hippocampal levels of tnf-α in hfd-fed rats were reduced by mlt treatment. |
2020-01-09 |
2023-08-13 |
rat |
| Juan de Dios Rodríguez-Callejas, Daniel Cuervo-Zanatta, Abraham Rosas-Arellano, Caroline Fonta, Eberhard Fuchs, Claudia Perez-Cru. Loss of ferritin-positive microglia relates to increased iron, RNA oxidation, and dystrophic microglia in the brains of aged male marmosets. American journal of primatology. vol 81. issue 2. 2020-01-08. PMID:30779205. |
we analyzed brains of male marmosets and observed an increased density of ferritin+ microglia with an activated phenotype in hippocampus and cortex of old marmosets (mean age 11.25 ± 0.70 years) compared to younger subjects. |
2020-01-08 |
2023-08-13 |
human |
| Claudia P Figueiredo, Fernanda G Q Barros-Aragão, Rômulo L S Neris, Paula S Frost, Carolina Soares, Isis N O Souza, Julianna D Zeidler, Daniele C Zamberlan, Virginia L de Sousa, Amanda S Souza, André Luis A Guimarães, Maria Bellio, Jorge Marcondes de Souza, Soniza V Alves-Leon, Gilda A Neves, Heitor A Paula-Neto, Newton G Castro, Fernanda G De Felice, Iranaia Assunção-Miranda, Julia R Clarke, Andrea T Da Poian, Sergio T Ferreir. Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice. Nature communications. vol 10. issue 1. 2020-01-06. PMID:31488835. |
microglia are found to engulf hippocampal presynaptic terminals during acute infection. |
2020-01-06 |
2023-08-13 |
mouse |
| Rebecca K West, Jessica I Wooden, Emily A Barton, J Leigh Leasur. Recurrent binge ethanol is associated with significant loss of dentate gyrus granule neurons in female rats despite concomitant increase in neurogenesis. Neuropharmacology. vol 148. 2019-12-27. PMID:30659841. |
using stereology, we quantified the number and/or size of neurons in the medial prefrontal cortex (mpfc) and hippocampal dentate gyrus (dg), as well as the number and activation state of microglia. |
2019-12-27 |
2023-08-13 |
rat |
| Rebecca K West, Jessica I Wooden, Emily A Barton, J Leigh Leasur. Recurrent binge ethanol is associated with significant loss of dentate gyrus granule neurons in female rats despite concomitant increase in neurogenesis. Neuropharmacology. vol 148. 2019-12-27. PMID:30659841. |
in the hippocampus and mpfc, the number of microglia with morphology indicative of partial activation was increased by recurrent binge ethanol and decreased by exercise. |
2019-12-27 |
2023-08-13 |
rat |
| Els van der Goot, Vibeke M Bruinenberg, Femke M Hormann, Ulrich L M Eisel, Francjan J van Spronsen, Eddy A Van der Ze. Hippocampal microglia modifications in C57Bl/6 Pah Neurobiology of learning and memory. vol 160. 2019-12-24. PMID:29772389. |
hippocampal microglia modifications in c57bl/6 pah toxic levels of phenylalanine in blood and brain is a characteristic of (untreated) phenylketonuria (pku), leading to cognitive deficits in pku mice. |
2019-12-24 |
2023-08-13 |
mouse |
| Els van der Goot, Vibeke M Bruinenberg, Femke M Hormann, Ulrich L M Eisel, Francjan J van Spronsen, Eddy A Van der Ze. Hippocampal microglia modifications in C57Bl/6 Pah Neurobiology of learning and memory. vol 160. 2019-12-24. PMID:29772389. |
sleep loss has been linked to increased activation of microglia in the hippocampus. |
2019-12-24 |
2023-08-13 |
mouse |
| Els van der Goot, Vibeke M Bruinenberg, Femke M Hormann, Ulrich L M Eisel, Francjan J van Spronsen, Eddy A Van der Ze. Hippocampal microglia modifications in C57Bl/6 Pah Neurobiology of learning and memory. vol 160. 2019-12-24. PMID:29772389. |
in this study, we set out to examine morphological features of the microglia population in the hippocampus of the mouse pku model, using both the c57bl/6 and the btbr strain and their wild-type controls (age 5.3 ± 0.5 months; n = 16 per group, both males and females; n = 8 each). |
2019-12-24 |
2023-08-13 |
mouse |
| Els van der Goot, Vibeke M Bruinenberg, Femke M Hormann, Ulrich L M Eisel, Francjan J van Spronsen, Eddy A Van der Ze. Hippocampal microglia modifications in C57Bl/6 Pah Neurobiology of learning and memory. vol 160. 2019-12-24. PMID:29772389. |
we measured the number of microglia in seven subregions of the dorsal hippocampus. |
2019-12-24 |
2023-08-13 |
mouse |
| Els van der Goot, Vibeke M Bruinenberg, Femke M Hormann, Ulrich L M Eisel, Francjan J van Spronsen, Eddy A Van der Ze. Hippocampal microglia modifications in C57Bl/6 Pah Neurobiology of learning and memory. vol 160. 2019-12-24. PMID:29772389. |
results showed subtle but statistical significant activation of hippocampal microglia in the c57bl6, but not in the btbr, pku mice when compared with their wild-type controls. |
2019-12-24 |
2023-08-13 |
mouse |
| Els van der Goot, Vibeke M Bruinenberg, Femke M Hormann, Ulrich L M Eisel, Francjan J van Spronsen, Eddy A Van der Ze. Hippocampal microglia modifications in C57Bl/6 Pah Neurobiology of learning and memory. vol 160. 2019-12-24. PMID:29772389. |
it is concluded that the c57bl/6 pku mouse has mildly higher microglia activity, which may support rather than hamper hippocampal homeostasis. |
2019-12-24 |
2023-08-13 |
mouse |
| Els van der Goot, Vibeke M Bruinenberg, Femke M Hormann, Ulrich L M Eisel, Francjan J van Spronsen, Eddy A Van der Ze. Hippocampal microglia modifications in C57Bl/6 Pah Neurobiology of learning and memory. vol 160. 2019-12-24. PMID:29772389. |
it is currently unknown why the two pku mouse strains show these differences in number and activation level of their hippocampal microglia, and to what extent it influences hippocampal functioning. |
2019-12-24 |
2023-08-13 |
mouse |
| Lin Zhang, Shuqin Xu, Qingjun Huang, Haiyun X. N-acetylcysteine attenuates the cuprizone-induced behavioral changes and oligodendrocyte loss in male C57BL/7 mice via its anti-inflammation actions. Journal of neuroscience research. vol 96. issue 5. 2019-12-23. PMID:29114910. |
the mice exposed to cpz for 10 days showed significantly lower spontaneous alternation in the y-maze, lower activity of total superoxide dismutase, and glutathione peroxidase, but higher levels of malondialdehyde in the cerebral cortex and hippocampus, elevated concentrations of interleukin-1β and tumor necrosis factor-α in the brain regions mentioned above and caudate putamen, and a decreased number of mature oligodendrocytes, but increased number of microglia in all the brain regions examined. |
2019-12-23 |
2023-08-13 |
mouse |
| Lin Li, Zhan Liu, Yong-Ying Jiang, Wei-Xing Shen, Yu-Ping Peng, Yi-Hua Qi. Acetylcholine suppresses microglial inflammatory response via α7nAChR to protect hippocampal neurons. Journal of integrative neuroscience. vol 18. issue 1. 2019-12-23. PMID:31091848. |
investigation of microglia in lipopolysaccharide-induced hippocampal neuronal toxicity employed α7nachr gene silencing and demonstrated that both the anti-inflammatory and neuroprotective effects of acetylcholine rely on α7nachr pathways. |
2019-12-23 |
2023-08-13 |
Not clear |
| Lin Li, Zhan Liu, Yong-Ying Jiang, Wei-Xing Shen, Yu-Ping Peng, Yi-Hua Qi. Acetylcholine suppresses microglial inflammatory response via α7nAChR to protect hippocampal neurons. Journal of integrative neuroscience. vol 18. issue 1. 2019-12-23. PMID:31091848. |
these findings establish that ach activates α7nachr in microglia, which in turn protects hippocampal neurons. |
2019-12-23 |
2023-08-13 |
Not clear |
| Qiuying Zhao, Qiaozhi Wang, Jiutai Wang, Minmin Tang, Shugui Huang, Ke Peng, Yue Han, Jinqiang Zhang, Guangyi Liu, Qi Fang, Zili Yo. Maternal immune activation-induced PPARγ-dependent dysfunction of microglia associated with neurogenic impairment and aberrant postnatal behaviors in offspring. Neurobiology of disease. vol 125. 2019-12-16. PMID:30659984. |
these results indicated that the mia-induced long-term changes in microglia phenotypes were associated with hippocampal neurogenesis and neurobehavioral abnormalities in offspring. |
2019-12-16 |
2023-08-13 |
Not clear |
| Chunyan Zhu, Qionghong Xu, Zhiyun Mao, Na Li. The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation. Scientific reports. vol 8. issue 1. 2019-12-13. PMID:30115941. |
the chinese medicine wu-tou decoction relieves neuropathic pain by inhibiting hippocampal microglia activation. |
2019-12-13 |
2023-08-13 |
mouse |
| Chunyan Zhu, Qionghong Xu, Zhiyun Mao, Na Li. The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation. Scientific reports. vol 8. issue 1. 2019-12-13. PMID:30115941. |
in addition, hippocampal neurons were proven sensitive to harms induced by microglia and rescued by wtd, which in sum indicated hippocampal microglia as the critical modulator of co-curation. |
2019-12-13 |
2023-08-13 |
mouse |
| Chunyan Zhu, Qionghong Xu, Zhiyun Mao, Na Li. The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation. Scientific reports. vol 8. issue 1. 2019-12-13. PMID:30115941. |
to validate this hypothesis the hippocampal microglia were mal-activated in shamed mice, in which the atrophy of hippocampus and the development of np syndromes were consolidated and proven rescued by wtd. |
2019-12-13 |
2023-08-13 |
mouse |
| Chunyan Zhu, Qionghong Xu, Zhiyun Mao, Na Li. The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation. Scientific reports. vol 8. issue 1. 2019-12-13. PMID:30115941. |
on the contrary, in the snl mice, the failure to control hippocampal microglia was sufficient to void all the rescues mediated by wtd. |
2019-12-13 |
2023-08-13 |
mouse |