| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiajia Dai, Zhuofeng Ding, Jie Zhang, Wei Xu, Qulian Guo, Wangyuan Zou, Yunchuan Xiong, Yingqi Weng, Yong Yang, Sisi Chen, Jun-Ming Zhang, Zongbin Son. Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus. Anesthesia and analgesia. vol 129. issue 6. 2020-04-08. PMID:31743195. |
in this study, we investigated the roles of microglia in the hippocampus in the comorbidity of bone cancer pain and depressive-like behaviors in an animal model of bone cancer pain. |
2020-04-08 |
2023-08-13 |
rat |
| Victoria Schiffer, Estibaliz Santiago-Mujika, Stefanie Flunkert, Staffan Schmidt, Martina Farcher, Tina Loeffler, Irene Schilcher, Maria Posch, Joerg Neddens, Ying Sun, Jan Kehr, Birgit Hutter-Paie. Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease. PloS one. vol 15. issue 1. 2020-04-08. PMID:31929594. |
furthermore, animals present strong motor deficits that are accompanied by increased glucosylceramide and glucosylsphingosine levels in the brain, astrocytosis and activated microglia in the cortex and hippocampus as well as reduced calbindin levels in the cerebellum. |
2020-04-08 |
2023-08-13 |
mouse |
| David J Clarke, Tariq W Chohan, Mustafa S Kassem, Kristie L Smith, Rose Chesworth, Tim Karl, Michael P Kuligowski, Sandra Y Fok, Maxwell R Bennett, Jonathon C Arnol. Neuregulin 1 Deficiency Modulates Adolescent Stress-Induced Dendritic Spine Loss in a Brain Region-Specific Manner and Increases Complement 4 Expression in the Hippocampus. Schizophrenia bulletin. vol 45. issue 2. 2020-04-06. PMID:29566220. |
stress in wt mice promoted dendritic spine loss and microglial cell activation in the prefrontal cortex and the hippocampus. |
2020-04-06 |
2023-08-13 |
mouse |
| David J Clarke, Tariq W Chohan, Mustafa S Kassem, Kristie L Smith, Rose Chesworth, Tim Karl, Michael P Kuligowski, Sandra Y Fok, Maxwell R Bennett, Jonathon C Arnol. Neuregulin 1 Deficiency Modulates Adolescent Stress-Induced Dendritic Spine Loss in a Brain Region-Specific Manner and Increases Complement 4 Expression in the Hippocampus. Schizophrenia bulletin. vol 45. issue 2. 2020-04-06. PMID:29566220. |
however, nrg1 deficiency rendered mice resilient to stress-induced dendritic spine loss in the infralimbic cortex and the ca3 region of the hippocampus without affecting stress-induced microglial cell activation in these brain regions. |
2020-04-06 |
2023-08-13 |
mouse |
| Yihang Zhao, Qianxu Wang, Mengzhen Jia, Shangchen Fu, Junru Pan, Chuanqi Chu, Xiaoning Liu, Xuebo Liu, Zhigang Li. (+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation. The Journal of nutritional biochemistry. vol 64. 2020-04-06. PMID:30445417. |
moreover, sesamin treatment significantly prevented cums-induced neuroinflammation by inhibiting over-activation of microglia and expressions of inflammatory mediators including inos, cox-2, tnf-α and il-1β in stressed mice hippocampus and cortex. |
2020-04-06 |
2023-08-13 |
mouse |
| Maryam Kamarehei, Sussan Kabudanian Ardestani, Masoumeh Firouzi, Hamid Zahednasab, Hossein Keyvani, Mohammad Hossein Harirchia. Increased expression of endoplasmic reticulum stress-related caspase-12 and CHOP in the hippocampus of EAE mice. Brain research bulletin. vol 147. 2020-04-06. PMID:30738137. |
furthermore, immunofluorescent dual-label staining verified elevated levels of caspase-12/chop in astrocytes, oligodendrocytes, and microglia in the hippocampus section of eae mice. |
2020-04-06 |
2023-08-13 |
mouse |
| Maryam Kamarehei, Sussan Kabudanian Ardestani, Masoumeh Firouzi, Hamid Zahednasab, Hossein Keyvani, Mohammad Hossein Harirchia. Increased expression of endoplasmic reticulum stress-related caspase-12 and CHOP in the hippocampus of EAE mice. Brain research bulletin. vol 147. 2020-04-06. PMID:30738137. |
higher levels of caspase-12/chop in hippocampal oligodendrocytes as compared with microglia and astrocytes denote that oligodendrocytes are particularly sensitive to er-mediated apoptosis. |
2020-04-06 |
2023-08-13 |
mouse |
| Liang Zhao, Chuanyang Zhang, Guilin Cao, Xueyi Dong, Dongliang Li, Lei Jian. Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A. Neurochemical research. vol 44. issue 11. 2020-04-06. PMID:31486012. |
one week after exposure, freezing as measured by fear conditioning test, microglia activity, proinflammatory cytokine expression and nadph oxidase-dependent reactive oxygen species (ros) production in the hippocampus (a key brain structure involved in learning and memory) were comparable between vehicle-treated rats exposed to control and vehicle-treated rats exposed to sevoflurane. |
2020-04-06 |
2023-08-13 |
rat |
| Liang Zhao, Chuanyang Zhang, Guilin Cao, Xueyi Dong, Dongliang Li, Lei Jian. Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A. Neurochemical research. vol 44. issue 11. 2020-04-06. PMID:31486012. |
tmao treatment, which increased plasma tmao before and 1 week after control or sevoflurane exposure, significantly reduced freezing to contextual fear conditioning, which was associated with increases in microglia activity, proinflammatory cytokine expression and nadph oxidase-dependent ros production in the hippocampus in rats exposed to sevoflurane but not in rats exposed to control. |
2020-04-06 |
2023-08-13 |
rat |
| Radha Raghuraman, Aparna Karthikeyan, Wong Lik Wei, S Thameem Dheen, Sreedharan Sajikuma. Activation of microglia in acute hippocampal slices affects activity-dependent long-term potentiation and synaptic tagging and capture in area CA1. Neurobiology of learning and memory. vol 163. 2020-04-02. PMID:31278985. |
activation of microglia in acute hippocampal slices affects activity-dependent long-term potentiation and synaptic tagging and capture in area ca1. |
2020-04-02 |
2023-08-13 |
Not clear |
| Radha Raghuraman, Aparna Karthikeyan, Wong Lik Wei, S Thameem Dheen, Sreedharan Sajikuma. Activation of microglia in acute hippocampal slices affects activity-dependent long-term potentiation and synaptic tagging and capture in area CA1. Neurobiology of learning and memory. vol 163. 2020-04-02. PMID:31278985. |
treatment of hippocampal slices with clodronate, a specific inhibitor of microglia, resulted in an activated morphology of microglia but not of the hippocampal pyramidal neurons, oligodendrocytes or astrocytes. |
2020-04-02 |
2023-08-13 |
Not clear |
| Annette Masuch, Knut Bibe. Replenishment of Organotypic Hippocampal Slice Cultures with Neonatal or Adult Microglia. Methods in molecular biology (Clifton, N.J.). vol 2034. 2020-04-01. PMID:31392682. |
replenishment of organotypic hippocampal slice cultures with neonatal or adult microglia. |
2020-04-01 |
2023-08-13 |
mouse |
| Annette Masuch, Knut Bibe. Replenishment of Organotypic Hippocampal Slice Cultures with Neonatal or Adult Microglia. Methods in molecular biology (Clifton, N.J.). vol 2034. 2020-04-01. PMID:31392682. |
this protocol describes a method to deplete and repopulate organotypic hippocampal slice cultures with ramified microglia. |
2020-04-01 |
2023-08-13 |
mouse |
| Thuy-Truc Ta, Hasan Onur Dikmen, Simone Schilling, Bruno Chausse, Andrea Lewen, Jan-Oliver Hollnagel, Oliver Kan. Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 10. 2020-03-30. PMID:30782788. |
we explored the effects of chronic ifn-γ exposure on microglia in hippocampal slice cultures, i.e., postnatal parenchyma lacking leukocyte infiltration (adaptive immunity). |
2020-03-30 |
2023-08-13 |
Not clear |
| Sami Alzarea, Shafiqur Rahma. Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice. Behavioural brain research. vol 366. 2020-03-26. PMID:30877025. |
following lps treatment, pnu120596 hindered activation markers of the microglia and astrocytes (cluster of differentiation molecule 11b and glial fibrillary acidic protein) and upregulation of proinflammatory cytokines such as interleukin 1 beta and tumor necrosis factor-alpha in the hippocampus and prefrontal cortex. |
2020-03-26 |
2023-08-13 |
mouse |
| Ahmad Gholamhosseinian, Roghayeh Abbasalipourkabir, Nasrin Ziamajidi, Mahtab Sayadi, Khatere Sayad. The anti-inflammatory effect of omega-3 polyunsaturated fatty acids dramatically decreases by iron in the hippocampus of diabetic rats. Life sciences. vol 245. 2020-03-23. PMID:32017872. |
the purpose of this study was to investigate the effect of concomitant use of omega-3 polyunsaturated fatty acids (ω-3 pufas) with iron supplements on microglial cell activation and inflammatory conditions in the hippocampus of type 2 diabetic rats. |
2020-03-23 |
2023-08-13 |
rat |
| I Berkiks, L M Garcia-Segura, A Nassiri, A Mesfioui, A Ouichou, S Boulbaroud, Y Bahbiti, A B Lopez-Rodriguez, El Hasnaoui, A El Hessn. The sex differences of the behavior response to early Life immune stimulation: Microglia and astrocytes involvement. Physiology & behavior. vol 199. 2020-03-19. PMID:30529512. |
hippocampal proinflammatory cytokine tnf-alpha concentration and the number of astrocytes and microglia were estimated in the dentate gyrus, ca1, and ca3 in two regions of the hippocampus (ventral and dorsal). |
2020-03-19 |
2023-08-13 |
rat |
| I Berkiks, L M Garcia-Segura, A Nassiri, A Mesfioui, A Ouichou, S Boulbaroud, Y Bahbiti, A B Lopez-Rodriguez, El Hasnaoui, A El Hessn. The sex differences of the behavior response to early Life immune stimulation: Microglia and astrocytes involvement. Physiology & behavior. vol 199. 2020-03-19. PMID:30529512. |
however, the lps-administration increased the number of microglia in the dorsal and ventral hippocampus areas in females more than male, while no significant differences in tnfα level had been detected between the lps-rats treated and their controls. |
2020-03-19 |
2023-08-13 |
rat |
| Monique Michels, Pricila Ávila, Bruna Pescador, Andriele Vieira, Mariane Abatti, Luana Cucker, Heloisa Borges, Amanda Indalécio Goulart, Celso Carvalho Junior, Tatiana Barichello, João Quevedo, Felipe Dal-Pizzo. Microglial Cells Depletion Increases Inflammation and Modifies Microglial Phenotypes in an Animal Model of Severe Sepsis. Molecular neurobiology. vol 56. issue 11. 2020-03-13. PMID:31020614. |
clod-lip treatment was effective in decreasing microglia density in the hippocampus of animals. |
2020-03-13 |
2023-08-13 |
Not clear |
| Allison McIntosh, Virginia Mela, Conor Harty, Aedin M Minogue, Derek A Costello, Christian Kerskens, Marina A Lync. Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice. Brain pathology (Zurich, Switzerland). vol 29. issue 5. 2020-03-09. PMID:30661261. |
analysis of app/ps1 mice by magnetic resonance imaging (mri) revealed genotype-related hypointense areas in the hippocampus consistent with iron deposition, and immunohistochemical analysis indicated that the iron accumulated in microglia, particularly in microglia that decorated aβ deposits. |
2020-03-09 |
2023-08-13 |
mouse |