| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danka A Kozareva, Gerard M Moloney, Alan E Hoban, Valerio Rossini, Ken Nally, John F Cryan, Yvonne M Nola. A role for the orphan nuclear receptor TLX in the interaction between neural precursor cells and microglia. Neuronal signaling. vol 3. issue 1. 2020-09-28. PMID:32269832. |
microglia are an essential component of the neurogenic niche in the adult hippocampus and are involved in the control of neural precursor cell (npc) proliferation, differentiation and the survival and integration of newborn neurons in hippocampal circuitry. |
2020-09-28 |
2023-08-13 |
mouse |
| Danka A Kozareva, Gerard M Moloney, Alan E Hoban, Valerio Rossini, Ken Nally, John F Cryan, Yvonne M Nola. A role for the orphan nuclear receptor TLX in the interaction between neural precursor cells and microglia. Neuronal signaling. vol 3. issue 1. 2020-09-28. PMID:32269832. |
the orphan nuclear receptor tlx (nr2e1; homologue of the drosophila tailless gene) is a key regulator of hippocampal neurogenesis, and we have shown that in its absence microglia exhibit a pro-inflammatory activation phenotype. |
2020-09-28 |
2023-08-13 |
mouse |
| Xuerui Wang, Xiaolong Xu, Yuhong Guo, Po Huang, Yanxiang Ha, Rui Zhang, Yunjing Bai, Xuran Cui, Shasha He, Qingquan Li. Qiang Xin 1 Formula Suppresses Excessive Pro-Inflammatory Cytokine Responses and Microglia Activation to Prevent Cognitive Impairment and Emotional Dysfunctions in Experimental Sepsis. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32457609. |
biological processes including synaptic transmission, microglia cell activation, cytokine production, microglia cell polarization, as well as inflammatory responses related to signaling pathways including the mapk signaling pathway and the nf-κb signaling pathway were altered prominently by qx1 formula treatment in the hippocampus of septic mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Yujie Yang, Shanshan Li, Hong Huang, Jingwei Lv, Shanguang Chen, Alberto Carlos Pires Dias, Yujiao Li, Xinmin Liu, Qiong Wan. Comparison of the Protective Effects of Ginsenosides Rb1 and Rg1 on Improving Cognitive Deficits in SAMP8 Mice Based on Anti-Neuroinflammation Mechanism. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32587516. |
in addition, although rb1 and rg1 treatments showed significant protective effects in repairing neuronal cells loss and inhibiting the activation of astrocyte and microglia in hippocampus of samp8 mice, rb1 was more effective than rg1. |
2020-09-28 |
2023-08-13 |
mouse |
| Joana Sa de Almeida, Mariana Vargas, João Fonseca-Gomes, Sara Ramalho Tanqueiro, Rita F Belo, Catarina Miranda-Lourenço, Ana M Sebastião, Maria José Diógenes, Teresa F Pai. Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32625056. |
here we found that decreased levels of sirtuin 2 (sirt2) deacetylase in microglia affects hippocampal synaptic plasticity under inflammatory conditions. |
2020-09-28 |
2023-08-13 |
mouse |
| Jinqiang Zhang, Lijuan Zhang, Saini Yi, Xue Jiang, Yan Qiao, Yue Zhang, Chenghong Xiao, Tao Zho. Mouse Astrocytes Promote Microglial Ramification by Releasing TGF-β and Forming Glial Fibers. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32754014. |
effects on microglial ramification were analyzed after microinjecting the toxin l-alpha-aminoadipic acid (l-aaa) in the mouse cortex or hippocampus to ablate astrocytes, and after culturing microglia on their own in an astrocyte-conditioned medium (acm) or together with astrocytes in coculture. |
2020-09-28 |
2023-08-13 |
mouse |
| Zhangxin Guan, Zuolong Chen, Shumei Fu, Linbin Dai, Yong She. Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32973454. |
here, using the 5xfad ad mouse model, we show that intrahippocampal injection of pgrn protein leads to a reduction of aβ plaques, downregulation of beta-secretase 1 (bace1), and enhanced microglia aβ phagocytosis in the mouse hippocampus. |
2020-09-28 |
2023-08-13 |
mouse |
| Lanfen Lin, Xuan Chen, Qiuping Zhou, Peixian Huang, Shuqi Jiang, Huifang Wang, Yiyu Den. Synaptic structure and alterations in the hippocampus in neonatal rats exposed to lipopolysaccharide. Neuroscience letters. vol 709. 2020-09-24. PMID:31288048. |
we conclude that lps injection in neonatal rats can cause synaptic disruption in the hippocampus which may be attributed to inflammatory response due to excess production of proinflammatory cytokines e.g., il-1β derived from activated microglia. |
2020-09-24 |
2023-08-13 |
rat |
| Yang Wu, Juan Dou, Xing Wan, Yan Leng, Xuke Liu, Lili Chen, Qianni Shen, Bo Zhao, Qingtao Meng, Jiabao Ho. Histone Deacetylase Inhibitor MS-275 Alleviates Postoperative Cognitive Dysfunction in Rats by Inhibiting Hippocampal Neuroinflammation. Neuroscience. vol 417. 2020-09-24. PMID:31430527. |
furthermore, pretreatment with ms-275 decreased activated microglia levels and increased psd95 protein expression in the hippocampus. |
2020-09-24 |
2023-08-13 |
rat |
| Jianxing Lian, Kai Li, Jing Gao, Xiaoyue Tan, Zhuo Yan. Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment. Behavioural brain research. vol 376. 2020-09-22. PMID:31509774. |
additionally, cus exposure significantly decreased the expression of hippocampal synapse related proteins and the cell density in the dg region, accompanied by increasing the expression of hippocampal inflammatory cytokines and promoting the activation of microglia in the hippocampus. |
2020-09-22 |
2023-08-13 |
mouse |
| M A Berezutsky, N A Durnova, T A Andronova, O V Sinichkin. [Alzheimer's disease: experimental and clinical researches of Chinese herbal medicine neurobiological effects (a review).] Advances in gerontology = Uspekhi gerontologii. vol 33. issue 2. 2020-09-22. PMID:32593241. |
various neurobiological effects of various herbal decoctions in the cells of hippocampus were demonstrated - the inhibition of amyloid β peptides aggregation, increasing of neurons quantity with normal morphology and decreasing of apoptotic cells, decreasing of inducible nitric oxide synthase (inos) production, decreasing of reactive expression level of rage and increasing reactive expression level of lrp-1, decreasing of tau protein phosphorylation at thr231 and ser422, inhibition of expression of gsk-3β and cdk-5, decreasing of activation and inflammation of microglia, production of 15 types of n-glycans in the cerebral cortex layers, which are absent in experimental animals. |
2020-09-22 |
2023-08-13 |
mouse |
| Jeremy D Hill, Viviana Zuluaga-Ramirez, Sachin Gajghate, Malika Winfield, Yuri Persidsk. Chronic Intrahippocampal Infusion of HIV-1 Neurotoxic Proteins: A Novel Mouse Model of HIV-1 Associated Inflammation and Neural Stem Cell Dysfunction. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 3. 2020-09-18. PMID:30905008. |
intrahippocampal administration of gp120 or tat induced microglial activation within the hippocampus as determined by increases in microglial number and increases in the volume of the microglia (2.5-3-fold, evaluated by double iba-1/cd68 staining). |
2020-09-18 |
2023-08-13 |
mouse |
| Deblina Dey, Vipan K Parihar, Gergely G Szabo, Peter M Klein, Jenny Tran, Jonathan Moayyad, Faizy Ahmed, Quynh-Anh Nguyen, Alexandria Murry, David Merriott, Brandon Nguyen, Jodi Goldman, Maria C Angulo, Daniele Piomelli, Ivan Soltesz, Janet E Baulch, Charles L Limol. Neurological Impairments in Mice Subjected to Irradiation and Chemotherapy. Radiation research. vol 193. issue 5. 2020-09-14. PMID:32134362. |
combined treatment also elicited a transient early increase in activated microglia in the hippocampus, suggesting therapy-induced neuroinflammation that subsided by 15 weeks. |
2020-09-14 |
2023-08-13 |
mouse |
| Prabhuanand Selvaraj, Jie Wen, Mikiei Tanaka, Yumin Zhan. Therapeutic Effect of a Novel Fatty Acid Amide Hydrolase Inhibitor PF04457845 in the Repetitive Closed Head Injury Mouse Model. Journal of neurotrauma. vol 36. issue 10. 2020-09-11. PMID:30526351. |
the accumulation of microglia and astrocytes and the expression of proinflammatory cytokines, including interleukin (il)-1β, il-6, and tumor necrosis factor alpha (tnf-α), in the ipsilateral tbi mouse cortex and hippocampus were significantly reduced by drug treatment. |
2020-09-11 |
2023-08-13 |
mouse |
| Wenbin Ding, Hongyan Lin, Xin Hong, Dongliang Ji, Feng W. Poloxamer 188-mediated anti-inflammatory effect rescues cognitive deficits in paraquat and maneb-induced mouse model of Parkinson's disease. Toxicology. vol 436. 2020-08-31. PMID:32169474. |
pathological synapse loss might be attributed to increased microglial phagocytic activity and cell density, and p188 prevented p + m-induced phagocytic state changes of microglia, such as increase in cell body size and decrease in process length, and upregulated microglia abundance in hippocampus. |
2020-08-31 |
2023-08-13 |
mouse |
| Wenbin Ding, Hongyan Lin, Xin Hong, Dongliang Ji, Feng W. Poloxamer 188-mediated anti-inflammatory effect rescues cognitive deficits in paraquat and maneb-induced mouse model of Parkinson's disease. Toxicology. vol 436. 2020-08-31. PMID:32169474. |
consistently, p188 attenuated p + m-mediated increased mrna levels of microglia proliferation related csf1r and csf2ra, microglial engulfment associated cd68, icam1, and icam2, and pro-inflammatory il-6, il-1β, cd11b, and tnf-α in hippocampus. |
2020-08-31 |
2023-08-13 |
mouse |
| Fangxia Guan, Xinkui Zhou, Peng Li, Yaping Wang, Ming Liu, Fangfang Li, Yuanbo Cui, Tuanjie Huang, Minghao Yao, Yanting Zhang, Jianjie Ma, Shanshan M. MG53 attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation via inhibiting TLR4/NF-κB pathway in vitro and in vivo. Progress in neuro-psychopharmacology & biological psychiatry. vol 95. 2020-08-26. PMID:31260721. |
interestingly, mg53 significantly promoted newborn cell survival, improved neurogenesis, and mitigated neuroinflammation evidenced by lower production of il-1β and il-6, less activation of microglia in the hippocampus of lps treated mice. |
2020-08-26 |
2023-08-13 |
mouse |
| Min Yu, He Huang, Shiyang Dong, Huanhuan Sha, Wei Wei, Cunming Li. High mobility group box-1 mediates hippocampal inflammation and contributes to cognitive deficits in high-fat high-fructose diet-induced obese rats. Brain, behavior, and immunity. vol 82. 2020-08-25. PMID:31430517. |
the hippocampal inflammatory responses were enhanced in the hfhfd-induced obesity, including the activation of tlr4 and nf-κb, the production of il-1β, tnf-α and il-6, as well as the activation of microglia and astrocytes. |
2020-08-25 |
2023-08-13 |
rat |
| Irune Diaz-Aparicio, Iñaki Paris, Virginia Sierra-Torre, Ainhoa Plaza-Zabala, Noelia Rodríguez-Iglesias, Mar Márquez-Ropero, Sol Beccari, Paloma Huguet, Oihane Abiega, Elena Alberdi, Carlos Matute, Irantzu Bernales, Angela Schulz, Lilla Otrokocsi, Beata Sperlagh, Kaisa E Happonen, Greg Lemke, Mirjana Maletic-Savatic, Jorge Valero, Amanda Sierr. Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 7. 2020-08-19. PMID:31896673. |
microglia actively remodel adult hippocampal neurogenesis through the phagocytosis secretome. |
2020-08-19 |
2023-08-13 |
mouse |
| Irune Diaz-Aparicio, Iñaki Paris, Virginia Sierra-Torre, Ainhoa Plaza-Zabala, Noelia Rodríguez-Iglesias, Mar Márquez-Ropero, Sol Beccari, Paloma Huguet, Oihane Abiega, Elena Alberdi, Carlos Matute, Irantzu Bernales, Angela Schulz, Lilla Otrokocsi, Beata Sperlagh, Kaisa E Happonen, Greg Lemke, Mirjana Maletic-Savatic, Jorge Valero, Amanda Sierr. Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 7. 2020-08-19. PMID:31896673. |
during adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. |
2020-08-19 |
2023-08-13 |
mouse |