| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Martínez-Torres, Laura Cutando, Antoni Pastor, Ako Kato, Kenji Sakimura, Rafael de la Torre, Emmanuel Valjent, Rafael Maldonado, Masanobu Kano, Andrés Ozait. Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31251974. |
treatment with the cox-2 inhibitor ns398 during 5 days prevented the deficits in cerebellar function and the cerebellar microglia reactivity in magl ko, without affecting hippocampal reactivity. |
2020-08-14 |
2023-08-13 |
mouse |
| Maria Teresa Golia, Silvia Poggini, Silvia Alboni, Stefano Garofalo, Naomi Ciano Albanese, Aurelia Viglione, Maria Antonietta Ajmone-Cat, Abygaël St-Pierre, Nicoletta Brunello, Cristina Limatola, Igor Branchi, Laura Magg. Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31279682. |
in addition, it led to increased levels of inflammatory markers expression, both in the total hippocampus and in isolated microglia cells, including interleukin (il)-1β, and enhanced the concentration of prostaglandin e |
2020-08-14 |
2023-08-13 |
mouse |
| Weijie Xie, Ting Zhu, Xi Dong, Fengwei Nan, Xiangbao Meng, Ping Zhou, Guibo Sun, Xiaobo Su. HMGB1-triggered inflammation inhibition of notoginseng leaf triterpenes against cerebral ischemia and reperfusion injury via MAPK and NF-κB signaling pathways. Biomolecules. vol 9. issue 10. 2020-08-12. PMID:31547018. |
the immunofluorescence and western blot analysis showed pngl decreased hmgb1 expression, suppressed the hmgb1-triggered inflammation, and inhibited microglia activation (iba1) in hippocampus and cortex, thus dose-dependently downregulating inflammatory cytokines including vcam-1, mmp-9, mmp-2, and icam-1 concentrations in ischemic brains. |
2020-08-12 |
2023-08-13 |
rat |
| Man Cheng, Liu Yang, Zhiping Dong, Mengying Wang, Yan Sun, Huan Liu, Xuan Wang, Na Sai, Guowei Huang, Xumei Zhan. Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells. Journal of cellular and molecular medicine. vol 23. issue 7. 2020-08-06. PMID:31087489. |
the protein expressions of proinflammatory cytokines such as tumour necrosis factor-α, interleukin-1β and interleukin-6 were also augmented by fd treatment in microglial cells of the post-ischaemic hippocampus and in vitro ogd-stressed microglia model. |
2020-08-06 |
2023-08-13 |
rat |
| Matteo Pedrazzoli, Morris Losurdo, Giovanna Paolone, Manuela Medelin, Lejdi Jaupaj, Barbara Cisterna, Anna Slanzi, Manuela Malatesta, Silvia Coco, Mario Buffell. Glucocorticoid receptors modulate dendritic spine plasticity and microglia activity in an animal model of Alzheimer's disease. Neurobiology of disease. vol 132. 2020-08-06. PMID:31394203. |
in this study, we evaluated, using combined golgi cox and immunofluorescence techniques, the role of gr agonists and antagonists on dendritic spine plasticity and microglia activation in hippocampus of 3xtg-ad mice. |
2020-08-06 |
2023-08-13 |
mouse |
| Matteo Pedrazzoli, Morris Losurdo, Giovanna Paolone, Manuela Medelin, Lejdi Jaupaj, Barbara Cisterna, Anna Slanzi, Manuela Malatesta, Silvia Coco, Mario Buffell. Glucocorticoid receptors modulate dendritic spine plasticity and microglia activity in an animal model of Alzheimer's disease. Neurobiology of disease. vol 132. 2020-08-06. PMID:31394203. |
we found that dexamethasone, an agonist of grs, was able to significantly reduce dendritic spine density and induced proliferation and activation of microglia in ca1 region of hippocampus of 3xtg-ad mice at 6 and 10 months of age. |
2020-08-06 |
2023-08-13 |
mouse |
| Lin-Lin Liu, Jia-Mei Li, Wen-Jun Su, Bo Wang, Chun-Lei Jian. Sex differences in depressive-like behaviour may relate to imbalance of microglia activation in the hippocampus. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31181346. |
sex differences in depressive-like behaviour may relate to imbalance of microglia activation in the hippocampus. |
2020-08-04 |
2023-08-13 |
mouse |
| Lin-Lin Liu, Jia-Mei Li, Wen-Jun Su, Bo Wang, Chun-Lei Jian. Sex differences in depressive-like behaviour may relate to imbalance of microglia activation in the hippocampus. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31181346. |
although recent studies implicated that over-activated microglia played a crucial role in depression, whether hippocampal microglia associates with the sex difference of depressive-like behaviours is intriguing. |
2020-08-04 |
2023-08-13 |
mouse |
| Lin-Lin Liu, Jia-Mei Li, Wen-Jun Su, Bo Wang, Chun-Lei Jian. Sex differences in depressive-like behaviour may relate to imbalance of microglia activation in the hippocampus. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31181346. |
generally, hippocampal microglia were activated regardless of sex, but the expressions of pro- and anti-inflammatory factors induced by cums were sex-specific. |
2020-08-04 |
2023-08-13 |
mouse |
| Florian Olde Heuvel, Sarah Holl, Akila Chandrasekar, Zhenghui Li, Yibin Wang, Rida Rehman, Philip Förstner, Daniela Sinske, Annette Palmer, Diana Wiesner, Albert Ludolph, Markus Huber-Lang, Borna Relja, Thomas Wirth, Tamás Röszer, Bernd Baumann, Tobias Boeckers, Bernd Knöll, Francesco Rosell. STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31207335. |
the neuroinflammatory response in the hippocampus was assessed by monitoring the expression levels of >20 cytokines, the phosphorylation status of transcription factors and the phenotype of microglia and astrocytes. |
2020-08-04 |
2023-08-13 |
mouse |
| Qing Li, Dexiang Liu, Fang Pan, Cyrus S H Ho, Roger C M H. Ethanol Exposure Induces Microglia Activation and Neuroinflammation through TLR4 Activation and SENP6 Modulation in the Adolescent Rat Hippocampus. Neural plasticity. vol 2019. 2020-07-27. PMID:31781182. |
ethanol exposure induces microglia activation and neuroinflammation through tlr4 activation and senp6 modulation in the adolescent rat hippocampus. |
2020-07-27 |
2023-08-13 |
rat |
| Kristie Leigh Smith, Mustafa S Kassem, David J Clarke, Michael P Kuligowski, Miguel A Bedoya-Pérez, Stephanie M Todd, Jim Lagopoulos, Maxwell R Bennett, Jonathon C Arnol. Microglial cell hyper-ramification and neuronal dendritic spine loss in the hippocampus and medial prefrontal cortex in a mouse model of PTSD. Brain, behavior, and immunity. vol 80. 2020-07-20. PMID:31158497. |
microglial cell hyper-ramification and neuronal dendritic spine loss in the hippocampus and medial prefrontal cortex in a mouse model of ptsd. |
2020-07-20 |
2023-08-13 |
mouse |
| Kristie Leigh Smith, Mustafa S Kassem, David J Clarke, Michael P Kuligowski, Miguel A Bedoya-Pérez, Stephanie M Todd, Jim Lagopoulos, Maxwell R Bennett, Jonathon C Arnol. Microglial cell hyper-ramification and neuronal dendritic spine loss in the hippocampus and medial prefrontal cortex in a mouse model of PTSD. Brain, behavior, and immunity. vol 80. 2020-07-20. PMID:31158497. |
the shock triggered loss of dendritic spines on pyramidal neurons was accompanied by increased microglial cell number and complexity in the medial prefrontal cortex and dorsal hippocampus, but not in the amygdala. |
2020-07-20 |
2023-08-13 |
mouse |
| Burak I Arioz, Bora Tastan, Emre Tarakcioglu, Kemal Ugur Tufekci, Melis Olcum, Nevin Ersoy, Alper Bagriyanik, Kursad Genc, Sermin Gen. Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway. Frontiers in immunology. vol 10. 2020-07-15. PMID:31327964. |
we assessed the effects of melatonin on behavioral changes and inflammatory cytokine expression in hippocampus of mice in lps-induced dlb, as well as its effects on nlr family pyrin domain containing 3 (nlrp3) inflammasome activation, oxidative stress and pyroptotic cell death in murine microglia |
2020-07-15 |
2023-08-13 |
mouse |
| Kamar E Ameen-Ali, Julie E Simpson, Stephen B Wharton, Paul R Heath, Paul S Sharp, Gaia Brezzo, Jason Berwic. The Time Course of Recognition Memory Impairment and Glial Pathology in the hAPP-J20 Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 68. issue 2. 2020-07-14. PMID:30814360. |
reactive microglia and astrocyte activation in the hippocampus were significantly greater in the j20 mice at 9 months, compared to wild-types. |
2020-07-14 |
2023-08-13 |
mouse |
| Titikorn Chunchai, Puntarik Keawtep, Apiwan Arinno, Napatsorn Saiyasit, Dillon Prus, Nattayaporn Apaijai, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. N-acetyl cysteine, inulin and the two as a combined therapy ameliorate cognitive decline in testosterone-deprived rats. Aging. vol 11. issue 11. 2020-07-13. PMID:31160542. |
our previous studies reported that testosterone-deprived rats developed cognitive decline as a result of increased brain oxidative stress, microglia hyperactivity, and hippocampal dysplasticity. |
2020-07-13 |
2023-08-13 |
rat |
| Titikorn Chunchai, Puntarik Keawtep, Apiwan Arinno, Napatsorn Saiyasit, Dillon Prus, Nattayaporn Apaijai, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. N-acetyl cysteine, inulin and the two as a combined therapy ameliorate cognitive decline in testosterone-deprived rats. Aging. vol 11. issue 11. 2020-07-13. PMID:31160542. |
all treatments equally ameliorated cognitive decline by improving gut dysbiosis, alleviating bbb dysfunction, decreasing hippocampal ros production, decreasing hippocampal apoptosis, and reducing microglia and astrocyte activity. |
2020-07-13 |
2023-08-13 |
rat |
| Paola Di Pietro, Raffaella D'Auria, Andrea Viggiano, Elena Ciaglia, Rosaria Meccariello, Rossana Dello Russo, Annibale Alessandro Puca, Carmine Vecchione, Stefania Lucia Nori, Antonietta Santor. Bisphenol A induces DNA damage in cells exerting immune surveillance functions at peripheral and central level. Chemosphere. vol 254. 2020-07-09. PMID:32334263. |
immunofluorescence analysis of rat hippocampus corroborated in vitro findings showing that bpa induced ɣh2ax phosphorylation in microglia and astrocytosis by decreasing erα expression within the dentate gyrus. |
2020-07-09 |
2023-08-13 |
human |
| Bin Xu, Li-Min Lang, Shi-Ze Li, Jing-Ru Guo, Jian-Fa Wang, Huan-Min Yang, Shuai Lia. Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure. Biomolecules. vol 9. issue 9. 2020-07-06. PMID:31480279. |
microglia activated by excess cortisol induce hmgb1 acetylation and neuroinflammation in the hippocampal dg region of mice following cold exposure. |
2020-07-06 |
2023-08-13 |
mouse |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
various immunohistochemical techniques and western blot analyses were applied to examine expressions of trem2, microglia, aβ, neuronal migration protein doublecortin (dcx) and bdnf in the hippocampus of mice. |
2020-06-26 |
2023-08-13 |
mouse |