| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruili Dang, Yan-Yan Guo, Kun Zhang, Pei Jiang, Ming-Gao Zha. Predictable chronic mild stress promotes recovery from LPS-induced depression. Molecular brain. vol 12. issue 1. 2020-05-26. PMID:31053149. |
concurrent with the reversal of abnormal behavioral changes, pcms suppressed lps-induced proinflammatory cytokine expression, microglia activation, and oxidative stress in hippocampus. |
2020-05-26 |
2023-08-13 |
mouse |
| Julie C Savage, Marie-Ève Trembla. Studying Laboratory Mice - Into the Wild. Trends in neurosciences. vol 42. issue 9. 2020-05-20. PMID:31171382. |
in a recent paper, cope and colleagues (hippocampus, 2019) showed that exposing laboratory mice to outdoor living, either with or without peripheral worm infection, increased adult neurogenesis and had major effects on microglia, but only outdoor living coupled with worm infection increased anxiety. |
2020-05-20 |
2023-08-13 |
mouse |
| Elise C Cope, Maya Opendak, Elizabeth A LaMarca, Sahana Murthy, Christin Y Park, Lyra B Olson, Susana Martinez, Jacqueline M Leung, Andrea L Graham, Elizabeth Goul. The effects of living in an outdoor enclosure on hippocampal plasticity and anxiety-like behavior in response to nematode infection. Hippocampus. vol 29. issue 4. 2020-05-19. PMID:30252982. |
we infected mice with parasitic worms and studied their effects on adult neurogenesis, microglia, and functions associated with the hippocampus, including cognition and anxiety regulation. |
2020-05-19 |
2023-08-13 |
mouse |
| Elise C Cope, Maya Opendak, Elizabeth A LaMarca, Sahana Murthy, Christin Y Park, Lyra B Olson, Susana Martinez, Jacqueline M Leung, Andrea L Graham, Elizabeth Goul. The effects of living in an outdoor enclosure on hippocampal plasticity and anxiety-like behavior in response to nematode infection. Hippocampus. vol 29. issue 4. 2020-05-19. PMID:30252982. |
while outdoor living prevented increases in microglial reactivity induced by infection in both the dorsal and ventral hippocampus, outdoor mice with infection had fewer microglia and microglial processes in the ventral hippocampus. |
2020-05-19 |
2023-08-13 |
mouse |
| Jie Li, Jingyu Zhang, Yusuo Zhang, Zichuang Wang, Yanmei Song, Shanwen Wei, Meijun He, Shoujiang You, Jia Jia, Jian Chen. TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis. Cell death & disease. vol 10. issue 5. 2020-05-19. PMID:30988281. |
traf2 expression and necroptosis were induced in mouse primary microglia treated with conditioned medium collected from neurons subject to oxygen and glucose deprivation (ogd) and in tnfα-treated mouse hippocampal neuronal ht-22 cells in the presence of the pan-caspase inhibitor z-vad. |
2020-05-19 |
2023-08-13 |
mouse |
| Chao-Zhi Tang, Dong-Fang Zhang, Jun-Tang Yang, Qing-Hui Liu, Ya-Ru Wang, Wen-Sheng Wan. Overexpression of microRNA-301b accelerates hippocampal microglia activation and cognitive impairment in mice with depressive-like behavior through the NF-κB signaling pathway. Cell death & disease. vol 10. issue 4. 2020-05-18. PMID:30962417. |
overexpression of microrna-301b accelerates hippocampal microglia activation and cognitive impairment in mice with depressive-like behavior through the nf-κb signaling pathway. |
2020-05-18 |
2023-08-13 |
mouse |
| Chao-Zhi Tang, Dong-Fang Zhang, Jun-Tang Yang, Qing-Hui Liu, Ya-Ru Wang, Wen-Sheng Wan. Overexpression of microRNA-301b accelerates hippocampal microglia activation and cognitive impairment in mice with depressive-like behavior through the NF-κB signaling pathway. Cell death & disease. vol 10. issue 4. 2020-05-18. PMID:30962417. |
following that, the microglia activation and inflammation in hippocampus were evaluated, with the expressions of inflammatory factors being examined. |
2020-05-18 |
2023-08-13 |
mouse |
| Chao-Zhi Tang, Dong-Fang Zhang, Jun-Tang Yang, Qing-Hui Liu, Ya-Ru Wang, Wen-Sheng Wan. Overexpression of microRNA-301b accelerates hippocampal microglia activation and cognitive impairment in mice with depressive-like behavior through the NF-κB signaling pathway. Cell death & disease. vol 10. issue 4. 2020-05-18. PMID:30962417. |
in addition, overexpression of mir-301b activated microglia and stimulated inflammation in hippocampus, accompanied by enhanced release of tumor necrosis factor-α (tnf-α), interleukin-iβ (il-iβ) and cyclooxygenase-2(cox-2). |
2020-05-18 |
2023-08-13 |
mouse |
| Chao-Zhi Tang, Dong-Fang Zhang, Jun-Tang Yang, Qing-Hui Liu, Ya-Ru Wang, Wen-Sheng Wan. Overexpression of microRNA-301b accelerates hippocampal microglia activation and cognitive impairment in mice with depressive-like behavior through the NF-κB signaling pathway. Cell death & disease. vol 10. issue 4. 2020-05-18. PMID:30962417. |
taken together, the evidence provided by the current study indicated that overexpression of mir-301b augmented hippocampal microglia activation, thus exacerbating cognitive impairment and inflammation in mice with depressive-like behavior by activating the nf-κb signaling pathway. |
2020-05-18 |
2023-08-13 |
mouse |
| Yue Han, Lijuan Zhang, Qiaozhi Wang, Dingding Zhang, Qiuying Zhao, Jinqiang Zhang, Lei Xie, Guangyi Liu, Zili Yo. Minocycline inhibits microglial activation and alleviates depressive-like behaviors in male adolescent mice subjected to maternal separation. Psychoneuroendocrinology. vol 107. 2020-05-18. PMID:31078757. |
maternal separation and second stress up-regulated pro-inflammatory markers and down-regulated anti-inflammatory markers in the hippocampus, and they activated microglia and promoted pro-inflammatory transitions in microglia. |
2020-05-18 |
2023-08-13 |
mouse |
| T M Lancaster, M J Hill, R Sims, J William. Microglia - mediated immunity partly contributes to the genetic association between Alzheimer's disease and hippocampal volume. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30776473. |
microglia - mediated immunity partly contributes to the genetic association between alzheimer's disease and hippocampal volume. |
2020-05-13 |
2023-08-13 |
Not clear |
| Andrew J Jacobs, Alexandra Castillo-Ruiz, Carla D Cisternas, Nancy G Forge. Microglial Depletion Causes Region-Specific Changes to Developmental Neuronal Cell Death in the Mouse Brain. Developmental neurobiology. vol 79. issue 8. 2020-05-13. PMID:31207134. |
microglia produce cytokines which mediate many of their effects, and we found higher expression of inflammatory cytokines in the hippocampus than in the septum, independent of clodronate treatment. |
2020-05-13 |
2023-08-13 |
mouse |
| Isabella R Grifasi, William Andrew Evans, Annie D Rexha, Lansana W Sako, S Alex Marshal. A comparison of hippocampal microglial responses in aged and young rodents following dependent and non-dependent binge drinking. International review of neurobiology. vol 148. 2020-05-11. PMID:31733666. |
as such, this study tested the hypothesis that the effects of alcohol on hippocampal microglia are exacerbated in aged versus younger rodents in two aud models. |
2020-05-11 |
2023-08-13 |
mouse |
| Isabella R Grifasi, William Andrew Evans, Annie D Rexha, Lansana W Sako, S Alex Marshal. A comparison of hippocampal microglial responses in aged and young rodents following dependent and non-dependent binge drinking. International review of neurobiology. vol 148. 2020-05-11. PMID:31733666. |
hippocampal subregional and model/species-specific effects of alcohol were observed, but overall, aging did not appear to increase the alcohol-induced microglia reactivity as measured by iba-1 densitometry. |
2020-05-11 |
2023-08-13 |
mouse |
| Nathan A Hirshman, Francis M Hughes, Huixia Jin, William T Harrison, Simon W White, Isabelle Doan, Shelby N Harper, Patrick D Leidig, J Todd Purve. Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats. American journal of physiology. Renal physiology. vol 318. issue 2. 2020-05-11. PMID:31869244. |
evans blue extravasation demonstrated breakdown of the blood-brain barrier in the hippocampal region and activated microglia were present in the fascia dentata. |
2020-05-11 |
2023-08-13 |
rat |
| Daniele Lana, Filippo Ugolini, Gary L Wenk, Maria Grazia Giovannini, Sandra Zecchi-Orlandini, Daniele Nos. Microglial distribution, branching, and clearance activity in aged rat hippocampus are affected by astrocyte meshwork integrity: evidence of a novel cell-cell interglial interaction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 3. 2020-05-07. PMID:30496700. |
our findings suggest that a microglia-astroglia interaction occurs in rat hippocampus via cell-cell contacts, mediating microglial cell branching in the presence of inflammation. |
2020-05-07 |
2023-08-13 |
rat |
| Daniele Lana, Filippo Ugolini, Gary L Wenk, Maria Grazia Giovannini, Sandra Zecchi-Orlandini, Daniele Nos. Microglial distribution, branching, and clearance activity in aged rat hippocampus are affected by astrocyte meshwork integrity: evidence of a novel cell-cell interglial interaction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 3. 2020-05-07. PMID:30496700. |
these data support the idea that generally accepted functional boundaries between microglia and astrocytes should be re-evaluated to better understand how their functions overlap and interact.-lana, d., ugolini, f., wenk, g. l., giovannini, m. g., zecchi-orlandini, s., nosi, d. microglial distribution, branching, and clearance activity in aged rat hippocampus are affected by astrocyte meshwork integrity: evidence of a novel cell-cell interglial interaction. |
2020-05-07 |
2023-08-13 |
rat |
| Matthew C Valdez, Danielle Freeborn, Joseph M Valdez, Andrew F M Johnstone, Samantha J Snow, Alan H Tennant, Urmila P Kodavanti, Prasada Rao S Kodavant. Mitochondrial Bioenergetics in Brain Following Ozone Exposure in Rats Maintained on Coconut, Fish and Olive Oil-Rich Diets. International journal of molecular sciences. vol 20. issue 24. 2020-04-28. PMID:31847143. |
microglial morphology and gfap immunoreactivity were assessed across diet groups; results indicated that fish oil consistently decreased reactive microglia in the hypothalamus and hippocampus. |
2020-04-28 |
2023-08-13 |
rat |
| Rong-Hao Mu, Yuan-Zhi Tan, Li-Li Fu, Mohammad Nazmul Islam, Mei Hu, Hao Hong, Su-Su Tan. 1-Methylnicotinamide attenuates lipopolysaccharide-induced cognitive deficits via targeting neuroinflammation and neuronal apoptosis. International immunopharmacology. vol 77. 2020-04-24. PMID:31639616. |
importantly, mna treatment suppressed the protein expression of nuclear factor-kappa b p65 (nf-κb p65), pro-inflammatory cytokines (tnf-α, il-6) and decreased the activation of microglia and astrocytes in the hippocampus and frontal cortex of lps-induced mice. |
2020-04-24 |
2023-08-13 |
mouse |
| Jiajia Dai, Zhuofeng Ding, Jie Zhang, Wei Xu, Qulian Guo, Wangyuan Zou, Yunchuan Xiong, Yingqi Weng, Yong Yang, Sisi Chen, Jun-Ming Zhang, Zongbin Son. Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus. Anesthesia and analgesia. vol 129. issue 6. 2020-04-08. PMID:31743195. |
minocycline relieves depressive-like behaviors in rats with bone cancer pain by inhibiting microglia activation in hippocampus. |
2020-04-08 |
2023-08-13 |
rat |