| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sabrina Strobel, Edna Grünblatt, Helmut Heinsen, Peter Riederer, Thomas Espach, Michael Meder, Camelia-Maria Monoran. Astrocyte- and Microglia-Specific Mitochondrial DNA Deletions Levels in Sporadic Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 67. issue 1. 2020-03-02. PMID:30475765. |
our results reflect a higher vulnerability of hippocampal astrocytes and microglia to oxidative stress compared to other brain regions, such as cerebellum and brainstem. |
2020-03-02 |
2023-08-13 |
Not clear |
| Lumei Liu, Zhengxiao Zhao, Linwei Lu, Jiaqi Liu, Jing Sun, Jingcheng Don. Icariin and icaritin ameliorated hippocampus neuroinflammation via mediating HMGB1 expression in social defeat model in mice. International immunopharmacology. vol 75. 2020-02-13. PMID:31401387. |
moreover, recombinant human hmgb1 protein (rhmgb1) pretreatment could suppress hmgb1-rage signaling and tlr4-xbp1s-er stress related nf-κb signaling, resulted in a suppressed microglia activation in mice hippocampus. |
2020-02-13 |
2023-08-13 |
mouse |
| Minori Koga, Shin Nakagawa, Akiko Kato, Ichiro Kusum. Caffeic acid reduces oxidative stress and microglial activation in the mouse hippocampus. Tissue & cell. vol 60. 2020-02-11. PMID:31582013. |
however, caffeic acid-treated mice exhibited significantly lower levels of 4-hydroxynonenal, an oxidative stress marker, in the hippocampus, as well as significantly fewer activated microglia. |
2020-02-11 |
2023-08-13 |
mouse |
| Alberto Sepulveda-Rodriguez, Pinggan Li, Tahiyana Khan, James D Ma, Colby A Carlone, P Lorenzo Bozzelli, Katherine E Conant, Patrick A Forcelli, Stefano Vicin. Electroconvulsive Shock Enhances Responsive Motility and Purinergic Currents in Microglia in the Mouse Hippocampus. eNeuro. vol 6. issue 2. 2020-02-10. PMID:31058213. |
electroconvulsive shock enhances responsive motility and purinergic currents in microglia in the mouse hippocampus. |
2020-02-10 |
2023-08-13 |
mouse |
| Alberto Sepulveda-Rodriguez, Pinggan Li, Tahiyana Khan, James D Ma, Colby A Carlone, P Lorenzo Bozzelli, Katherine E Conant, Patrick A Forcelli, Stefano Vicin. Electroconvulsive Shock Enhances Responsive Motility and Purinergic Currents in Microglia in the Mouse Hippocampus. eNeuro. vol 6. issue 2. 2020-02-10. PMID:31058213. |
hippocampal microglia become activated after prolonged, damaging seizures known as status epilepticus (se). |
2020-02-10 |
2023-08-13 |
mouse |
| Alberto Sepulveda-Rodriguez, Pinggan Li, Tahiyana Khan, James D Ma, Colby A Carlone, P Lorenzo Bozzelli, Katherine E Conant, Patrick A Forcelli, Stefano Vicin. Electroconvulsive Shock Enhances Responsive Motility and Purinergic Currents in Microglia in the Mouse Hippocampus. eNeuro. vol 6. issue 2. 2020-02-10. PMID:31058213. |
in this study, we use electroconvulsive shock (ecs) to study the effect of neuronal hyperactivity without neuronal degeneration on mouse hippocampal microglia. |
2020-02-10 |
2023-08-13 |
mouse |
| Lihe Li, Baoyang Li. ROCK inhibitor Y‑27632 protects rats against cerebral ischemia/reperfusion‑induced behavioral deficits and hippocampal damage. Molecular medicine reports. vol 20. issue 4. 2020-02-04. PMID:31432130. |
in conclusion, the present study offered evidence of a protective effect of y‑27632 administration on cerebral ischemia/reperfusion induced behavioral and hippocampal damage by activating astrocytes and microglia. |
2020-02-04 |
2023-08-13 |
rat |
| Nikita Girish Deshpande, Juhi Saxena, Tristan G Pesaresi, Casey Dylan Carrell, Grayson Breneman Ashby, Min-Ken Liao, Linnea Ruth Freema. High fat diet alters gut microbiota but not spatial working memory in early middle-aged Sprague Dawley rats. PloS one. vol 14. issue 5. 2020-01-29. PMID:31141574. |
our data reveal a significant change to the gut microbiome without subsequent effects to neuroinflammation (as measured by microglia characterization and counts in the cortex, hippocampus, and hypothalamus) or cognitive performance under the parameters of our study. |
2020-01-29 |
2023-08-13 |
rat |
| Rocio Saravia, Marc Ten-Blanco, María T Grande, Rafael Maldonado, Fernando Berrender. Anti-inflammatory agents for smoking cessation? Focus on cognitive deficits associated with nicotine withdrawal in male mice. Brain, behavior, and immunity. vol 75. 2020-01-23. PMID:30391635. |
treatment with the non-psychoactive cannabinoid cannabidiol abolished memory impairment of nicotine withdrawal and microglia reactivity, reduced the expression of il1β and ifnγ in the hippocampus and the prefrontal cortex, respectively, and normalized ki67 levels. |
2020-01-23 |
2023-08-13 |
mouse |
| Chin Wai Hui, Sanjeev K Bhardwaj, Kaushik Sharma, Antoneta T Joseph, Kanchan Bisht, Katherine Picard, Marie-Ève Tremblay, Lalit K Srivastav. Microglia in the developing prefrontal cortex of rats show dynamic changes following neonatal disconnection of the ventral hippocampus. Neuropharmacology. vol 146. 2020-01-23. PMID:30537477. |
microglia in the developing prefrontal cortex of rats show dynamic changes following neonatal disconnection of the ventral hippocampus. |
2020-01-23 |
2023-08-13 |
rat |
| Takayo Odaira, Osamu Nakagawasai, Kohei Takahashi, Wataru Nemoto, Wakana Sakuma, Jia-Rong Lin, Koichi Tan-N. Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression. Neuropharmacology. vol 150. 2020-01-21. PMID:30914305. |
phosphorylated ampk was detected in mature and immature hippocampal neurons and microglia, while phosphorylated nf-κb was detected only in neurons in aicar-treated obx mice. |
2020-01-21 |
2023-08-13 |
mouse |
| Anirudh Patir, Barbara Shih, Barry W McColl, Tom C Freema. A core transcriptional signature of human microglia: Derivation and utility in describing region-dependent alterations associated with Alzheimer's disease. Glia. vol 67. issue 7. 2020-01-16. PMID:30758077. |
these analyses highlighted the reactive response of microglia in vulnerable brain regions such as the entorhinal cortex and hippocampus, additionally implicating pathways associated with disease progression. |
2020-01-16 |
2023-08-13 |
mouse |
| Ya-Nan Xu, Li-Jun Zhou, Ying-Tao Jie, Chun-Lin Mai, Jun Zhang, Zhen-Jia Lin, Zhi Ta. [A modified protocol of mouse hippocampal primary microglia culture by using manual dissociation, magnetic activated cell sorting and TIC medium]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 6. 2020-01-15. PMID:31879744. |
[a modified protocol of mouse hippocampal primary microglia culture by using manual dissociation, magnetic activated cell sorting and tic medium]. |
2020-01-15 |
2023-08-13 |
mouse |
| Ya-Nan Xu, Li-Jun Zhou, Ying-Tao Jie, Chun-Lin Mai, Jun Zhang, Zhen-Jia Lin, Zhi Ta. [A modified protocol of mouse hippocampal primary microglia culture by using manual dissociation, magnetic activated cell sorting and TIC medium]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 6. 2020-01-15. PMID:31879744. |
in this study, we improved the culture method of mouse hippocampal primary microglia to obtain hippocampal ramified microglia with high activity and purity, which were resemble to the resting status of normal microglia in healthy brain in vivo. |
2020-01-15 |
2023-08-13 |
mouse |
| Ya-Nan Xu, Li-Jun Zhou, Ying-Tao Jie, Chun-Lin Mai, Jun Zhang, Zhen-Jia Lin, Zhi Ta. [A modified protocol of mouse hippocampal primary microglia culture by using manual dissociation, magnetic activated cell sorting and TIC medium]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 6. 2020-01-15. PMID:31879744. |
the results showed that: (1) the cell viability was (56.03 ± 2.10)% by manual dissociation of hippocampus; (2) compared with immunopanning, two-step macs sorting allowed for efficient enrichment of microglia with higher purity of (86.20 ± 0.68)%; (3) after being incubated in tic medium for 4 d, microglia exhibited branching, quiescent morphology; (4) the results from qrt-pcr assay showed that the levels of tnf-α, il-1β and ccl2 mrna in tic cultured-microglia were similar to freshly isolated microglia, while those were much higher in cm cultured-microglia after incubation for 4 d and 7 d (p < 0.05). |
2020-01-15 |
2023-08-13 |
mouse |
| Ya-Nan Xu, Li-Jun Zhou, Ying-Tao Jie, Chun-Lin Mai, Jun Zhang, Zhen-Jia Lin, Zhi Ta. [A modified protocol of mouse hippocampal primary microglia culture by using manual dissociation, magnetic activated cell sorting and TIC medium]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 6. 2020-01-15. PMID:31879744. |
taken together, compared to the conventional approaches, this modified protocol of mouse hippocampal primary microglia culture by using macs and tic medium enables the increased yield and purity of microglia in the quiescent state, which is similar to normal ramified microglia in healthy brain in vivo. |
2020-01-15 |
2023-08-13 |
mouse |
| Angeles Vinuesa, Melisa Bentivegna, Gastón Calfa, Fabia Filipello, Carlos Pomilio, María Marta Bonaventura, Victoria Lux-Lantos, María Eugenia Matzkin, Amal Gregosa, Jessica Presa, Michela Matteoli, Juan Beauquis, Flavia Saravi. Early Exposure to a High-Fat Diet Impacts on Hippocampal Plasticity: Implication of Microglia-Derived Exosome-like Extracellular Vesicles. Molecular neurobiology. vol 56. issue 7. 2020-01-14. PMID:30474797. |
the isolated exosome fraction from palmitate-stimulated microglia induced an immature dendritic spine phenotype in primary gfp+ hippocampal neurons, in line with the in vivo findings. |
2020-01-14 |
2023-08-13 |
mouse |
| A N vonderEmbse, Q Hu, J C DeWit. Dysfunctional microglia:neuron interactions with significant female bias in a developmental gene x environment rodent model of Alzheimer's disease. International immunopharmacology. vol 71. 2020-01-14. PMID:30927734. |
by postnatal day (pnd) 240, microglia from gxe females also sequestered less neurotoxic iron in the hippocampus. |
2020-01-14 |
2023-08-13 |
mouse |
| A N vonderEmbse, Q Hu, J C DeWit. Dysfunctional microglia:neuron interactions with significant female bias in a developmental gene x environment rodent model of Alzheimer's disease. International immunopharmacology. vol 71. 2020-01-14. PMID:30927734. |
in the same gxe female population, measures of neuronal parameters, such as hippocampal trkb expression, revealed evidence of disharmonious and compensatory interactions with microglia within the pathological progression. |
2020-01-14 |
2023-08-13 |
mouse |
| Kimberley E Stuart, Anna E King, Natalie E King, Jessica M Collins, James C Vickers, Jenna M Ziebel. Late-life environmental enrichment preserves short-term memory and may attenuate microglia in male APP/PS1 mice. Neuroscience. vol 408. 2020-01-09. PMID:30999032. |
app/ps1 mice in sh had significantly increased microglia occupying the neocortex and hippocampus (p = 0.02; p = 0.004, respectively) relative to wt animals. |
2020-01-09 |
2023-08-13 |
mouse |