| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunyan Zhu, Qionghong Xu, Zhiyun Mao, Na Li. The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation. Scientific reports. vol 8. issue 1. 2019-12-13. PMID:30115941. |
in sum, our study points out that the effective modulation of microglia in hippocampus is of pivotal importance for the co-curation by wtd. |
2019-12-13 |
2023-08-13 |
mouse |
| Dan Zhang, Na Li, Yuanyuan Wang, Wenbin Lu, Yongyan Zhang, Yuanjie Chen, Xiaoming Deng, Xiya Y. Methane ameliorates post-operative cognitive dysfunction by inhibiting microglia NF-κB/MAPKs pathway and promoting IL-10 expression in aged mice. International immunopharmacology. vol 71. 2019-12-12. PMID:30877874. |
the result showed that methane attenuated spatial memory loss in morris water maze (mwm) with decreasing pro-inflammatory cytokines production and activation of microglia in hippocampus after surgery. |
2019-12-12 |
2023-08-13 |
mouse |
| Minhui Gao, Peili Hu, Zixuan Cai, Yue Wu, Dan Wang, Wenfeng Hu, Xing Xu, Yaru Zhang, Xu Lu, Dongjian Chen, Zhuo Chen, Kai Ma, Jie Wen, Hui Wang, Chao Huan. Identification of a microglial activation-dependent antidepressant effect of amphotericin B liposome. Neuropharmacology. vol 151. 2019-12-10. PMID:30954529. |
chronic stress-induced decline in microglia in the hippocampus is a newly hypothesized mechanism of depression, and reversal of this decline by microglial activators has been shown to suppress depression-like behaviors in mice. |
2019-12-10 |
2023-08-13 |
mouse |
| Minhui Gao, Peili Hu, Zixuan Cai, Yue Wu, Dan Wang, Wenfeng Hu, Xing Xu, Yaru Zhang, Xu Lu, Dongjian Chen, Zhuo Chen, Kai Ma, Jie Wen, Hui Wang, Chao Huan. Identification of a microglial activation-dependent antidepressant effect of amphotericin B liposome. Neuropharmacology. vol 151. 2019-12-10. PMID:30954529. |
immunofluorescence analysis showed that amphotericin b liposome reversed the cus-induced decline in dentate gyrus (dg) microglia, and inhibition or ablation of microglia in the hippocampus by minocycline (40 mg/kg) or plx3397 pre-treatment (290 mg/kg) abrogated the antidepressant effect of the amphotericin b liposome in cus-treated mice. |
2019-12-10 |
2023-08-13 |
mouse |
| Elizabeth Spangenberg, Paul L Severson, Lindsay A Hohsfield, Joshua Crapser, Jiazhong Zhang, Elizabeth A Burton, Ying Zhang, Wayne Spevak, Jack Lin, Nicole Y Phan, Gaston Habets, Andrey Rymar, Garson Tsang, Jason Walters, Marika Nespi, Parmveer Singh, Stephanie Broome, Prabha Ibrahim, Chao Zhang, Gideon Bollag, Brian L West, Kim N Gree. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nature communications. vol 10. issue 1. 2019-12-09. PMID:31434879. |
altered gene expression in the 5xfad hippocampus is also reversed by the absence of microglia. |
2019-12-09 |
2023-08-13 |
mouse |
| Sarah J Spencer, Bashirah Basri, Luba Sominsky, Alita Soch, Monica T Ayala, Philipp Reineck, Brant C Gibson, Ruth M Barriento. High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner. Neurobiology of aging. vol 74. 2019-11-26. PMID:30448612. |
hippocampal microglia are vulnerable to the effects of aging, displaying a primed phenotype and hyper-responsiveness to various stimuli. |
2019-11-26 |
2023-08-13 |
rat |
| Sarah J Spencer, Bashirah Basri, Luba Sominsky, Alita Soch, Monica T Ayala, Philipp Reineck, Brant C Gibson, Ruth M Barriento. High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner. Neurobiology of aging. vol 74. 2019-11-26. PMID:30448612. |
aging led to the expected priming of hippocampal microglia in that it increased microglial numbers and reduced branching in this region. |
2019-11-26 |
2023-08-13 |
rat |
| Tabish Hussain, Hyunsuk Kil, Bharathi Hattiangady, Jaeho Lee, Maheedhar Kodali, Bing Shuai, Sahithi Attaluri, Yoko Takata, Jianjun Shen, Martin C Abba, Ashok K Shetty, C Marcelo Alda. Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus. Neurobiology of disease. vol 121. 2019-11-21. PMID:30290271. |
wwox deletion leads to reduced gaba-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus. |
2019-11-21 |
2023-08-13 |
mouse |
| Monika Fleshner, Benjamin N Greenwood, Raz Yirmiy. Neuronal-glial mechanisms of exercise-evoked stress robustness. Current topics in behavioral neurosciences. vol 18. 2019-11-20. PMID:24481547. |
specifically, we propose that sedentary animals respond to an intense acute uncontrollable stressor with excessive serotonin (5-ht) and noradrenergic (ne) activity and/or prolonged down-regulation of the cx3cl1-cx3cr1 axis resulting in activation and proliferation of hippocampal microglia in the absence of pathogenic signals and consequent hippocampal-dependent memory deficits and reduced neurogenesis. |
2019-11-20 |
2023-08-12 |
Not clear |
| Jin Hee Kim, Byung Hoon Yoo, Seok Joon Won, Bo Young Choi, Bo Eun Lee, In Yeol Kim, Ara Kho, Song Hee Lee, Min Sohn, Sang Won Su. Melatonin Reduces Hypoglycemia-Induced Neuronal Death in Rats. Neuroendocrinology. vol 102. issue 4. 2019-11-20. PMID:26065386. |
microglia activation was robust in the hippocampus after hypoglycemia, which was almost completely prevented by melatonin treatment. |
2019-11-20 |
2023-08-13 |
human |
| Jong Hee Choi, Minhee Jang, Eun-Jeong Kim, Hocheol Kim, Sang-Kyu Ye, Ik-Hyun Ch. Oriental Medicine Woohwangchungsimwon Attenuates Kainic Acid-Induced Seizures and Neuronal Cell Death in the Hippocampus. Rejuvenation research. vol 19. issue 5. 2019-11-20. PMID:26981959. |
moreover, this wcw-induced neuroprotection was accompanied by a reduction in microglia activation and tumor necrosis factor-alpha, interleukin (il)-1β, il-6, inducible nitric oxide synthase, and cyclooxyganase-2 in the hippocampus. |
2019-11-20 |
2023-08-13 |
Not clear |
| Massimiliano Di Filippo, Antonio de Iure, Carmela Giampà, Davide Chiasserini, Alessandro Tozzi, Pier Luigi Orvietani, Veronica Ghiglieri, Michela Tantucci, Valentina Durante, Ana Quiroga-Varela, Andrea Mancini, Cinzia Costa, Paola Sarchielli, Francesca Romana Fusco, Paolo Calabres. Erratum: Persistent activation of microglia and NADPH oxidase drive hippocampal dysfunction in experimental multiple sclerosis. Scientific reports. vol 6. 2019-11-20. PMID:27073028. |
erratum: persistent activation of microglia and nadph oxidase drive hippocampal dysfunction in experimental multiple sclerosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Rajiv Tikamdas, Sarthak Singhal, Ping Zhang, Justin A Smith, Eric G Krause, Stanley M Stevens, Sihong Song, Bin Li. Ischemia-responsive protein 94 is a key mediator of ischemic neuronal injury-induced microglial activation. Journal of neurochemistry. vol 142. issue 6. 2019-11-20. PMID:28640931. |
conditioned media (cm) from hippocampal and cortical neurons exposed to oxygen/glucose deprivation and reoxygenation induced significant activation of microglial cells as well as primary microglia, evidenced by up-regulation of inducible nitric oxide synthase, increased production of nitrite and reactive oxygen species, and increased expression of microglial markers. |
2019-11-20 |
2023-08-13 |
Not clear |
| Hyun-Sun Park, Arum Han, Hye-Lim Yeo, Min-Jung Park, Min-Jung You, Hyun Jin Choi, Chang-Won Hong, Sang-Hyuk Lee, Seung Hyun Kim, Borah Kim, Min-Soo Kwo. Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069807. |
in the hippocampus, chc increased tnf-α and il-6 mrna expression with microglia activation while reduced glucocorticoid receptor expression. |
2019-11-20 |
2023-08-13 |
mouse |
| Joanna Ruth Appel, Shiyang Ye, Fulei Tang, Dong Sun, Hongsheng Zhang, Lin Mei, Wen-Cheng Xion. Increased Microglial Activity, Impaired Adult Hippocampal Neurogenesis, and Depressive-like Behavior in Microglial VPS35-Depleted Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 26. 2019-10-28. PMID:29853629. |
conditional knocking out of vps35 in microglia of male mice results in regionally increased microglial density and activity in the subgranular zone of the hippocampal dentate gyrus (dg), accompanied by elevated neural progenitor proliferation, but decreased neuronal differentiation. |
2019-10-28 |
2023-08-13 |
mouse |
| Melissa K Edler, Chet C Sherwood, Richard S Meindl, Emily L Munger, William D Hopkins, John J Ely, Joseph M Erwin, Daniel P Perl, Elliott J Mufson, Patrick R Hof, Mary Ann Raghant. Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. The Journal of comparative neurology. vol 526. issue 18. 2019-10-28. PMID:30069930. |
using immunohistochemical and stereological techniques, we quantified the density of activated microglia and morphological variants (ramified, intermediate, and amoeboid) in postmortem chimpanzee brain samples from prefrontal cortex, middle temporal gyrus, and hippocampus, areas that show a high degree of ad pathology in humans. |
2019-10-28 |
2023-08-13 |
human |
| Ji Peng, Peng Zhang, Han Zheng, Yun-Qin Ren, Hong Ya. Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3. Chinese journal of traumatology = Zhonghua chuang shang za zhi. vol 22. issue 3. 2019-10-18. PMID:31056470. |
dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting nlrp3. |
2019-10-18 |
2023-08-13 |
Not clear |
| Ji Peng, Peng Zhang, Han Zheng, Yun-Qin Ren, Hong Ya. Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3. Chinese journal of traumatology = Zhonghua chuang shang za zhi. vol 22. issue 3. 2019-10-18. PMID:31056470. |
to investigate whether dexmedetomidine (dex) can reduce the production of inflammatory factor il-1β by inhibiting the activation of nlrp3 inflammasome in hippocampal microglia, thereby alleviating the inflammatory response of the central nervous system induced by surgical injury. |
2019-10-18 |
2023-08-13 |
Not clear |
| Sara Merlo, Simona Federica Spampinato, Martina Beneventano, Maria Angela Sortin. The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death. Scientific reports. vol 8. issue 1. 2019-10-14. PMID:29740062. |
a low concentration of aggregated aβ42 induced selective up-regulation of mature brain-derived neurotrophic factor (bdnf) expression and release in rat organotypic hippocampal cultures as well as in cortical pure microglia. |
2019-10-14 |
2023-08-13 |
rat |
| Xin Wu, Ramkumar Kuruba, Doodipala Samba Redd. Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. The Journal of pharmacology and experimental therapeutics. vol 367. issue 2. 2019-10-08. PMID:30115757. |
dfp exposure resulted in massive neuronal injury or necrosis, neurodegeneration of principal cells and interneurons, and neuroinflammation as evident by extensive activation of microglia and astrocytes in the hippocampus, amygdala, and other brain regions. |
2019-10-08 |
2023-08-13 |
rat |