| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Ziswiler, K Steinmann-Niggli, A Kappeler, C Daniel, H P Mart. Mycophenolic acid: a new approach to the therapy of experimental mesangial proliferative glomerulonephritis. Journal of the American Society of Nephrology : JASN. vol 9. issue 11. 1999-01-19. PMID:9808091. |
therapy of nephritic rats by mmf resulted in a significant amelioration of glomerular histology, assessed by glomerular cellularity, synthesis of alpha-smooth muscle actin, extracellular matrix deposition, and glomerular hypertrophy. |
1999-01-19 |
2023-08-12 |
rat |
| M E Cooper, Z Cao, J R Rumble, K Jandeleit, T J Allen, R E Gilber. Attenuation of diabetes-associated mesenteric vascular hypertrophy with perindopril: morphological and molecular biological studies. Metabolism: clinical and experimental. vol 47. issue 12 Suppl 1. 1999-01-15. PMID:9867067. |
diabetes was associated with smooth muscle hypertrophy and extracellular matrix (ecm) accumulation. |
1999-01-15 |
2023-08-12 |
human |
| K Umemura, S Kikuchi, Y Suzuki, M Nakashim. Inhibitory effect of tranilast on hypertrophic collagen production in the spontaneously hypertensive rat heart. Japanese journal of pharmacology. vol 78. issue 2. 1999-01-14. PMID:9829619. |
in the present study, we have investigated the effect of this drug on cardiac hypertrophy in spontaneously hypertensive rats (shr), with a focus on the cardiac collagen matrix, which is associated with myocardial stiffness. |
1999-01-14 |
2023-08-12 |
rat |
| A Aszódi, D Chan, E Hunziker, J F Bateman, R Fässle. Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. The Journal of cell biology. vol 143. issue 5. 1999-01-07. PMID:9832566. |
our studies also show that chondrocytes do not need a collagen ii environment to express cartilage-specific matrix components and to hypertrophy. |
1999-01-07 |
2023-08-12 |
mouse |
| I S Park, H Kiyomoto, F Alvarez, Y C Xu, H E Abboud, S L Abbou. Preferential expression of insulin-like growth factor binding proteins-1, -3, and -5 during early diabetic renal hypertrophy in rats. American journal of kidney diseases : the official journal of the National Kidney Foundation. vol 32. issue 6. 1999-01-04. PMID:9856516. |
the renal insulin-like growth factor-i (igf-i) system has been implicated in the pathogenesis of renal hypertrophy, altered hemodynamics, and extracellular matrix expansion associated with early diabetes. |
1999-01-04 |
2023-08-12 |
rat |
| S Loty, J M Sautier, C Loty, H Boulekbache, T Kokubo, N Fores. Cartilage formation by fetal rat chondrocytes cultured in alginate beads: a proposed model for investigating tissue-biomaterial interactions. Journal of biomedical materials research. vol 42. issue 2. 1998-12-29. PMID:9773817. |
morphological data confirmed chondrocyte differentiation with the appearance of hypertrophic chondrocytes scattered in the alginate gel and a dense extracellular matrix containing filamentous structures and matrix vesicles. |
1998-12-29 |
2023-08-12 |
rat |
| D Grimm, E P Kromer, W Böcker, G Bruckschlegel, S R Holmer, G A Riegger, H Schunker. Regulation of extracellular matrix proteins in pressure-overload cardiac hypertrophy: effects of angiotensin converting enzyme inhibition. Journal of hypertension. vol 16. issue 9. 1998-12-04. PMID:9746122. |
regulation of extracellular matrix proteins in pressure-overload cardiac hypertrophy: effects of angiotensin converting enzyme inhibition. |
1998-12-04 |
2023-08-12 |
Not clear |
| Y Tsutsumi, H Matsubara, N Ohkubo, Y Mori, Y Nozawa, S Murasawa, K Kijima, K Maruyama, H Masaki, Y Moriguchi, Y Shibasaki, H Kamihata, M Inada, T Iwasak. Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression. Circulation research. vol 83. issue 10. 1998-12-03. PMID:9815151. |
cardiac hypertrophy suggested by atrial and brain natriuretic peptide levels was comparably increased in omi and dcm, whereas accumulation of matrix proteins such as collagen type 1 and fibronectin was much more prominent in dcm than in omi. |
1998-12-03 |
2023-08-12 |
human |
| U I Chung, B Lanske, K Lee, E Li, H Kronenber. The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 22. 1998-11-24. PMID:9789035. |
moreover, abnormal chondrocyte differentiation affects mineralization of cartilaginous matrix in a non-cell autonomous fashion; matrix mineralization requires a critical mass of adjacent ectopic hypertrophic chondrocytes. |
1998-11-24 |
2023-08-12 |
mouse |
| M A Ross. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. Journal of hypertension. vol 16. issue 7. 1998-11-20. PMID:9794745. |
pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. |
1998-11-20 |
2023-08-12 |
Not clear |
| M A Ross. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. Journal of hypertension. vol 16. issue 7. 1998-11-20. PMID:9794745. |
to investigate pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. |
1998-11-20 |
2023-08-12 |
Not clear |
| E A Jaimes, J M Galceran, L Rai. Angiotensin II induces superoxide anion production by mesangial cells. Kidney international. vol 54. issue 3. 1998-11-17. PMID:9734602. |
indeed, growth stimulating signals driven by ang ii promote mesangial cell (mc) hypertrophy and extracellular matrix production, prominent features of progressive glomerular injury. |
1998-11-17 |
2023-08-12 |
Not clear |
| P A Tooney, T Sakai, K Sakai, D Aeschlimann, D F Moshe. Restricted localization of thrombospondin-2 protein during mouse embryogenesis: a comparison to thrombospondin-1. Matrix biology : journal of the International Society for Matrix Biology. vol 17. issue 2. 1998-11-03. PMID:9694593. |
tsp1 was found in cartilage proper with diminished staining around chondrocytes undergoing differentiation and hypertrophy, whereas tsp2 was restricted to the matrix surrounding chondrocytes of the growth zone cartilage. |
1998-11-03 |
2023-08-12 |
mouse |
| P Bianco, F D Cancedda, M Riminucci, R Cancedd. Bone formation via cartilage models: the "borderline" chondrocyte. Matrix biology : journal of the International Society for Matrix Biology. vol 17. issue 3. 1998-11-03. PMID:9707341. |
in vitro, when replated as adherent cells in the presence of ascorbic acid, hypertrophic chondrocytes resume cell proliferation, switch from the synthesis of the cartilage-characteristic type ii and x collagens to the synthesis of type i collagen, and organize a mineralizing bone matrix. |
1998-11-03 |
2023-08-12 |
Not clear |
| P Bianco, F D Cancedda, M Riminucci, R Cancedd. Bone formation via cartilage models: the "borderline" chondrocyte. Matrix biology : journal of the International Society for Matrix Biology. vol 17. issue 3. 1998-11-03. PMID:9707341. |
in bones formed via cartilage models, the first mineralized bone matrix (the earliest bony collar preceding vascular invasion and the onset of endochondral bone formation) is deposited at the outer aspect of the mid-diaphysis between rows of early hypertrophic chondrocytes and osteoblasts, which are arranged in a peculiar "vis à vis" fashion. |
1998-11-03 |
2023-08-12 |
Not clear |
| P Bianco, F D Cancedda, M Riminucci, R Cancedd. Bone formation via cartilage models: the "borderline" chondrocyte. Matrix biology : journal of the International Society for Matrix Biology. vol 17. issue 3. 1998-11-03. PMID:9707341. |
hypertrophic chondrocytes located in different cartilage areas are exposed to an inappropriate matrix and endocrine/paracrine environment, cannot differentiate to osteoblast-like cells and therefore undergo apoptosis. |
1998-11-03 |
2023-08-12 |
Not clear |
| D Chan, O Jacenk. Phenotypic and biochemical consequences of collagen X mutations in mice and humans. Matrix biology : journal of the International Society for Matrix Biology. vol 17. issue 3. 1998-11-03. PMID:9707340. |
this review focuses on how these two approaches are being used to address the role of collagen x, the major extracellular matrix component of the focal zone of endochondral ossification, the hypertrophic cartilage zone. |
1998-11-03 |
2023-08-12 |
mouse |
| R A Terkeltaub, K Johnson, D Rohnow, R Goomer, D Burton, L J Defto. Bone morphogenetic proteins and bFGF exert opposing regulatory effects on PTHrP expression and inorganic pyrophosphate elaboration in immortalized murine endochondral hypertrophic chondrocytes (MCT cells). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 13. issue 6. 1998-10-22. PMID:9626624. |
opposing effects of bfgf and bmps also were exerted on the elaboration of inorganic pyrophosphatase (ppi), which regulates the ability of hypertrophic chondrocytes to mineralize the matrix. |
1998-10-22 |
2023-08-12 |
Not clear |
| H I Roach, J E Baker, N M Clark. Initiation of the bony epiphysis in long bones: chronology of interactions between the vascular system and the chondrocytes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 13. issue 6. 1998-10-22. PMID:9626626. |
where at least two vessels were in apposition, a new pseudo-ossification center was initiated: chondrocytes became hypertrophic and the matrix calcified. |
1998-10-22 |
2023-08-12 |
chicken |
| S Otsuka, M Sugano, N Makino, S Sawada, T Hata, Y Nih. Interaction of mRNAs for angiotensin II type 1 and type 2 receptors to vascular remodeling in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 32. issue 3. 1998-10-15. PMID:9740612. |
these results indicate that at1 receptor, but not at2 receptor, plays a crucial role in the remodeling of matrix tissue, while at2 receptor may play a role in the development of hypertrophy of smooth muscle in aorta in shr, and that the reduction of hypertrophy of smooth muscle does not fully account for the suppression of hypertension. |
1998-10-15 |
2023-08-12 |
rat |