| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danzeng Dunzhu, Gao Han, Qin Shanshan, Shangshi Li, Jiali Yang, Jian He, Siyu Gou, Gang Dong, Chunrong Jiang, Jun Ho. The role of Perilipin 5 in pathological myocardial remodeling. Frontiers in pharmacology. vol 16. 2025-04-01. PMID:40166465. |
it damages cardiac tissue, alters energy metabolism, increases oxidative stress, and cause matrix metalloproteinase activation, cardiomyocyte hypertrophy, and interstitial fibrosis, leading to hf. |
2025-04-01 |
2025-04-03 |
Not clear |
| Océane Pointeau, Romain Barbosa, Maéva Loriot, Julia Leemput, Elisabeth Dubus, Sébastien Zwe Causse, Laurent Demizieux, Patricia Passilly-Degrace, Pascal Degrace, Bruno Vergès, Tony Jourda. A Simplified and Robust Model for the Study of Diabetic Nephropathy: Streptozotocin-Induced Diabetic Mice Fed a High-Protein Diet. International journal of molecular sciences. vol 26. issue 6. 2025-03-27. PMID:40141119. |
current models often fail to fully mimic human dn, showing only mild albuminuria, glomerular hypertrophy, and limited mesangial matrix expansion. |
2025-03-27 |
2025-03-30 |
mouse |
| Hongsu Yang, Yanxin Zheng, Tao Yu, Biao Wu, Zhihong Liu, Shufang Liu, Xiujun Sun, Liqing Zho. A functional role for myostatin in muscle hyperplasia and hypertrophy revealed by comparative transcriptomics in Yesso scallop Patinopecten yessoensis. International journal of biological macromolecules. 2025-03-21. PMID:40118415. |
the comparative transcriptomics revealed that growth factors and cytokines, extracellular matrix proteins and ubiquitin-proteasome system are potentially involved in muscle hypertrophy and hyperplasia. |
2025-03-21 |
2025-03-24 |
Not clear |
| Rodrigo López-Vaca, Carlos A Narváez-Tovar, Raj Das, Gregory de Boer, Salah Ramtani, Abdelkader Boucetta, Diego A Garzón-Alvarad. Mechanobiological Model of Endochondral Ossification and Trabecular Bone Modeling. International journal for numerical methods in biomedical engineering. vol 41. issue 3. 2025-03-14. PMID:40084415. |
this approach involves the interaction of two molecular factors (vegf and mmp13) released by hypertrophic chondrocytes that diffuse and interact within a hyaline cartilage matrix. |
2025-03-14 |
2025-03-16 |
Not clear |
| Yongping Wang, Tiantian Zhang, Hao Song, Cheng Yan. Lapatinib ameliorates skin fibrosis by inhibiting TGF-β1/Smad and non-Smad signaling pathway. Scientific reports. vol 15. issue 1. 2025-03-12. PMID:40069312. |
skin fibrosis, characterized by excessive accumulation of extracellular matrix (ecm) in the dermis, can lead to hypertrophic scars and impaired mobility. |
2025-03-12 |
2025-03-14 |
Not clear |
| Ruo-Yu Shang, Jia-Cai Yang, Wen-Gang Hu, Rong Xiao, Dong-Sheng Hu, Zhi-Chen Lin, Song Li, Nan-Nan Wang, Yin Zheng, Zhi-Hui Liu, Yun-Xia Chen, Min-Jie Wang, Chao Wang, Bo Jiang, Guo-An Lin, Xiao-Liang Li, Xin-Zhi Shang, Tian-Tian Yan, Gao-Xing Luo, Wei-Feng H. Artesunate attenuates skin hypertrophic scar formation by inhibiting fibroblast activation and EndMT of vascular endothelial cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2025-03-07. PMID:40055124. |
background hypertrophic scarring is an abnormal condition involving excessive fibroblast activation, aberrant extracellular matrix deposition, and persistent inflammation. |
2025-03-07 |
2025-03-12 |
human |
| Estefanía Luna-Figueroa, Judith Bernal-Ramírez, Eduardo Vázquez-Garza, Lázaro Huerta-Arcos, Gerardo García-Rivas, Flavio F Contreras-Torre. Angiotensin II-Induced Hypertrophy in H9c2 Cells Reveals Severe Cytotoxicity of Graphene Oxide. ACS omega. vol 10. issue 7. 2025-03-04. PMID:40028060. |
additionally, rat cardiac myoblasts of the h9c2 cell line were subjected to ang ii to induce cellular hypertrophy, leading to cytoskeleton remodeling, increased cardiac myocyte surface area, extracellular matrix alterations, and collagen type 1a upregulation. |
2025-03-04 |
2025-03-06 |
rat |
| Jun Lai, Likang Li, Jun Liu, Qingwei Yan, Zhicheng Xu, Meifang Leng, Wen Jin, Zebing Y. CELF1 Promotes Post-myocardial Infarction Cardiac Remodeling Via Suppression of FMO2. Cardiovascular toxicology. 2025-02-28. PMID:40021568. |
lad ligation induced cardiac remodeling [cardiac enlargement, myocardial tissue damage, increased myocardial collagen fiber tissues, poor cardiac function, cardiomyocyte hypertrophy, myocardial apoptosis, and extracellular matrix (ecm) deposition]. |
2025-02-28 |
2025-03-04 |
mouse |
| Tianbai Wang, Celina C Maldonado, Bor-Lin Huang, Enkhjargal Budbazar, Andrew Martin, Matthew D Layne, Joanne E Murphy-Ullrich, Mark W Grinstaff, Michael B Albr. A Bio-inspired Latent TGF-β Conjugated Scaffold Improves Neocartilage Development. bioRxiv : the preprint server for biology. 2025-02-20. PMID:39975171. |
while this approach enhances cartilage extracellular matrix (ecm) biosynthesis, it further promotes tissue features detrimental to hyaline cartilage function, including the induction of tissue swelling, hyperplasia, hypertrophy, and ecm heterogeneities. |
2025-02-20 |
2025-02-23 |
cattle |
| Boya Yu, Yalei Cao, Pianpian Lin, Lixia Zhang, Minliang Che. Enhancement of Ndrg2 promotes hypertrophic scar fibrosis by regulating PI3K/AKT signaling pathway. Cellular signalling. vol 129. 2025-02-18. PMID:39956247. |
hypertrophic scar (hts) is a prevalent chronic inflammatory skin disorder characterized by abnormal proliferation and extracellular matrix deposition. |
2025-02-18 |
2025-02-23 |
mouse |
| Isabella Silva Barreto, Marianne Liebi, Sophie Le Cann, Saima Ahmed, Leonard C Nielsen, Tilman A Grünewald, Hector Dejea, Viviane Lutz-Bueno, Niamh C Nowlan, Hanna Isaksso. Lack of embryonic skeletal muscle in mice leads to abnormal mineral deposition and growth. Journal of structural biology. 2025-02-16. PMID:39956301. |
the decrease in collagen content in the hypertrophic zone due to resorption of the cartilage collagen matrix was less distinct in muscle-less limbs compared to controls. |
2025-02-16 |
2025-02-23 |
mouse |
| Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Ha. Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation. Biology direct. vol 20. issue 1. 2025-02-05. PMID:39905520. |
hypertrophic scar (hs) is a common fibrotic skin disorder characterized by the excessive deposition of extracellular matrix (ecm). |
2025-02-05 |
2025-02-07 |
Not clear |
| Essam-Elden M Mohamed, Hazem L Abd-Elaleem, Samar Ali Abodief Zahra. Silicone gel versus combination of silicone gel and a 577-nm diode laser in the treatment of post-surgery hypertrophic scar (comparative study). Archives of dermatological research. vol 317. issue 1. 2025-02-01. PMID:39891719. |
hypertrophic scars, resulting from alterations in the normal processes of cutaneous wound healing, are characterized by proliferation of dermal tissue with excessive deposition of fibroblast-derived extracellular matrix proteins, especially collagen, over long periods, and by persistent inflammation and fibrosis. |
2025-02-01 |
2025-02-04 |
Not clear |
| Alexandre Aubert, Jenna Goeres, Amy Liu, Martin Kao, Katlyn C Richardson, Karen Jung, Boris Hinz, Richard I Crawford, David J Granvill. Potential implications of granzyme B in keloids and hypertrophic scars through extracellular matrix remodeling and latent TGF-β activation. Frontiers in immunology. vol 15. 2025-01-31. PMID:39885984. |
potential implications of granzyme b in keloids and hypertrophic scars through extracellular matrix remodeling and latent tgf-β activation. |
2025-01-31 |
2025-02-02 |
Not clear |
| Alexandre Aubert, Jenna Goeres, Amy Liu, Martin Kao, Katlyn C Richardson, Karen Jung, Boris Hinz, Richard I Crawford, David J Granvill. Potential implications of granzyme B in keloids and hypertrophic scars through extracellular matrix remodeling and latent TGF-β activation. Frontiers in immunology. vol 15. 2025-01-31. PMID:39885984. |
keloid scars (ks) and hypertrophic scars (hs) are fibroproliferative wound healing defects characterized by excessive accumulation of extracellular matrix (ecm) in the dermis of affected individuals. |
2025-01-31 |
2025-02-02 |
Not clear |
| Ting-Yuan Tu, Yu-Chia Hsu, Chia-En Yang, Yan-Jye Shyong, Cheng-Hsiang Kuo, Yuan-Fu Liu, Shu-Shien Shih, Cheng-Li Li. Variations in ECM Topography, Fiber Alignment, Mechanical Stiffness, and Cellular Composition Between Ventral and Dorsal Ligamentum Flavum Layers: Insights Into Hypertrophy Pathogenesis. JOR spine. vol 8. issue 1. 2025-01-31. PMID:39886656. |
previous studies have suggested that changes in the composition of the extracellular matrix (ecm) play a significant role in the development of ligamentum flavum hypertrophy (lfh) and the histological differences between the ventral and dorsal layers of the hypertrophied ligamentum flavum. |
2025-01-31 |
2025-02-02 |
Not clear |
| Qiaoling Zhang, Yan Zhang, Baiyu Li, Chenhao Wang, Zhanqing Yang, Bin Guo, Zhanpeng Yu. Melatonin promotes the proliferation and differentiation of antler chondrocytes via RUNX2 dependent on the interaction between NOTCH1 and SHH signaling pathways. Cell biology international. 2024-12-31. PMID:39737592. |
the results showed that mt promoted the proliferation of antler chondrocytes and induced the differentiation of chondrocytes into hypertrophic chondrocytes as evidenced by the significant increase of collagen type x (col x), alkaline phosphatase (alp) and matrix metalloproteinase 13 (mmp13) expression and alp activity, the well-established markers for hypertrophic chondrocytes, but this effectiveness was neutralized by the addition of mt receptor antagonist. |
2024-12-31 |
2025-01-02 |
Not clear |
| Kelly Carter, Eshan Shah, Jessica Waite, Dhruv Rana, Zhi-Qing Zha. Pathophysiology of Angiotensin II-Mediated Hypertension, Cardiac Hypertrophy, and Failure: A Perspective from Macrophages. Cells. vol 13. issue 23. 2024-12-17. PMID:39682749. |
the transendothelial migration of monocyte-derived macrophages exerts significant biological effects on the proliferation of fibroblasts, deposition of extracellular matrix proteins, induction of perivascular/interstitial fibrosis, and development of hypertension, cardiac hypertrophy and heart failure. |
2024-12-17 |
2024-12-21 |
Not clear |
| Jonathan Bennett, George D Thornton, Christian Nitsche, Francisco F Gama, Nikoo Aziminia, Uzma Gul, Abhishek Shetye, Peter Kellman, Rhodri H Davies, James C Moon, Thomas A Treibe. Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement. Circulation. Cardiovascular imaging. 2024-12-04. PMID:39629586. |
left ventricular hypertrophy in aortic stenosis: early cell and matrix regression 2 months post-aortic valve replacement. |
2024-12-04 |
2024-12-06 |
Not clear |
| Jonathan Bennett, George D Thornton, Christian Nitsche, Francisco F Gama, Nikoo Aziminia, Uzma Gul, Abhishek Shetye, Peter Kellman, Rhodri H Davies, James C Moon, Thomas A Treibe. Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement. Circulation. Cardiovascular imaging. 2024-12-04. PMID:39629586. |
in aortic stenosis, the myocardium responds with left ventricular hypertrophy, which is characterized by increased left ventricular mass due to cellular hypertrophy and extracellular matrix expansion. |
2024-12-04 |
2024-12-06 |
Not clear |