| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelly Carter, Eshan Shah, Jessica Waite, Dhruv Rana, Zhi-Qing Zha. Pathophysiology of Angiotensin II-Mediated Hypertension, Cardiac Hypertrophy, and Failure: A Perspective from Macrophages. Cells. vol 13. issue 23. 2024-12-17. PMID:39682749. |
the transendothelial migration of monocyte-derived macrophages exerts significant biological effects on the proliferation of fibroblasts, deposition of extracellular matrix proteins, induction of perivascular/interstitial fibrosis, and development of hypertension, cardiac hypertrophy and heart failure. |
2024-12-17 |
2024-12-21 |
Not clear |
| Jonathan Bennett, George D Thornton, Christian Nitsche, Francisco F Gama, Nikoo Aziminia, Uzma Gul, Abhishek Shetye, Peter Kellman, Rhodri H Davies, James C Moon, Thomas A Treibe. Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement. Circulation. Cardiovascular imaging. 2024-12-04. PMID:39629586. |
left ventricular hypertrophy in aortic stenosis: early cell and matrix regression 2 months post-aortic valve replacement. |
2024-12-04 |
2024-12-06 |
Not clear |
| Jonathan Bennett, George D Thornton, Christian Nitsche, Francisco F Gama, Nikoo Aziminia, Uzma Gul, Abhishek Shetye, Peter Kellman, Rhodri H Davies, James C Moon, Thomas A Treibe. Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement. Circulation. Cardiovascular imaging. 2024-12-04. PMID:39629586. |
in aortic stenosis, the myocardium responds with left ventricular hypertrophy, which is characterized by increased left ventricular mass due to cellular hypertrophy and extracellular matrix expansion. |
2024-12-04 |
2024-12-06 |
Not clear |
| b' L Ba\\xc4\\x8d\\xc3\\xa1kov\\xc3\\xa1, A Sedl\\xc3\\xa1\\xc5\\x99, J Mus\\xc3\\xadlkov\\xc3\\xa1, A Eckhardt, M \\xc5\\xbdaloud\\xc3\\xadkov\\xc3\\xa1, F Kol\\xc3\\xa1\\xc5\\x99, H Maxov\\xc3\\xa. Mechanisms Controlling the Behavior of Vascular Smooth Muscle Cells in Hypoxic Pulmonary Hypertension. Physiological research. vol 73. issue S2. 2024-11-26. PMID:39589304.' |
keywords: vasoconstriction, remodeling, oxidation, degradation, extracellular matrix, collagen, proteolytic enzymes, metalloproteinases, macrophages, mast cells, smooth muscle cells, endothelial cells, fibroblasts, mesenchymal stem cells, hypoxia-inducible factor, microrna, galectins, hyperplasia, hypertrophy, therapy of hypoxic pulmonary hypertension. |
2024-11-26 |
2024-11-28 |
rat |
| Michael Kohlhauser, Marcel Mayrhofer, Lars-Peter Kamolz, Christian Smoll. An Update on Molecular Mechanisms of Scarring-A Narrative Review. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39519131. |
hypertrophic scars, keloids and atrophic scars arise from dysregulated wound healing processes characterized by persistent inflammation, aberrant collagen deposition, and impaired extracellular matrix remodeling. |
2024-11-09 |
2024-11-17 |
Not clear |
| Michael Kohlhauser, Marcel Mayrhofer, Lars-Peter Kamolz, Christian Smoll. An Update on Molecular Mechanisms of Scarring-A Narrative Review. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39519131. |
through the analysis of current knowledge, this review seeks to identify the key cellular and molecular mechanisms involved in fibroblast activation, collagen synthesis, and extracellular matrix remodeling in hypertrophic scar, keloid, or atrophic scar formation. |
2024-11-09 |
2024-11-17 |
Not clear |
| Ja Hyang Cho, Hae Woon Jung, Kye Shik Shi. Growth plate closure and therapeutic interventions. Clinical and experimental pediatrics. 2024-10-28. PMID:39463341. |
after senescence, hypertrophic chondrocytes are replaced by osteocytes, the extracellular matrix is calcified and va-scularized, the growth plate is closed, and longitudinal bone growth is complete. |
2024-10-28 |
2024-10-30 |
human |
| Zhaodi Wang, Yihan Chen, Weidong Li, Chuanyu Gao, Jing Zhang, Xiaobiao Zang, Zhihan Zhao, Hongkun Fan, Yonghui Zha. Identification and validation of diagnostic biomarkers and immune infiltration in dilated cardiomyopathies with heart failure and construction of diagnostic model. Gene. 2024-10-20. PMID:39427832. |
the present study revealed that differentially expressed genes were enriched in the extracellular matrix organization, cardiac muscle hypertrophy, and other immune-related biological processes. |
2024-10-20 |
2024-10-23 |
mouse |
| Li-Jen Soh, Siam-Yee Lee, Margaret M Roebuck, Pooi-Fong Won. Unravelling the interplay between ER stress, UPR and the cGAS-STING pathway: Implications for osteoarthritis pathogenesis and treatment strategy. Life sciences. 2024-10-08. PMID:39378929. |
the reparative effort induces the proliferation of hypertrophic chondrocytes and matrix protein synthesis. |
2024-10-08 |
2024-10-11 |
Not clear |
| Xiang-Fang Yu, Bin Teng, Jun-Feng Li, Jian V Zhang, Zhe Su, Pei-Gen Re. Novel Function of Osteocalcin in Chondrocyte Differentiation and Endochondral Ossification Revealed on a CRISPR/Cas9 International journal of molecular sciences. vol 25. issue 18. 2024-09-28. PMID:39337434. |
osteocalcin (ocn), a protein abundant in bone matrix, also exhibits high expression in chondrocytes, especially hypertrophic chondrocytes, while its role in endochondral ossification remains unclear. |
2024-09-28 |
2024-10-01 |
Not clear |
| Siddharth Sunilkumar, Esma I Yerlikaya, Allyson L Toro, Han Chen, Yandong Zhou, Donald L Gill, Scot R Kimball, Michael D Denni. Podocyte-Specific Expression of the Stress Response Protein REDD1 is Necessary for Diabetes-induced Podocytopenia. Diabetes. 2024-09-25. PMID:39320924. |
podocyte-specific redd1 deletion protected against renal injury, as evidenced by reduced albuminuria, glomerular hypertrophy, and mesangial matrix deposition in streptozotocin (stz)-induced diabetic mice. |
2024-09-25 |
2024-09-27 |
mouse |
| Atilla Engi. Lipid Storage, Lipolysis, and Lipotoxicity in Obesity. Advances in experimental medicine and biology. vol 1460. 2024-09-17. PMID:39287850. |
hypoxia in obese adipose tissue due to hypertrophic adipocytes results in excess deposition of extracellular matrix (ecm) components. |
2024-09-17 |
2024-09-20 |
Not clear |
| Atilla Engi. Adipose Tissue Hypoxia in Obesity: Clinical Reappraisal of Hypoxia Hypothesis. Advances in experimental medicine and biology. vol 1460. 2024-09-17. PMID:39287857. |
upon reaching a hypertrophic threshold beyond the adipocyte fat loading capacity, excess extracellular matrix (ecm) components are deposited, causing fibrosis. |
2024-09-17 |
2024-09-20 |
human |
| Lili Zhuang, Wenjin Liu, Xiao-Qing Tsai, Connor Outtrim, Anna Tang, Zhou Wang, Yufeng Huan. Repurposing Niclosamide to Modulate Renal RNA-Binding Protein HuR for the Treatment of Diabetic Nephropathy in db/db Mice. International journal of molecular sciences. vol 25. issue 17. 2024-09-14. PMID:39273597. |
untreated db/db mice exhibited obesity, progressive hyperglycemia, albuminuria, kidney hypertrophy and glomerular mesangial matrix expansion, increased renal production of fibronectin and a-smooth muscle actin, and decreased glomerular wt-1 |
2024-09-14 |
2024-09-16 |
mouse |
| Nirupama Chatterjee, Rishabh Sharma, Pratibha R Kale, Nirupma Trehanpati, Gayatri Ramakrishn. Is the liver resilient to the process of ageing? Annals of hepatology. 2024-09-14. PMID:39276981. |
the various adaptive mechanism possibly include:(a) cellular hypertrophy to maintain physiological capacity even before proliferation initiates, (b) the "ploidy conveyor" as a genetic adaptation to endure aging-related stress, (c) sustained telomere length indicative of youthfulness (d) active extracellular matrix remodelling for normal cellular functioning, (e) mitochondria-endoplasmic reticulum based metabolic adaptation and (c) cellular plasticity as fitness mechanisms for healthy aging. |
2024-09-14 |
2024-09-18 |
Not clear |
| Levente Stankovics, Anna Ungvari, Mónika Fekete, Adam Nyul-Toth, Peter Mukli, Roland Patai, Boglarka Csik, Rafal Gulej, Shannon Conley, Anna Csiszar, Peter Tot. The vasoprotective role of IGF-1 signaling in the cerebral microcirculation: prevention of cerebral microhemorrhages in aging. GeroScience. 2024-09-13. PMID:39271571. |
vascular smooth muscle cells (vsmcs) adapt to hypertension by undergoing hypertrophy and producing extracellular matrix (ecm) components, which reinforce vessel walls. |
2024-09-13 |
2024-09-16 |
Not clear |
| Nader Pazyar, Sedigheh Sananzadeh, Reza Yaghoobi, Nima Bakhtiar. Comparison of Intralesional Vitamin D with Intralesional Triamcinolone Acetonide in the Treatment of Keloids. World journal of plastic surgery. vol 13. issue 2. 2024-08-28. PMID:39193238. |
hypertrophic scars and keloids are disorders caused by the excessive growth of connective tissue, associated with the accumulation of collagen and cellular matrix components. |
2024-08-28 |
2024-08-30 |
Not clear |
| Manuel Sigle, Anne-Katrin Rohlfing, Melanie Cruz Santos, Timo Kopp, Konstantin Krutzke, Vincent Gidlund, Ferdinand Kollotzek, Julia Marzi, Saskia von Ungern-Sternberg, Antti Poso, Mathias Heikenwälder, Katja Schenke-Layland, Peter Seizer, Julia Möllmann, Nikolaus Marx, Robert Feil, Susanne Feil, Robert Lukowski, Oliver Borst, Tilman E Schäffer, Karin Anne Lydia Müller, Meinrad P Gawaz, David Heinzman. Targeting Cyclophilin A in the Cardiac Microenvironment Preserves Heart Function and Structure in Failing Hearts. Circulation research. 2024-08-14. PMID:39140165. |
cardiac hypertrophy is characterized by remodeling of the myocardium, which involves alterations in the ecm (extracellular matrix) and cardiomyocyte structure. |
2024-08-14 |
2024-08-16 |
Not clear |
| Kaili Ye, Yanling Zhao, Wen Huang, Yonglin Zh. Sodium butyrate improves renal injury in diabetic nephropathy through AMPK/SIRT1/PGC-1α signaling pathway. Scientific reports. vol 14. issue 1. 2024-08-01. PMID:39090182. |
our findings demonstrate that exogenous nab supplementation can improve hyperglycemia and albuminuria, reduce renal tissue inflammation, inhibit extracellular matrix accumulation and glomerular hypertrophy, and could alter the gut microbiota composition in dn. |
2024-08-01 |
2024-08-05 |
mouse |
| L C Nath, A Saljic, R Buhl, A Elliott, A La Gerche, C Ye, H Schmidt Royal, K Lundgren Virklund, T A Agbaedeng, A Stent, S Frankli. Histological evaluation of cardiac remodelling in equine athletes. Scientific reports. vol 14. issue 1. 2024-07-19. PMID:39030282. |
horses in the ath group had myocyte hypertrophy at all sites; increased fibrosis at all sites other than the laa; increased fibroblast infiltration but a reduction in the overall extracellular matrix (ecm) volume in the raa, lvapm, and ivs-r compared to sed horses. |
2024-07-19 |
2024-07-22 |
Not clear |