All Relations between hypertrophic and matrix compartment

Publication Sentence Publish Date Extraction Date Species
Shaohui Li, Yunwei Wang, Yang Chen, Hao Zhang, Peng Cao, Kuo Shen, Hao Gua. PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL. Archives of biochemistry and biophysics. 2024-02-07. PMID:38325773. hypertrophic scar (hs) is a dermatological condition characterized by an excessive accumulation of proteins in the extracellular matrix (ecm) and an elevated cell count. 2024-02-07 2024-02-10 Not clear
Shaohui Li, Yunwei Wang, Yang Chen, Hao Zhang, Peng Cao, Kuo Shen, Hao Gua. PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL. Archives of biochemistry and biophysics. 2024-02-07. PMID:38325773. the findings of our study provide validation for the role of pten in inhibiting the development of hypertrophic scars (hs) by modulating the expression of extracellular matrix (ecm) proteins and promoting apoptosis in hypertrophic scar fibroblasts (hsfs) via bcl-xl. 2024-02-07 2024-02-10 Not clear
Jacob J Robino, Alexander P Plekhanov, Qingzhang Zhu, Michael D Jensen, Philipp E Scherer, Charles T Roberts, Oleg Varlamo. Adipose Tissue Analysis Toolkit (ATAT) for Automated Analysis of Adipocyte Size and Extracellular Matrix in White Adipose Tissue. bioRxiv : the preprint server for biology. 2024-02-06. PMID:38318208. the pathological expansion of white adipose tissue (wat) in obesity involves adipocyte hypertrophy accompanied by expansion of collagen-rich pericellular extracellular matrix (ecm) and the development of crown-like structures (cls). 2024-02-06 2024-02-09 Not clear
Jacob J Robino, Alexander P Plekhanov, Qingzhang Zhu, Michael D Jensen, Philipp E Scherer, Charles T Roberts, Oleg Varlamo. Adipose Tissue Analysis Toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue. Obesity (Silver Spring, Md.). 2024-02-06. PMID:38321231. the pathological expansion of white adipose tissue (wat) in obesity involves adipocyte hypertrophy accompanied by expansion of the collagen-rich pericellular extracellular matrix (ecm) and development of crown-like structures (cls). 2024-02-06 2024-02-09 Not clear
Mohammad Ali Mohammadkhani, Soraya Shahrzad, Mehrdad Haghighi, Reza Ghanbari, Ashraf Mohamadkhan. Insights into Organochlorine Pesticides Exposure in the Development of Cardiovascular Diseases: A Systematic Review. Archives of Iranian medicine. vol 26. issue 10. 2024-02-04. PMID:38310416. changes in the regulatory function of peroxisome proliferator-activated γ receptor (pparγ), reduction of paroxonase activity (pon1), epigenetic changes of histone through induction of reactive oxygen species, vascular endothelial inflammation with mir-expression 126 and mir-31, increased collagen synthesis enzymes in the extracellular matrix and left ventricular hypertrophy (lvh) and fibrosis are mechanisms by which pcbs increase the risk of cvd. 2024-02-04 2024-02-06 human
Fabrizio E Mancini, Paul E A Humphreys, Steven Woods, Nicola Bates, Sara Cuvertino, Julieta O'Flaherty, Leela Biant, Marco A N Domingos, Susan J Kimbe. Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis. Scientific reports. vol 14. issue 1. 2024-02-01. PMID:38302538. chondroprogenitors obtained from rapid-e could generate cartilaginous pellets that expressed ac-related matrix proteins such as lubricin, aggrecan, and collagen ii, but additionally expressed collagen x, indicative of hypertrophy. 2024-02-01 2024-02-04 human
Boya Yu, Yalei Cao, Shiyi Li, Ruiqi Bai, Guiwen Zhou, Qiang Fu, Liming Liang, Weijie Gu, Lixia Zhang, Minliang Che. Identification and validation of CRLF1 and NRG1 as immune-related signatures in hypertrophic scar. Genomics. 2024-01-23. PMID:38262564. hypertrophic scar (hts) is a prevalent chronic inflammatory skin disorder characterized by abnormal proliferation and extracellular matrix deposition and the precise mechanisms underlying hts remain elusive. 2024-01-23 2024-01-26 Not clear
Saida Mebarek, Rene Buchet, Slawomir Pikula, Agnieszka Strzelecka-Kiliszek, Leyre Brizuela, Giada Corti, Federica Collacchi, Genevieve Anghieri, Andrea Magrini, Pietro Ciancaglini, Jose Luis Millan, Owen Davies, Massimo Bottin. Do Media Extracellular Vesicles and Extracellular Vesicles Bound to the Extracellular Matrix Represent Distinct Types of Vesicles? Biomolecules. vol 14. issue 1. 2024-01-23. PMID:38254642. mineralization-competent cells, including hypertrophic chondrocytes, mature osteoblasts, and osteogenic-differentiated smooth muscle cells secrete media extracellular vesicles (media vesicles) and extracellular vesicles bound to the extracellular matrix (matrix vesicles). 2024-01-23 2024-01-25 Not clear
Nilotpal Majumder, Subhadeep Roy, Aarushi Sharma, Shuchi Arora, Raju Vaishya, Amitabha Bandyopadhyay, Sourabh Ghos. Assessing the advantages of 3D bioprinting and 3D spheroids in deciphering the osteoarthritis healing mechanism using human chondrocytes and polarized macrophages. Biomedical materials (Bristol, England). 2024-01-10. PMID:38198731. additionally, the presence of anti-inflammatory m2 macrophages  significantly upregulated the expression of chondrogenic biomarkers (col-ii, acan) with an attenuated expression of the chondrocyte hypertrophy (col-x), chondrocyte dedifferentiation (col-i) and matrix catabolism (mmp-1 and mmp-13) genes even in the absence of the interleukins. 2024-01-10 2024-01-13 human
Ilaria Bernabei, Elodie Faure, Mario Romani, Julien Wegrzyn, Jürgen Brinckmann, Véronique Chobaz, Alexander So, Thomas Hugle, Nathalie Busso, Sonia Nas. Inhibiting Lysyl Oxidases prevents pathologic cartilage calcification. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 171. 2024-01-06. PMID:38183742. through unbiased transcriptomic analysis we confirmed a positive correlation between lox(l) genes and genes for calcification, hypertrophy and extracellular matrix catabolism. 2024-01-06 2024-01-09 mouse
Zilu Qu, Yao Chen, Kun Du, JiaXi Qiao, Liuqing Chen, Jinbo Chen, Li We. ALA-PDT promotes the death and contractile capacity of hypertrophic scar fibroblasts through inhibiting the TGF-β1/Smad2/3/4 signaling pathway. Photodiagnosis and photodynamic therapy. vol 45. 2023-12-21. PMID:38128289. hypertrophic scars, an abnormal wound-healing response to burn injuries, are characterized by massive fibroblast proliferation and excessive deposition of extracellular matrix and collagen. 2023-12-21 2023-12-24 Not clear
Xiaoming Zhang, Jared M McLendon, Bailey D Peck, Biyi Chen, Long-Sheng Song, Ryan L Boudrea. Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix. Molecular therapy. Nucleic acids. vol 34. 2023-12-19. PMID:38111915. the integration of rna sequencing and mirna-target interactomes reveals that mir-29 regulates genes involved in calcium handling, cell stress and hypertrophy, metabolism, ion transport, and extracellular matrix remodeling. 2023-12-19 2023-12-21 mouse
Zhenyu Feng, Ningning Zhang, Jie Bai, Qiu-Yue Lin, Yunpeng Xie, Yun-Long Xi. Biochanin A inhibits cardiac hypertrophy and fibrosis in vivo and in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-13. PMID:38091641. the heart undergoes pathological cardiac hypertrophy as an adaptive response to prolonged pathological stimulation, leading to cardiomyocyte hypertrophy, fibroblast proliferation, and an increase in extracellular matrix. 2023-12-13 2023-12-17 mouse
Qian Xu, Kunping Zhuo, Xiaotian Zhang, Yanru Zhen, Limin Liu, Lu Zhang, Yufan Gu, Hui Jia, Qing Chen, Meixi Liu, Jiawei Dong, Ming-Sheng Zho. The role of angiotensin II activation of yes-associated protein/PDZ-binding motif signaling in hypertensive cardiac and vascular remodeling. European journal of pharmacology. vol 962. 2023-12-12. PMID:38061470. treatment with verteporfin significantly reduced ang ii-induced cardiac and vascular hypertrophy with a mild reduction in systolic blood pressure (sbp), verteporfin attenuated ang ii-induced cardiac and aortic fibrosis with the inhibition of transform growth factor (tgf)β/smad2/3 fibrotic signaling and extracellular matrix collagen i deposition. 2023-12-12 2023-12-17 Not clear
Ying Zhang, Qian Fang, Yinan Liu, Dan Zhang, Ying He, Fei Liu, Kun Sun, Jinghong Che. Increased FGFR3 is involved in T-2 toxin-induced lesions of hypertrophic cartilage associated with endemic osteoarthritis. Human & experimental toxicology. vol 42. 2023-12-07. PMID:38059300. inhibiting the fgfr3 signal could alleviate extracellular matrix degradation, abnormal chondrocytes differentiation, and excessive cell death in t-2 toxin-induced hypertrophic chondrocytes. 2023-12-07 2023-12-10 rat
Dongxu Feng, Huixia Li, Xiao Ma, Wenjuan Liu, Yangjun Zhu, Xiaomin Kan. Downregulation of extracellular matrix protein 1 effectively ameliorates osteoarthritis progression in vivo. International immunopharmacology. vol 126. 2023-12-01. PMID:38039715. although extracellular matrix protein 1 (ecm1) serves as a central regulator of chondrocyte proliferation and hypertrophy, its role in oa remains largely unknown. 2023-12-01 2023-12-10 mouse
Peter Wolf, Luigi Maione, Peter Kamenický, Philippe Chanso. Acromegalic Cardiomyopathy: An Entity on its own? The Effects of GH and IGF-I Excess and Treatment on Cardiovascular Risk Factors. Archives of medical research. 2023-12-01. PMID:38040526. myocardial hypertrophy in acromegaly is due to a homogeneous increase in the intracellular myocardial mass and extracellular myocardial matrix and improves following successful treatment through intracellular changes. 2023-12-01 2023-12-10 Not clear
Fang Ma, Honglin Liu, Tongtong Xia, Zhenghao Zhang, Shengchao Ma, Yinju Hao, Jiangyong Shen, Yideng Jiang, Nan L. HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8. Acta biochimica et biophysica Sinica. 2023-11-25. PMID:38006215. human hypertrophic scar-derived fibroblasts (hsfbs) have been shown to exert more potent promoting effects on extracellular matrix (ecm) accumulation than normal skin-derived fibroblasts (nsfbs) and are associated with enhanced hs formation. 2023-11-25 2023-11-28 human
Binyu Song, Yuhan Zhu, Ying Zhao, Kai Wang, Yixuan Peng, Lin Chen, Zhou Yu, Baoqiang Son. Machine learning and single-cell transcriptome profiling reveal regulation of fibroblast activation through THBS2/TGFβ1/P-Smad2/3 signalling pathway in hypertrophic scar. International wound journal. 2023-11-21. PMID:37986676. hypertrophic scar (hs) is a chronic inflammatory skin disorder characterized by excessive deposition of extracellular matrix, and the mechanisms underlying their formation remain poorly understood. 2023-11-21 2023-11-29 Not clear
Marc G Jeschke, Fiona M Wood, Esther Middelkoop, Ardeshir Bayat, Luc Teot, Rei Ogawa, Gerd G Gauglit. Scars. Nature reviews. Disease primers. vol 9. issue 1. 2023-11-16. PMID:37973792. although the underlying mechanisms of hypertrophic scars and keloid lesions are not well defined, evidence suggests that the changes in the extracellular matrix are perpetuated by ongoing inflammation in susceptible individuals, resulting in a fibrotic phenotype. 2023-11-16 2023-11-20 Not clear