All Relations between hypertrophic and matrix compartment

Publication Sentence Publish Date Extraction Date Species
Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Kumar Sharma, Goutam Ghosh Choudhur. High glucose-induced downregulation of PTEN-Long is sufficient for proximal tubular cell injury in diabetic kidney disease. Experimental cell research. 2024-06-03. PMID:38830568. during the progression of diabetic kidney disease, proximal tubular epithelial cells respond to high glucose to induce hypertrophy and matrix expansion leading to renal fibrosis. 2024-06-03 2024-06-06 mouse
Chae Syng Lee, Rui Shang, Fulong Wang, Parisa Khayambashi, Hualin Wang, Gala Araujo, Karanjit Puri, Israel Vlodavsky, Bahira Hussein, Brian Rodrigue. Heparanase Stimulation of Physiological Cardiac Hypertrophy is Suppressed Following Chronic Diabetes Resulting in Cardiac Remodeling and Dysfunction. Diabetes. 2024-05-21. PMID:38771953. as heparanase, with exclusive expression in endothelial cells, enables extracellular matrix remodeling, angiogenesis, metabolic reprogramming, and cell survival, it is conceivable that it could also encourage development of cardiac hypertrophy. 2024-05-21 2024-05-27 rat
Somanshu Banerjee, Varina R Clark Onwunyi, Jason Hong, Sandra Martineau, Gregory A Fishbein, Sandra Breuils Bonnet, Steeve Provencher, Sébastien Bonnet, Soban Uma. RV-specific Targeting of Snai1 Rescues Pulmonary Hypertension-induced Right Ventricular Failure by Inhibiting EndMT and Fibrosis bioRxiv : the preprint server for biology. 2024-05-15. PMID:38746200. rv-specific targeting of snai1 rescues pulmonary hypertension-induced right ventricular failure by inhibiting endmt and fibrosis pulmonary hypertension (ph)-induced right ventricular (rv) failure (ph-rvf) is a significant prognostic determinant of mortality and is characterized by rv hypertrophy, endothelial-to-mesenchymal transition (endmt), fibroblast-to-myofibroblast transition (fmt), fibrosis, and extracellular matrix (ecm)-remodeling. 2024-05-15 2024-05-27 Not clear
I V Zyubanova, A Yu Falkovckaya, M A Manukyan, E I Solonskaya, A A Vtorushina, S A Khunkhinova, A M Gusakova, S E Pekarskiy, V F Mordovi. Features of The Dynamics of Profibrotic Markers and Regression of Left Ventricular Hypertrophy After Renal Denervation in Patients With Resistant Hypertension and Stenosing Atherosclerosis of the Coronary Arteries. Kardiologiia. vol 64. issue 4. 2024-05-14. PMID:38742515. to compare the changes in serum concentrations of matrix metalloproteinases (mmps) and their tissue inhibitor (timp) to the dynamics of blood pressure (bp) and parameters of left ventricular hypertrophy (lvh) 6 months after renal denervation (rd) in patients with resistant arterial hypertension (rah) and complicated coronary atherosclerosis. 2024-05-14 2024-05-27 Not clear
Yize Li, Yujie Xiao, Yongfeng Han, Huayu Zhu, Juntao Han, Hongtao Wan. Blocking the MIR155HG/miR-155 axis reduces CTGF-induced inflammatory cytokine production and α-SMA expression via upregulating AZGP1 in hypertrophic scar fibroblasts. Cellular signalling. 2024-05-10. PMID:38729323. hypertrophic scarring (hs) is a pathological condition characterized by excessive fibrosis and inflammation, resulting in excessive extracellular matrix formation in the skin. 2024-05-10 2024-05-27 Not clear
Kumara Kaluarachchi, Lakshman Samaranayak. The first report of the presence of collagen X in mammalian dentinal matrix. Morphologie : bulletin de l'Association des anatomistes. vol 108. issue 362. 2024-04-05. PMID:38579391. collagen x is an extracellular matrix protein, usually found in the hypertrophic cartilage destined to be mineralized. 2024-04-05 2024-04-10 Not clear
Laura Dönges, Atharva Damle, Andrea Mainardi, Thomas Bock, Monica Schönenberger, Ivan Martin, Andrea Barber. Engineered human osteoarthritic cartilage organoids. Biomaterials. vol 308. 2024-03-30. PMID:38554643. here, by imposing specific inflammatory challenges upon mesenchymal stromal cells at a defined stage of chondrogenesis, we engineered a human organotypic model which recapitulates main oa pathological traits such as chondrocyte hypertrophy, cartilage matrix mineralization, enhanced catabolism and mechanical stiffening. 2024-03-30 2024-04-02 human
Shubha S Bellur, Stéphan Troyanov, Olga Vorobyeva, Rosanna Coppo, Ian Sd Robert. Evidence from the large VALIGA cohort validates the subclassification of focal segmental glomerulosclerosis in IgA nephropathy. Kidney international. 2024-03-30. PMID:38554992. all biopsies were evaluated for glomeruli with segmental capillary occlusion by matrix ("not otherwise specified", nos lesion), simple capsular adhesion without capillary occlusion (adh), tip lesions, and podocyte hypertrophy (ph). 2024-03-30 2024-04-02 Not clear
Wen-Hai Zhuo, Hwee Weng Dennis Hey, Wing Moon Raymond Lam, Xiaoyun Chloe Chan, Loo Hoey Lit, Yong Soon Chiong, Hee-Kit Won. Increased matrix metalloproteinase-2 in ligamentum flavum hypertrophy and the regulation of MMP-2/TIMPs by elastin-derived peptides. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2024-03-28. PMID:38546147. increased matrix metalloproteinase-2 in ligamentum flavum hypertrophy and the regulation of mmp-2/timps by elastin-derived peptides. 2024-03-28 2024-03-30 rat
Wen-Hai Zhuo, Hwee Weng Dennis Hey, Wing Moon Raymond Lam, Xiaoyun Chloe Chan, Loo Hoey Lit, Yong Soon Chiong, Hee-Kit Won. Increased matrix metalloproteinase-2 in ligamentum flavum hypertrophy and the regulation of MMP-2/TIMPs by elastin-derived peptides. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2024-03-28. PMID:38546147. the study aimed to examine matrix metalloproteinase-2 (mmp-2) expression in a rat ligamentum flavum (lf) hypertrophy model in vivo, and the effect of elastin-derived peptides (edps) on mmp-2 and tissue inhibitors of metalloproteinases (timps) in rat lf cells in vitro. 2024-03-28 2024-03-30 rat
Peng Pi, Liqing Zeng, Zhipeng Zeng, Keqiang Zong, Bing Han, Xizhe Bai, Yan Wan. The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review. Frontiers in endocrinology. vol 15. 2024-03-21. PMID:38510704. disorders of glucose metabolism can lead to chondrocyte hypertrophy and extracellular matrix degradation, and promote the occurrence and development of oa. 2024-03-21 2024-03-23 Not clear
Samantha Donsante, Alice Pievani, Biagio Palmisano, Melissa Finamore, Grazia Fazio, Alessandro Corsi, Andrea Biondi, Shunji Tomatsu, Rocco Piazza, Marta Serafini, Mara Riminucc. Modeling skeletal dysplasia in Hurler syndrome using patient-derived bone marrow osteoprogenitor cells. JCI insight. vol 9. issue 5. 2024-03-08. PMID:38456506. we also noticed that mps ih hypertrophic cartilage was characterized by dysregulation of signaling pathways controlling cartilage hypertrophy and fate, extracellular matrix organization, and glycosaminoglycan metabolism. 2024-03-08 2024-03-10 Not clear
Gurcharan Kaur, Biming Wu, Sanjana Murali, Thomas Lanigan, Rhima M Colema. A synthetic, closed-looped gene circuit for the autonomous regulation of RUNX2 activity during chondrogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 4. 2024-02-26. PMID:38407380. finally, we show the efficacy of inhibiting runx2 in preventing matrix loss in human mesenchymal stem cell-derived (hmsc-derived) cartilage under conditions that induce chondrocyte hypertrophic differentiation, including inflammation. 2024-02-26 2024-02-28 human
Shaohui Li, Yunwei Wang, Yang Chen, Hao Zhang, Peng Cao, Kuo Shen, Hao Gua. PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL. Archives of biochemistry and biophysics. 2024-02-07. PMID:38325773. hypertrophic scar (hs) is a dermatological condition characterized by an excessive accumulation of proteins in the extracellular matrix (ecm) and an elevated cell count. 2024-02-07 2024-02-10 Not clear
Shaohui Li, Yunwei Wang, Yang Chen, Hao Zhang, Peng Cao, Kuo Shen, Hao Gua. PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL. Archives of biochemistry and biophysics. 2024-02-07. PMID:38325773. the findings of our study provide validation for the role of pten in inhibiting the development of hypertrophic scars (hs) by modulating the expression of extracellular matrix (ecm) proteins and promoting apoptosis in hypertrophic scar fibroblasts (hsfs) via bcl-xl. 2024-02-07 2024-02-10 Not clear
Jacob J Robino, Alexander P Plekhanov, Qingzhang Zhu, Michael D Jensen, Philipp E Scherer, Charles T Roberts, Oleg Varlamo. Adipose Tissue Analysis Toolkit (ATAT) for Automated Analysis of Adipocyte Size and Extracellular Matrix in White Adipose Tissue. bioRxiv : the preprint server for biology. 2024-02-06. PMID:38318208. the pathological expansion of white adipose tissue (wat) in obesity involves adipocyte hypertrophy accompanied by expansion of collagen-rich pericellular extracellular matrix (ecm) and the development of crown-like structures (cls). 2024-02-06 2024-02-09 Not clear
Jacob J Robino, Alexander P Plekhanov, Qingzhang Zhu, Michael D Jensen, Philipp E Scherer, Charles T Roberts, Oleg Varlamo. Adipose Tissue Analysis Toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue. Obesity (Silver Spring, Md.). 2024-02-06. PMID:38321231. the pathological expansion of white adipose tissue (wat) in obesity involves adipocyte hypertrophy accompanied by expansion of the collagen-rich pericellular extracellular matrix (ecm) and development of crown-like structures (cls). 2024-02-06 2024-02-09 Not clear
Mohammad Ali Mohammadkhani, Soraya Shahrzad, Mehrdad Haghighi, Reza Ghanbari, Ashraf Mohamadkhan. Insights into Organochlorine Pesticides Exposure in the Development of Cardiovascular Diseases: A Systematic Review. Archives of Iranian medicine. vol 26. issue 10. 2024-02-04. PMID:38310416. changes in the regulatory function of peroxisome proliferator-activated γ receptor (pparγ), reduction of paroxonase activity (pon1), epigenetic changes of histone through induction of reactive oxygen species, vascular endothelial inflammation with mir-expression 126 and mir-31, increased collagen synthesis enzymes in the extracellular matrix and left ventricular hypertrophy (lvh) and fibrosis are mechanisms by which pcbs increase the risk of cvd. 2024-02-04 2024-02-06 human
Fabrizio E Mancini, Paul E A Humphreys, Steven Woods, Nicola Bates, Sara Cuvertino, Julieta O'Flaherty, Leela Biant, Marco A N Domingos, Susan J Kimbe. Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis. Scientific reports. vol 14. issue 1. 2024-02-01. PMID:38302538. chondroprogenitors obtained from rapid-e could generate cartilaginous pellets that expressed ac-related matrix proteins such as lubricin, aggrecan, and collagen ii, but additionally expressed collagen x, indicative of hypertrophy. 2024-02-01 2024-02-04 human
Boya Yu, Yalei Cao, Shiyi Li, Ruiqi Bai, Guiwen Zhou, Qiang Fu, Liming Liang, Weijie Gu, Lixia Zhang, Minliang Che. Identification and validation of CRLF1 and NRG1 as immune-related signatures in hypertrophic scar. Genomics. 2024-01-23. PMID:38262564. hypertrophic scar (hts) is a prevalent chronic inflammatory skin disorder characterized by abnormal proliferation and extracellular matrix deposition and the precise mechanisms underlying hts remain elusive. 2024-01-23 2024-01-26 Not clear