| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hirai Suito, Kaoru Fujikawa, Masafumi Ohsak. ENPP1 downregulation and FGF23 upregulation in growth-related calcification of the tibial tuberosity in rats. Journal of anatomy. 2023-10-10. PMID:37814911. |
the extracellular matrix of hypertrophic chondrocytes was calcified. |
2023-10-10 |
2023-10-15 |
rat |
| Kevin G Burt, Dan C Viola, Lauren E Lisiewski, Joseph M Lombardi, Louis F Amorosa, Nadeen O Chahin. An in vivo model of ligamentum flavum hypertrophy from early-stage inflammation to fibrosis. JOR spine. vol 6. issue 3. 2023-10-02. PMID:37780823. |
in this study, we created an injury model to test the hypothesis that lf needle scrape injury in the rat will result in hypertrophy of the lf characterized by altered tissue geometry, matrix organization, composition and inflammation. |
2023-10-02 |
2023-10-07 |
rat |
| Xue Bai, Hongyan Sun, Lina Jia, Junjie Xu, Peng Zhang, Deyuan Zhang, Yu Gu, Bo Chen, Lin Fen. Chondrocyte targeting gold nanoparticles protect growth plate against inflammatory damage by maintaining cartilage balance. Materials today. Bio. vol 23. 2023-09-28. PMID:37766899. |
aunps inhibited the formation of gaps, without chondrocytes and extracellular matrix, between the proliferative and hypertrophy zones of the gp cartilage, and the gaps were noticeable in the lps group. |
2023-09-28 |
2023-10-07 |
mouse |
| Yunxian Dong, Xiaoling Cao, Jinsheng Huang, Zhicheng Hu, Chufen Chen, Miao Chen, Qian Long, Zhongye Xu, Dongming Lv, Yanchao Rong, Shengkang Luo, Haibin Wang, Wuguo Deng, Bing Tan. Melatonin inhibits fibroblast cell functions and hypertrophic scar formation by enhancing autophagy through the MT2 receptor-inhibited PI3K/Akt /mTOR signaling. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-22. PMID:37739092. |
hypertrophic scar (hs) is a fibrotic skin condition and characterized by abnormal proliferation of myofibroblasts and accumulation of extracellular matrix. |
2023-09-22 |
2023-10-07 |
human |
| Liu Yang, Yajuan Song, Tong Wang, Zhiwei Cui, JunZheng Wu, Yi Shi, Zhou Yu, Baoqiang Son. Transcription factor c-Maf drives macrophages to promote hypertrophic scar formation. Journal of cosmetic dermatology. 2023-09-15. PMID:37710417. |
hypertrophic scar (hs) is caused by the abnormal proliferation of fibroblasts and excessive deposition of extracellular matrix (ecm). |
2023-09-15 |
2023-10-07 |
Not clear |
| Natalia J Braams, Azar Kianzad, Jessie van Wezenbeek, Jeroen N Wessels, Samara M A Jansen, Stine Andersen, Anco Boonstra, Esther J Nossent, J Tim Marcus, Ahmed A Bayoumy, Clarissa Becher, Marie-José Goumans, Asger Andersen, Anton Vonk Noordegraaf, Frances S de Man, Harm Jan Bogaard, Lilian J Meijboo. Long-Term Effects of Pulmonary Endarterectomy on Right Ventricular Stiffness and Fibrosis in Chronic Thromboembolic Pulmonary Hypertension. Circulation. Heart failure. 2023-09-07. PMID:37675561. |
it is unknown whether incomplete reversal of rv remodeling results from extracellular matrix expansion (diffuse interstitial fibrosis) or cellular hypertrophy, and whether residual rv remodeling relates to altered diastolic function. |
2023-09-07 |
2023-10-07 |
Not clear |
| Roberto Boi, Kerstin Ebefors, Jenny Nyströ. The role of the mesangium in glomerular function. Acta physiologica (Oxford, England). 2023-09-02. PMID:37658606. |
the expansion is normally due to matrix expansion in combination with either proliferation or hypertrophy. |
2023-09-02 |
2023-09-07 |
Not clear |
| Daniel Naveed Tavakol, Trevor R Nash, Youngbin Kim, Siyu He, Sharon Fleischer, Pamela L Graney, Jessie A Brown, Martin Liberman, Manuel Tamargo, Andrew Harken, Adolfo A Ferrando, Sally Amundson, Guy Garty, Elham Azizi, Kam W Leong, David J Brenner, Gordana Vunjak-Novakovi. Modeling and countering the effects of cosmic radiation using bioengineered human tissues. Biomaterials. vol 301. 2023-08-26. PMID:37633022. |
we further determined the extent of inflammatory, oxidative stress, and matrix remodeling gene expression changes, and found that these changes were associated with an early hypertrophic phenotype in ect and myeloid skewing in ebm. |
2023-08-26 |
2023-09-07 |
human |
| Domenico Ribatti, Antonio d'Amat. Bone angiocrine factors. Frontiers in cell and developmental biology. vol 11. 2023-08-21. PMID:37601109. |
vascular endothelial growth factor (vegf), one of several angiogenic molecules, is a significant regulator of blood vessel invasion, cartilage remodeling, and ossification of freshly created bone matrix; chondrocyte proliferation and hypertrophy are facilitated by the production of vegfa and vegf receptor-2 (vegfr-2), which is stimulated by fibroblast growth factors (fgfs). |
2023-08-21 |
2023-09-07 |
Not clear |
| Sree Samanvitha Kuppa, Hyung-Keun Kim, Ju-Yeon Kang, Seok-Cheol Lee, Hong-Yeol Yang, Jaishree Sankaranarayanan, Jong-Keun Seo. Polynucleotides Suppress Inflammation and Stimulate Matrix Synthesis in an In Vitro Cell-Based Osteoarthritis Model. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569659. |
chondrocyte hypertrophy and inflammation promote extracellular matrix degradation (ecm). |
2023-08-12 |
2023-08-16 |
human |
| Francesca Veronesi, Viviana Costa, Daniele Bellavia, Valentina Basoli, Gianluca Giavares. Epigenetic Modifications of MiRNAs in Osteoarthritis: A Systematic Review on Their Methylation Levels and Effects on Chondrocytes, Extracellular Matrix and Joint Inflammation. Cells. vol 12. issue 14. 2023-07-29. PMID:37508486. |
osteoarthritis (oa) is a joint disorder characterized by progressive degeneration of cartilage extracellular matrix (ecm), chondrocyte hypertrophy and apoptosis and inflammation. |
2023-07-29 |
2023-08-14 |
Not clear |
| Milos Jesenak, Peter Durdik, Dasa Oppova, Sona Franova, Zuzana Diamant, Kornel Golebski, Peter Banovcin, Jarmila Vojtkova, Elena Novakov. Dysfunctional mucociliary clearance in asthma and airway remodeling - New insights into an old topic. Respiratory medicine. 2023-07-29. PMID:37516275. |
components of airway remodeling include epithelial cell shedding and dysfunction, goblet cell hyperplasia, subepithelial matrix protein deposition, fibrosis, neoangiogenesis, airway smooth muscle cell hypertrophy and hyperplasia. |
2023-07-29 |
2023-08-14 |
Not clear |
| Ning Chen, Robin W H Wu, Yan Lam, Wilson C W Chan, Danny Cha. Hypertrophic chondrocytes at the junction of musculoskeletal structures. Bone reports. vol 19. 2023-07-24. PMID:37485234. |
the amazing journey of a chondrocyte from being entrapped in the extracellular matrix environment to becoming proliferative then hypertrophic will be discussed. |
2023-07-24 |
2023-08-14 |
Not clear |
| Yuanyuan Chen, Yuchan Yuan, Yuhan Chen, Xueze Jiang, Xuesheng Hua, Zhiyong Chen, Julie Wang, Hua Liu, Qing Zhou, Ying Yu, Zhenwei Yang, Yi Yu, Yongqin Wang, Qunshan Wang, Yigang Li, Jie Chen, Yuepeng Wan. Novel signaling axis of FHOD1-RNF213-Col1α/Col3α in the pathogenesis of hypertension-induced tunica media thickening. Journal of molecular and cellular cardiology. vol 182. 2023-07-23. PMID:37482037. |
pathogenically, tmt originates from both vascular smooth muscle cells (vsmcs) hypertrophy due to synthesizing more amount of intracellular contractile proteins and excess secretion of extracellular matrix. |
2023-07-23 |
2023-08-14 |
rat |
| Dhanalakshmi Jeyachandran, Monzur Murshed, Lisbet Haglund, Marta Cerrut. A Bioglass-Poly(lactic-co-glycolic Acid) Scaffold@Fibrin Hydrogel Construct to Support Endochondral Bone Formation. Advanced healthcare materials. 2023-07-18. PMID:37462089. |
results show that bg-plga@fibrin induces hypertrophy, as well as matrix mineralization and osteogenesis; it also promotes a change in morphology of the mscs at the gel/scaffold interface, possibly a sign of osteoblast-like differentiation of hypertrophic chondrocytes. |
2023-07-18 |
2023-08-14 |
Not clear |
| Wan-Ching Cheng, Charlotte Lawson, Hui-Hsuan Liu, Lois Wilkie, Melanie Dobromylskyj, Virginia Luis Fuentes, Jayesh Dudhia, David J Connoll. Exploration of Mediators Associated with Myocardial Remodelling in Feline Hypertrophic Cardiomyopathy. Animals : an open access journal from MDPI. vol 13. issue 13. 2023-07-14. PMID:37443910. |
clinically, hcm is characterised by significant diastolic dysfunction due to a reduction in ventricular compliance and relaxation associated with extracellular matrix (ecm) remodelling and the development of ventricular hypertrophy. |
2023-07-14 |
2023-08-14 |
human |
| Binyu Song, Wei Liu, Yuhan Zhu, Yixuan Peng, Zhiwei Cui, Botao Gao, Lin Chen, Zhou Yu, Baoqiang Son. Deciphering the contributions of cuproptosis in the development of hypertrophic scar using single-cell analysis and machine learning techniques. Frontiers in immunology. vol 14. 2023-07-06. PMID:37409114. |
hypertrophic scar (hs) is a chronic inflammatory skin disease characterized by excessive deposition of extracellular matrix, but the exact mechanisms related to its formation remain unclear, making it difficult to treat. |
2023-07-06 |
2023-08-14 |
Not clear |
| Piero Antonio Zecca, Marcella Reguzzoni, Marina Borgese, Marina Protasoni, Marta Filibian, Mario Raspant. Investigating the interfaces of the epiphyseal plate: An integrated approach of histochemistry, microtomography and SEM. Journal of anatomy. 2023-07-01. PMID:37391907. |
on the diaphyseal side the hypertrophic chondrocytes were arranged in tall columns packed in a sort of compact palisade; the interposed extracellular matrix was actively calcifying into a thick mineralized crust growing towards the epiphysis. |
2023-07-01 |
2023-08-14 |
Not clear |
| Mengmeng Duan, Shuang Xia, Yang Liu, Xiaohua Pu, Yukun Chen, Yilin Zhou, Minglei Huang, Caixia Pi, Demao Zhang, Jing Xi. Stiffened fibre-like microenvironment based on patterned equidistant micropillars directs chondrocyte hypertrophy. Materials today. Bio. vol 20. 2023-06-12. PMID:37304578. |
taken together, these results revealed the cell responses of chondrocytes in terms of cell morphology, cytoskeleton, focal adhesion, nuclei and cell hypertrophy, and may be beneficial for understanding the cellular functional changes affected by the matrix stiffening that occurs during the transition from a normal state to a state of osteoarthritis. |
2023-06-12 |
2023-08-14 |
Not clear |
| Mahdia Taieb, Dima Ghannoum, Lydia Barré, Mohamed Ouzzin. Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate. Cell death & disease. vol 14. issue 6. 2023-06-11. PMID:37296099. |
we found that loss of xylt-i induces hypertrophic phenotype-like of chondrocytes associated with reduced interterritorial matrix. |
2023-06-11 |
2023-08-14 |
Not clear |