Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Jianfei Li, Feiju M. Polo-Like Kinase 2 Is Identified in Hypertrophy, Extracellular Matrix Accumulation, and Oxidative Stress of Mesangial Cells in Diabetic Nephropathy through p38-MAPK Signaling. Annals of clinical and laboratory science. vol 53. issue 2. 2023-04-24. PMID:37094847. |
polo-like kinase 2 is identified in hypertrophy, extracellular matrix accumulation, and oxidative stress of mesangial cells in diabetic nephropathy through p38-mapk signaling. |
2023-04-24 |
2023-08-14 |
Not clear |
Maria Uscategui Calderon, Brittany A Gonzalez, Katherine E Yutze. Cardiomyocyte-fibroblast crosstalk in the postnatal heart. Frontiers in cell and developmental biology. vol 11. 2023-04-20. PMID:37077417. |
moreover, postnatal cardiomyocytes undergo binucleation and cell cycle arrest with induction of hypertrophic growth, while cardiac fibroblasts proliferate and produce extracellular matrix (ecm) that transitions from components that support cellular maturation to production of the mature fibrous skeleton of the heart. |
2023-04-20 |
2023-08-14 |
Not clear |
L Chen, H Yan, B Zhou, Y F Xu, J L. [New research advances in hypertrophic scar formation, prevention and treatment]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 57. issue 4. 2023-04-09. PMID:37032171. |
excessive fb proliferation which produces the excessive collagen deposition, including increased extracellular matrix synthesis or insufficient decomposition, typically contributes to hypertrophic scar(hs) formation. |
2023-04-09 |
2023-08-14 |
Not clear |
Minghao Qu, Mingjue Chen, Weiyuan Gong, Shaochuan Huo, Qinnan Yan, Qing Yao, Yumei Lai, Di Chen, Xiaohao Wu, Guozhi Xia. Pip5k1c Loss in Chondrocytes Causes Spontaneous Osteoarthritic Lesions in Aged Mice. Aging and disease. vol 14. issue 2. 2023-04-03. PMID:37008048. |
pip5k1c loss promotes extracellular matrix (ecm) degradation, chondrocyte hypertrophy and apoptosis, and inhibits chondrocyte proliferation in the articular cartilage of aged mice. |
2023-04-03 |
2023-08-14 |
mouse |
Qian Yu, Qiang Dai, Zonglin Huang, Chen Li, Li Yan, Xin Fu, Qian Wang, Yi Zhang, Lei Cai, Zhigang Yang, Ran Xia. Microfat exerts an anti-fibrotic effect on human hypertrophic scar via fetuin-A/ETV4 axis. Journal of translational medicine. vol 21. issue 1. 2023-04-02. PMID:37004048. |
hypertrophic scar is a fibrotic disease following wound healing and is characterized by excessive extracellular matrix deposition. |
2023-04-02 |
2023-08-14 |
human |
Manjula P Mony, Kelly A Harmon, Ryan Hess, Amir H Dorafshar, Sasha H Shafikhan. An Updated Review of Hypertrophic Scarring. Cells. vol 12. issue 5. 2023-03-11. PMID:36899815. |
hypertrophic scarring (hts) is an aberrant form of wound healing that is associated with excessive deposition of extracellular matrix and connective tissue at the site of injury. |
2023-03-11 |
2023-08-14 |
Not clear |
Shenyi Jiang, Shuhao Qian, Lingxi Zhou, Jia Meng, Rushan Jiang, Chuncheng Wang, Xinguo Fang, Chen Yang, Zhihua Ding, Shuangmu Zhuo, Zhiyi Li. Mapping the 3D remodeling of the extracellular matrix in human hypertrophic scar by multi-parametric multiphoton imaging using endogenous contrast. Heliyon. vol 9. issue 2. 2023-03-06. PMID:36873151. |
mapping the 3d remodeling of the extracellular matrix in human hypertrophic scar by multi-parametric multiphoton imaging using endogenous contrast. |
2023-03-06 |
2023-08-14 |
human |
Irina V Kologrivova, Natalia V Naryzhnaya, Olga A Koshelskaya, Tatiana E Suslova, Elena S Kravchenko, Olga A Kharitonova, Vladimir V Evtushenko, Alla A Boshchenk. Association of Epicardial Adipose Tissue Adipocytes Hypertrophy with Biomarkers of Low-Grade Inflammation and Extracellular Matrix Remodeling in Patients with Coronary Artery Disease. Biomedicines. vol 11. issue 2. 2023-02-25. PMID:36830779. |
association of epicardial adipose tissue adipocytes hypertrophy with biomarkers of low-grade inflammation and extracellular matrix remodeling in patients with coronary artery disease. |
2023-02-25 |
2023-08-14 |
Not clear |
Lei Huang, Meng Jin, Ruiying Gu, Kunlin Xiao, Mengnan Lu, Xinyu Huo, Mengyao Sun, Zhi Yang, Zhiyuan Wang, Weijie Zhang, Liqiang Zhi, Ziang Meng, Jie Ma, Jianbing Ma, Rui Zhan. miR-199a-5p Reduces Chondrocyte Hypertrophy and Attenuates Osteoarthritis Progression via the Indian Hedgehog Signal Pathway. Journal of clinical medicine. vol 12. issue 4. 2023-02-25. PMID:36835852. |
further investigations demonstrated that mir-199a-5p could directly regulate ihh expression and reduce chondrocyte hypertrophy and matrix degradation via the ihh signal pathway in the primary human chondrocytes. |
2023-02-25 |
2023-08-14 |
human |
Chin-Chan Lee, Chia-Chun Chen, Cheng-Kai Hsu, Yih-Ting Chen, Chun-Yu Chen, Kai-Jie Yang, Ming-Jui Hung, I-Wen W. Urinary microRNA in Diabetic Kidney Disease: A Literature Review. Medicina (Kaunas, Lithuania). vol 59. issue 2. 2023-02-25. PMID:36837555. |
previous literatures have reported its potential role in the pathophysiology of diabetic kidney disease, including regulation of transforming growth factor-β1-mediated fibrosis, extracellular matrix and cell adhesion proteins, cellular hypertrophy, growth factor, cytokine production, and redox system activation. |
2023-02-25 |
2023-08-14 |
Not clear |
Joshua S Godwin, Casey L Sexton, Nicholas J Kontos, Bradley A Ruple, Darryn S Willoughby, Kaelin C Young, C Brooks Mobley, Michael D Robert. Extracellular matrix content and remodeling markers do not differ in college-aged men classified as higher- and lower-responders to resistance training. Journal of applied physiology (Bethesda, Md. : 1985). 2023-02-09. PMID:36759158. |
we determined if skeletal muscle extracellular matrix (ecm) content and remodeling markers adapted with resistance training or were associated with hypertrophic outcomes. |
2023-02-09 |
2023-08-14 |
human |
Charly Robert, Frédéric Kerff, Fabrice Bouillenne, Maxime Gavage, Marylène Vandevenne, Patrice Filée, André Matagn. Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition. The Journal of biological chemistry. 2023-01-15. PMID:36642181. |
additionally, several in vitro cell-based assays, including enzymatic measurements, rt-qpcr and matrix staining, demonstrated their biological activity during cell chondrogenic and hypertrophic differentiation. |
2023-01-15 |
2023-08-14 |
human |
Guoqing Li, Su Liu, Huihui Xu, Yixiao Chen, Jiapeng Deng, Ao Xiong, Deli Wang, Jian Weng, Fei Yu, Liang Gao, Changhai Ding, Hui Zen. Potential effects of teriparatide (PTH (1-34)) on osteoarthritis: a systematic review. Arthritis research & therapy. vol 25. issue 1. 2023-01-07. PMID:36609338. |
in vitro studies (n = 11) concluded that pth (1-34) was important for chondrocytes via increasing the proliferation and matrix synthesis but preventing apoptosis or hypertrophy. |
2023-01-07 |
2023-08-14 |
Not clear |
James T Pearso. Set7 methyltransferase roles in myocardial protection from chronic stressors. Clinical science (London, England : 1979). vol 137. issue 1. 2023-01-05. PMID:36601782. |
recent transcriptome and fourier transform infrared spectroscopy analyses and in vivo assessments of cardiac function by lunardon and colleagues now reveal a clear role of set7 in the regulation of the extracellular matrix composition and cardiac hypertrophy in response to chronic isoproterenol induced cardiac stress. |
2023-01-05 |
2023-08-14 |
Not clear |
Helena M Viola, Caitlyn Richworth, Tanya Solomon, Ian L Chin, Henrietta Cserne Szappanos, Srinivasan Sundararaj, Dmitry Shishmarev, Marco G Casarotto, Yu Suk Choi, Livia C Hoo. A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology. Communications biology. vol 6. issue 1. 2023-01-03. PMID:36596888. |
a maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology. |
2023-01-03 |
2023-08-14 |
human |
Helena M Viola, Caitlyn Richworth, Tanya Solomon, Ian L Chin, Henrietta Cserne Szappanos, Srinivasan Sundararaj, Dmitry Shishmarev, Marco G Casarotto, Yu Suk Choi, Livia C Hoo. A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology. Communications biology. vol 6. issue 1. 2023-01-03. PMID:36596888. |
we identify a mechanosensing feedback mechanism between the extracellular matrix and cytoskeletal network that regulates mitochondrial function under healthy conditions, but participates in the progression of hypertrophic cardiomyopathy pathophysiology resulting from sarcomeric gene mutations. |
2023-01-03 |
2023-08-14 |
human |
Hubert Kol. Obese visceral fat tissue inflammation: from protective to detrimental? BMC medicine. vol 20. issue 1. 2022-12-27. PMID:36575472. |
eventual lipid overload of hypertrophic adipocytes leads to endoplasmic reticulum stress and the secretion of a variety of signals causing increased sympathetic tone, lipolysis by adipocytes, lipid uptake by macrophages, matrix remodeling, angiogenesis, and immune cell activation. |
2022-12-27 |
2023-08-14 |
Not clear |
Shikha Chawla, Andrea Mainardi, Nilotpal Majumder, Laura Dönges, Bhupendra Kumar, Paola Occhetta, Ivan Martin, Christian Egloff, Sourabh Ghosh, Amitabha Bandyopadhyay, Andrea Barber. Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic Strategies. Cells. vol 11. issue 24. 2022-12-23. PMID:36552796. |
afterwards, we will present the strategies developed and proposed to impede chondrocyte hypertrophy and cartilage matrix mineralization/calcification. |
2022-12-23 |
2023-08-14 |
Not clear |
Zhencheng Yu, Yun Li, Rao Fu, Yaxin Xue, Danyang Zhao, Dong Ha. Platycodin D inhibits the proliferation and migration of hypertrophic scar-derived fibroblasts and promotes apoptosis through a caspase-dependent pathway. Archives of dermatological research. 2022-12-16. PMID:36526799. |
abnormal fibroblast proliferation and excessive extracellular matrix (ecm) deposition lead to the formation of hypertrophic scars (hss). |
2022-12-16 |
2023-08-14 |
human |
Ashley A Thurstin, Allison N Egeli, Edie C Goldsmith, Francis G Spinale, Holly A LaVoi. Tissue Inhibitor of Metalloproteinase 4 (Timp4) Deletion in Mice Impacts Maternal Cardiac Function during Pregnancy and Postpartum. American journal of physiology. Heart and circulatory physiology. 2022-12-02. PMID:36459450. |
reversible physiological cardiac hypertrophy of the maternal heart occurs during pregnancy and involves extracellular matrix (ecm) remodeling. |
2022-12-02 |
2023-08-14 |
mouse |