| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alejandro Gugliucc. Biomarkers of dysfunctional visceral fat. Advances in clinical chemistry. vol 109. 2022-08-11. PMID:35953124. |
this leads to the ominous triad: inflammation, fibrosis (extracellular matrix hypertrophy) and impaired angiogenesis as well as consequent unresolved hypoxia. |
2022-08-11 |
2023-08-14 |
Not clear |
| Jessica M Overstreet, Cody C Gifford, Jiaqi Tang, Paul J Higgins, Rohan Samarakoo. Emerging role of tumor suppressor p53 in acute and chronic kidney diseases. Cellular and molecular life sciences : CMLS. vol 79. issue 9. 2022-08-08. PMID:35941392. |
tgf-β1-induced micro-rnas (such as mir-192) could facilitate p53 activation, leading to renal hypertrophy and matrix expansion in response to diabetic insults while aa-mediated mir-192 induction regulates p53 dependent epithelial g |
2022-08-08 |
2023-08-14 |
mouse |
| Xuechun Sun, Yu Yang, Xiaodan Sun, Huali Meng, Wenhao Hao, Jialin Yin, Fuzhe Ma, Xin Guo, Lei Du, Lei Sun, Hao W. Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy. Journal of agricultural and food chemistry. 2022-08-02. PMID:35916281. |
the diabetic mice developed albuminuria, mesangial matrix accumulation, glomerular hypertrophy, and fibrosis formation, with an increase in renal proinflammatory, oxidative and profibrotic gene expression. |
2022-08-02 |
2023-08-14 |
mouse |
| Camille R Brightwell, Christine M Latham, Nicholas T Thomas, Alexander R Keeble, Kevin A Murach, Christopher S Fr. A Glitch in the Matrix: The Pivotal Role for Extracellular Matrix Remodeling During Muscle Hypertrophy. American journal of physiology. Cell physiology. 2022-07-25. PMID:35876284. |
a glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy. |
2022-07-25 |
2023-08-14 |
Not clear |
| Yawei Bian, Chonglin Shi, Shan Song, Lin Mu, Ming Wu, Duojun Qiu, Jiajia Dong, Wei Zhang, Chen Yuan, Dongyun Wang, Zihui Zhou, Xuan Dong, Yonghong Sh. Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy. Cell and tissue research. 2022-07-13. PMID:35821438. |
sesn2 overexpression improved renal function and decreased glomerular hypertrophy, albuminuria, mesangial expansion, extracellular matrix accumulation, and tgf-β1 expression, as well as oxidative stress in diabetic mice. |
2022-07-13 |
2023-08-14 |
mouse |
| Ilaria Stadiotti, Rosaria Santoro, Alessandro Scopece, Sergio Pirola, Anna Guarino, Gianluca Polvani, Angela Serena Maione, Flora Ascione, Qingsen Li, Domenico Delia, Marco Foiani, Giulio Pompilio, Elena Sommariv. Pressure Overload Activates DNA-Damage Response in Cardiac Stromal Cells: A Novel Mechanism Behind Heart Failure With Preserved Ejection Fraction? Frontiers in cardiovascular medicine. vol 9. 2022-07-11. PMID:35811699. |
aortic valve stenosis can cause an hfpef-like syndrome by inducing sustained pressure overload (po) and cardiac remodeling, as cardiomyocyte (cm) hypertrophy and fibrotic matrix deposition. |
2022-07-11 |
2023-08-14 |
Not clear |
| Patsy Gomez-Picos, Katie Ovens, B Frank Eame. Limb Mesoderm and Head Ectomesenchyme Both Express a Core Transcriptional Program During Chondrocyte Differentiation. Frontiers in cell and developmental biology. vol 10. 2022-07-05. PMID:35784462. |
immature chondrocytes (imm) represent the early stages of cartilage differentiation, while mature chondrocytes (mat) undergo additional stages of differentiation, including hypertrophy and stimulating matrix mineralization and degradation. |
2022-07-05 |
2023-08-14 |
chicken |
| Jeanne Hsieh, Kelsie L Becklin, Sophie Givens, Elizabeth R Komosa, Juan E Abrahante Lloréns, Forum Kamdar, Branden S Moriarity, Beau R Webber, Bhairab N Singh, Brenda M Ogl. Myosin Heavy Chain Converter Domain Mutations Drive Early-Stage Changes in Extracellular Matrix Dynamics in Hypertrophic Cardiomyopathy. Frontiers in cell and developmental biology. vol 10. 2022-07-05. PMID:35784482. |
myosin heavy chain converter domain mutations drive early-stage changes in extracellular matrix dynamics in hypertrophic cardiomyopathy. |
2022-07-05 |
2023-08-14 |
Not clear |
| Mingsheng Xie, Yiqian Zhang, Zixuan Xiong, Sophie Hines, Yingzi Shangjing, Karen L Clark, Susheng Tan, Peter G Alexander, Hang Li. Generation of hyaline-like cartilage tissue from human mesenchymal stromal cells within the self-generated extracellular matrix. Acta biomaterialia. 2022-07-02. PMID:35779770. |
previously, we developed a method to induce hmsc chondrogenesis within self-generated extracellular matrix (mecm), which formed a cartilage tissue with a lower hypertrophy level than conventional hmsc pellets. |
2022-07-02 |
2023-08-14 |
human |
| Fang Xie, Li Teng, Jianjian Lu, Jiajie Xu, Chao Zhang, Liya Yang, Xiaoyang Ma, Minghao Zha. Interleukin-10-Modified Adipose-Derived Mesenchymal Stem Cells Prevent Hypertrophic Scar Formation via Regulating the Biological Characteristics of Fibroblasts and Inflammation. Mediators of inflammation. vol 2022. 2022-07-01. PMID:35774067. |
in vitro, il-10-admsc could highly express il-10 and exhibited stronger inhibition of hypertrophic scar fibroblasts (hsfs) proliferation, migration, and extracellular matrix synthesis (the expression of collagen i, collagen iii, fn, and |
2022-07-01 |
2023-08-14 |
Not clear |
| Hui Wang, Zhengzheng Li, Yinan Liu, Meng Zhang, Yawen Shi, Ying Zhang, Ge Mi, Mengying Wang, Ying He, Yonghui Chen, Chen Chen, Jinghong Che. Effects of Selenoprotein S Knockdown on Endoplasmic Reticulum Stress in ATDC5 Cells and Gene Expression Profiles in Hypertrophic Chondrocytes. Biological trace element research. 2022-06-21. PMID:35725994. |
knocking down sels can cause abnormal expression of adhesion molecules and matrix homeostasis disorder in hypertrophic chondrocytes. |
2022-06-21 |
2023-08-14 |
rat |
| A Ushakov, V Ivanchenko, A Gagarin. Heart Failure and Type 2 Diabetes Mellitus: Neurohumoral, Histological and Molecular Interconnections. Current cardiology reviews. 2022-06-20. PMID:35718961. |
in this review we discuss the complex interplay between systemic neurohumoral regulation and local cardiac mechanisms participating in myocardial remodeling and hf development in t2dm with a special attention to cardiomyocyte energy metabolism, mitochondrial function and calcium metabolism, cardiomyocyte hypertrophy and death, extracellular matrix remodeling. |
2022-06-20 |
2023-08-14 |
Not clear |
| Jiazhi Liu, Guo Tang, Wenjun Liu, Yi Zhou, Cunyi Fan, Wei Zhan. MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2. Bioengineered. vol 13. issue 5. 2022-06-16. PMID:35707845. |
western blotting displayed that mir-20a-5p inhibition decreased protein levels of cartilage matrix markers but enhanced those of catabolic and hypertrophic chondrocyte markers in bmscs. |
2022-06-16 |
2023-08-14 |
mouse |
| Naranjan S Dhalla, Sukhwinder K Bhullar, Anureet Kaur Sha. Future scope and challenges for congestive heart failure: Moving towards development of pharmacotherapy. Canadian journal of physiology and pharmacology. 2022-06-15. PMID:35704943. |
in order to determine specific targets for future drug development, we have discussed different mechanisms involving both cardiomyocytes and non-myocyte (extracellular matrix) alterations for the transition of cardiac hypertrophy to heart failure as well as for the progression of heart failure. |
2022-06-15 |
2023-08-14 |
Not clear |
| Yogendra Pratap Singh, Joseph Christakiran Moses, Ashutosh Bandyopadhyay, Biman B Manda. 3D Bioprinted Silk-Based In Vitro Osteochondral Model for Osteoarthritis Therapeutics. Advanced healthcare materials. 2022-06-07. PMID:35670084. |
in addition, catabolic markers (matrix metalloproteinases (mmps) and aggrecanase-1), indicative of hypertrophic and apoptosing chondrocytes, are significantly downregulated in the treatment groups; while the transcript and protein levels required for osteochondral health are attenuated. |
2022-06-07 |
2023-08-14 |
human |
| Toshihisa Komor. Whole Aspect of Runx2 Functions in Skeletal Development. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628587. |
in endochondral ossification, runx2 induces chondrocyte maturation, enhances chondrocyte proliferation through indian hedgehog (ihh) induction, and induces the expression of vascular endothelial growth factor a (vegfa), secreted phosphoprotein 1 (spp1), integrin-binding sialoprotein (ibsp), and matrix metallopeptidase 13 (mmp13) in the terminal hypertrophic chondrocytes. |
2022-05-28 |
2023-08-13 |
mouse |
| Qing Zhang, Lin Shi, Hong He, Xingmou Liu, Yong Huang, Dan Xu, Mengyun Yao, Ning Zhang, Yicheng Guo, Yifei Lu, Haisheng Li, Junyi Zhou, Jianglin Tan, Malcolm Xing, Gaoxing Lu. Down-Regulating Scar Formation by Microneedles Directly ACS nano. 2022-05-26. PMID:35617518. |
down-regulating scar formation by microneedles directly excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue dysfunction. |
2022-05-26 |
2023-08-13 |
rabbit |
| Maria Barilli, Maria Cristina Tavera, Serafina Valente, Alberto Palazzuol. Structural and Hemodynamic Changes of the Right Ventricle in PH-HFpEF. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35562945. |
conversely, ph related to hfpef is primarily due to an increase of venules/capillaries parietal fibrosis, extracellular matrix deposition, and myocyte hypertrophy with a secondary "arteriolarization" of the vessels. |
2022-05-14 |
2023-08-13 |
Not clear |
| Joshua S Godwin, Bradley Ruple, Casey Sexton, Morgan Smith, Andrew Fruge, Kaelin Young, Christopher Mobley, Michael Robert. Extracellular Matrix Content and Remodeling Does Not Differ Between Higher-Responders and Lower-Responders to Resistance Training. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555323. |
to determine if markers of skeletal muscle extracellular matrix (ecm) content and ecm remodeling are indicators of hypertrophy in previously untrained collage aged males. |
2022-05-13 |
2023-08-13 |
Not clear |
| Chen Chen, Xiyu Zhang, Cuiting Zheng, Zhenqiang Gao, Xi Jiang, Yunfei Bai, Yan Men. Sulfasalazine exacerbates Angiotensin II induced cardiac remodeling by activating Akt signal pathway. Clinical and experimental pharmacology & physiology. 2022-05-11. PMID:35538895. |
angiotensin ii (ang ii) results in cardiac fibrosis and hypertrophy partly through activation of inflammation, which increases the fibroblasts and promotes extracellular matrix production. |
2022-05-11 |
2023-08-13 |
mouse |