| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiazhi Liu, Guo Tang, Wenjun Liu, Yi Zhou, Cunyi Fan, Wei Zhan. MiR-20a-5p facilitates cartilage repair in osteoarthritis via suppressing mitogen-activated protein kinase kinase kinase 2. Bioengineered. vol 13. issue 5. 2022-06-16. PMID:35707845. |
western blotting displayed that mir-20a-5p inhibition decreased protein levels of cartilage matrix markers but enhanced those of catabolic and hypertrophic chondrocyte markers in bmscs. |
2022-06-16 |
2023-08-14 |
mouse |
| Naranjan S Dhalla, Sukhwinder K Bhullar, Anureet Kaur Sha. Future scope and challenges for congestive heart failure: Moving towards development of pharmacotherapy. Canadian journal of physiology and pharmacology. 2022-06-15. PMID:35704943. |
in order to determine specific targets for future drug development, we have discussed different mechanisms involving both cardiomyocytes and non-myocyte (extracellular matrix) alterations for the transition of cardiac hypertrophy to heart failure as well as for the progression of heart failure. |
2022-06-15 |
2023-08-14 |
Not clear |
| Yogendra Pratap Singh, Joseph Christakiran Moses, Ashutosh Bandyopadhyay, Biman B Manda. 3D Bioprinted Silk-Based In Vitro Osteochondral Model for Osteoarthritis Therapeutics. Advanced healthcare materials. 2022-06-07. PMID:35670084. |
in addition, catabolic markers (matrix metalloproteinases (mmps) and aggrecanase-1), indicative of hypertrophic and apoptosing chondrocytes, are significantly downregulated in the treatment groups; while the transcript and protein levels required for osteochondral health are attenuated. |
2022-06-07 |
2023-08-14 |
human |
| Toshihisa Komor. Whole Aspect of Runx2 Functions in Skeletal Development. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628587. |
in endochondral ossification, runx2 induces chondrocyte maturation, enhances chondrocyte proliferation through indian hedgehog (ihh) induction, and induces the expression of vascular endothelial growth factor a (vegfa), secreted phosphoprotein 1 (spp1), integrin-binding sialoprotein (ibsp), and matrix metallopeptidase 13 (mmp13) in the terminal hypertrophic chondrocytes. |
2022-05-28 |
2023-08-13 |
mouse |
| Qing Zhang, Lin Shi, Hong He, Xingmou Liu, Yong Huang, Dan Xu, Mengyun Yao, Ning Zhang, Yicheng Guo, Yifei Lu, Haisheng Li, Junyi Zhou, Jianglin Tan, Malcolm Xing, Gaoxing Lu. Down-Regulating Scar Formation by Microneedles Directly ACS nano. 2022-05-26. PMID:35617518. |
down-regulating scar formation by microneedles directly excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue dysfunction. |
2022-05-26 |
2023-08-13 |
rabbit |
| Maria Barilli, Maria Cristina Tavera, Serafina Valente, Alberto Palazzuol. Structural and Hemodynamic Changes of the Right Ventricle in PH-HFpEF. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35562945. |
conversely, ph related to hfpef is primarily due to an increase of venules/capillaries parietal fibrosis, extracellular matrix deposition, and myocyte hypertrophy with a secondary "arteriolarization" of the vessels. |
2022-05-14 |
2023-08-13 |
Not clear |
| Joshua S Godwin, Bradley Ruple, Casey Sexton, Morgan Smith, Andrew Fruge, Kaelin Young, Christopher Mobley, Michael Robert. Extracellular Matrix Content and Remodeling Does Not Differ Between Higher-Responders and Lower-Responders to Resistance Training. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555323. |
to determine if markers of skeletal muscle extracellular matrix (ecm) content and ecm remodeling are indicators of hypertrophy in previously untrained collage aged males. |
2022-05-13 |
2023-08-13 |
Not clear |
| Chen Chen, Xiyu Zhang, Cuiting Zheng, Zhenqiang Gao, Xi Jiang, Yunfei Bai, Yan Men. Sulfasalazine exacerbates Angiotensin II induced cardiac remodeling by activating Akt signal pathway. Clinical and experimental pharmacology & physiology. 2022-05-11. PMID:35538895. |
angiotensin ii (ang ii) results in cardiac fibrosis and hypertrophy partly through activation of inflammation, which increases the fibroblasts and promotes extracellular matrix production. |
2022-05-11 |
2023-08-13 |
mouse |
| Abu Mohammad Syed, Sourav Kundu, Chetan Ram, Uttam Kulhari, Akhilesh Kumar, Madhav Nilakanth Mugale, Purusottam Mohapatra, Upadhyayula Suryanarayana Murty, Bidya Dhar Sah. Up-regulation of Nrf2/HO-1 and inhibition of TGF-β1/Smad2/3 signaling axis by daphnetin alleviates transverse aortic constriction-induced cardiac remodeling in mice. Free radical biology & medicine. 2022-05-05. PMID:35513128. |
oxidative damage and accumulation of extracellular matrix (ecm) components play a crucial role in the adverse outcome of cardiac hypertrophy. |
2022-05-05 |
2023-08-13 |
mouse |
| Kyle Sylakowski, Mintai Peter Hwang, Amritha Justin, Diana Whaley, Yadong Wang, Alan Well. The matricellular protein decorin delivered intradermally with coacervate improves wound resolution in the CXCR3-deficient mouse model of hypertrophic scarring. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2022-04-26. PMID:35470921. |
we investigated the use of decorin as a therapeutic by administering the matrix protein anchored in a slow-release coacervate in a hypertrophic scarring mouse model. |
2022-04-26 |
2023-08-13 |
mouse |
| Gianluca Di Bella, Francesco Cappelli, Roberto Licordari, Paolo Piaggi, Mariapaola Campisi, Diego Bellavia, Fabio Minutoli, Luca Gentile, Massimo Russo, Cesare de Gregorio, Federico Perfetto, Anna Mazzeo, Calogero Falletta, Francesco Clemenza, Giuseppe Vita, Scipione Carerj, Giovanni Donato Aquar. Prevalence and diagnostic value of extra-left ventricle echocardiographic findings in transthyretin-related cardiac amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 2022-04-25. PMID:35465808. |
cardiac amyloidosis (ca) is cardiomyopathy with a hypertrophic phenotype characterised by diffuse deposition of anomalous fibrillar proteins in the extracellular matrix. |
2022-04-25 |
2023-08-13 |
Not clear |
| Sandra Fawcett, Raida Al Kassas, Iain M Dykes, Alun Tl Hughes, Fawaz Ghali, Kehinde Ros. A time to heal: microRNA and circadian dynamics in cutaneous wound repair. Clinical science (London, England : 1979). vol 136. issue 8. 2022-04-21. PMID:35445708. |
on the other hand, keloids and hypertrophic scars arise from overactive repair mechanisms that fail to cease in a timely fashion, leading to excessive production of extracellular matrix (ecm) components such as such as collagen. |
2022-04-21 |
2023-08-13 |
Not clear |
| Hui Song Cui, Dong Hyun Kim, So Young Joo, Yoon Soo Cho, June-Bum Kim, Cheong Hoon Se. Exosomes derived from human hypertrophic scar fibroblasts induces smad and TAK1 signaling in normal dermal fibroblasts. Archives of biochemistry and biophysics. 2022-04-17. PMID:35430216. |
post-burn hypertrophic scars are characterized by excessive accumulation of extracellular matrix secreted by fibroblasts. |
2022-04-17 |
2023-08-13 |
human |
| Bo-Yu Yang, Zhi-Yuan Zhou, Shi-Yun Liu, Ming-Jun Shi, Xi-Jian Liu, Tian-Ming Cheng, Guo-Ying Deng, Ye Tian, Jian Song, Xuan-Hao L. Porous Se@SiO Frontiers in bioengineering and biotechnology. vol 10. 2022-04-07. PMID:35387298. |
porous se@sio hypertrophic scarring, which is characterized by excessive extracellular matrix deposition and abnormal fibroblast homeostasis, is an undesirable outcome of dermal wound healing. |
2022-04-07 |
2023-08-13 |
Not clear |
| Zhaojie Lyu, Yifeng Da, Hongkai Liu, Zhihao Wang, Yong Zhu, Jing Tia. Chsy1 deficiency reduces extracellular matrix productions and aggravates cartilage injury in osteoarthritis. Gene. 2022-04-07. PMID:35390446. |
it was found that chsy1 deficiency resulted in a reduction of extracellular matrix production in chondrocytes and a promotion of endochondral osteogenesis, which was indicated by the decreased expression of early chondrocytes genes (col2a1, sox9), and the increased expression of cartilage hypertrophy genes (col10a1, runx2, mmp13, mmp3). |
2022-04-07 |
2023-08-13 |
mouse |
| Amy Larson, Christina J Codden, Gordon S Huggins, Hassan Rastegar, Frederick Y Chen, Barry J Maron, Ethan J Rowin, Martin S Maron, Michael T Chi. Altered intercellular communication and extracellular matrix signaling as a potential disease mechanism in human hypertrophic cardiomyopathy. Scientific reports. vol 12. issue 1. 2022-03-26. PMID:35338173. |
altered intercellular communication and extracellular matrix signaling as a potential disease mechanism in human hypertrophic cardiomyopathy. |
2022-03-26 |
2023-08-13 |
human |
| Y B Meng, J Lei, H R Zhang, Z M Hao, P Y Bai, P Dua. [Clinical effects of in situ perforation of preserved split scar matrix in combination with scalp transplantation and vacuum sealing drainage in the treatment of hypertrophic scar in non-functional sites after burns]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 38. issue 3. 2022-03-24. PMID:35325970. |
[clinical effects of in situ perforation of preserved split scar matrix in combination with scalp transplantation and vacuum sealing drainage in the treatment of hypertrophic scar in non-functional sites after burns]. |
2022-03-24 |
2023-08-13 |
Not clear |
| Alberto Aimo, Oriol Iborra-Egea, Nicola Martini, Carolina Galvez-Monton, Silvia Burchielli, Giorgia Panichella, Claudio Passino, Michele Emdin, Antoni Bayes-Geni. Cardiac protection by pirfenidone after myocardial infarction: a bioinformatic analysis. Scientific reports. vol 12. issue 1. 2022-03-19. PMID:35304529. |
we identified 6 causative motives of post-mi remodeling (cardiomyocyte cell death, impaired myocyte contractility, extracellular matrix remodeling and fibrosis, hypertrophy, renin-angiotensin-aldosterone system activation, and inflammation), 4 pirfenidone targets and 21 bioflags (indirect effectors). |
2022-03-19 |
2023-08-13 |
Not clear |
| Ye Lu, Chengyuan Zhang, Shilin Jiang, Feng Yua. Anti-Dlx5 Retards the Progression of Osteoarthritis through Inhibiting Chondrocyte Hypertrophy and Apoptosis. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-03-14. PMID:35280506. |
the results showed that administration of anti-dlx5 improved pathological changes of osteoarthritis cartilages, characterized by decreased chondrocyte proliferation, chondrocyte hypertrophy, and matrix damage. |
2022-03-14 |
2023-08-13 |
Not clear |
| Kimberley C W Wang, Graham M Donovan, Sejal Saglani, Thais Mauad, Alan L James, John G Elliot, Peter B Nobl. Growth of the airway smooth muscle layer from late gestation to childhood is mediated initially by hypertrophy and subsequently hyperplasia. Respirology (Carlton, Vic.). 2022-03-10. PMID:35266251. |
this study characterized thickening of the asm layer from foetal life to childhood and elucidated the underlying mechanism in terms of hypertrophy, hyperplasia and extracellular matrix (ecm) deposition. |
2022-03-10 |
2023-08-13 |
Not clear |