| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaodong Li, Zeliang He, Julei Zhang, Yan Ha. Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA sequencing. FEBS open bio. vol 11. issue 6. 2021-11-08. PMID:33932142. |
hypertrophic scarring (hs) is a dermal fibroproliferative disorder characterized by excessive deposition of collagen and other extracellular matrix components. |
2021-11-08 |
2023-08-13 |
human |
| Shawn A Hallett, Wanida Ono, Noriaki On. The hypertrophic chondrocyte: To be or not to be. Histology and histopathology. 2021-11-03. PMID:34137454. |
hypertrophic chondrocytes orchestrate endochondral ossification by regulating osteogenic-angiogenic and osteogenic-osteoclastic coupling through the production of vascular endothelial growth factor (vegf), receptor activator of nuclear factor kappa-b ligand (rankl) and matrix metallopeptidases-9/13 (mmp-9/13). |
2021-11-03 |
2023-08-13 |
Not clear |
| Shawn A Hallett, Wanida Ono, Noriaki On. The hypertrophic chondrocyte: To be or not to be. Histology and histopathology. 2021-11-03. PMID:34137454. |
hypertrophic chondrocytes also indirectly regulate resorption of the cartilaginous extracellular matrix, by controlling formation of a special subtype of osteoclasts termed "chondroclasts". |
2021-11-03 |
2023-08-13 |
Not clear |
| Sijia Xu, Wenxin Dong, Yu Sh. LncRNA PICSAR binds to miR-485-5p and activates TGF-β1/Smad to promote abnormal proliferation of hypertrophic scar fibroblasts (HSFs) and excessive deposition of extracellular matrix (ECM). Medical molecular morphology. vol 54. issue 4. 2021-11-01. PMID:34255190. |
lncrna picsar binds to mir-485-5p and activates tgf-β1/smad to promote abnormal proliferation of hypertrophic scar fibroblasts (hsfs) and excessive deposition of extracellular matrix (ecm). |
2021-11-01 |
2023-08-13 |
Not clear |
| Jan M Leerink, Mabel van de Ruit, Elizabeth A M Feijen, Leontien C M Kremer, Annelies M C Mavinkurve-Groothuis, Yigal M Pinto, Esther E Creemers, Wouter E M Ko. Extracellular matrix remodeling in animal models of anthracycline-induced cardiomyopathy: a meta-analysis. Journal of molecular medicine (Berlin, Germany). vol 99. issue 9. 2021-10-29. PMID:34052857. |
collagens, matrix metalloproteinases (mmps), inflammation markers, transforming growth factor ß signaling markers, and markers for cardiac hypertrophy were upregulated, whereas the protein kinase b (akt) pro-survival pathway was downregulated. |
2021-10-29 |
2023-08-13 |
mouse |
| Alan Christhian Bahr, Julia Paim DA Luz, Rayane Brinck Teixeira, Patrick Türck, Alexsandra Zimmer, Alexandre Luz DE Castro, Eduardo Echer Dos Reis, Fernanda Visioli, Adriane Belló-Klein, Alex Sander DA Rosa Araujo, Paulo Cavalheiro Schenke. The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction. Anais da Academia Brasileira de Ciencias. vol 93. issue suppl 4. 2021-10-29. PMID:34706009. |
methylprednisolone acetate attenuated matrix metalloproteinase-2 activity, cardiac dilatation, and prevented the onset of pulmonary congestion, as well as avoided cardiac hypertrophy. |
2021-10-29 |
2023-08-13 |
rat |
| Keshvad Hedayatyanfard, Nazgol-Sadat Haddadi, Seyed Ali Ziai, Hossein Karim, Feizollah Niazi, Ulrike Muscha Steckelings, Behnam Habibi, Ali Modarressi, Ahmad-Reza Dehpou. The renin-angiotensin system in cutaneous hypertrophic scar and keloid formation. Experimental dermatology. vol 29. issue 9. 2021-10-28. PMID:32678966. |
hypertrophic scar and keloid are two types of fibroproliferative conditions that result from excessive extracellular matrix production. |
2021-10-28 |
2023-08-13 |
Not clear |
| Aykhan Yusifov, Vikram E Chhatre, Jacob M Zumo, Ross F Cook, Benjamin D McNair, Emily E Schmitt, Kathleen C Woulfe, Danielle R Brun. Cardiac response to adrenergic stress differs by sex and across the lifespan. GeroScience. vol 43. issue 4. 2021-10-28. PMID:33651247. |
adults increased myocyte cell size and deposited fibrotic matrix in response to iso, while juvenile and aged animals did not show evidence of hypertrophy or fibrosis. |
2021-10-28 |
2023-08-13 |
mouse |
| Natalya Bildyu. Integrins in cardiac hypertrophy: lessons learned from culture systems. ESC heart failure. vol 8. issue 5. 2021-10-28. PMID:34232557. |
the lessons learned from culture experiments on the models of hypertrophy induced by stretch, stimulating factors, and/or extracellular matrix components are summarized, demonstrating the major involvement of integrin-mediated signalling in cardiac hypertrophic response and its apparent crosstalk with signal pathways induced by stretch or hypertrophy stimulating factors. |
2021-10-28 |
2023-08-13 |
Not clear |
| Wen Shi, Yan Wu, Donghui Bia. p75NTR silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the PI3K/Akt/mTOR pathway. Canadian journal of physiology and pharmacology. vol 99. issue 4. 2021-10-27. PMID:32726570. |
p75ntr silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the pi3k/akt/mtor pathway. |
2021-10-27 |
2023-08-13 |
Not clear |
| Wen Shi, Yan Wu, Donghui Bia. p75NTR silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the PI3K/Akt/mTOR pathway. Canadian journal of physiology and pharmacology. vol 99. issue 4. 2021-10-27. PMID:32726570. |
hypertrophic scar (hs) results from abnormal wound healing, accompanied by excessive hypercellularity, migration, and extracellular matrix (ecm) deposition. |
2021-10-27 |
2023-08-13 |
Not clear |
| Susumu Horikoshi, Mikihito Kajiya, Souta Motoike, Mai Yoshino, Shin Morimoto, Hiroki Yoshii, Tomoya Ogawa, Hisakatsu Sone, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Noriyoshi Mizuno, Hidemi Kurihar. Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Generated with Xeno-Free Chondro-Inductive Medium Induce Bone Regeneration via Endochondral Ossification. Biomedicines. vol 9. issue 10. 2021-10-26. PMID:34680525. |
c-mscs generated with xf-cim showed enlarged round cells, cartilage matrix, and hypertrophic chondrocytes genes elevation in vitro. |
2021-10-26 |
2023-08-13 |
mouse |
| Florian A Wenzl, Samuele Ambrosini, Shafeeq A Mohammed, Simon Kraler, Thomas F Lüscher, Sarah Costantino, Francesco Panen. Inflammation in Metabolic Cardiomyopathy. Frontiers in cardiovascular medicine. vol 8. 2021-10-22. PMID:34671656. |
at the cellular level, inflammation-induced oxidative stress, mitochondrial dysfunction, impaired calcium handling, and lipotoxicity contribute to cardiomyocyte hypertrophy and dysfunction, extracellular matrix accumulation and microvascular disease. |
2021-10-22 |
2023-08-13 |
Not clear |
| Donghong Fang, Xuesi Wan, Wanping Deng, Hongyu Guan, Weijian Ke, Haipeng Xiao, Yanbing L. Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats. Experimental and therapeutic medicine. vol 4. issue 5. 2021-10-21. PMID:23226741. |
however, only middle and high doses of fxst prevented glomerular hypertrophy in diabetic rats, and the high dose showed the greatest inhibitory effect with regard to mesangial matrix expansion. |
2021-10-21 |
2023-08-12 |
rat |
| Zhi Cong Wang, Hui Jun Sun, Kai Hua Li, Chao Fu, Mo Zhen Li. Icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy Experimental and therapeutic medicine. vol 8. issue 5. 2021-10-21. PMID:25289054. |
icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy icariin (ica), a traditional chinese medicine, has been demonstrated to be a promoting compound for extracellular matrix synthesis and gene expression of chondrocytes. |
2021-10-21 |
2023-08-13 |
rat |
| Ning Wang, Lu Lu, Qi Feng Cao, Subo Qian, Jie Ding, Chen Wang, Huangqi Duan, Haibo Shen, Jun Q. Partial inhibition of activin receptor-like kinase 4 alleviates bladder fibrosis caused by bladder outlet obstruction. Experimental cell research. vol 406. issue 1. 2021-10-19. PMID:34237300. |
the bladder undergoes profound structural alterations after bladder outlet obstruction (boo), characterized by hypertrophy of the bladder wall and accumulation of extracellular matrix (ecm). |
2021-10-19 |
2023-08-13 |
mouse |
| Matthew Anderson-Baron, Melanie Kunze, Aillette Mulet-Sierra, Martin Osswald, Khalid Ansari, Hadi Seikaly, Adetola B Adesid. Nasal Chondrocyte-Derived Soluble Factors Affect Chondrogenesis of Cocultured Mesenchymal Stem Cells. Tissue engineering. Part A. vol 27. issue 1-2. 2021-10-15. PMID:32122264. |
engineered cartilage from cocultures exposed to the pure nc construct exhibited reduced chondrogenic potential relative to control constructs, shown by reduced extracellular matrix deposition and increased expression of hypertrophic markers. |
2021-10-15 |
2023-08-13 |
human |
| Irma Bernadette Simbolon Sitohang, Sondang Aemilia P Sirait, Fadhila Dea Safir. Fractional carbon dioxide laser for treating hypertrophic scars: A systematic review of randomised trials. The Australasian journal of dermatology. 2021-10-12. PMID:34628639. |
hypertrophic scars present collagen deposition and an abnormal extracellular matrix that cause abnormal shape changes and limit normal movement. |
2021-10-12 |
2023-08-13 |
Not clear |
| Sunghyun Park, Yoshie Arai, Alvin Bello, Hansoo Park, Dohyun Kim, Kyung-Soon Park, Soo-Hong Le. SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression. NPJ Regenerative medicine. vol 6. issue 1. 2021-10-06. PMID:34535669. |
the knockdown of spry4 in healthy chondrocytes caused an increase in hypertrophy, senescence, reactive oxygen species (ros) production, and extracellular matrix (ecm) protease expression. |
2021-10-06 |
2023-08-13 |
human |
| Song Tian, Yongjun Zheng, Shichu Xiao, Pengfei Luo, Rongju Sun, Jun Liu, Zhaofan Xi. Ivermectin inhibits cell proliferation and the expression levels of type I collagen, α‑SMA and CCN2 in hypertrophic scar fibroblasts. Molecular medicine reports. vol 24. issue 1. 2021-10-05. PMID:33955514. |
a hypertrophic scar (hps) is characterized by abnormal cell proliferation and the overproduction of extracellular matrix. |
2021-10-05 |
2023-08-13 |
Not clear |