| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cristina Cavinato, Sae-Il Murtada, Alexia Rojas, Jay D Humphre. Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy. Mechanisms of ageing and development. vol 196. 2021-07-27. PMID:33741396. |
the media similarly showed a progressive decrease in smooth muscle cell density and alignment though with inter-lamellar widening from intermediate to older ages, suggesting cell hypertrophy, matrix accumulation, or both. |
2021-07-27 |
2023-08-13 |
mouse |
| Karol Alí Apaza Alccayhuaman, Stefan Tangl, Stéphane Blouin, Markus A Hartmann, Patrick Heimel, Ulrike Kuchler, Jung-Seok Lee, Reinhard Grube. Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study. Biomedicines. vol 9. issue 7. 2021-07-27. PMID:34202317. |
histology revealed, apart from the characteristic woven bone formation, areas of round-shaped hypertrophic chondrocyte-like cells surrounded by a mineralized extracellular matrix. |
2021-07-27 |
2023-08-13 |
rat |
| Guo Chen, Xi Jin, Xiaoshuai Gao, Jianzhong Ai, Deyi Luo, Liang Zhou, Kaiwen Xiao, Zirui Li, Hong Li, Kunjie Wan. Monocyte Chemotactic Protein-1 Regulates Proliferation and Contractility of Human Bladder Smooth Muscle Cells Under Hydrostatic Pressure. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 40. issue 5. 2021-07-19. PMID:32091964. |
bladder growth and development require continuous mechanical stimuli; however, abnormal mechanical conditions caused by partial bladder outlet obstruction (pboo) result in detrusor smooth muscle hypertrophy and extracellular matrix accumulation. |
2021-07-19 |
2023-08-13 |
human |
| Susan J Wilson, Jonathan A Ward, Helen M Pickett, Simonetta Baldi, Ana R Sousa, Peter J Sterk, Kian Fan Chung, Ratko Djukanovic, Barbro Dahlen, Bo Billing, Dominick Shaw, Norbert Krug, Thomas Sandstrӧm, Christopher Brightling, Peter H Howart. Airway Elastin is increased in severe asthma and relates to proximal wall area: histological and computed tomography findings from the U-BIOPRED severe asthma study. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 51. issue 2. 2021-07-19. PMID:33342006. |
airway remodelling, which may include goblet cell hyperplasia / hypertrophy, changes in epithelial integrity, accumulation of extracellular matrix components, smooth muscle hypertrophy and thickening of the lamina reticularis, is a feature of severe asthma and contributes to the clinical phenotype. |
2021-07-19 |
2023-08-13 |
Not clear |
| Gerhild Euler, Fabian Locquet, Joanna Kociszewska, Yvonne Osygus, Jacqueline Heger, Rolf Schreckenberg, Klaus-Dieter Schlüter, Éva Kenyeres, Tamara Szabados, Péter Bencsik, Péter Ferdinandy, Rainer Schul. Matrix Metalloproteinases Repress Hypertrophic Growth in Cardiac Myocytes. Cardiovascular drugs and therapy. vol 35. issue 2. 2021-07-15. PMID:33400052. |
matrix metalloproteinases repress hypertrophic growth in cardiac myocytes. |
2021-07-15 |
2023-08-13 |
rat |
| Changxu Deng, Jin Yang, Hongtao He, Zhenjiang Ma, Wenhao Wang, Yuxin Zhang, Tao Li, Chuanglong He, Jinwu Wan. 3D bio-printed biphasic scaffolds with dual modification of silk fibroin for the integrated repair of osteochondral defects. Biomaterials science. vol 9. issue 14. 2021-07-15. PMID:34047307. |
in vitro results indicated that the gm + sf-ma bio-ink had good mechanical properties, while the gm + sf-pth bio-ink inhibited the hypertrophy of chondrocytes and was beneficial for the production of hyaline cartilage extracellular matrix. |
2021-07-15 |
2023-08-13 |
rabbit |
| Timothy D Smith, Rebecca L Reynolds, Nanami Mano, Brody J Wood, Lanre Oladipupo, Gabriel K Hughes, Hayley M Corbin, Jane Taylor, Alexander Ufelle, Anne M Burrows, Emily Durham, Christopher J Vinyard, James J Cray, Valerie B DeLeo. Cranial synchondroses of primates at birth. Anatomical record (Hoboken, N.J. : 2007). vol 304. issue 5. 2021-07-13. PMID:33015949. |
each synchondrosis was examined for characteristics of active growth centers, including a zonal distribution of proliferating and hypertrophic chondrocytes, as well as corresponding changes in matrix characteristics (i.e., density and organization of type ii collagen). |
2021-07-13 |
2023-08-13 |
monkey |
| Lisha Li, Weiqiang Han, Yun Chen, Yuhua Che. MiR-3613-3p inhibits hypertrophic scar formation by down-regulating arginine and glutamate-rich 1. Molecular and cellular biochemistry. vol 476. issue 2. 2021-07-13. PMID:33165823. |
hypertrophic scar (hs) is a severe skin disorder characterized by excessive extracellular matrix production and abnormal function of fibroblasts. |
2021-07-13 |
2023-08-13 |
Not clear |
| Wei-Wen Lim, Ben Corden, Lei Ye, Sivakumar Viswanathan, Anissa A Widjaja, Chen Xie, Liping Su, Nicole G Z Tee, Sebastian Schafer, Stuart A Coo. Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload. Clinical and experimental pharmacology & physiology. vol 48. issue 4. 2021-07-13. PMID:33462828. |
aac surgery induced the expression of il11, il11ra and extracellular matrix (ecm) genes that was associated with cardiac hypertrophy and aortic remodelling. |
2021-07-13 |
2023-08-13 |
mouse |
| He Shen, Yuchen He, Ning Wang, Madalyn R Fritch, Xinyu Li, Hang Lin, Rocky S Tua. Enhancing the potential of aged human articular chondrocytes for high-quality cartilage regeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 3. 2021-07-13. PMID:33617078. |
moreover, chondrocytes subjected to suspension culture formed new cartilage in vitro with higher quality and quantity, with enhanced cartilage matrix deposition, concomitant with lower levels of hypertrophy and cellular senescence markers. |
2021-07-13 |
2023-08-13 |
human |
| Takeshi Kimura, Michaela Bosakova, Yosuke Nonaka, Eva Hruba, Kie Yasuda, Satoshi Futakawa, Takuo Kubota, Bohumil Fafilek, Tomas Gregor, Sara P Abraham, Regina Gomolkova, Silvie Belaskova, Martin Pesl, Fabiana Csukasi, Ivan Duran, Masatoshi Fujiwara, Michaela Kavkova, Tomas Zikmund, Josef Kaiser, Marcela Buchtova, Deborah Krakow, Yoshikazu Nakamura, Keiichi Ozono, Pavel Krejc. An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice. Science translational medicine. vol 13. issue 592. 2021-07-12. PMID:33952673. |
in cultured rat chondrocytes or mouse embryonal tibia organ culture, rbm-007 rescued the proliferation arrest, degradation of cartilaginous extracellular matrix, premature senescence, and impaired hypertrophic differentiation induced by fgfr3 signaling. |
2021-07-12 |
2023-08-13 |
mouse |
| Mengtong Guan, Ying Zhu, Bo Liao, Qiaoyan Tan, Huabing Qi, Bin Zhang, Junlan Huang, Xiaolan Du, Dingqun Ba. Low-intensity pulsed ultrasound inhibits VEGFA expression in chondrocytes and protects against cartilage degeneration in experimental osteoarthritis. FEBS open bio. vol 10. issue 3. 2021-07-09. PMID:31975545. |
in addition, we found that lipus ameliorated vegfa-mediated disorders in cartilage extracellular matrix metabolism and chondrocyte hypertrophy during oa development. |
2021-07-09 |
2023-08-13 |
mouse |
| Claire Hippert, Anna B Graca, Mark Basche, Aikaterini A Kalargyrou, Anastasios Georgiadis, Joana Ribeiro, Ayako Matsuyama, Nozie Aghaizu, James W Bainbridge, Alexander J Smith, Robin R Ali, Rachael A Pearso. RNAi-mediated suppression of vimentin or glial fibrillary acidic protein prevents the establishment of Müller glial cell hypertrophy in progressive retinal degeneration. Glia. vol 69. issue 9. 2021-07-09. PMID:34029407. |
gliosis is a complex process comprising upregulation of intermediate filament (if) proteins, particularly glial fibrillary acidic protein (gfap) and vimentin, changes in glial cell morphology (hypertrophy) and increased deposition of inhibitory extracellular matrix molecules. |
2021-07-09 |
2023-08-13 |
Not clear |
| Maria Felicia Faienza, Mariangela Chiarito, Giacomina Brunetti, Gabriele D'Amat. Growth plate gene involment and isolated short stature. Endocrine. vol 71. issue 1. 2021-07-08. PMID:32504378. |
this process results from chondrocyte proliferation, hypertrophy, and extracellular matrix secretion, and it is perfectly coordinated by complex networks of local paracrine and endocrine factors. |
2021-07-08 |
2023-08-13 |
Not clear |
| Elizabeth Eremenko, Jie Ding, Peter Kwan, Edward E Tredge. The Biology of Extracellular Matrix Proteins in Hypertrophic Scarring. Advances in wound care. 2021-07-06. PMID:33913776. |
the biology of extracellular matrix proteins in hypertrophic scarring. |
2021-07-06 |
2023-08-13 |
Not clear |
| Campbell Rolia. Endochondral ossification and the evolution of limb proportions. Wiley interdisciplinary reviews. Developmental biology. vol 9. issue 4. 2021-06-30. PMID:31997553. |
in growth plates, chondrocytes undergo a tightly orchestrated life cycle of proliferation, matrix production, hypertrophy, and cell death/transdifferentiation. |
2021-06-30 |
2023-08-13 |
Not clear |
| Junmin Lee, Oju Jeon, Ming Kong, Amr A Abdeen, Jung-Youn Shin, Ha Neul Lee, Yu Bin Lee, Wujin Sun, Praveen Bandaru, Daniel S Alt, KangJu Lee, Han-Jun Kim, Sang Jin Lee, Somali Chaterji, Su Ryon Shin, Eben Alsberg, Ali Khademhossein. Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell-based cartilage tissue engineering. Science advances. vol 6. issue 21. 2021-06-30. PMID:32494742. |
here, by using engineered biomaterials and a high-throughput system for screening of combinatorial cues in cartilage microenvironments, we demonstrate that biomaterial cross-linking density that regulates matrix degradation and stiffness-together with defined presentation of growth factors, mechanical stimulation, and arginine-glycine-aspartic acid (rgd) peptides-can guide human mesenchymal stem cell (hmsc) differentiation into articular or hypertrophic cartilage phenotypes. |
2021-06-30 |
2023-08-13 |
human |
| Xiaomin Kang, Zhuang Qian, Jiali Liu, Dongxu Feng, Huixia Li, Zhuanmin Zhang, Xinxin Jin, Zhengmin Ma, Mao Xu, Fang Li, Ying Zhang, Xin Gao, Hongzhi Sun, Shufang W. Neuropeptide Y Acts Directly on Cartilage Homeostasis and Exacerbates Progression of Osteoarthritis Through NPY2R. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 35. issue 7. 2021-06-29. PMID:32101625. |
intra-articular administration of npy significantly promoted chondrocyte hypertrophy and cartilage matrix degradation, with a higher oarsi score than that of control mice, whereas inhibition of npy2r but not npy1r with its specific antagonist remarkably ameliorated npy-mediated effects. |
2021-06-29 |
2023-08-13 |
mouse |
| Cheong Hoon Seo, Hui Song Cui, June-Bum Ki. Calpastatin-Mediated Inhibition of Calpain Ameliorates Skin Scar Formation after Burn Injury. International journal of molecular sciences. vol 22. issue 11. 2021-06-28. PMID:34071277. |
hypertrophic scars, the most common complication of burn injuries, are characterized by excessive deposition of fibroblast-derived extracellular matrix proteins. |
2021-06-28 |
2023-08-13 |
human |
| Yijun Liang, Xuxin Zeng, Jialiang Guo, Hui Liu, Bao He, Renyu Lai, Quan Zhu, Zhaoguang Zhen. Scopoletin and umbelliferone from Cortex Mori as protective agents in high glucose-induced mesangial cell as The Chinese journal of physiology. vol 64. issue 3. 2021-06-28. PMID:34169921. |
then, their effects on rat glomerular mesangial cells (rgmcs, hbzy-1) proliferation, hypertrophy, extracellular matrix (ecm) proliferation, expression of fibronectin, transforming growth factor-beta (tgf-β), and connective tissue growth factor (ctgf) induced by high glucose were studied in vitro model of diabetic glomerulosclerosis. |
2021-06-28 |
2023-08-13 |
rat |