| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soumya Maity, Falguni Das, Balakuntalam S Kasinath, Nandini Ghosh-Choudhury, Goutam Ghosh Choudhur. TGFβ acts through PDGFRβ to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 295. issue 42. 2021-02-23. PMID:32732288. |
interaction of transforming growth factor-β (tgfβ)-induced canonical signaling with the noncanonical kinase cascades regulates glomerular hypertrophy and matrix protein deposition, which are early features of glomerulosclerosis. |
2021-02-23 |
2023-08-13 |
mouse |
| Soumya Maity, Falguni Das, Balakuntalam S Kasinath, Nandini Ghosh-Choudhury, Goutam Ghosh Choudhur. TGFβ acts through PDGFRβ to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 295. issue 42. 2021-02-23. PMID:32732288. |
thus, pursuing tgfβ noncanonical signaling, we identified how tgfβ receptor i achieves mtorc1 activation through pdgfrβ-mediated akt/pras40 phosphorylation to spur mesangial cell hypertrophy and matrix protein accumulation. |
2021-02-23 |
2023-08-13 |
mouse |
| Nihui Zhang, Tao Gao, Yao Wang, Juan Liu, Junwei Zhang, Ruijuan Yao, Fang W. Modulating cationicity of chitosan hydrogel to prevent hypertrophic scar formation during wound healing. International journal of biological macromolecules. vol 154. 2021-02-19. PMID:32194120. |
an optimum window of chitosan cationicity (5% in our case) demonstrated potential to mitigate hypertrophic scar in wound healing by suppressing the expression of a-smooth muscle actin (a-sma) and promoting secretion of type i matrix metalloproteinases (mmp-1). |
2021-02-19 |
2023-08-13 |
Not clear |
| Reginald W Taylor, Georgia K Mitchell, Jon Lee Andrade, Kathy K Svobod. Expression of Collagen Types I, II, IX, and X in the Mineralizing Turkey Gastrocnemius Tendon. Anatomical record (Hoboken, N.J. : 2007). vol 303. issue 6. 2021-02-16. PMID:30768858. |
type x collagen was in the pericellular matrix of hypertrophic chondrocytes and in some calcified matrix. |
2021-02-16 |
2023-08-13 |
Not clear |
| Yu Gao, Changhong Ren, Xiaohua Li, Wantong Yu, Sijie Li, Haiyan Li, Yan Wang, Dong Li, Ming Ren, Xunming J. Ischemic Conditioning Ameliorated Hypertension and Vascular Remodeling of Spontaneously Hypertensive Rat via Inflammatory Regulation. Aging and disease. vol 12. issue 1. 2021-02-06. PMID:33532132. |
lric ameliorated vascular remodeling by decreasing cross-sectional area, suppressing deposition of the extracellular matrix, and hypertrophy of smooth muscle cell in conduit artery and small resistance artery (n = 7). |
2021-02-06 |
2023-08-13 |
rat |
| Serdar Korpayev, Özge Toprak, Gülşah Kaygusuz, Murat Şen, Kaan Orhan, Ayşe Karakeçil. Regulation of chondrocyte hypertrophy in an osteochondral interface mimicking gel matrix. Colloids and surfaces. B, Biointerfaces. vol 193. 2021-02-03. PMID:32531647. |
regulation of chondrocyte hypertrophy in an osteochondral interface mimicking gel matrix. |
2021-02-03 |
2023-08-13 |
Not clear |
| Mário Morais Silva, Fernando Pedro de Souza-Neto, Itamar Couto Guedes de Jesus, Gleisy Kelly Gonçalves, Melissa de Carvalho Santuchi, Bruno de Lima Sanches, Thaís Cristina de Alcântara-Leonídio, Marcos Barrouin Melo, Maria Aparecida Ribeiro Vieira, Silvia Guatimosim, Robson Augusto Souza Santos, Rafaela Fernandes da Silv. Alamandine improves cardiac remodeling induced by transverse aortic constriction in mice. American journal of physiology. Heart and circulatory physiology. vol 320. issue 1. 2021-02-01. PMID:33124885. |
tac induced myocyte hypertrophy, collagen deposition, and the expression of matrix metalloproteinase (mmp)-2 and transforming growth factor (tgf)-β in the left ventricle. |
2021-02-01 |
2023-08-13 |
mouse |
| Wen-Feng Xiao, Yu-Sheng Li, Ang Deng, Yun-Tao Yang, Miao H. Functional role of hedgehog pathway in osteoarthritis. Cell biochemistry and function. vol 38. issue 2. 2021-01-29. PMID:31833076. |
usually in oa, activation of hedgehog induces up-regulation of the expression of hypertrophic markers, including type x collagen, increases production of nitric oxide and prostaglandin e2, several matrix-degrading enzymes including matrix metalloproteinase and a disintegrin and metalloproteinase with thrombospondin motifs in human knee joint cartilage leading to cartilage degeneration, and thus contributes in oa. |
2021-01-29 |
2023-08-13 |
human |
| Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takako Hattori, Takuo Kuboki, Takayoshi Nakano, Takuya Matsumot. Bioinspired Mineralization Using Chondrocyte Membrane Nanofragments. ACS biomaterials science & engineering. vol 4. issue 2. 2021-01-11. PMID:33418750. |
instead, chondrocyte membrane nanofragments were found in the fibrous matrix surrounding the hypertrophic chondrocytes. |
2021-01-11 |
2023-08-13 |
mouse |
| Jianlin Feng, Maria K Armillei, Albert S Yu, Bruce T Liang, Loren W Runnels, Lixia Yu. Ca Journal of cardiovascular development and disease. vol 6. issue 4. 2021-01-10. PMID:31547577. |
ca cardiac fibrosis is the excessive deposition of extracellular matrix proteins by cardiac fibroblasts and myofibroblasts, and is a hallmark feature of most heart diseases, including arrhythmia, hypertrophy, and heart failure. |
2021-01-10 |
2023-08-13 |
Not clear |
| Behzad Javaheri, Soraia P Caetano-Silva, Ioannis Kanakis, George Bou-Gharios, Andrew A Pitsillide. The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within? Frontiers in bioengineering and biotechnology. vol 6. 2021-01-09. PMID:29619368. |
endochondral ossification (eo), by which long bones of the axial skeleton form, is a tightly regulated process involving chondrocyte maturation with successive stages of proliferation, maturation, and hypertrophy, accompanied by cartilage matrix synthesis, calcification, and angiogenesis, followed by osteoblast-mediated ossification. |
2021-01-09 |
2023-08-13 |
Not clear |
| Bishara S Atiye. Nonsurgical Management of Hypertrophic Scars: Evidence-Based Therapies, Standard Practices, and Emerging Methods. Aesthetic plastic surgery. vol 44. issue 4. 2021-01-06. PMID:32766921. |
hypertrophic scars, resulting from alterations in the normal processes of cutaneous wound healing, are characterized by proliferation of dermal tissue with excessive deposition of fibroblast-derived extracellular matrix proteins, especially collagen, over long periods, and by persistent inflammation and fibrosis. |
2021-01-06 |
2023-08-13 |
Not clear |
| Mazaher Gholipourmalekabadi, Sadjad Khosravimelal, Zeinab Nokhbedehghan, Marzieh Sameni, Vahid Jajarmi, Aleksandra M Urbanska, Hadi Mirzaei, Maryam Salimi, Narendra Pal Singh Chauhan, Mohammadmahdi Mobaraki, Rui L Reis, Ali Samadikuchaksaraei, Subhas C Kund. Modulation of Hypertrophic Scar Formation Using Amniotic Membrane/Electrospun Silk Fibroin Bilayer Membrane in a Rabbit Ear Model. ACS biomaterials science & engineering. vol 5. issue 3. 2021-01-06. PMID:33405623. |
hypertrophic scarring is a dermal disorder resulting from collagen and other extra cellular matrix protein depositions following the deep trauma, severe burn injury, and surgery incisions. |
2021-01-06 |
2023-08-13 |
human |
| Heather Fairfield, Samantha Costa, Victoria DeMambro, Celine Schott, Janaina Da Silva Martins, Mathieu Ferron, Calvin Vary, Michaela R Reaga. Targeting Bone Cells During Sexual Maturation Reveals Sexually Dimorphic Regulation of Endochondral Ossification. JBMR plus. vol 4. issue 11. 2020-11-21. PMID:33210065. |
in endochondral ossification, chondroblasts become embedded in their matrix and become chondrocytes, which are mature cells that continue to proliferate, eventually becoming hypertrophic. |
2020-11-21 |
2023-08-13 |
mouse |
| Heather Fairfield, Samantha Costa, Victoria DeMambro, Celine Schott, Janaina Da Silva Martins, Mathieu Ferron, Calvin Vary, Michaela R Reaga. Targeting Bone Cells During Sexual Maturation Reveals Sexually Dimorphic Regulation of Endochondral Ossification. JBMR plus. vol 4. issue 11. 2020-11-21. PMID:33210065. |
hypertrophic chondrocytes produce cartilage that is then resorbed by osteoclasts prior to bone matrix replacement via osteoblasts. |
2020-11-21 |
2023-08-13 |
mouse |
| Luis Hortells, Iñigo Valiente-Alandi, Zachary M Thomas, Emma J Agnew, Dan J Schnell, Allen J York, Ronald J Vagnozzi, Evan C Meyer, Jeffery D Molkentin, Katherine E Yutze. A specialized population of Periostin-expressing cardiac fibroblasts contributes to postnatal cardiomyocyte maturation and innervation. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 35. 2020-11-13. PMID:32817558. |
during the postnatal period in mammals, the cardiac muscle transitions from hyperplasic to hypertrophic growth, the extracellular matrix (ecm) undergoes remodeling, and the heart loses regenerative capacity. |
2020-11-13 |
2023-08-13 |
mouse |
| Amanda R Tucci, Francisco O R de Oliveira, Guilherme C Lechuga, Gabriel M Oliveira, Ana Carolina Eleuterio, Liliane B de Mesquita, Priscila S G Farani, Constança Britto, Otacílio C Moreira, Mirian Claudia S Pereir. Role of FAK signaling in chagasic cardiac hypertrophy. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. vol 24. issue 5. 2020-11-09. PMID:32931757. |
c57bl/6 mice infected with t. cruzi (brazil strain) were evaluated for electrocardiographic (ecg) changes, plasma levels of endothelin-1 (et-1) and activation of signaling pathways involved in cardiac hypertrophy, including fak and erk1/2, as well as expression of hypertrophy marker and components of the extracellular matrix in the different stages of t. cruzi infection (60-210 dpi). |
2020-11-09 |
2023-08-13 |
mouse |
| Margot Neefjes, Arjan P M van Caam, Peter M van der Kraa. Transcription Factors in Cartilage Homeostasis and Osteoarthritis. Biology. vol 9. issue 9. 2020-10-28. PMID:32937960. |
in this review, we discuss crucial transcription factors for extracellular matrix metabolism, chondrocyte hypertrophy, chondrocyte senescence, and autophagy in chondrocytes. |
2020-10-28 |
2023-08-13 |
Not clear |
| Qiyu Liu, Zhe Yang, Ning Ma, Weixing Wang, Yangqun L. MMP-2 and TIMP-2 expression, quantitative analysis and biomechanical changes in scar hypertrophy after autologous free transplantation of rabbit oral mucosa and scrotal skin. Saudi journal of biological sciences. vol 27. issue 11. 2020-10-28. PMID:33100864. |
this study aimed to investigate the long-term scar hypertrophy in the rabbit transplanted oral mucosa and scrotal skin with changed matrix environment, as well as the scar location expression, quantitative analysis of matrix metalloproteinase-2 (mmp-2) and tissue inhibitor of metalloproteinase-2 (timp-2) and biomechanical changes in the transplanted tissues. |
2020-10-28 |
2023-08-13 |
rabbit |
| Kirsty L Culley, Samantha G Lessard, Jordan D Green, Justin Quinn, Jun Chang, Tyler Khilnani, Elisabeth B Wondimu, Cecilia L Dragomir, Kenneth B Marcu, Mary B Goldring, Miguel Oter. Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31222033. |
chuk/ikkα contributes to collagenase-driven extracellular matrix remodeling and chondrocyte hypertrophic differentiation in vitro, in a kinase-independent manner. |
2020-10-27 |
2023-08-13 |
Not clear |