| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laércia K D Paiva Ferreira, Larissa A M Paiva Ferreira, Grasiela C Bezerra Barros, Talissa Mozzini Monteiro, Luiz A de Araújo Silva, Ramon de A Pereira, Pedro T R Figueiredo, Adriano Francisco Alves, Luís Cezar Rodrigues, Marcia Regina Piuveza. MHTP, a synthetic alkaloid, attenuates combined allergic rhinitis and asthma syndrome through downregulation of the p38/ERK1/2 MAPK signaling pathway in mice. International immunopharmacology. vol 96. 2021-06-22. PMID:33857802. |
the mhtp treatment also reduced the pulmonary hyperactivity by decreasing the smooth muscle layer hypertrophy and the collagen fiber deposition in the extracellular matrix. |
2021-06-22 |
2023-08-13 |
mouse |
| Benjamin D Pope, Curtis R Warren, Madeleine O Dahl, Christina V Pizza, Douglas E Henze, Nina R Sinatra, Grant M Gonzalez, Huibin Chang, Qihan Liu, Aaron L Glieberman, John P Ferrier, Chad A Cowan, Kevin Kit Parke. Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes Lab on a chip. vol 20. issue 22. 2021-06-21. PMID:33034335. |
to model adaptive adipocyte hypertrophy in vitro, we designed and built fat-on-a-chip using fiber networks inspired by extracellular matrix in adipose tissue. |
2021-06-21 |
2023-08-13 |
human |
| Chrystelle V Garat, Susan M Majka, Timothy M Sullivan, Joseph T Crossno, Jane E B Reusch, Dwight J Klem. CREB depletion in smooth muscle cells promotes medial thickening, adventitial fibrosis and elicits pulmonary hypertension. Pulmonary circulation. vol 10. issue 2. 2021-06-16. PMID:32313640. |
isolated murine creb-null smooth muscle cells exhibited serum-independent proliferation and hypertrophy in vitro and medium conditioned by creb-null smooth muscle cells stimulated proliferation and expression of extracellular matrix proteins by adventitial fibroblasts. |
2021-06-16 |
2023-08-13 |
mouse |
| D Joe Millwar. Interactions between Growth of Muscle and Stature: Mechanisms Involved and Their Nutritional Sensitivity to Dietary Protein: The Protein-Stat Revisited. Nutrients. vol 13. issue 3. 2021-06-02. PMID:33668846. |
cellular mechanisms of muscle growth during development are then reviewed identifying (a) the difficulties posed by the need to maintain its ultrastructure during myofibre hypertrophy within the extracellular matrix and the concept of muscle as concentric "bags" allowing growth to be conceived as bag enlargement and filling, (b) the cellular and molecular mechanisms involved in the mechanotransduction of satellite and mesenchymal stromal cells, to enable both connective tissue remodelling and provision of new myonuclei to aid myofibre hypertrophy and (c) the implications of myofibre hypertrophy for protein turnover within the myonuclear domain. |
2021-06-02 |
2023-08-13 |
human |
| Hyunbum Kim, Laurensia Danis Anggradita, Sun-Jae Lee, Sung Sik Hur, Joonsuk Bae, Nathaniel Suk-Yeon Hwang, Seung Min Nam, Yongsung Hwan. Ameliorating Fibrotic Phenotypes of Keloid Dermal Fibroblasts through an Epidermal Growth Factor-Mediated Extracellular Matrix Remodeling. International journal of molecular sciences. vol 22. issue 4. 2021-06-01. PMID:33672186. |
keloid and hypertrophic scars are skin fibrosis-associated disorders that exhibit an uncontrollable proliferation of fibroblasts and their subsequent contribution to the excessive accumulation of extracellular matrix (ecm) in the dermis. |
2021-06-01 |
2023-08-13 |
Not clear |
| Grasiela Costa Bezerra Barros, Laércia K D Paiva Ferreira, Larissa A M P Ferreira, Talissa Mozzini Monteiro, Adriano Francisco Alves, Ramon de Alencar Pereira, Marcia Regina Piuveza. 4-Carvomenthenol ameliorates the murine combined allergic rhinitis and asthma syndrome by inhibiting IL-13 and mucus production via p38MAPK/NF-κB signaling pathway axis. International immunopharmacology. vol 88. 2021-05-27. PMID:33182052. |
in addition, the histological analyzes demonstrated that sick mice presented hyperplasia and hypertrophy of the lung smooth muscle layer followed by increasing of extracellular matrix and carvo (50 mg/kg) inhibited these asthmatic parameters. |
2021-05-27 |
2023-08-13 |
mouse |
| Ling Jiang, Ying Deng, Wei Li, Yang L. Arctigenin suppresses fibroblast activity and extracellular matrix deposition in hypertrophic scarring by reducing inflammation and oxidative stress. Molecular medicine reports. vol 22. issue 6. 2021-05-25. PMID:33174021. |
arctigenin suppresses fibroblast activity and extracellular matrix deposition in hypertrophic scarring by reducing inflammation and oxidative stress. |
2021-05-25 |
2023-08-13 |
mouse |
| Ling Jiang, Ying Deng, Wei Li, Yang L. Arctigenin suppresses fibroblast activity and extracellular matrix deposition in hypertrophic scarring by reducing inflammation and oxidative stress. Molecular medicine reports. vol 22. issue 6. 2021-05-25. PMID:33174021. |
hypertrophic scars (hss) are a progressive fibroproliferation disorder caused by abnormal tissue repair after deep skin injury, and are characterized by continuous activation of fibroblasts and excessive deposition of extracellular matrix. |
2021-05-25 |
2023-08-13 |
mouse |
| Chang Yeop Han, Inkyung Kang, Mohamed Omer, Shari Wang, Tomasz Wietecha, Thomas N Wight, Alan Chai. Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties. JCI insight. vol 5. issue 20. 2021-05-19. PMID:32970631. |
because we recently found that the major extracellular matrix proteoglycan produced by hypertrophic adipocytes is versican, whereas activated adipose tissue macrophages produce mainly biglycan, we further investigated the role of proteoglycans in determining the antiinflammatory properties of hdl. |
2021-05-19 |
2023-08-13 |
mouse |
| Jingting Li, Karthikeyan Narayanan, Ying Zhang, Ryan C Hill, Fan He, Kirk C Hansen, Ming Pe. Role of lineage-specific matrix in stem cell chondrogenesis. Biomaterials. vol 231. 2021-05-14. PMID:31864016. |
interestingly, secm expanded cells had less potential for hypertrophy compared to those grown on other decms, indicating that a tissue-specific matrix might provide a superior microenvironment for stem cell chondrogenic differentiation. |
2021-05-14 |
2023-08-13 |
human |
| Rosanne M Raftery, Arlyng G Gonzalez Vazquez, Gang Chen, Fergal J O'Brie. Activation of the SOX-5, SOX-6, and SOX-9 Trio of Transcription Factors Using a Gene-Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification. Advanced healthcare materials. vol 9. issue 10. 2021-05-14. PMID:32329217. |
it is shown that delivery of the sox-trio induced mscs to over-express col2a1 and acan and deposit a sulfated and collagen type ii rich extracellular matrix while hypertrophic gene expression and collagen type x deposition is inhibited. |
2021-05-14 |
2023-08-13 |
Not clear |
| Franziska Meyer, Annalena Dittmann, Uwe Kornak, Maria Herbster, Thomas Pap, Christoph H Lohmann, Jessica Bertran. Chondrocytes From Osteoarthritic and Chondrocalcinosis Cartilage Represent Different Phenotypes. Frontiers in cell and developmental biology. vol 9. 2021-05-14. PMID:33981699. |
patients with radiologically detectable cc presented calcification mainly on the cartilage surface, whereas oa patients showed calcification mainly in the pericellular matrix of hypertrophic chondrocytes. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chen Fan, Samir El Andaloussi, Taavi Lehto, Kiat Whye Kong, Yiqi Seo. Smad‑binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33173952. |
smad‑binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts. |
2021-05-13 |
2023-08-13 |
human |
| Vivek Jeyakumar, Nedaa Amraish, Eugenia Niculescu-Morsza, Christoph Bauer, Dieter Pahr, Stefan Nehre. Decellularized Cartilage Extracellular Matrix Incorporated Silk Fibroin Hybrid Scaffolds for Endochondral Ossification Mediated Bone Regeneration. International journal of molecular sciences. vol 22. issue 8. 2021-05-12. PMID:33919985. |
hbmsc's were primed two weeks for chondrogenesis, followed by six weeks for hypertrophy onto hybrid cd-ecm/sf or sf alone scaffolds and evaluated for the mineralized matrix formation in vitro. |
2021-05-12 |
2023-08-13 |
Not clear |
| Xinhang Dong, Mingzi Zhang, Xiaolei Ji. The Mechanism of miR-222 Targets Matrix Metalloproteinase 1 in Regulating Fibroblast Proliferation in Hypertrophic Scars. Aesthetic plastic surgery. 2021-05-08. PMID:33963427. |
the mechanism of mir-222 targets matrix metalloproteinase 1 in regulating fibroblast proliferation in hypertrophic scars. |
2021-05-08 |
2023-08-13 |
Not clear |
| Ying Kui Zhong, Bao Lan Lu, Si Yun Huang, Yu Jun Chen, Zi Ping Li, Jordi Rimola, Xue Hua L. Cross-sectional imaging for assessing intestinal fibrosis in Crohn's disease. Journal of digestive diseases. vol 21. issue 6. 2021-04-30. PMID:32418328. |
excessive deposition of extracellular matrix components in the submucosa and smooth muscle hypertrophy or hyperplasia are the main features of fibrosis in cd. |
2021-04-30 |
2023-08-13 |
Not clear |
| Zachary M Working, Elizabeth R Morris, Jiun Chiun Chang, Ryan F Coghlan, Brian Johnstone, Theodore Miclau, William A Horton, Chelsea S Bahne. A quantitative serum biomarker of circulating collagen X effectively correlates with endochondral fracture healing. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 1. 2021-04-30. PMID:32533783. |
prior to converting to the bone, cartilage undergoes hypertrophic maturation, characterized by the deposition of a provisional collagen x matrix. |
2021-04-30 |
2023-08-13 |
mouse |
| Kathrin Maly, Enrique Andres Sastre, Eric Farrell, Andrea Meurer, Frank Zauck. COMP and TSP-4: Functional Roles in Articular Cartilage and Relevance in Osteoarthritis. International journal of molecular sciences. vol 22. issue 5. 2021-04-29. PMID:33668140. |
the usually quiescent chondrocytes become reactivated and accumulate in cell clusters, become hypertrophic, and intensively produce not only degrading enzymes, but also ecm proteins, like the cartilage oligomeric matrix protein (comp) and thrombospondin-4 (tsp-4). |
2021-04-29 |
2023-08-13 |
Not clear |
| Yi Zhang, Wei-Long Hong, Zhi-Ming Li, Qi-Yu Zhang, Kang Zen. The Mechanism of miR-222 Targets Matrix Metalloproteinase 1 in Regulating Fibroblast Proliferation in Hypertrophic Scars. Aesthetic plastic surgery. vol 45. issue 2. 2021-04-19. PMID:32350561. |
the mechanism of mir-222 targets matrix metalloproteinase 1 in regulating fibroblast proliferation in hypertrophic scars. |
2021-04-19 |
2023-08-13 |
Not clear |
| Yanping Wei, Tingting Wang, Ningning Zhang, Yunyun Ma, Siji Shi, Ruxing Zhang, Xianzhao Zheng, Lindong Zha. LncRNA TRHDE-AS1 inhibit the scar fibroblasts proliferation via miR-181a-5p/PTEN axis. Journal of molecular histology. vol 52. issue 2. 2021-04-17. PMID:33675502. |
hypertrophic scar (hs), a fibroproliferative disorder caused by abnormal wound healing after skin injury, which is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. |
2021-04-17 |
2023-08-13 |
Not clear |