| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kirsty L Culley, Samantha G Lessard, Jordan D Green, Justin Quinn, Jun Chang, Tyler Khilnani, Elisabeth B Wondimu, Cecilia L Dragomir, Kenneth B Marcu, Mary B Goldring, Miguel Oter. Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31222033. |
these processes contribute to osteoarthritis (oa), where chondrocytes experience a phenotypic shift towards hypertrophy concomitant with abnormal matrix remodeling. |
2020-10-27 |
2023-08-13 |
Not clear |
| Lorenzo R Sewanan, Jonas Schwan, Jonathan Kluger, Jinkyu Park, Daniel L Jacoby, Yibing Qyang, Stuart G Campbel. Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes. JACC. Basic to translational science. vol 4. issue 4. 2020-10-27. PMID:31468004. |
extracellular matrix from hypertrophic myocardium provokes impaired twitch dynamics in healthy cardiomyocytes. |
2020-10-27 |
2023-08-13 |
mouse |
| Julie K Nguyen, Evan Austin, Alisen Huang, Andrew Mamalis, Jared Jagde. The IL-4/IL-13 axis in skin fibrosis and scarring: mechanistic concepts and therapeutic targets. Archives of dermatological research. vol 312. issue 2. 2020-10-27. PMID:31493000. |
skin fibrosis, characterized by excessive fibroblast proliferation and extracellular matrix deposition in the dermis, is the histopathologic hallmark of dermatologic diseases such as systemic sclerosis, hypertrophic scars, and keloids. |
2020-10-27 |
2023-08-13 |
Not clear |
| Kelsie E Oatmen, Elizabeth Cull, Francis G Spinal. Heart failure as interstitial cancer: emergence of a malignant fibroblast phenotype. Nature reviews. Cardiology. vol 17. issue 8. 2020-10-26. PMID:31686012. |
in animal models, a major factor driving progression from pressure-overload hypertrophy (poh) to hfpef is the activation and proliferation of an abnormal fibroblast phenotype that is resistant to apoptosis, degrades normal stromal matrix and is replaced with a fibrotic matrix structure. |
2020-10-26 |
2023-08-13 |
Not clear |
| Fumiko Yano, Shinsuke Ohba, Yasutaka Murahashi, Sakae Tanaka, Taku Saito, Ung-Il Chun. Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation. Scientific reports. vol 9. issue 1. 2020-10-14. PMID:31113964. |
runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation. |
2020-10-14 |
2023-08-13 |
Not clear |
| Weike Feng, Yue Zhao, Xiaotong Song, Yuan Wang, Qian Chen, Haijun Zhao, Guangying Lu, Hongyan Yuan, Zhichun Wu, Huayun Y. Zi Shen Huo Luo Formula Prevents Aldosterone-Induced Cardiomyocyte Hypertrophy and Cardiac Fibroblast Proliferation by Regulating the Striatin-Mediated MR/EGFR/ERK Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-10-06. PMID:33014117. |
excessive aldosterone can lead to myocardial extracellular matrix collagen proliferation, fibrosis, and cardiomyocyte hypertrophy and aggravate maladaptive remodeling. |
2020-10-06 |
2023-08-13 |
rat |
| Mitsuo Kat. Noncoding RNAs as therapeutic targets in early stage diabetic kidney disease. Kidney research and clinical practice. vol 37. issue 3. 2020-10-01. PMID:30254844. |
major features of dkd include accumulation of extracellular matrix proteins and glomerular hypertrophy, especially in early stage. |
2020-10-01 |
2023-08-13 |
human |
| Benazir Siddeek, Claire Mauduit, Hassib Chehade, Guillaume Blin, Marjorie Liand, Mariapia Chindamo, Mohamed Benahmed, Umberto Simeon. Long-term impact of maternal high-fat diet on offspring cardiac health: role of micro-RNA biogenesis. Cell death discovery. vol 5. 2020-10-01. PMID:30854230. |
in this model, offspring exposed to maternal high-fat diet developed cardiac hypertrophy and increased extracellular matrix depot compared to those exposed to chow diet. |
2020-10-01 |
2023-08-13 |
human |
| Chengjie Lian, Xudong Wang, Xianjian Qiu, Zizhao Wu, Bo Gao, Lei Liu, Guoyan Liang, Hang Zhou, Xiaoming Yang, Yan Peng, Anjing Liang, Caixia Xu, Dongsheng Huang, Peiqiang S. Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction. Bone research. vol 7. 2020-10-01. PMID:30854241. |
collagen type ii (col2a1) was previously considered to be only a structural component of the cartilage matrix, but recently, it has been revealed to be an extracellular signaling molecule that can significantly suppress chondrocyte hypertrophy. |
2020-10-01 |
2023-08-13 |
Not clear |
| Neil A Turner, Nicola M Blyth. Cardiac Fibroblast p38 MAPK: A Critical Regulator of Myocardial Remodeling. Journal of cardiovascular development and disease. vol 6. issue 3. 2020-10-01. PMID:31394846. |
one important signaling node that has been identified involves p38 mapk; a family of kinases activated in response to stress and inflammatory stimuli that modulates multiple aspects of cardiac fibroblast function, including inflammatory responses, myofibroblast differentiation, extracellular matrix turnover and the paracrine induction of cardiomyocyte hypertrophy. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yuanheng Yang, Yuwei Liu, Zixuan Lin, He Shen, Caitlin Lucas, Biao Kuang, Rocky S Tuan, Hang Li. Condensation-Driven Chondrogenesis of Human Mesenchymal Stem Cells within Their Own Extracellular Matrix: Formation of Cartilage with Low Hypertrophy and Physiologically Relevant Mechanical Properties. Advanced biosystems. vol 3. issue 12. 2020-10-01. PMID:32648682. |
condensation-driven chondrogenesis of human mesenchymal stem cells within their own extracellular matrix: formation of cartilage with low hypertrophy and physiologically relevant mechanical properties. |
2020-10-01 |
2023-08-13 |
human |
| Masayo Aoki, Noriko M Matsumoto, Teruyuki Dohi, Hiroaki Kuwahawa, Satoshi Akaishi, Yuri Okubo, Rei Ogawa, Hirofumi Yamamoto, Kazuaki Takab. Direct Delivery of Apatite Nanoparticle-Encapsulated siRNA Targeting TIMP-1 for Intractable Abnormal Scars. Molecular therapy. Nucleic acids. vol 22. 2020-10-01. PMID:32911344. |
hypertrophic scars (hss) and keloids are histologically characterized by excessive extracellular matrix (ecm) deposition. |
2020-10-01 |
2023-08-13 |
mouse |
| Danyang Zhao, Yu Wang, Chao Du, Shengzhou Shan, Yifan Zhang, Zijing Du, Dong Ha. Honokiol Alleviates Hypertrophic Scar by Targeting Transforming Growth Factor-β/Smad2/3 Signaling Pathway. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:28469575. |
hypertrophic scar (hps) presents as excessive extracellular matrix deposition and abnormal function of fibroblasts. |
2020-10-01 |
2023-08-13 |
Not clear |
| Melissa A Lyle, Jonathan P Davis, Frank V Brozovic. Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy. Frontiers in physiology. vol 8. 2020-10-01. PMID:28878690. |
there are two primary components that produce pulmonary arterial hypertension (pah); aberrant structural changes (smooth muscle cell proliferation, smooth muscle cell hypertrophy, and the deposition of matrix proteins within the media of pulmonary arterial vessels), and excess vasoconstriction. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yi Zhang, Xiaohua Lin, Li Zhang, Weilong Hong, Kang Zen. MicroRNA-222 regulates the viability of fibroblasts in hypertrophic scars via matrix metalloproteinase 1. Experimental and therapeutic medicine. vol 15. issue 2. 2020-10-01. PMID:29434768. |
microrna-222 regulates the viability of fibroblasts in hypertrophic scars via matrix metalloproteinase 1. |
2020-10-01 |
2023-08-13 |
Not clear |
| Hong-Wei Wang, Yi-He Chen, Yan-Yan Chen, Wei Huang, Xian-Dong Zhu, Fu-Biao Ni, Guo-Di Wu, Zi-Qiang Xu, Zhou-Qing Huang, Bi-Cheng Chen, Fang-Yi Xia. Islet transplantation attenuates cardiac fibrosis in diabetic rats through inhibition of TGF-β American journal of translational research. vol 10. issue 8. 2020-09-30. PMID:30210683. |
in addition, islet transplantation attenuated the increased levels of ctn-i and ck-mb, cleaved-caspase-3 in response to dm, and ameliorated diabetic-induced cardiac hypertrophy and interstitial fibrosis, along with improved extracellular matrix (ecm) deposition. |
2020-09-30 |
2023-08-13 |
rat |
| Aurore Van de Walle, Waïss Faissal, Claire Wilhelm, Nathalie Lucian. Role of growth factors and oxygen to limit hypertrophy and impact of high magnetic nanoparticles dose during stem cell chondrogenesis. Computational and structural biotechnology journal. vol 16. 2020-09-30. PMID:30524668. |
a major difficulty is to drive the chondrogenic differentiation of the cells such as they produce an extracellular matrix free of hypertrophic collagen. |
2020-09-30 |
2023-08-13 |
human |
| Aurore Van de Walle, Waïss Faissal, Claire Wilhelm, Nathalie Lucian. Role of growth factors and oxygen to limit hypertrophy and impact of high magnetic nanoparticles dose during stem cell chondrogenesis. Computational and structural biotechnology journal. vol 16. 2020-09-30. PMID:30524668. |
we focus on the synthesis of two of the most important constituents present in the cartilaginous extracellular matrix (collagen ii and aggrecan) and on the expression of collagen x, the signature of hypertrophic cartilage, in order to provide a quantitative index of the type of cartilage produced (i.e. |
2020-09-30 |
2023-08-13 |
human |
| I A Marino-Martínez, A G Martínez-Castro, V M Peña-Martínez, C A Acosta-Olivo, F Vílchez-Cavazos, A Guzmán-López, Edelmiro Pérez Rodríguez, V J Romero-Díaz, J A Ortega-Blanco, J Lara-Aria. Human amniotic membrane intra-articular injection prevents cartilage damage in an osteoarthritis model. Experimental and therapeutic medicine. vol 17. issue 1. 2020-09-30. PMID:30651759. |
at 6 weeks post-injection, the left knees exhibited hypertrophy, cracks, cell clusters, decreased matrix staining and structure loss. |
2020-09-30 |
2023-08-13 |
human |
| Yue Zhou, Mo Chen, Regis J O'Keefe, Jie Shen, Zhi Li, Jian Zhou, Xuedong Zhou, Jeremy J Ma. Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis. American journal of translational research. vol 11. issue 3. 2020-09-30. PMID:30972197. |
dnmt3b deficiency using conditional knockout mice led to the onset of osteoarthritis-like conditions including cartilage clefts, cartilage matrix loss and premature chondrocyte hypertrophy, which suggested that dnmt3b functioned as a osteoarthritis suppressor. |
2020-09-30 |
2023-08-13 |
mouse |