| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenzhen Lu, Yifei Zhong, Wangyi Liu, Ling Xiang, Yueyi Den. The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease. Journal of diabetes research. vol 2019. 2020-02-27. PMID:31534972. |
the pathological features of dkd are the hypertrophy of mesangial cells, apoptosis of podocytes, glomerular basement membrane (gbm) thickening, accumulation of extracellular matrix (ecm), glomerular sclerosis, and tubulointerstitial fibrosis. |
2020-02-27 |
2023-08-13 |
Not clear |
| Falguni Das, Soumya Maity, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. The Journal of biological chemistry. vol 294. issue 24. 2020-02-25. PMID:31028173. |
deacetylation of s6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. |
2020-02-25 |
2023-08-13 |
rat |
| Falguni Das, Soumya Maity, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. The Journal of biological chemistry. vol 294. issue 24. 2020-02-25. PMID:31028173. |
s6 kinase acts as a driver for renal hypertrophy and matrix accumulation, two key pathologic signatures of diabetic nephropathy. |
2020-02-25 |
2023-08-13 |
rat |
| Falguni Das, Soumya Maity, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. The Journal of biological chemistry. vol 294. issue 24. 2020-02-25. PMID:31028173. |
the role of this acetylation to regulate kidney glomerular cell hypertrophy and matrix expansion is not known. |
2020-02-25 |
2023-08-13 |
rat |
| Falguni Das, Soumya Maity, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. The Journal of biological chemistry. vol 294. issue 24. 2020-02-25. PMID:31028173. |
in aggregate, our data uncovered a previously unrecognized role of s6 kinase deacetylation in high glucose-induced mesangial cell hypertrophy and matrix protein expression. |
2020-02-25 |
2023-08-13 |
rat |
| Atlante S Mendes, Marcela M Blascke de Mello, Juliana M Parente, Ana Carolina M Omoto, Evandro M Neto-Neves, Rubens Fazan, Jose E Tanus-Santos, Michele M Castr. Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. Life sciences. vol 244. 2020-02-19. PMID:31830479. |
verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. |
2020-02-19 |
2023-08-13 |
rat |
| Atlante S Mendes, Marcela M Blascke de Mello, Juliana M Parente, Ana Carolina M Omoto, Evandro M Neto-Neves, Rubens Fazan, Jose E Tanus-Santos, Michele M Castr. Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats. Life sciences. vol 244. 2020-02-19. PMID:31830479. |
increased activity of calpain-1 and matrix metalloproteinase (mmp)-2 was observed in different models of arterial hypertension and contribute to thicken the left ventricle (lv) walls and to hypertrophy cardiac myocytes. |
2020-02-19 |
2023-08-13 |
rat |
| Kentaro Endo, Naoki Fujita, Takayuki Nakagawa, Ryohei Nishimur. Comparison of the effect of growth factors on chondrogenesis of canine mesenchymal stem cells. The Journal of veterinary medical science. vol 81. issue 8. 2020-02-11. PMID:31167981. |
the expression of cartilage matrix or hypertrophic gene/protein was also evaluated by qpcr and immunohistochemistry. |
2020-02-11 |
2023-08-13 |
Not clear |
| Edoardo Gronda, Stefania Sacchi, Giuditta Benincasa, Emilio Vanoli, Claudio Napol. Unresolved issues in left ventricular postischemic remodeling and progression to heart failure. Journal of cardiovascular medicine (Hagerstown, Md.). vol 20. issue 10. 2020-02-03. PMID:31343451. |
we focused our attention on multiple factors, which include myocyte loss, hypertrophy, hyperplasia, extracellular matrix changes linked to myocardial fibrosis and scar, metabolic imbalance, as well as immunologic response occurring in the acute myocardial aftermath. |
2020-02-03 |
2023-08-13 |
Not clear |
| Magdalena Rodica Trăistaru, Diana Kamal, Daniela Teodora Maria, Marian Valentin Zorilă, Dragoş Ovidiu Alexandru, Otilia Constantina Rogoveanu, Mirela Radu, Kamal Constantin Kama. Complex evaluation in patients with knee osteoarthritis. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 60. issue 1. 2020-01-27. PMID:31263841. |
in the histological assessment of our patients, we observed that the cells of the superficial areas were round and hypertrophic, the cartilage tissue had few proteoaminoglycans and glycosaminoglycans, with an airy aspect of the matrix and degenerate cells, numerically reduced. |
2020-01-27 |
2023-08-13 |
Not clear |
| Xiaoyang Wang, Jia Guo, Qiujie Wu, Cong Niu, Genyang Cheng, Dong Liu, Zhangsuo Liu, Zhanzheng Zhao, Jing Xia. Chemerin/chemR23 association with endothelial-mesenchymal transition in diabetic nephropathy. International journal of clinical and experimental pathology. vol 10. issue 7. 2020-01-26. PMID:31966583. |
mild glomerular hypertrophy was observed at 4 weeks and mild glomerular basement membrane thickening and mesangial matrix proliferation at 12 weeks. |
2020-01-26 |
2023-08-13 |
rat |
| Xiao-Ping Li, Pei Liu, Yan-Feng Li, Gan-Lin Zhang, De-Shan Zeng, Da-Lie Li. LPS induces activation of the TLR4 pathway in fibroblasts and promotes skin scar formation through collagen I and TGF-β in skin lesions. International journal of clinical and experimental pathology. vol 12. issue 6. 2020-01-17. PMID:31934034. |
hypertrophic scars are proliferative diseases of dermal fibroblasts that produce abundant amounts of collagen and extracellular matrix in the skin after severe burns, inflammation and trauma. |
2020-01-17 |
2023-08-13 |
Not clear |
| Lingzhi Zhong, Haojie Hao, Deyun Chen, Qian Hou, Ziying Zhu, Wenjun He, Sujing Sun, Mengli Sun, Meirong Li, Xiaobing F. Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway. Journal of cellular physiology. vol 234. issue 3. 2020-01-09. PMID:30317545. |
tissue contraction and the extracellular matrix deposition are part of the pathogenesis of hypertrophic scars. |
2020-01-09 |
2023-08-13 |
Not clear |
| Hua Wang, Haiyan Zhang, Qiuyi Sun, Jian Yang, Chun Zeng, Changhai Ding, Daozhang Cai, Anling Liu, Xiaochun Ba. Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression. Journal of cellular physiology. vol 234. issue 3. 2020-01-09. PMID:30145794. |
mechanistically, mtorc1 controls the hdac4-dependent expression of mir-483-5p to stimulate chondrocyte hypertrophy, extracellular matrix degradation, and subchondral bone angiogenesis, and it consequently initiates and accelerates the development of oa. |
2020-01-09 |
2023-08-13 |
mouse |
| Renuga D Rajaram, Romain Dissard, Vincent Jaquet, Sophie de Seigneu. Potential benefits and harms of NADPH oxidase type 4 in the kidneys and cardiovascular system. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 34. issue 4. 2020-01-06. PMID:29931336. |
diabetes elevates nox4 expression in podocytes and mesangial cells, which was shown to damage glomeruli leading to podocyte loss, mesangial cell hypertrophy and matrix accumulation. |
2020-01-06 |
2023-08-13 |
mouse |
| Daisuke Maeda, Tateki Kubo, Koichiro Kiya, Kenichiro Kawai, Shinsuke Matsuzaki, Daichi Kobayashi, Toshihiro Fujiwara, Taiichi Katayama, Ko Hosokaw. Periostin is induced by IL-4/IL-13 in dermal fibroblasts and promotes RhoA/ROCK pathway-mediated TGF-β1 secretion in abnormal scar formation. Journal of plastic surgery and hand surgery. vol 53. issue 5. 2019-12-31. PMID:31066603. |
excess scar formation can occur after skin injurふy and lead to abnormal scar formation, such as keloids and hypertrophic scars, which are characterised by substantial deposition of extracellular matrix in the dermis. |
2019-12-31 |
2023-08-13 |
human |
| Huan Zhou, Bin Wang, Ying-Xi Yang, Qiu-Jin Jia, Ao Zhang, Zhong-Wen Qi, Jun-Ping Zhan. Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature. BioMed research international. vol 2019. 2019-12-30. PMID:31355277. |
in addition, neat1, ak139328, apf, caif, ak088388, carl, malat1, hotair, xist, and nrf are involved in postischemia myocardial remodeling, while mhrt, chast, chrf, ror, h19, plscr4, and miat are involved in myocardial hypertrophy, and malat1, wisper, meg3, and h19 are involved in extracellular matrix (ecm) reconstitution. |
2019-12-30 |
2023-08-13 |
Not clear |
| Gabor A Fulop, Francisco I Ramirez-Perez, Tamas Kiss, Stefano Tarantini, Marta Noa Valcarcel Ares, Peter Toth, Andriy Yabluchanskiy, Shannon M Conley, Praveen Ballabh, Luis A Martinez-Lemus, Zoltan Ungvari, Anna Csisza. IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 74. issue 4. 2019-12-26. PMID:29931048. |
mcas of control mice exhibited structural adaptation to hypertension, manifested as a significant increase in wall thickness, vascular smooth muscle cell (vsmc) hypertrophy, decreased internal diameter and up-regulation of extracellular matrix (ecm)-related genes. |
2019-12-26 |
2023-08-13 |
mouse |
| Marijn Rutgers, Frances Bach, Luciënne Vonk, Mattie van Rijen, Vanessa Akrum, Antonette van Boxtel, Wouter Dhert, Laura Creemer. PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation. PloS one. vol 14. issue 4. 2019-12-19. PMID:30947269. |
extracellular matrix production, (pre)hypertrophy and pth signaling were assessed by rt-qpcr and/or immunohistochemistry for collagen type i, ii, x, runx2, mmp13, pthr1 and ihh and by determining glycosaminoglycan production and dna content. |
2019-12-19 |
2023-08-13 |
human |
| Marijn Rutgers, Frances Bach, Luciënne Vonk, Mattie van Rijen, Vanessa Akrum, Antonette van Boxtel, Wouter Dhert, Laura Creemer. PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation. PloS one. vol 14. issue 4. 2019-12-19. PMID:30947269. |
in conclusion, pth supplementation to healthy human articular chondrocytes did not affect hypertrophic differentiation, but negatively influenced cartilage quality, the tissues' extracellular matrix and cell content. |
2019-12-19 |
2023-08-13 |
human |