| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi-Feng Xiao, Guo-Yi Su, Yu Hou, Shu-Dong Chen, Ding-Kun Li. Cartilage degradation in osteoarthritis: A process of osteochondral remodeling resembles the endochondral ossification in growth plate? Medical hypotheses. vol 121. 2019-03-05. PMID:30396477. |
many factors such as mechanics, inflammation and immunological abnormality could drive the joint tissues metabolic and disturb the steady state of cartilage and bone, which further devoted to a serial pathological manifestations, consisting of hypertrophy and apoptosis of articular chondrocytes, degradation of cartilage matrix, angiogenesis and calcification of hyaline cartilage, replication of tidemark, formation of osteophytes, degeneration of ligaments and, in the knee, the menisci, hypertrophy of the joint capsule and remodeling of subchondral bone along with increased permeability of the osteochondral interface. |
2019-03-05 |
2023-08-13 |
Not clear |
| Safdar Hussain, Mengyao Sun, Yuanxu Guo, Nosheen Mushtaq, Yitong Zhao, Ying Yuan, Nazim Hussain, Ezra Osoro, Abubakar Suleiman, Muhammad Sadiq, Fujun Zhang, Yan Han, Jian Sun, Shemin L. SFMBT2 positively regulates SOX9 and chondrocyte proliferation. International journal of molecular medicine. vol 42. issue 6. 2019-02-25. PMID:30272322. |
sox9 deletion in chondrocytes at the late stages of cartilage development results in decreased chondrocyte proliferation; inhibited expression of cartilage matrix genes, including indian hedgehog and the downstream parathyroid hormone‑related protein; and premature conversion of proliferating chondrocytes into hypertrophic chondrocytes, which mineralize their matrix prematurely. |
2019-02-25 |
2023-08-13 |
human |
| Xabier Unamuno, Javier Gómez-Ambrosi, Amaia Rodríguez, Sara Becerril, Gema Frühbeck, Victoria Catalá. Adipokine dysregulation and adipose tissue inflammation in human obesity. European journal of clinical investigation. vol 48. issue 9. 2019-01-28. PMID:29995306. |
the mechanisms underlying adipose tissue dysfunction include adipocyte hypertrophy and hyperplasia, increased inflammation, impaired extracellular matrix remodelling and fibrosis together with an altered secretion of adipokines. |
2019-01-28 |
2023-08-13 |
human |
| Yinjie Liu, Ying Xiao, Jiaming Liu, Li Feng, Y James Kan. Copper-induced reduction in myocardial fibrosis is associated with increased matrix metalloproteins in a rat model of cardiac hypertrophy. Metallomics : integrated biometal science. vol 10. issue 1. 2019-01-14. PMID:29302675. |
copper-induced reduction in myocardial fibrosis is associated with increased matrix metalloproteins in a rat model of cardiac hypertrophy. |
2019-01-14 |
2023-08-13 |
rat |
| Ruzanna Shkhyan, Ben Van Handel, Jacob Bogdanov, Siyoung Lee, Yifan Yu, Mila Scheinberg, Nicholas W Banks, Sean Limfat, Arthur Chernostrik, Carlos Eduardo Franciozi, Mohammad Parvez Alam, Varghese John, Ling Wu, Gabriel B Ferguson, Ali Nsair, Frank A Petrigliano, C Thomas Vangsness, Kanagasabai Vadivel, Paul Bajaj, Liming Wang, Nancy Q Liu, Denis Evseenk. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Annals of the rheumatic diseases. vol 77. issue 5. 2019-01-14. PMID:29436471. |
human adult articular cartilage (ac) has little capacity for repair, and joint surface injuries often result in osteoarthritis (oa), characterised by loss of matrix, hypertrophy and chondrocyte apoptosis. |
2019-01-14 |
2023-08-13 |
mouse |
| Maday Fernández-Mayola, Lázaro Betancourt, Alicia Molina-Kautzman, Sucel Palomares, Yssel Mendoza-Marí, Dayana Ugarte-Moreno, Ana Aguilera-Barreto, Yilian Bermúdez-Álvarez, Vladimir Besada, Luis J González, Ariana García-Ojalvo, Ana J Mir-Benítez, Aleida Urquiza-Rodríguez, Jorge Berlanga-Acost. Growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome study. International wound journal. vol 15. issue 4. 2019-01-14. PMID:29464859. |
hypertrophic scars (hts) and keloids are forms of aberrant cutaneous healing with excessive extracellular matrix (ecm) deposition. |
2019-01-14 |
2023-08-13 |
Not clear |
| Kine Andenæs, Ida G Lunde, Naiyereh Mohammadzadeh, Christen P Dahl, Jan Magnus Aronsen, Mari E Strand, Sheryl Palmero, Ivar Sjaastad, Geir Christensen, Kristin V T Engebretsen, Theis Tønnesse. The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling. PloS one. vol 13. issue 7. 2019-01-14. PMID:30052659. |
cardiac remodeling comprises cardiomyocyte hypertrophic growth, extracellular matrix alterations including fibrosis, and inflammation. |
2019-01-14 |
2023-08-13 |
mouse |
| Grace C Limandjaja, Lenie J van den Broek, Melanie Breetveld, Taco Waaijman, Stan Monstrey, Edith M de Boer, Rik J Scheper, Frank B Niessen, Susan Gibb. Characterization of In Vitro Reconstructed Human Normotrophic, Hypertrophic, and Keloid Scar Models. Tissue engineering. Part C, Methods. vol 24. issue 4. 2018-12-21. PMID:29490604. |
notably, the expression of extracellular matrix associated genes showed distinguishing profiles between all scar types and normal skin (hyaluronan synthase-1, matrix-metalloprotease-3), between keloid and normal skin (collagen type iv), between normal scar and keloid (laminin α1), and between keloid and hypertrophic scar (matrix-metalloprotease-1, integrin α5). |
2018-12-21 |
2023-08-13 |
human |
| Guo Wei, Qingqing Xu, Lin Liu, Huanhuan Zhang, Xi Tan, Chunhong Zhang, Changyu Han, Yanxia Guo, Ganwen Han, Chunmin Zhan. LY2109761 reduces TGF-β1-induced collagen production and contraction in hypertrophic scar fibroblasts. Archives of dermatological research. vol 310. issue 8. 2018-12-17. PMID:30046895. |
hypertrophic scars (hs) are fibro-hyperproliferative dermal lesions with effusive continuous accumulation of extracellular matrix components, particularly collagen. |
2018-12-17 |
2023-08-13 |
Not clear |
| Yuan Luo, Yiwen Zhang, Yuanliang Huan. Icariin Reduces Cartilage Degeneration in a Mouse Model of Osteoarthritis and is Associated with the Changes in Expression of Indian Hedgehog and Parathyroid Hormone-Related Protein. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-12. PMID:30244259. |
results icariin treatment (mice in the aclt + ica group) significantly reduced degeneration of cartilage in oa with increased cartilage thickness, associated with increased expression of collagen type ii alpha 1 (col2a1), decreased chondrocyte hypertrophy, and decreased expression of collagen type x (colx) and matrix metalloproteinase 13 (mmp13). |
2018-12-12 |
2023-08-13 |
mouse |
| Jingcheng Deng, Yuan Shi, Zhen Gao, Wenjie Zhang, Xiaoli Wu, Weigang Cao, Wei Li. Inhibition of Pathological Phenotype of Hypertrophic Scar Fibroblasts Via Coculture with Adipose-Derived Stem Cells. Tissue engineering. Part A. vol 24. issue 5-6. 2018-12-11. PMID:28562226. |
hypertrophic scar (hs) is a dermal fibroproliferative disease characterized by fibroblast over-proliferation, overproduction, and deposition of the extracellular matrix. |
2018-12-11 |
2023-08-13 |
Not clear |
| Musaddique Hussain, Chengyun Xu, Meiping Lu, Xiling Wu, Lanfang Tang, Ximei W. Wnt/β-catenin signaling links embryonic lung development and asthmatic airway remodeling. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 12. 2018-12-11. PMID:28866134. |
wnt/β-catenin is a signaling protein that exhibits the pivotal role in lung development, injury and repair while aberrant expression of wnt/β-catenin signaling leads to asthmatic airway remodeling: characterized by hyperplasia and hypertrophy of airway smooth muscle cells, alveolar and vascular damage goblet cells metaplasia, and deposition of extracellular matrix; resulting in decreased lung compliance and increased airway resistance. |
2018-12-11 |
2023-08-13 |
Not clear |
| Soumya Maity, Amit Bera, Nandini Ghosh-Choudhury, Falguni Das, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. microRNA-181a downregulates deptor for TGFβ-induced glomerular mesangial cell hypertrophy and matrix protein expression. Experimental cell research. vol 364. issue 1. 2018-12-11. PMID:29397070. |
microrna-181a downregulates deptor for tgfβ-induced glomerular mesangial cell hypertrophy and matrix protein expression. |
2018-12-11 |
2023-08-13 |
Not clear |
| Soumya Maity, Amit Bera, Nandini Ghosh-Choudhury, Falguni Das, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. microRNA-181a downregulates deptor for TGFβ-induced glomerular mesangial cell hypertrophy and matrix protein expression. Experimental cell research. vol 364. issue 1. 2018-12-11. PMID:29397070. |
tgfβ contributes to mesangial cell hypertrophy and matrix protein increase in various kidney diseases including diabetic nephropathy. |
2018-12-11 |
2023-08-13 |
Not clear |
| Mike Jager, Mi-Jeong Lee, Chendi Li, Stephen R Farmer, Susan K Fried, Matthew D Layn. Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue. PloS one. vol 13. issue 5. 2018-12-11. PMID:29799877. |
white adipose tissue expands through both adipocyte hypertrophy and hyperplasia and it is hypothesized that fibrosis or excess accumulation of extracellular matrix within adipose tissue may limit tissue expansion contributing to metabolic dysfunction. |
2018-12-11 |
2023-08-13 |
mouse |
| Halil İbrahim Saygı, Zeynep Banu Güngör, Fatma Kalay, İsmail Seçki. In glomerular cells of puromycin aminonucleoside nephrosis rats both phosphorylated and total STAT3 levels increased during proteinuria. Acta histochemica. vol 120. issue 6. 2018-11-08. PMID:30054017. |
ultrastructural examinations showed glomerular damages such as significant decrease in slit pore number, a significant gradual increase in glomerular basement membrane thickness and podocyte hypertrophy on 5th and 15th days; besides significant increase in mesangial matrix. |
2018-11-08 |
2023-08-13 |
rat |
| Andre L P Tavares, Jessie A Brown, Emily C Ulrich, Katerina Dvorak, Raymond B Runya. Runx2-I is an Early Regulator of Epithelial-Mesenchymal Cell Transition in the Chick Embryo. Developmental dynamics : an official publication of the American Association of Anatomists. vol 247. issue 3. 2018-11-07. PMID:28631378. |
emt can be separated into an activation stage involving hypertrophy and cell separation and an invasion stage where cells invade the extracellular matrix. |
2018-11-07 |
2023-08-13 |
mouse |
| Ding-Sheng Jiang, Hao-Long Zeng, Rui Li, Bo Huo, Yun-Shu Su, Jing Fang, Qing Yang, Li-Gang Liu, Min Hu, Cai Cheng, Xue-Hai Zhu, Xin Yi, Xiang We. Aberrant Epicardial Adipose Tissue Extracellular Matrix Remodeling in Patients with Severe Ischemic Cardiomyopathy: Insight from Comparative Quantitative Proteomics. Scientific reports. vol 7. 2018-11-06. PMID:28256566. |
the hypertrophic cardiomyopathy, adrenergic signaling in cardiomyocytes, extracellular matrix (ecm)-receptor interaction, phagosome, glycolysis/gluconeogenesis, and ppar signaling pathway were highlighted by the kegg pathway analysis. |
2018-11-06 |
2023-08-13 |
human |
| Alek G Erickson, Taylor D Laughlin, Sarah M Romereim, Catherine N Sargus-Patino, Angela K Pannier, Andrew T Dudle. A Tunable, Three-Dimensional In Vitro Culture Model of Growth Plate Cartilage Using Alginate Hydrogel Scaffolds. Tissue engineering. Part A. vol 24. issue 1-2. 2018-11-05. PMID:28525313. |
in bead cultures, encapsulated chondrocytes showed high viability, cartilage matrix deposition, low levels of chondrocyte hypertrophy, and a progressive increase in cell proliferation over 7 days in culture. |
2018-11-05 |
2023-08-13 |
mouse |
| Zhouyangfan Peng, Yapei Li, Pingyu Zeng, Xiaohui L. [Progress in the study on roles of cathepsin in hypertension]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 42. issue 12. 2018-10-24. PMID:29317587. |
cathepsins are widely expressed in human various tissue and cells and they are involved in the pathogenesis of hypertension through activation of renin - angiotensin system, degradation of cytoplasmic matrix, proliferation of smooth muscle cell and hypertrophy of myocyte. |
2018-10-24 |
2023-08-13 |
human |