| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rodolphe Rakic, Bastien Bourdon, Magali Demoor, Stéphane Maddens, Nathalie Saulnier, Philippe Galér. Differences in the intrinsic chondrogenic potential of equine umbilical cord matrix and cord blood mesenchymal stromal/stem cells for cartilage regeneration. Scientific reports. vol 8. issue 1. 2019-12-06. PMID:30217993. |
we carried out an exhaustive characterization of the extracellular matrix generated by both these two types of mscs after the induction of chondrogenesis through evaluation of hyaline cartilage, hypertrophic and osteogenic markers (mrna, protein and histology levels). |
2019-12-06 |
2023-08-13 |
Not clear |
| De Luca F, Baro. Control of Bone Growth by Fibroblast Growth Factors. Trends in endocrinology and metabolism: TEM. vol 10. issue 2. 2019-11-20. PMID:10322396. |
in organ culture, fgf-2 inhibits growth by decreasing growth plate chondrocyte proliferation, hypertrophy and cartilage matrix synthesis. |
2019-11-20 |
2023-08-12 |
mouse |
| Cintia do Carmo E Silva, Jônathas Fernandes Queiroz de Almeida, Larissa Matuda Macedo, Marcos Barrouin Melo, Gustavo Rodrigues Pedrino, Fernanda Cristina Alcantara Dos Santos, Manoel Francisco Biancardi, Robson Augusto Souza Dos Santos, Adryano Augustto Valladão de Carvalho, Elizabeth Pereira Mendes, Diego Basile Colugnati, Renata Mazaro-Costa, Carlos Henrique de Castr. Mas receptor contributes to pregnancy-induced cardiac remodelling. Clinical science (London, England : 1979). vol 130. issue 24. 2019-11-20. PMID:27624141. |
in conclusion, these data show that although mas receptor blockade or deletion decreases physiological hypertrophy of pregnancy, it is associated with more extracellular matrix deposition. |
2019-11-20 |
2023-08-13 |
mouse |
| Mitsuo Kato, Mei Wang, Zhuo Chen, Kirti Bhatt, Hyung Jung Oh, Linda Lanting, Supriya Deshpande, Ye Jia, Jennifer Y C Lai, Christopher L O'Connor, YiFan Wu, Jeffrey B Hodgin, Robert G Nelson, Markus Bitzer, Rama Nataraja. An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy. Nature communications. vol 7. 2019-11-20. PMID:27686049. |
targeting early features of dn, including renal extracellular matrix accumulation (ecm) and glomerular hypertrophy, can prevent disease progression. |
2019-11-20 |
2023-08-13 |
mouse |
| N V Medvedev, N K Gorshunov. [Apoptosis and interstitial fibrosis in development of myocardial remodelling in elderly patients with arterial hypertension]. Advances in gerontology = Uspekhi gerontologii. vol 26. issue 2. 2019-11-20. PMID:28976159. |
structural reorganization of a myocardium from concentric to eccentric hypertrophy and concentric remodelling of left ventricle was characterized by strengthening of cellular apoptosis and interstitial myocardial fibrosis in extracellular matrix expressiveness, prevalence of collagen synthesis over collagen degradation, progressing of myocardium dysfunction. |
2019-11-20 |
2023-08-13 |
Not clear |
| Qian Tang, Gang Zheng, Zhenhua Feng, Minji Tong, Jianxiang Xu, Zhiyan Hu, Ping Shang, Yu Chen, Chenggui Wang, Yiting Lou, Deheng Chen, Di Zhang, Majid Nisar, Xiaolei Zhang, Huazi Xu, Haixiao Li. Wogonoside inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis. Oncotarget. vol 8. issue 37. 2019-11-20. PMID:28977876. |
the inflammatory environment is correlated with extracellular matrix (ecm) degradation and chondrocyte hypertrophy in the development of osteoarthritis (oa). |
2019-11-20 |
2023-08-13 |
mouse |
| Jihong Shi, Shan Shi, Bin Wu, Jian Zhang, Yan Li, Xue Wu, Julei Zhang, Kejia Wang, Bin Zhao, Weixia Cai, Xiaozhi Bai, Dahai Hu, Hao Gua. Autophagy protein LC3 regulates the fibrosis of hypertrophic scar by controlling Bcl-xL in dermal fibroblasts. Oncotarget. vol 8. issue 55. 2019-11-20. PMID:29212187. |
hypertrophic scar (hs) is a serious skin fibrotic disease characterized by excessive hypercellularity and extracellular matrix (ecm) component deposition. |
2019-11-20 |
2023-08-13 |
rabbit |
| Chunpeng Zou, Weixin Li, Yong Pan, Zia A Khan, Jieli Li, Xixi Wu, Yi Wang, Liancheng Deng, Guang Liang, Yunjie Zha. 11β-HSD1 inhibition ameliorates diabetes-induced cardiomyocyte hypertrophy and cardiac fibrosis through modulation of EGFR activity. Oncotarget. vol 8. issue 56. 2019-11-20. PMID:29221204. |
we also show that high levels of glucose caused cardiomyocyte hypertrophy and increased matrix protein deposition in culture. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xinhua Hu, Xing Ji, Mengting Yang, Shihao Fan, Jirong Wang, Meiping Lu, Wei Shi, Liu Mei, Chengyun Xu, Xueying Fan, Musaddique Hussain, Jingyu Du, Junsong Wu, Ximei W. Cdc42 Is Essential for Both Articular Cartilage Degeneration and Subchondral Bone Deterioration in Experimental Osteoarthritis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 33. issue 5. 2019-10-23. PMID:29314205. |
specifically, genetic disruption of cdc42, knockdown of cdc42 expression, or inhibition of cdc42 activity robustly attenuates the dmm-induced destruction, hypertrophy, high expression of matrix metallopeptidase-13 and collagen x, and activation of stat3 in articular cartilages. |
2019-10-23 |
2023-08-13 |
mouse |
| Xinning Yu, Tengfei Zhao, Yiying Qi, Jianyang Luo, Jinghua Fang, Xianyan Yang, Xiaonan Liu, Tengjing Xu, Quanming Yang, Zhongru Gou, Xuesong Da. In vitro Chondrocyte Responses in Mg-doped Wollastonite/Hydrogel Composite Scaffolds for Osteochondral Interface Regeneration. Scientific reports. vol 8. issue 1. 2019-10-18. PMID:30559344. |
an increase in csi-mg10 content is desirable for promoting the hypertrophy and mineralization of chondrocytes, as well as cell proliferation and matrix deposition. |
2019-10-18 |
2023-08-13 |
human |
| Xinning Yu, Tengfei Zhao, Yiying Qi, Jianyang Luo, Jinghua Fang, Xianyan Yang, Xiaonan Liu, Tengjing Xu, Quanming Yang, Zhongru Gou, Xuesong Da. In vitro Chondrocyte Responses in Mg-doped Wollastonite/Hydrogel Composite Scaffolds for Osteochondral Interface Regeneration. Scientific reports. vol 8. issue 1. 2019-10-18. PMID:30559344. |
it is noteworthy that the hdzcs in the 6% csi-mg10 scaffolds maintained a higher expression of the calcified cartilage zone specific extracellular matrix marker and hypertrophic marker, collagen type x. immunohistochemical and alizarin red staining reconfirmed these findings. |
2019-10-18 |
2023-08-13 |
human |
| Hanneke N Monsuur, Lenie J van den Broek, Pieter Koolwijk, Frank B Niessen, Susan Gibb. Endothelial cells enhance adipose mesenchymal stromal cell-mediated matrix contraction via ALK receptors and reduced follistatin: Potential role of endothelial cells in skin fibrosis. Journal of cellular physiology. vol 233. issue 10. 2019-10-03. PMID:29345319. |
in conclusion, our study shows that ec may play a critical role in fibrotic events, as seen in hypertrophic scars, by stimulating asc-mediated matrix contraction via regulation of fibrosis-related proteins. |
2019-10-03 |
2023-08-13 |
Not clear |
| Aaron J Rogers, Ramaswamy Kannappan, Hadil Abukhalifeh, Mohammed Ghazal, Jessica M Miller, Ayman El-Baz, Vladimir G Fast, Palaniappan Seth. Hemodynamic Stimulation Using the Biomimetic Cardiac Tissue Model (BCTM) Enhances Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cells, tissues, organs. vol 206. issue 1-2. 2019-09-19. PMID:30840966. |
following 7 days of gradually increasing stimulation, we show that hemodynamic loading results in (a) enhanced alignment of the cells and extracellular matrix, (b) significant increases in genes associated with physiological hypertrophy, (c) noticeable changes in sarcomeric organization and potential changes to cellular metabolism, and (d) a significant increase in fractional shortening, suggestive of a positive force frequency response. |
2019-09-19 |
2023-08-13 |
human |
| Marcela M Blascke de Mello, Juliana M Parente, Richard Schulz, Michele M Castr. Matrix metalloproteinase (MMP)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension. Vascular pharmacology. vol 116. 2019-09-03. PMID:30339939. |
matrix metalloproteinase (mmp)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension. |
2019-09-03 |
2023-08-13 |
rat |
| Xiaolu Ye, Zhiying Pang, Ningwen Zh. Dihydromyricetin attenuates hypertrophic scar formation by targeting activin receptor-like kinase 5. European journal of pharmacology. vol 852. 2019-09-03. PMID:30807748. |
hypertrophic scar (hps) is a manifestation of abnormal tissue repair, representing excessive extracellular matrix production and abnormal function of fibroblasts, for which no satisfactory treatment is available at present. |
2019-09-03 |
2023-08-13 |
mouse |
| Ang Li, Yiyong Wei, Clark Hung, Gordana Vunjak-Novakovi. Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix. Biomaterials. vol 173. 2019-08-13. PMID:29758546. |
cartilage ecm promoted msc proliferation, production of cartilaginous matrix, and maturity of chondrogenic differentiation, and inhibited the hypertrophic differentiation of msc-derived chondrocytes. |
2019-08-13 |
2023-08-13 |
human |
| John E Madia. Letter by Madias Regarding Article, "Left Ventricular Hypertrophy Revisited: Cell and Matrix Expansion Have Disease-Specific Relationships". Circulation. vol 137. issue 24. 2019-08-02. PMID:29891629. |
letter by madias regarding article, "left ventricular hypertrophy revisited: cell and matrix expansion have disease-specific relationships". |
2019-08-02 |
2023-08-13 |
Not clear |
| Rebecca Kozor, James C Moon, Thomas A Treibe. Response by Kozor et al to Letter Regarding Article, "Left Ventricular Hypertrophy Revisited: Cell and Matrix Expansion Have Disease-Specific Relationships". Circulation. vol 137. issue 24. 2019-08-02. PMID:29891630. |
response by kozor et al to letter regarding article, "left ventricular hypertrophy revisited: cell and matrix expansion have disease-specific relationships". |
2019-08-02 |
2023-08-13 |
Not clear |
| Thomas A Treibel, Paul Richard Scully, James C Moo. Myocardial Hypertrophy, Matrix Expansion, and Focal Scar: Progression and Regression in Aortic Stenosis. Circulation. Cardiovascular imaging. vol 11. issue 6. 2019-07-31. PMID:29914870. |
myocardial hypertrophy, matrix expansion, and focal scar: progression and regression in aortic stenosis. |
2019-07-31 |
2023-08-13 |
Not clear |
| Xia Lu, Sheng Luan, Ping Dai, Kun Luo, Baolong Chen, Baoxiang Cao, Li Sun, Yunjun Yan, Jie Kon. Insights into the molecular basis of immunosuppression and increasing pathogen infection severity of ammonia toxicity by transcriptome analysis in pacific white shrimp Litopenaeus vannamei. Fish & shellfish immunology. vol 88. 2019-07-25. PMID:30885745. |
a total of 13 pathways were obtained mainly involving in this process, which mainly led to the following changes: (1) increasing the immunosuppression, anemia, endocrine dysfunction, neurotoxic effect and neuroinvasion, atherosclerosis and thrombogenesis, blood-brain barrier penetration, thyroid disorder, necrosis, inflammation, and circadian disturbance; (2) reducing the ability of vascular remodeling, angiogenesis, cell survival, migration, apoptosis, and lymph transferred to blood stream; (3) leading to cell hypertrophy, cellular shape changes, and mesangial matrix expansion. |
2019-07-25 |
2023-08-13 |
Not clear |