| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew C Hal. The Role of Chondrocyte Morphology and Volume in Controlling Phenotype-Implications for Osteoarthritis, Cartilage Repair, and Cartilage Engineering. Current rheumatology reports. vol 21. issue 8. 2020-09-01. PMID:31203465. |
however, chondrocytes are phenotypically unstable and, if they de-differentiate into hypertrophic or fibroblastic forms, will produce a defective and weak matrix. |
2020-09-01 |
2023-08-13 |
Not clear |
| Mateusz S Wietecha, Marco Pensalfini, Michael Cangkrama, Bettina Müller, Juyoung Jin, Jürgen Brinckmann, Edoardo Mazza, Sabine Werne. Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds. Nature communications. vol 11. issue 1. 2020-08-24. PMID:32451392. |
matrix deposition is essential for wound repair, but when excessive, leads to hypertrophic scars and fibrosis. |
2020-08-24 |
2023-08-13 |
Not clear |
| Sara Al-Ghadban, Walter Cromer, Marisol Allen, Christopher Ussery, Michael Badowski, David Harris, Karen L Herbs. Dilated Blood and Lymphatic Microvessels, Angiogenesis, Increased Macrophages, and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue. Journal of obesity. vol 2019. 2020-08-10. PMID:30949365. |
case reports of lipedema tissue samples demonstrate fluid and fibrosis in the interstitial matrix, increased macrophages, and adipocyte hypertrophy. |
2020-08-10 |
2023-08-13 |
Not clear |
| Selvaraj Vimalra. Alkaline phosphatase: Structure, expression and its function in bone mineralization. Gene. vol 754. 2020-08-05. PMID:32522695. |
mineralization is the production, inside matrix vesicles, of hydroxyapatite crystals that bud from the outermembrane of hypertrophic osteoblasts and chondrocytes. |
2020-08-05 |
2023-08-13 |
Not clear |
| Hiroaki Ichikawa, Michiko Shimada, Masato Narita, Ikuyo Narita, Yoshihiro Kimura, Makoto Tanaka, Tomohiro Osanai, Ken Okumura, Hirofumi Tomit. Rivaroxaban, a Direct Factor Xa Inhibitor, Ameliorates Hypertensive Renal Damage Through Inhibition of the Inflammatory Response Mediated by Protease-Activated Receptor Pathway. Journal of the American Heart Association. vol 8. issue 8. 2020-07-23. PMID:30957622. |
moreover, rivaroxaban treatment attenuated histologic changes of glomerular hypertrophy, mesangial matrix expansion, effacement of the podocyte foot process, and thickened glomerular basement membrane in the ren-tg. |
2020-07-23 |
2023-08-13 |
mouse |
| Macarena Orejudo, Ana B García-Redondo, Raúl R Rodrigues-Diez, Raquel Rodrigues-Díez, Laura Santos-Sanchez, Antonio Tejera-Muñoz, Jesús Egido, Rafael Selgas, Mercedes Salaices, Ana M Briones, Marta Ruiz-Orteg. Interleukin-17A induces vascular remodeling of small arteries and blood pressure elevation. Clinical science (London, England : 1979). vol 134. issue 5. 2020-07-20. PMID:32104886. |
the mechanisms of il-17a seem to involve an induction of vascular smooth muscle cell (vsmc) hypertrophy and phenotype changes, in the absence of extracellular matrix (ecm) proteins accumulation. |
2020-07-20 |
2023-08-13 |
mouse |
| Laia Cañes, Ingrid Martí-Pàmies, Carme Ballester-Servera, Adela Herraiz-Martínez, Judith Alonso, María Galán, J Francisco Nistal, Pedro Muniesa, Jesús Osada, Leif Hove-Madsen, Cristina Rodríguez, José Martínez-Gonzále. Neuron-derived orphan receptor-1 modulates cardiac gene expression and exacerbates angiotensin II-induced cardiac hypertrophy. Clinical science (London, England : 1979). vol 134. issue 3. 2020-07-15. PMID:31985010. |
nor-1 transgenesis up-regulated two key genes involved in cardiac hypertrophy (myh7, encoding for β-myosin heavy chain (β-mhc)) and fibrosis (loxl2, encoding for the extracellular matrix (ecm) modifying enzyme, loxl2). |
2020-07-15 |
2023-08-13 |
mouse |
| Gui-Fang Sun, Hong-Chang Li, Yue-Ping Zhan, Xiao-Fen Zhang, Li-Yun Pan, Ya-Feng Chen, Ke Xu, Dian-Xu Fen. SnoN residue (1-366) attenuates hypertrophic scars through resistance to transforming growth factor-β1-induced degradation. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 12. 2020-06-29. PMID:31409891. |
hypertrophic scars (hss) are characterized by fibroblast hyperproliferation and excessive matrix deposition. |
2020-06-29 |
2023-08-13 |
human |
| Yujin Ma, Jingxia Shi, Feifei Wang, Shipeng Li, Jie Wang, Chaoxia Zhu, Liping Li, Haibo Lu, Chun Li, Junqiang Yan, Xin Zhang, Hongwei Jian. MiR-130b increases fibrosis of HMC cells by regulating the TGF-β1 pathway in diabetic nephropathy. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-22. PMID:30260005. |
basement membrane thickening, glomerular hypertrophy, and deposition of multiple extracellular matrix characterize the pathological basis of diabetic nephropathy (dn), a condition which ultimately leads to glomerular and renal interstitial fibrosis. |
2020-06-22 |
2023-08-13 |
human |
| Jiaji Yue, Shanzi Jin, Shizhong Gu, Rui Sun, Qingwei Lian. High concentration magnesium inhibits extracellular matrix calcification and protects articular cartilage via Erk/autophagy pathway. Journal of cellular physiology. vol 234. issue 12. 2020-06-12. PMID:31161622. |
the significant cytopathological changes of osteoarthritis are chondrocyte hypertrophy, proteoglycan loss, extracellular matrix (ecm) calcification, and terminally, the replacement of cartilage by bone. |
2020-06-12 |
2023-08-13 |
Not clear |
| Xu Chen, Jie Su, Jianyu Feng, Liang Cheng, Qing Li, Chen Qiu, Qijun Zhen. TRIM72 contributes to cardiac fibrosis via regulating STAT3/Notch-1 signaling. Journal of cellular physiology. vol 234. issue 10. 2020-05-19. PMID:30820965. |
we developed a cardiac hypertrophy model using transverse aortic constriction (tac) to uncover mechanisms relevant to excessive deposition of extracellular matrix in mouse myocardial cells. |
2020-05-19 |
2023-08-13 |
mouse |
| Jianmei Li, Fei Kang, Xiaoshan Gong, Yun Bai, Jingjin Dai, Chunrong Zhao, Ce Dou, Zhen Cao, Mengmeng Liang, Rui Dong, Hong Jiang, Xiaochao Yang, Shiwu Don. Ceria nanoparticles enhance endochondral ossification-based critical-sized bone defect regeneration by promoting the hypertrophic differentiation of BMSCs FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 5. 2020-05-12. PMID:30776318. |
however, inadequate chondrocyte hypertrophy can hinder vascular invasion and matrix mineralization during endochondral ossification. |
2020-05-12 |
2023-08-13 |
mouse |
| Manuel F Landecho, Carlota Tuero, Víctor Valentí, Idoia Bilbao, Magdalena de la Higuera, Gema Frühbec. Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk. Nutrients. vol 11. issue 11. 2020-04-28. PMID:31694146. |
the mechanisms underlying adipose tissue dysfunction include adipocyte hypertrophy and hyperplasia, increased inflammation, impaired extracellular matrix remodeling, and fibrosis together with an altered secretion of adipokines. |
2020-04-28 |
2023-08-13 |
Not clear |
| Anda Mariana Braşoveanu, Laurenţiu Mogoantă, Gheorghe Dan Mălăescu, Octavian Ion Predescu, Bogdan Virgil Cotoi, Feng Ifrim Che. Hypertensive cardiomyopathy - histopathological and immunohistochemical aspects. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 60. issue 2. 2020-04-21. PMID:31658322. |
in hypertensive patients, it progresses into the left ventricle hypertrophy, as a result of some major changes of the cardiomyocytes, but also of the extracellular conjunctive matrix (ecm). |
2020-04-21 |
2023-08-13 |
Not clear |
| Gil Soon Park, Min Kyun An, Ji Ha Yoon, Seok Soon Park, Sung Hoon Koh, Theodora M Mauro, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Ki. Botulinum toxin type A suppresses pro-fibrotic effects via the JNK signaling pathway in hypertrophic scar fibroblasts. Archives of dermatological research. vol 311. issue 10. 2020-04-20. PMID:31501922. |
hypertrophic scar is a dermal fibroproliferative disease characterized by the overproduction and deposition of extracellular matrix, and the hyperproliferation and enhanced angiogenesis of fibroblasts, along with their enhanced differentiation to myofibroblasts. |
2020-04-20 |
2023-08-13 |
human |
| Girish Pattappa, Ruth Schewior, Isabelle Hofmeister, Jennifer Seja, Johannes Zellner, Brian Johnstone, Denitsa Docheva, Peter Angel. Physioxia Has a Beneficial Effect on Cartilage Matrix Production in Interleukin-1 Beta-Inhibited Mesenchymal Stem Cell Chondrogenesis. Cells. vol 8. issue 8. 2020-04-06. PMID:31434236. |
in vivo, articular chondrocytes reside under a low oxygen environment between 2-5% oxygen (physioxia) and have been shown to enhance in vitro msc chondrogenic matrix content with reduced hypertrophic marker expression under these conditions. |
2020-04-06 |
2023-08-13 |
Not clear |
| Tingxia Wang, Yun Li, Juan Chen, Lijian Xie, Tingting Xia. TGF-β1/Smad3 signaling promotes collagen synthesis in pulmonary artery smooth muscle by down-regulating miR-29b. International journal of clinical and experimental pathology. vol 11. issue 12. 2020-03-25. PMID:31949646. |
deposition of fibronectin and collagen in the extracellular matrix (ecm) and the proliferation, migration, and hypertrophy of vascular smooth muscle cells (vsmcs) result in pulmonary arterial (pa) hypertrophy and muscularization, leading to increased pulmonary vascular resistance in pulmonary arterial hypertension (pah). |
2020-03-25 |
2023-08-13 |
rat |
| Lifan Liao, Shanxing Zhang, Guang-Qian Zhou, Ling Ye, Jian Huang, Lan Zhao, Di Che. Deletion of Runx2 in condylar chondrocytes disrupts TMJ tissue homeostasis. Journal of cellular physiology. vol 234. issue 4. 2020-03-16. PMID:30387127. |
the histologic and immunohistochemical data showed that runx2 deficiency caused condylar tissue disorganization, including loss of hc and reduced hypertrophic zone, reduced proliferative chondrocytes, and decreased cartilage matrix production. |
2020-03-16 |
2023-08-13 |
mouse |
| Lian Xu, Mengxia Fu, Dongrui Chen, Weiqing Han, Michael C Ostrowski, Paul Grossfeld, Pingjin Gao, Maoqing Y. Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition. BMB reports. vol 52. issue 10. 2020-03-12. PMID:30670148. |
the reduced cardiac fibrosis was accompanied by decreased expression of fibrotic matrix genes, reduced endmt with decreased snail, slug, twist, and zeb1 expression, as well as reduced cardiac hypertrophy and expression of hypertrophyassociated genes was observed. |
2020-03-12 |
2023-08-13 |
mouse |
| Van K Ninh, Elia C El Hajj, Alan J Mouton, Milad C El Hajj, Nicholas W Gilpin, Jason D Gardne. Chronic Ethanol Administration Prevents Compensatory Cardiac Hypertrophy in Pressure Overload. Alcoholism, clinical and experimental research. 2020-03-06. PMID:29846943. |
alcoholic cardiomyopathy is characterized by a dilated cardiac phenotype with extensive hypertrophy and extracellular matrix (ecm) remodeling. |
2020-03-06 |
2023-08-13 |
rat |