| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel Elieh Ali Komi, Leif Bjerme. Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights. Clinical reviews in allergy & immunology. vol 56. issue 2. 2019-07-23. PMID:30506113. |
the release of mc mediators and mc/airway cell interactions during remodeling phase of asthma results in persistent cellular and structural changes in the airway wall mainly epithelial cell shedding, goblet cell hyperplasia, hypertrophy of asm bundles, fibrosis in subepithelial region, abnormal deposition of extracellular matrix (ecm), increased tissue vascularity, and basement membrane thickening. |
2019-07-23 |
2023-08-13 |
human |
| Thomas A Treibel, Rebecca Kozor, Rebecca Schofield, Giulia Benedetti, Marianna Fontana, Anish N Bhuva, Amir Sheikh, Begoña López, Arantxa González, Charlotte Manisty, Guy Lloyd, Peter Kellman, Javier Díez, James C Moo. Reverse Myocardial Remodeling Following Valve Replacement in Patients With Aortic Stenosis. Journal of the American College of Cardiology. vol 71. issue 8. 2019-07-18. PMID:29471937. |
left ventricular (lv) hypertrophy, a key process in human cardiac disease, results from cellular (hypertrophy) and extracellular matrix expansion (interstitial fibrosis). |
2019-07-18 |
2023-08-13 |
human |
| Kazunori Hayashi, Akinobu Suzuki, Sayed Abdullah Ahmadi, Hidetomi Terai, Kentaro Yamada, Masatoshi Hoshino, Hiromitsu Toyoda, Shinji Takahashi, Koji Tamai, Shoichiro Ohyama, Akgar Javid, Mohammad Suhrab Rahmani, Maruf Mohammad Hasib, Hiroaki Nakamur. Mechanical stress induces elastic fibre disruption and cartilage matrix increase in ligamentum flavum. Scientific reports. vol 7. issue 1. 2019-06-28. PMID:29026131. |
these findings indicate that mechanical stress plays a crucial role in lf hypertrophy through cartilage matrix increase. |
2019-06-28 |
2023-08-13 |
Not clear |
| Jonathan C Bernhard, Elizabeth Hulphers, Bernhard Rieder, James Ferguson, Dominik Rünzler, Thomas Nau, Heinz Redl, Gordana Vunjak-Novakovi. Perfusion Enhances Hypertrophic Chondrocyte Matrix Deposition, But Not the Bone Formation. Tissue engineering. Part A. vol 24. issue 11-12. 2019-06-17. PMID:29373945. |
perfusion enhances hypertrophic chondrocyte matrix deposition, but not the bone formation. |
2019-06-17 |
2023-08-13 |
rat |
| Jonathan C Bernhard, Elizabeth Hulphers, Bernhard Rieder, James Ferguson, Dominik Rünzler, Thomas Nau, Heinz Redl, Gordana Vunjak-Novakovi. Perfusion Enhances Hypertrophic Chondrocyte Matrix Deposition, But Not the Bone Formation. Tissue engineering. Part A. vol 24. issue 11-12. 2019-06-17. PMID:29373945. |
we studied the effects of perfusion on hypertrophic chondrocyte differentiation, matrix production, and subsequent bone formation. |
2019-06-17 |
2023-08-13 |
rat |
| Yue Wang, Zong-Ji Zheng, Yi-Jie Jia, Yan-Lin Yang, Yao-Ming Xu. Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease. Journal of translational medicine. vol 16. issue 1. 2019-06-14. PMID:29848325. |
early renal hypertrophy is the main pathological feature, which gradually leads to the deposition of glomerular extracellular matrix and tubulointerstitial fibrosis, eventually developing irreversible structural damage to the kidneys. |
2019-06-14 |
2023-08-13 |
Not clear |
| Yi Zhang, Li Zhang, Qiyu Zhang, Weilong Hong, Xiaohua Li. [microRNA-222 regulates proliferation and apoptosis of fibroblasts in hypertrophic scar via matrix metalloproteinase 1]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 46. issue 6. 2019-05-20. PMID:29658663. |
[microrna-222 regulates proliferation and apoptosis of fibroblasts in hypertrophic scar via matrix metalloproteinase 1]. |
2019-05-20 |
2023-08-13 |
Not clear |
| Shikha Chawla, Sourabh Ghos. Regulation of fibrotic changes by the synergistic effects of cytokines, dimensionality and matrix: Towards the development of an in vitro human dermal hypertrophic scar model. Acta biomaterialia. vol 69. 2019-05-08. PMID:29330036. |
regulation of fibrotic changes by the synergistic effects of cytokines, dimensionality and matrix: towards the development of an in vitro human dermal hypertrophic scar model. |
2019-05-08 |
2023-08-13 |
human |
| Morag J Young, Gail K Adle. Aldosterone, the Mineralocorticoid Receptor and Mechanisms of Cardiovascular Disease. Vitamins and hormones. vol 109. 2019-04-22. PMID:30678863. |
aldosterone and the mr also play a key role in regulating tissue volume expansion in many tissues, via the regulation of hypertrophy and/or hyperplasia of cardiac or vascular smooth muscle cells and through regulation of the extra cellular matrix (ecm) and tissue fibrosis. |
2019-04-22 |
2023-08-13 |
Not clear |
| Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression. PloS one. vol 13. issue 11. 2019-04-15. PMID:30444896. |
akt2 causes tgfβ-induced deptor downregulation facilitating mtor to drive podocyte hypertrophy and matrix protein expression. |
2019-04-15 |
2023-08-13 |
rat |
| Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression. PloS one. vol 13. issue 11. 2019-04-15. PMID:30444896. |
tgfβ promotes podocyte hypertrophy and expression of matrix proteins in fibrotic kidney diseases such as diabetic nephropathy. |
2019-04-15 |
2023-08-13 |
rat |
| Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression. PloS one. vol 13. issue 11. 2019-04-15. PMID:30444896. |
importantly, inhibition of akt2 blocked tgfβ -induced podocyte hypertrophy and expression of the matrix protein fibronectin. |
2019-04-15 |
2023-08-13 |
rat |
| Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression. PloS one. vol 13. issue 11. 2019-04-15. PMID:30444896. |
furthermore, we provide the first evidence that deptor downstream of akt2 contributes to podocyte hypertrophy and matrix protein expression found in glomerulosclerosis in different renal diseases. |
2019-04-15 |
2023-08-13 |
rat |
| Ugo E Pazzaglia, Marcella Reguzzoni, Lavinia Casati, Andrea Minini, Andrea G Salvi, Valeria Sibili. Long bone human anlage longitudinal and circumferential growth in the fetal period and comparison with the growth plate cartilage of the postnatal age. Microscopy research and technique. vol 82. issue 3. 2019-04-03. PMID:30582248. |
measurement of multiple parameters (% lac area, % total matrix area, total lac density and mean single lac area), which characterize the cartilage anlage growth, suggested the following correlations with chondrocyte duplication rate: (a) slow duplication rate ≈ coupled, intralacunar chondrocytes (in central epiphysis); (b) repeated/frequent cell duplications ≈ clusters (in the basal epiphyseal layer); (c) clusters of chondrocytes before becoming hypertrophic were stacked up on the top of each other (both in the anlage transition zone or in the columns of metaphyseal growth plate); (d) enhanced osteoclastic resorption of the lacroix bone bark lower end, extended to the more external metaphyseal trabeculae counterbalancing the discrepancy between the epiphyseal and the diaphyseal circumferential growth. |
2019-04-03 |
2023-08-13 |
human |
| Ugo E Pazzaglia, Marcella Reguzzoni, Francesca Pagani, Valeria Sibilia, Terenzio Congiu, Andrea G Salvi, Anna Benett. Study of Endochondral Ossification in Human Fetalcartilage Anlagen of Metacarpals: Comparative Morphology of Mineral Deposition in Cartilage and in the Periosteal Bone Matrix. Anatomical record (Hoboken, N.J. : 2007). vol 301. issue 4. 2019-04-01. PMID:29266881. |
the progression of mineral phase deposition in hypertrophic cartilage and periosteal bone matrix was studied in human metacarpals primary ossification centers before vascular invasion began. |
2019-04-01 |
2023-08-13 |
human |
| Keshvad Hedayatyanfard, Seyed Ali Ziai, Feizollah Niazi, Iman Habibi, Behnam Habibi, Hamideh Moravve. Losartan ointment relieves hypertrophic scars and keloid: A pilot study. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 26. issue 4. 2019-04-01. PMID:30099811. |
keloid and hypertrophic scars are two types of fibrosis caused by extracellular matrix overexpression, and angiotensin ii via at |
2019-04-01 |
2023-08-13 |
Not clear |
| Nathaly Espitia Pinzón, John J P Brevé, John G J M Bol, Benjamin Drukarch, Wia Baron, Anne-Marie van Da. Tissue transglutaminase in astrocytes is enhanced by inflammatory mediators and is involved in the formation of fibronectin fibril-like structures. Journal of neuroinflammation. vol 14. issue 1. 2019-03-21. PMID:29282083. |
subsequently, hypertrophic astrocytes fill the lesion and produce extracellular matrix (ecm) proteins that together form the astroglial scar. |
2019-03-21 |
2023-08-13 |
Not clear |
| Shani Samuel, Raja Elina Ahmad, Thamil Selvee Ramasamy, Puvanan Karunanithi, Sangeetha Vasudevaraj Naveen, Tunku Kamaru. Platelet-rich concentrate in serum-free medium enhances cartilage-specific extracellular matrix synthesis and reduces chondrocyte hypertrophy of human mesenchymal stromal cells encapsulated in alginate. Platelets. vol 30. issue 1. 2019-03-15. PMID:29090639. |
platelet-rich concentrate in serum-free medium enhances cartilage-specific extracellular matrix synthesis and reduces chondrocyte hypertrophy of human mesenchymal stromal cells encapsulated in alginate. |
2019-03-15 |
2023-08-13 |
human |
| Shani Samuel, Raja Elina Ahmad, Thamil Selvee Ramasamy, Puvanan Karunanithi, Sangeetha Vasudevaraj Naveen, Tunku Kamaru. Platelet-rich concentrate in serum-free medium enhances cartilage-specific extracellular matrix synthesis and reduces chondrocyte hypertrophy of human mesenchymal stromal cells encapsulated in alginate. Platelets. vol 30. issue 1. 2019-03-15. PMID:29090639. |
results showed that the cells cultured in the presence of prc for 24 days maintained a chondrocytic phenotype and demonstrated minimal upregulation of cartilaginous extracellular matrix (ecm) marker genes (sox9, tnc, col2, acan, comp) and reduced expression of chondrocyte hypertrophy genes (col x, runx2) compared to the standard chondrogenic medium (p < 0.05). |
2019-03-15 |
2023-08-13 |
human |
| Thomas A Treibel, Rebecca Kozor, Katia Menacho, Silvia Castelletti, Heerajnarain Bulluck, Stefania Rosmini, Sabrina Nordin, Viviana Maestrini, Marianna Fontana, James C Moo. Left Ventricular Hypertrophy Revisited: Cell and Matrix Expansion Have Disease-Specific Relationships. Circulation. vol 136. issue 25. 2019-03-14. PMID:29255128. |
left ventricular hypertrophy revisited: cell and matrix expansion have disease-specific relationships. |
2019-03-14 |
2023-08-13 |
Not clear |