| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrícia M Ferrão, Líndice M Nisimura, Otacílio C Moreira, Marcelo G Land, Mirian C Pereira, Leila de Mendonça-Lima, Tania C Araujo-Jorge, Mariana C Waghabi, Luciana R Garzon. Inhibition of TGF-β pathway reverts extracellular matrix remodeling in T. cruzi-infected cardiac spheroids. Experimental cell research. vol 362. issue 2. 2018-10-05. PMID:29208458. |
in the present study, we tested in a three-dimensional (3d) model of cardiac cells culture (named cardiac spheroids), capable of mimicking the aspects of fibrosis and hypertrophy observed in cc, the role of tgf-β pathway inhibition in restoring extracellular matrix (ecm) balance disrupted by t. cruzi infection. |
2018-10-05 |
2023-08-13 |
Not clear |
| Oscar Orihuela-Rodríguez, Héctor A. Carmona-Ruíz, Fernando Laredo-Sánchez, José Ramón Paniagua-Sierr. Left ventricular hypertrophy, fibrosis heart, and diastolic dysfunction in chronic kidney disease Revista medica del Instituto Mexicano del Seguro Social. vol 55. issue Suppl. 2. 2018-10-02. PMID:29697909. |
myocardial hypertrophy induces the activation of cellular apoptosis signals and activates metabolic pathways able to increase extracellular matrix production up to fibrosis. |
2018-10-02 |
2023-08-13 |
Not clear |
| Durgesh Kumar, Umesh Kumar Goand, Sanchita Gupta, Kripa Shankar, Salil Varshney, Sujith Rajan, Ankita Srivastava, Abhishek Gupta, Achchhe Lal Vishwakarma, Anurag Kumar Srivastava, Anil N Gaikwa. Saroglitazar reduces obesity and associated inflammatory consequences in murine adipose tissue. European journal of pharmacology. vol 822. 2018-08-20. PMID:29331565. |
in the ewat of saroglitazar treated mice, histological analysis showed reduced adipocyte hypertrophy and matrix deposition (picrosirius red staining). |
2018-08-20 |
2023-08-13 |
mouse |
| Durgesh Kumar, Umesh Kumar Goand, Sanchita Gupta, Kripa Shankar, Salil Varshney, Sujith Rajan, Ankita Srivastava, Abhishek Gupta, Achchhe Lal Vishwakarma, Anurag Kumar Srivastava, Anil N Gaikwa. Saroglitazar reduces obesity and associated inflammatory consequences in murine adipose tissue. European journal of pharmacology. vol 822. 2018-08-20. PMID:29331565. |
saroglitazar exerted its beneficial effects on adipose tissue by limiting, diet-induced adipose tissue dysfunction, adipocyte hypertrophy, adipocyte cell damage and extracellular matrix deposition in obesity. |
2018-08-20 |
2023-08-13 |
mouse |
| Tangni Gómez-Leduc, Magalie Hervieu, Florence Legendre, Mouloud Bouyoucef, Nicolas Gruchy, Laurent Poulain, Claire de Vienne, Michel Herlicoviez, Magali Demoor, Philippe Galér. Chondrogenic commitment of human umbilical cord blood-derived mesenchymal stem cells in collagen matrices for cartilage engineering. Scientific reports. vol 6. 2018-08-13. PMID:27604951. |
although growth factors increased the transcription of hypertrophic chondrocyte markers such as col10a1 and mmp13, the cells present in the neo-tissue maintained their phenotype and did not progress to terminal differentiation and mineralization of the extracellular matrix after subcutaneous implantation in nude mice. |
2018-08-13 |
2023-08-13 |
mouse |
| Kevin A Murach, Christopher S Fry, Tyler J Kirby, Janna R Jackson, Jonah D Lee, Sarah H White, Esther E Dupont-Versteegden, John J McCarthy, Charlotte A Peterso. Starring or Supporting Role? Satellite Cells and Skeletal Muscle Fiber Size Regulation. Physiology (Bethesda, Md.). vol 33. issue 1. 2018-07-25. PMID:29212890. |
emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy. |
2018-07-25 |
2023-08-13 |
mouse |
| Jayaraman Jayamani, R Ravikanth Reddy, Balaraman Madhan, Ganesh Shanmuga. Disintegration of collagen fibrils by Glucono-δ-lactone: An implied lead for disintegration of fibrosis. International journal of biological macromolecules. vol 107. issue Pt A. 2018-07-24. PMID:28866016. |
excess accumulation of collagen (fibrosis) undergoes self-aggregation, which leads to fibrillar collagen, on the extracellular matrix is the hallmark of a number of diseases such as keloids, hypertrophic scars, and systemic scleroderma. |
2018-07-24 |
2023-08-13 |
Not clear |
| Paiyz E Mikael, Hyun S Kim, Syam P Nukavarap. Hybrid extracellular matrix design for cartilage-mediated bone regeneration. Journal of biomedical materials research. Part B, Applied biomaterials. vol 106. issue 1. 2018-07-17. PMID:28140522. |
thus, 70:30 ha-fb matrix demonstrated a healthy formation of chondrogenic and hypertrophic stages with rich stage-specific ecm components. |
2018-07-17 |
2023-08-13 |
human |
| Christoph Hoffmann, Cora Weiger. Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations. Cold Spring Harbor perspectives in medicine. vol 7. issue 11. 2018-06-25. PMID:28389517. |
myokines control adaptive processes in skeletal muscle by acting as paracrine regulators of fuel oxidation, hypertrophy, angiogenesis, inflammatory processes, and regulation of the extracellular matrix. |
2018-06-25 |
2023-08-13 |
Not clear |
| Zhong Li, Wei Zhan. Protective effect of berberine on renal fibrosis caused by diabetic nephropathy. Molecular medicine reports. vol 16. issue 2. 2018-06-11. PMID:29067464. |
pas and masson staining revealed that there was notable glomerular hypertrophy and mesangial matrix expansion in dn rats. |
2018-06-11 |
2023-08-13 |
rat |
| Jibin Sha, Bo Sui, Xiaoqing Su, Qingfang Meng, Chenggang Zhan. Alteration of oxidative stress and inflammatory cytokines induces apoptosis in diabetic nephropathy. Molecular medicine reports. vol 16. issue 5. 2018-06-06. PMID:28944839. |
the kidney was severely damaged in the diabetes model group, with inflammatory cell invasion, increasing amount of interstitial matrix and hypertrophy with vacuolar degeneration of renal tubular cells. |
2018-06-06 |
2023-08-13 |
Not clear |
| Meiling Zhu, Qian Feng, Yuxin Sun, Gang Li, Liming Bia. Effect of cartilaginous matrix components on the chondrogenesis and hypertrophy of mesenchymal stem cells in hyaluronic acid hydrogels. Journal of biomedical materials research. Part B, Applied biomaterials. vol 105. issue 8. 2018-05-24. PMID:27478104. |
effect of cartilaginous matrix components on the chondrogenesis and hypertrophy of mesenchymal stem cells in hyaluronic acid hydrogels. |
2018-05-24 |
2023-08-13 |
Not clear |
| Massimo Bottini, Saida Mebarek, Karen L Anderson, Agnieszka Strzelecka-Kiliszek, Lukasz Bozycki, Ana Maria Sper Simão, Maytê Bolean, Pietro Ciancaglini, Joanna Bandorowicz Pikula, Slawomir Pikula, David Magne, Niels Volkmann, Dorit Hanein, José Luis Millán, Rene Buche. Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models. Biochimica et biophysica acta. General subjects. vol 1862. issue 3. 2018-05-22. PMID:29108957. |
matrix vesicles (mvs) are released from hypertrophic chondrocytes and from mature osteoblasts, the cells responsible for endochondral and membranous ossification. |
2018-05-22 |
2023-08-13 |
Not clear |
| Hongrui Liu, Dongfang Li, Shanshan Liu, Zhaopeng Liu, Minqi L. Histochemical evidence of IGF2 mRNA-binding protein 2-mediated regulation of osteoclast function and adhesive ability. Histochemistry and cell biology. vol 149. issue 4. 2018-05-16. PMID:29322325. |
in our present study, imp2-deficient mice exhibited more immature bone structures, characterized by abundant residual cartilage cores; growth plates containing more rich cartilage matrix, which was arranged irregularly; and a significantly thicker hypertrophic chondrocyte layer in the femoral metaphysis, compared with wild-type mice. |
2018-05-16 |
2023-08-13 |
mouse |
| Ming Wang, Dan-Qian Chen, Min-Chang Wang, Hua Chen, Lin Chen, Dan Liu, Hui Zhao, Ying-Yong Zha. Poricoic acid ZA, a novel RAS inhibitor, attenuates tubulo-interstitial fibrosis and podocyte injury by inhibiting TGF-β/Smad signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 36. 2018-05-15. PMID:29157821. |
the pathogenesis of tubulo-interstitial fibrosis and glomerulosclerosisis was characterized by cellular hypertrophy, extracellular matrix accumulation and podocyte detachment. |
2018-05-15 |
2023-08-13 |
Not clear |
| Zhe Wang, Qibin Song, Hongqiu L. Suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849177. |
suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro. |
2018-05-11 |
2023-08-13 |
human |
| Zhe Wang, Qibin Song, Hongqiu L. Suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849177. |
a hypertrophic scar is characterized by fibroblast proliferation and excessive extracellular matrix deposition. |
2018-05-11 |
2023-08-13 |
human |
| Tangni Gómez-Leduc, Mélanie Desancé, Magalie Hervieu, Florence Legendre, David Ollitrault, Claire de Vienne, Michel Herlicoviez, Philippe Galéra, Magali Demoo. Hypoxia Is a Critical Parameter for Chondrogenic Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells in Type I/III Collagen Sponges. International journal of molecular sciences. vol 18. issue 9. 2018-05-03. PMID:28885597. |
however, hypoxia exerted more benefit by decreasing collagen x and matrix metalloproteinase-13 (mmp13) expression, two chondrocyte hypertrophy markers. |
2018-05-03 |
2023-08-13 |
human |
| Xiaoxia Wang, E Shen, Yanzhe Wang, Junhui Li, Dongsheng Cheng, Yuqiang Chen, Dingkun Gui, Niansong Wan. Cross talk between miR-214 and PTEN attenuates glomerular hypertrophy under diabetic conditions. Scientific reports. vol 6. 2018-05-02. PMID:27549568. |
this study aimed to investigate the therapeutic role of mirna in diabetic glomerular mcs hypertrophy and synthesis of extracellular matrix (ecm). |
2018-05-02 |
2023-08-13 |
mouse |
| Verena Dexheimer, Jessica Gabler, Katharina Bomans, Tanja Sims, Georg Omlor, Wiltrud Richte. Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation. Scientific reports. vol 6. 2018-05-02. PMID:27848974. |
conclusively, alk1,2,3,6-signalling was essential for msc-chondrogenesis and its prochondrogenic rather than prohypertrophic role may explain why inhibition of canonical bmp-signalling could not uncouple cartilage matrix production from hypertrophy as this was achieved with pulsed pthrp-application. |
2018-05-02 |
2023-08-13 |
Not clear |