| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoqian Ji, Changzheng Li, Yitao Ou, Ning Li, Kai Yuan, Guizhi Yang, Xiaoyan Chen, Zhicheng Yang, Bing Liu, Wai W Cheung, Lijing Wang, Ren Huang, Tian La. Andrographolide ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated renal oxidative stress and inflammation via Akt/NF-κB pathway. Molecular and cellular endocrinology. vol 437. 2017-11-07. PMID:27378149. |
diabetic nephropathy (dn) is characterized by proliferation of mesangial cells, mesangial hypertrophy and extracellular matrix (ecm) accumulation. |
2017-11-07 |
2023-08-13 |
mouse |
| Julia Münch, Maxim Avanesov, Peter Bannas, Dennis Säring, Elisabeth Krämer, Giulia Mearini, Lucie Carrier, Anna Suling, Gunnar Lund, Monica Patte. Serum Matrix Metalloproteinases as Quantitative Biomarkers for Myocardial Fibrosis and Sudden Cardiac Death Risk Stratification in Patients With Hypertrophic Cardiomyopathy. Journal of cardiac failure. vol 22. issue 10. 2017-11-02. PMID:27018569. |
serum matrix metalloproteinases as quantitative biomarkers for myocardial fibrosis and sudden cardiac death risk stratification in patients with hypertrophic cardiomyopathy. |
2017-11-02 |
2023-08-13 |
Not clear |
| Ling Chen, Jingyun Li, Qian Li, Hui Yan, Bei Zhou, Yanli Gao, Jun L. Non-Coding RNAs: The New Insight on Hypertrophic Scar. Journal of cellular biochemistry. vol 118. issue 8. 2017-11-02. PMID:28067426. |
hypertrophic scarring (hs), a fibroproliferative disorder caused by abnormal wound healing after skin injury, is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. |
2017-11-02 |
2023-08-13 |
Not clear |
| Hazel H Szeto, Shaoyi Liu, Yi Soong, Nazia Alam, Glen T Prusky, Surya V Sesha. Protection of mitochondria prevents high-fat diet-induced glomerulopathy and proximal tubular injury. Kidney international. vol 90. issue 5. 2017-10-31. PMID:27519664. |
the primary pathologic finding of obesity-related kidney disease is glomerulopathy, with glomerular hypertrophy, mesangial matrix expansion, and focal segmental glomerulosclerosis. |
2017-10-31 |
2023-08-13 |
mouse |
| Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion. American journal of physiology. Cell physiology. vol 313. issue 4. 2017-10-16. PMID:28701356. |
reciprocal regulation of mir-214 and pten by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion. |
2017-10-16 |
2023-08-13 |
mouse |
| Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion. American journal of physiology. Cell physiology. vol 313. issue 4. 2017-10-16. PMID:28701356. |
aberrant expression of micrornas (mirs) contributes to diabetic renal complications, including renal hypertrophy and matrix protein accumulation. |
2017-10-16 |
2023-08-13 |
mouse |
| Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion. American journal of physiology. Cell physiology. vol 313. issue 4. 2017-10-16. PMID:28701356. |
in addition, neutralization of high-glucose-stimulated mir-214 expression significantly inhibited cell hypertrophy and expression of the matrix protein fibronectin. |
2017-10-16 |
2023-08-13 |
mouse |
| E Fernlund, T Gyllenhammar, R Jablonowski, M Carlsson, A Larsson, J Ärnlöv, P Liub. Serum Biomarkers of Myocardial Remodeling and Coronary Dysfunction in Early Stages of Hypertrophic Cardiomyopathy in the Young. Pediatric cardiology. vol 38. issue 4. 2017-10-10. PMID:28361263. |
this is the first study demonstrating adverse changes in biomarkers reflecting myocardial matrix remodeling, microfibrosis, and vascular endotheliopathy in early stage of hypertrophic cardiomyopathy in the young. |
2017-10-10 |
2023-08-13 |
Not clear |
| Jun-Ichi Suzuki, Hiroki Sato, Makoto Kaneko, Asuka Yoshida, Norio Aoyama, Shouta Akimoto, Kouji Wakayama, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Yuichi Izumi, Mitsuaki Isobe, Issei Komur. Periodontitis and myocardial hypertrophy. Hypertension research : official journal of the Japanese Society of Hypertension. vol 40. issue 4. 2017-09-26. PMID:27829660. |
in murine transverse aortic constriction models, a periodontal pathogen, aggregatibacter actinomycetemcomitans markedly enhanced cardiac hypertrophy with matrix metalloproteinase-2 activation, while another pathogen porphyromonas gingivalis (p.g.) |
2017-09-26 |
2023-08-13 |
Not clear |
| Jibo Han, Chunpeng Zou, Liqin Mei, Yali Zhang, Yuanyuan Qian, Shengban You, Yong Pan, Zheng Xu, Bin Bai, Weijian Huang, Guang Lian. MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway. Basic research in cardiology. vol 112. issue 1. 2017-09-26. PMID:28013347. |
in rat cardiomyocyte-like h9c2 cells as well as rat primary cardiomyocytes, inhibition of md2 by l6h21 or sirna knockdown suppressed the ang ii-induced tlr4 signaling pathway activation including myd88 recruitment, and reduced cardiomyocyte hypertrophy and matrix protein expression. |
2017-09-26 |
2023-08-13 |
mouse |
| Siva S V P Sakamuri, Anthony J Valente, Jalahalli M Siddesha, Patrice Delafontaine, Ulrich Siebenlist, Jason D Gardner, Chandrasekar Bysan. TRAF3IP2 mediates aldosterone/salt-induced cardiac hypertrophy and fibrosis. Molecular and cellular endocrinology. vol 429. 2017-09-25. PMID:27040306. |
however, traf3ip2 gene deletion attenuated aldosterone/salt-induced (i) p65 and c-jun activation, (ii) extracellular matrix (collagen iα1 and collagen iiiα1), matrix metalloproteinase (mmp2), lysyl oxidase (lox), inflammatory cytokine (il-6 and il-18), chemokine (cxcl1 and cxcl2), and adhesion molecule (icam1) mrna expression in hearts, (iii) il-6, il-18, and mmp2 protein levels, (iv) systemic il-6 and il-18 levels, and (iv) cardiac hypertrophy and fibrosis. |
2017-09-25 |
2023-08-13 |
mouse |
| Slava Malatiali, Issam Francis, Mario Barac-Niet. Insulin Prevents Hyperfiltration and Proteinuria but Not Glomerular Hypertrophy and Increases Mesangial Matrix Expansion in Diabetic Rats. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. vol 26. issue 1. 2017-09-25. PMID:27643698. |
insulin prevents hyperfiltration and proteinuria but not glomerular hypertrophy and increases mesangial matrix expansion in diabetic rats. |
2017-09-25 |
2023-08-13 |
rat |
| Q Li, Q Yu, R Na, B Li. Etanercept protects rat cardiomyocytes against hypertrophy by regulating inflammatory cytokines secretion and cell apoptosis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 50. issue 6. 2017-09-25. PMID:28513772. |
the mrna levels of myocardial hypertrophy marker genes, including atrial natriuretic factor (anf), matrix metalloproteinase (mmp)-9 and mmp-13, were detected by qrt-pcr, and the expressions of apoptosis-related proteins (bcl-2 and bax) were measured by western blotting. |
2017-09-25 |
2023-08-13 |
rat |
| Fen Shi, Xiaoling Cao, Zhicheng Hu, Da Ma, Dong Guo, Jian Zhang, Changlin Zhang, Peng Liu, Shanqiang Qu, Jiayuan Zhu, Wuguo Deng, Bing Tan. Pleiotropic FTY720 Is a Specific and Potent Therapy for Hypertrophic Scars. The Journal of investigative dermatology. vol 137. issue 7. 2017-09-13. PMID:28288846. |
hypertrophic scarring (hs) is a fibrotic skin condition characterized by aberrant fibroblast phenotypes and excessive deposition of extracellular matrix components. |
2017-09-13 |
2023-08-13 |
rabbit |
| Shilpa Rani, Pradeep Kumar Sreenivasaiah, Jin Ock Kim, Mi Young Lee, Wan Seok Kang, Yong Sook Kim, Youngkeun Ahn, Woo Jin Park, Chunghee Cho, Do Han Ki. Tauroursodeoxycholic acid (TUDCA) attenuates pressure overload-induced cardiac remodeling by reducing endoplasmic reticulum stress. PloS one. vol 12. issue 4. 2017-09-07. PMID:28426781. |
microarray analysis followed by gene ontology (go) and pathway analysis demonstrated that extracellular matrix genes responsible for hypertrophy and fibrosis, and mitochondrial genes responsible for apoptosis and fatty acid metabolism were significantly altered in the veh-tac group, but the alterations were normalized in the tudca-tac group, suggesting potential of tudca in treatment of heart diseases related to pressure-overload. |
2017-09-07 |
2023-08-13 |
mouse |
| Rajendra Ragho. An 'Omics' Perspective on Cardiomyopathies and Heart Failure. Trends in molecular medicine. vol 22. issue 9. 2017-08-29. PMID:27499035. |
unbiased omics studies have begun to provide a glimpse into the molecular framework underpinning altered mechanotransduction, mitochondrial energetics, oxidative stress, and extracellular matrix in the heart undergoing physiological and pathological hypertrophy. |
2017-08-29 |
2023-08-13 |
Not clear |
| Vanessa Pellegrinelli, Stefania Carobbio, Antonio Vidal-Pui. Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues. Diabetologia. vol 59. issue 6. 2017-08-28. PMID:27039901. |
wat is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. |
2017-08-28 |
2023-08-13 |
Not clear |
| Gordon A Begg, Arun V Holden, Gregory Y H Lip, Sven Plein, Muzahir H Tayebje. Assessment of atrial fibrosis for the rhythm control of atrial fibrillation. International journal of cardiology. vol 220. 2017-08-28. PMID:27389440. |
fibrosis causes an increase in volume of dysfunctional extracellular matrix, and is associated with cellular alterations such as hypertrophy, apoptosis and membrane dysfunction within the atrial myocardium. |
2017-08-28 |
2023-08-13 |
Not clear |
| Adrian Santos-Ledo, Marina Garcia-Macia, Philip D Campbell, Marta Gronska, Florence L Marlo. Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis. PLoS genetics. vol 13. issue 7. 2017-08-22. PMID:28715414. |
initial cartilage specification is intact; however, during remodeling, kif5blof chondrocytes die and the cartilage matrix devoid of hypertrophic chondrocytes remains and impedes normal ossification. |
2017-08-22 |
2023-08-13 |
zebrafish |
| Tatsuki Enoshiri, Motoko Naitoh, Satoko Yamawaki, Atsushi Kawaguchi, Rino Aya, Kazuo Noda, Yasuhiro Katayama, Takahiro Doi, Tetsuma Kawaji, Shigehiko Suzuk. β-Adrenergic Receptor Blockers Reduce the Occurrence of Keloids and Hypertrophic Scars after Cardiac Device Implantation: A Single-Institution Case-Control Study. Plastic and reconstructive surgery. vol 139. issue 5. 2017-08-17. PMID:28092339. |
keloids and hypertrophic scars are characterized by excessive proliferation of fibroblasts; abnormal accumulation of extracellular matrix; and clinical findings of raised, red, itchy, and painful lesions. |
2017-08-17 |
2023-08-13 |
Not clear |