| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Li, Chao Gao, Jian-Sheng Diao, Da-Lei Wang, Fei-Fei Chu, Yang Li, Gang Wang, Shu-Zhong Guo, Wei Xi. Aberrant Notch signalling contributes to hypertrophic scar formation by modulating the phenotype of keratinocytes. Experimental dermatology. vol 25. issue 2. 2017-01-10. PMID:26566963. |
hypertrophic scar (hs) is characterized by fibroblast hyperproliferation and excessive matrix deposition. |
2017-01-10 |
2023-08-13 |
rabbit |
| Rik Osinga, Nunzia Di Maggio, Atanas Todorov, Nima Allafi, Andrea Barbero, Frédéric Laurent, Dirk Johannes Schaefer, Ivan Martin, Arnaud Scherberic. Generation of a Bone Organ by Human Adipose-Derived Stromal Cells Through Endochondral Ossification. Stem cells translational medicine. vol 5. issue 8. 2016-12-28. PMID:27334490. |
hypertrophic maturation induced upregulation of type x collagen, bone sialoprotein, and matrix metalloproteinase13 (mmp13). |
2016-12-28 |
2023-08-13 |
human |
| Kelei Chen, Kian Siang Ng, Sujata Ravi, James C H Goh, Siew Lok To. In vitro generation of whole osteochondral constructs using rabbit bone marrow stromal cells, employing a two-chambered co-culture well design. Journal of tissue engineering and regenerative medicine. vol 10. issue 4. 2016-12-26. PMID:23495238. |
the cells in the intermediate region were found to be hypertrophic chondrocytes, embedded in a calcified extracellular matrix containing glycosaminoglycans and collagen types i, ii and x. |
2016-12-26 |
2023-08-12 |
rabbit |
| Toshina Ishiguro-Oonuma, Masako Suemoto, Muneyoshi Okada, Kazuki Yoshioka, Yukio Hara, Kazuyoshi Hashizume, Keiichiro Kizak. Aberrant gene expression of heparanase in ventricular hypertrophy induced by monocrotaline in rats. The Journal of veterinary medical science. vol 78. issue 3. 2016-12-26. PMID:26638897. |
the gene expression levels of heparanase, matrix metalloproteinase 2 (mmp2) and mmp9 were examined in ventricles after treatment with monocrotaline (mct) to induce cardiac hypertrophy in rats. |
2016-12-26 |
2023-08-13 |
rat |
| Hung-Wen Liu, Chu-Chun Wei, Sue-Joan Chan. Low-molecular-weight polyphenols protect kidney damage through suppressing NF-κB and modulating mitochondrial biogenesis in diabetic db/db mice. Food & function. vol 7. issue 4. 2016-12-22. PMID:26960417. |
oligonol attenuated serum resistin and il-6 levels and reduced glomerular hypertrophy and mesangial matrix expansion caused by diabetes. |
2016-12-22 |
2023-08-13 |
mouse |
| Alessia Arcaro, Flora Pirozzi, Annalisa Angelini, Cristina Chimenti, Lia Crotti, Carla Giordano, Daniele Mancardi, Daniele Torella, Carlo G Tocchett. Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions-A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology. Oxidative medicine and cellular longevity. vol 2016. 2016-12-14. PMID:26881035. |
myocardial redox imbalance is a hallmark of this syndrome, since excessive reactive oxygen and nitrogen species can behave as signaling molecules in the pathogenesis of hypertrophy and heart failure, leading to dysregulation of cellular calcium handling, of the contractile machinery, of myocardial energetics and metabolism, and of extracellular matrix deposition. |
2016-12-14 |
2023-08-13 |
human |
| H D Amin, C R Ethie. Differential effects of tyrosine-rich amelogenin peptide on chondrogenic and osteogenic differentiation of adult chondrocytes. Cell and tissue research. vol 364. issue 1. 2016-12-13. PMID:26404401. |
thus, a long-term aci strategy should ideally incorporate methods to 'prime' autologous chondrocytes to form a cartilage-specific matrix and suppress hypertrophic mineralization. |
2016-12-13 |
2023-08-13 |
human |
| Carina Prein, Niklas Warmbold, Zsuzsanna Farkas, Matthias Schieker, Attila Aszodi, Hauke Clausen-Schauman. Structural and mechanical properties of the proliferative zone of the developing murine growth plate cartilage assessed by atomic force microscopy. Matrix biology : journal of the International Society for Matrix Biology. vol 50. 2016-12-13. PMID:26454027. |
the growth plate (gp) is a dynamic tissue driving bone elongation through chondrocyte proliferation, hypertrophy and matrix production. |
2016-12-13 |
2023-08-13 |
Not clear |
| G Zaman, K A Staines, C Farquharson, P T Newton, J Dudhia, C Chenu, A A Pitsillides, G K Dhoo. Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing. Histochemistry and cell biology. vol 145. issue 1. 2016-12-13. PMID:26464246. |
sulf2 expression unlike sulf1 also spread to the calcifying matrix around the hypertrophic chondrocytes indicating its possible ligand inhibiting role through hspg desulphation. |
2016-12-13 |
2023-08-13 |
rat |
| Traci L Parry, Gopal Desai, Jonathan C Schisler, Luge Li, Megan T Quintana, Natalie Stanley, Pamela Lockyer, Cam Patterson, Monte S Willi. Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 25. issue 2. 2016-12-13. PMID:26764147. |
in addition to pathological hypertrophy, murf1-/- mice had an unexpected differential expression in genes associated with the pleiotropic effects of fenofibrate involved in the extracellular matrix, protease inhibition, hemostasis, and the sarcomere. |
2016-12-13 |
2023-08-13 |
mouse |
| Maria-Teresa Piccoli, Christian Bär, Thomas Thu. Non-coding RNAs as modulators of the cardiac fibroblast phenotype. Journal of molecular and cellular cardiology. vol 92. 2016-12-13. PMID:26764220. |
cardiac fibroblasts are the principal orchestrators of matrix formation and degradation and indirectly regulate cardiac hypertrophy and inflammation. |
2016-12-13 |
2023-08-13 |
Not clear |
| b' A Piek, R A de Boer, H H W Sillj\\xc3\\xa. The fibrosis-cell death axis in heart failure. Heart failure reviews. vol 21. issue 2. 2016-12-13. PMID:26883434.' |
whereas pathological and physiological (exercise, pregnancy) overload both stimulate cardiomyocyte growth (hypertrophy), only pathological remodeling is characterized by increased deposition of extracellular matrix proteins, termed fibrosis, and loss of cardiomyocytes by necrosis, apoptosis and/or phagocytosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| b' Wafa Bouaziz, Johanna Sigaux, Dominique Modrowski, Claire-Sophie Devignes, Thomas Funck-Brentano, Pascal Richette, Hang-Korng Ea, Sylvain Provot, Martine Cohen-Solal, Eric Ha\\xc3\\xb. Interaction of HIF1\\xce\\xb1 and \\xce\\xb2-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 19. 2016-12-13. PMID:27122313.' |
the major metalloproteinase matrix metalloproteinase 13 (mmp13) is also associated with chondrocyte hypertrophy in adult articular cartilage, the lack of which protects from cartilage degradation and osteoarthritis (oa) in mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Xiuqin Yang, Yangang Wang, Guanqi Ga. High glucose induces rat mesangial cells proliferation and MCP-1 expression via ROS-mediated activation of NF-κB pathway, which is inhibited by eleutheroside E. Journal of receptor and signal transduction research. vol 36. issue 2. 2016-11-14. PMID:26644089. |
high glucose induces rat mesangial cells proliferation and mcp-1 expression via ros-mediated activation of nf-κb pathway, which is inhibited by eleutheroside e. glomerular hypertrophy and extracellular matrix accumulation are early features of diabetic nephropathy (dn). |
2016-11-14 |
2023-08-13 |
rat |
| J Shi, H Wang, H Guan, S Shi, Y Li, X Wu, N Li, C Yang, X Bai, W Cai, F Yang, X Wang, L Su, Z Zheng, D H. IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. Cell death & disease. vol 7. 2016-11-14. PMID:26962683. |
hypertrophic scar (hs) is a serious skin fibrotic disease characterized by excessive hypercellularity and extracellular matrix (ecm) component deposition. |
2016-11-14 |
2023-08-13 |
Not clear |
| Matthew E Deren, Xu Yang, Yingjie Guan, Qian Che. Biological and Chemical Removal of Primary Cilia Affects Mechanical Activation of Chondrogenesis Markers in Chondroprogenitors and Hypertrophic Chondrocytes. International journal of molecular sciences. vol 17. issue 2. 2016-11-04. PMID:26861287. |
cyclic loading (1 hz, 10% matrix deformation) of atdc5 cells in three-dimensional (3d) culture stimulates the mrna levels of chondrogenesis marker type ii collagen (col ii), hypertrophic chondrocyte marker type x collagen (col x), and a molecular regulator of chondrogenesis and chondrocyte hypertrophy bone morphogenetic protein 2 (bmp-2). |
2016-11-04 |
2023-08-13 |
Not clear |
| Jonathan A Kirk, Oscar H Cingolan. Thrombospondins in the transition from myocardial infarction to heart failure. Journal of molecular and cellular cardiology. vol 90. 2016-10-11. PMID:26686988. |
in the present review, we provide basic as well as clinical evidence linking the thrombospondin proteins with the post myocardial infarction response, including inflammation, fibrotic matrix remodeling, angiogenesis, as well as myocyte hypertrophy, apoptosis, and contractile dysfunction in heart failure. |
2016-10-11 |
2023-08-13 |
Not clear |
| Anita Barzegar-Fallah, Houman Alimoradi, Ali Razmi, Ahmad Reza Dehpour, Mojgan Asgari, Massoumeh Shafie. Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy. European journal of pharmacology. vol 767. 2016-10-05. PMID:26481166. |
recent studies have shown that calcineurin plays a central role in hypertrophy and extracellular matrix (ecm) accumulation in glomeruli at the early stages of diabetic nephropathy. |
2016-10-05 |
2023-08-13 |
rat |
| Chris J Watson, Stephen Horgan, Roisin Neary, Nadezhda Glezeva, Isaac Tea, Niamh Corrigan, Ken McDonald, Mark Ledwidge, John Baug. Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis. Journal of cardiovascular pharmacology and therapeutics. vol 21. issue 1. 2016-09-26. PMID:26130616. |
these pathological changes involve excessive extracellular matrix deposition within the myocardial interstitium and myocyte hypertrophy. |
2016-09-26 |
2023-08-13 |
Not clear |
| Li Ma, Chengjun Gan, Yong Huang, Ying Wang, Gaoxing Luo, Jun W. Comparative proteomic analysis of extracellular matrix proteins secreted by hypertrophic scar with normal skin fibroblasts. Burns & trauma. vol 2. issue 2. 2016-09-07. PMID:27602365. |
comparative proteomic analysis of extracellular matrix proteins secreted by hypertrophic scar with normal skin fibroblasts. |
2016-09-07 |
2023-08-13 |
Not clear |