| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stacey C Skaalure, Stanley Chu, Stephanie J Bryan. An enzyme-sensitive PEG hydrogel based on aggrecan catabolism for cartilage tissue engineering. Advanced healthcare materials. vol 4. issue 3. 2016-05-03. PMID:25296398. |
in contrast, matrix deposition in the nondegradable hydrogels consists of aggrecan and collagens i, ii, and x, indicative of hypertrophic cartilage. |
2016-05-03 |
2023-08-13 |
cattle |
| Shuang Yang, Sumita Mishra, Lijun Chen, Jian-Ying Zhou, Daniel W Chan, Subroto Chatterjee, Hui Zhan. Integrated glycoprotein immobilization method for glycopeptide and glycan analysis of cardiac hypertrophy. Analytical chemistry. vol 87. issue 19. 2016-05-02. PMID:26378618. |
we identified 291 unique glycopeptides from 195 glycoproteins; the comparative studies between wt and tac mice indicate the overexpression of extracellular proteins for heart matrix remodeling and the down-regulation of proteins associated with energy metabolism in cardiac hypertrophy. |
2016-05-02 |
2023-08-13 |
mouse |
| T Akisaka, C V Ga. The plasma membrane and matrix vesicles of mouse growth plate chondrocytes during differentiation as revealed in freeze-fracture replicas. The American journal of anatomy. vol 173. issue 4. 2016-04-23. PMID:20726124. |
imp-aggregated and imp-free matrix vesicles became increasingly frequent in the later stages of differentiation, particularly in the late hypertrophic stage. |
2016-04-23 |
2023-08-12 |
mouse |
| Xiaozhi Bai, Ting He, Jiaqi Liu, Yunchuan Wang, Lei Fan, Ke Tao, Jihong Shi, Chaowu Tang, Linlin Su, Dahai H. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Experimental dermatology. vol 24. issue 5. 2016-04-22. PMID:25683490. |
loureirin b inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via tgf-β/smad pathway. |
2016-04-22 |
2023-08-13 |
human |
| Mario Notari, Julián Pulecio, Ángel Ray. Update on the Pathogenic Implications and Clinical Potential of microRNAs in Cardiac Disease. BioMed research international. vol 2015. 2016-04-21. PMID:26221581. |
for instance, acute myocardial infarction induces cardiac tissue necrosis and apoptosis but also initiates a pathological remodelling response of the left ventricle that includes hypertrophic growth of cardiomyocytes and fibrotic deposition of extracellular matrix components. |
2016-04-21 |
2023-08-13 |
Not clear |
| Chia-Li M Shih, Kolapo M Ajuwo. Inhibition of MMP-13 prevents diet-induced obesity in mice and suppresses adipogenesis in 3T3-L1 preadipocytes. Molecular biology reports. vol 42. issue 7. 2016-03-10. PMID:25682268. |
adipose tissue remodeling by the matrix metalloproteases (mmps) is critical for tissue hypertrophy and obesity. |
2016-03-10 |
2023-08-13 |
mouse |
| Jing-Jing Yang, Yan-ru Huang, Yi-gang Wan, Shan-mei Shen, Zhi-min Mao, Wei Wu, Jian Ya. [Regulative mechanisms of mammalian target of rapamycin signaling pathway in glomerular hypertrophy in diabetic nephropathy and interventional effects of Chinese herbal medicine]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 16. 2016-03-10. PMID:26790279. |
rapamycin, the inhibitor of mtor, could suppress glomerular inherent cell hypertrophy, cell proliferation, glomerular basement membrane (gbm) thickening and mesangial matrix deposition in model rats with dn. |
2016-03-10 |
2023-08-13 |
rat |
| Wei-Jian Ni, Hai-Hua Ding, Li-Qin Tan. Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms. European journal of pharmacology. vol 760. 2016-03-08. PMID:25912800. |
diabetic nephropathy is a progressive kidney disorder and is pathologically characterized by thickened glomerular and tubular basement membranes, accumulation of the extracellular matrix and increased mesangial hypertrophy. |
2016-03-08 |
2023-08-13 |
Not clear |
| Koichi Matsuo, Yukiko Kuroda, Nobuhito Nango, Kouji Shimoda, Yoshiaki Kubota, Masatsugu Ema, Latifa Bakiri, Erwin F Wagner, Yoshihiro Takeda, Wataru Yashiro, Atsushi Momos. Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus. Development (Cambridge, England). vol 142. issue 22. 2016-03-04. PMID:26428006. |
terminally differentiated hypertrophic chondrocytes are calcified, vascularized, and removed by chondroclasts before bone matrix is laid down by osteoblasts. |
2016-03-04 |
2023-08-13 |
mouse |
| Hirohisa Kawahata, Daisuke Sotobayashi, Motokuni Aoki, Hideo Shimizu, Hironori Nakagami, Toshio Ogihara, Ryuichi Morishit. Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse. Hypertension research : official journal of the Japanese Society of Hypertension. vol 38. issue 6. 2016-03-03. PMID:25693858. |
it was also confirmed by a significant increase in the mrna expression of sox9 and runt-related transcription factor 2 (runx2), which are genes related to chondrocyte differentiation, and type x collagen, matrix metalloproteinase (mmp)-13 and indian hedgehog (ihh), which are hypertrophic chondrocyte-specific molecular markers. |
2016-03-03 |
2023-08-13 |
mouse |
| Jianquan Chen, Nilsson Holguin, Yu Shi, Matthew J Silva, Fanxin Lon. mTORC2 signaling promotes skeletal growth and bone formation in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 30. issue 2. 2016-02-22. PMID:25196701. |
subsequently, the embryonic skeletal elements are shortened due to a delay in chondrocyte hypertrophy, with no change in proliferation, apoptosis, cell size, or matrix production. |
2016-02-22 |
2023-08-13 |
mouse |
| Nirmalya Dey, Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression. Cellular signalling. vol 27. issue 7. 2016-02-16. PMID:25797045. |
high glucose enhances microrna-26a to activate mtorc1 for mesangial cell hypertrophy and matrix protein expression. |
2016-02-16 |
2023-08-13 |
Not clear |
| Nirmalya Dey, Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression. Cellular signalling. vol 27. issue 7. 2016-02-16. PMID:25797045. |
high glucose milieu inhibits pten expression to activate akt kinase and induces glomerular mesangial cell hypertrophy and matrix protein expression in diabetic nephropathy. |
2016-02-16 |
2023-08-13 |
Not clear |
| Nirmalya Dey, Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression. Cellular signalling. vol 27. issue 7. 2016-02-16. PMID:25797045. |
akt-mediated phosphorylation of tuberin and pras40 regulates mtorc1, which is necessary for mesangial cell hypertrophy and matrix protein expression. |
2016-02-16 |
2023-08-13 |
Not clear |
| Nirmalya Dey, Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression. Cellular signalling. vol 27. issue 7. 2016-02-16. PMID:25797045. |
together our results provide the first evidence for the involvement of mir-26a in high glucose-induced mesangial cell hypertrophy and matrix protein expression. |
2016-02-16 |
2023-08-13 |
Not clear |
| Ilja L Krugliko. Microstructural inhomogeneity of electrical conductivity in subcutaneous fat tissue. PloS one. vol 10. issue 3. 2016-01-27. PMID:25734656. |
this effect is connected with different electrical conductivities of pathways inside (triglycerides in adipocytes) and outside (extra-cellular matrix) the cells and to the different weighting of these pathways in hypertrophic and hyperplastic types of swat. |
2016-01-27 |
2023-08-13 |
Not clear |
| Ilja L Krugliko. Microstructural inhomogeneity of electrical conductivity in subcutaneous fat tissue. PloS one. vol 10. issue 3. 2016-01-27. PMID:25734656. |
the application of the rf current to hypertrophic swat, which normally has a strongly developed extracellular matrix with high concentrations of hyaluronan and collagen in a peri-cellular space of adipocytes, can produce, micro-structurally, a highly inhomogeneous temperature distribution, characterized by strong temperature gradients between the peri-cellular sheath of the extra-cellular matrix around the hypertrophic adipocytes and their volumes. |
2016-01-27 |
2023-08-13 |
Not clear |
| Jenny Y Y Ooi, Natasha K Tuano, Haloom Rafehi, Xiao-Ming Gao, Mark Ziemann, Xiao-Jun Du, Assam El-Ost. HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. Epigenetics. vol 10. issue 5. 2016-01-25. PMID:25941940. |
pressure overload-induced cardiac hypertrophy was associated with histone acetylation of genes implicated in cardiac contraction, collagen deposition, inflammation, and extracellular matrix identified by chip-seq. |
2016-01-25 |
2023-08-13 |
human |
| Amaia Rodríguez, Silvia Ezquerro, Leire Méndez-Giménez, Sara Becerril, Gema Frühbec. Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism. American journal of physiology. Endocrinology and metabolism. vol 309. issue 8. 2016-01-25. PMID:26330344. |
the mechanisms underlying the development of obesity and its associated comorbidities include the hypertrophy and/or hyperplasia of adipocytes, adipose tissue inflammation, impaired extracellular matrix remodeling, and fibrosis together with an altered secretion of adipokines. |
2016-01-25 |
2023-08-13 |
Not clear |
| Laura Cinque, Alison Forrester, Rosa Bartolomeo, Maria Svelto, Rossella Venditti, Sandro Montefusco, Elena Polishchuk, Edoardo Nusco, Antonio Rossi, Diego L Medina, Roman Polishchuk, Maria Antonietta De Matteis, Carmine Settembr. FGF signalling regulates bone growth through autophagy. Nature. vol 528. issue 7581. 2016-01-15. PMID:26595272. |
we investigated the role of autophagy during bone growth, which is mediated by chondrocyte rate of proliferation, hypertrophic differentiation and extracellular matrix (ecm) deposition in growth plates. |
2016-01-15 |
2023-08-13 |
mouse |