| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yves Gorin, Rita C Cavaglieri, Khaled Khazim, Doug-Yoon Lee, Francesca Bruno, Sachin Thakur, Paolo Fanti, Cédric Szyndralewiez, Jeffrey L Barnes, Karen Block, Hanna E Abbou. Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes. American journal of physiology. Renal physiology. vol 308. issue 11. 2015-08-13. PMID:25656366. |
gkt137831 significantly reduced glomerular hypertrophy, mesangial matrix expansion, urinary albumin excretion, and podocyte loss in ove26 mice. |
2015-08-13 |
2023-08-13 |
mouse |
| Dylan E Lee, Ryan M Trowbridge, Nagi T Ayoub, Devendra K Agrawa. High-mobility Group Box Protein-1, Matrix Metalloproteinases, and Vitamin D in Keloids and Hypertrophic Scars. Plastic and reconstructive surgery. Global open. vol 3. issue 6. 2015-07-16. PMID:26180726. |
high-mobility group box protein-1, matrix metalloproteinases, and vitamin d in keloids and hypertrophic scars. |
2015-07-16 |
2023-08-13 |
Not clear |
| Dong Huang, Yingping Liu, Yongjun Huang, Youfu Xie, Kuanhong Shen, Dawei Zhang, Yong Mo. Mechanical compression upregulates MMP9 through SMAD3 but not SMAD2 modulation in hypertrophic scar fibroblasts. Connective tissue research. vol 55. issue 5-6. 2015-07-08. PMID:25166894. |
activation of transforming growth factor-β (tgf-β) signaling and matrix metalloproteinases are involved in hypertrophic scar (hs) formation. |
2015-07-08 |
2023-08-13 |
Not clear |
| Norikazu Hinamoto, Yohei Maeshima, Hiroko Yamasaki, Tatsuyo Nasu, Daisuke Saito, Hiroyuki Watatani, Haruyo Ujike, Katsuyuki Tanabe, Kana Masuda, Yuka Arata, Hitoshi Sugiyama, Yasufumi Sato, Hirofumi Makin. Exacerbation of diabetic renal alterations in mice lacking vasohibin-1. PloS one. vol 9. issue 9. 2015-06-22. PMID:25255225. |
furthermore, the renal and glomerular hypertrophy, glomerular accumulation of mesangial matrix and type iv collagen and activation of renal tgf-β1/smad3 signaling, a key mediator of renal fibrosis, were exacerbated in the diabetic vash1(+/-) mice compared with the diabetic wild-type littermates. |
2015-06-22 |
2023-08-13 |
mouse |
| Jennifer Fischer, Antje Aulmann, Verena Dexheimer, Tobias Grossner, Wiltrud Richte. Intermittent PTHrP(1-34) exposure augments chondrogenesis and reduces hypertrophy of mesenchymal stromal cells. Stem cells and development. vol 23. issue 20. 2015-06-12. PMID:24836507. |
pulsed pthrp exposure of mscs stimulated chondrogenesis and reduced endochondral differentiation apparently uncoupling chondrogenic matrix deposition from hypertrophic marker expression. |
2015-06-12 |
2023-08-13 |
human |
| Samy L Habi. Alterations in tubular epithelial cells in diabetic nephropathy. Journal of nephrology. vol 26. issue 5. 2015-06-04. PMID:24052469. |
renal hypertrophy, matrix protein accumulation and tubulointerstitial fibrosis are major pathological features of diabetic nephropathy (dn) that eventuate in renal failure. |
2015-06-04 |
2023-08-12 |
human |
| Shao-Qing Zhang, Yi-Ting Sun, Tian-Hua Xu, Xue-Feng Zhang, Ying-Zhong Liu, Ma Jian-Fei Ma, Li-Ning Wang, Li Ya. Protective effect of metformin on renal injury of C57BL/6J mouse treated with high fat diet. Die Pharmazie. vol 69. issue 12. 2015-06-02. PMID:25951664. |
at the end of 12th week, compared with mice on low fat diet (lfd), body weight (bw), the levels of fasting insulin (fins), plasma and renal triglyceride (tg) were higher and plasma high density lipoprotein (hdl) and insulin sensitivity index (isi) were significantly lower, but the levels of fasting blood glycemia (fbg), plasma total cholesterol (tc) and renal tc had no changes; oil red o staining revealed renal lipids deposition, masson staining and he staining revealed glomerular hypertrophy, matrix increasing, and inflammatory cells infiltration in glomerular; the expression of p-ampkα protein decreased and the expression of srebp-1c, tnf-α, nox4 mrna increased significantly in mouse treated with high fat diet (hfd). |
2015-06-02 |
2023-08-13 |
mouse |
| Meiling Zhu, Qian Feng, Liming Bia. Differential effect of hypoxia on human mesenchymal stem cell chondrogenesis and hypertrophy in hyaluronic acid hydrogels. Acta biomaterialia. vol 10. issue 3. 2015-05-12. PMID:24342044. |
in addition, at a constant high ha concentration, increasing hydrogel crosslinking density promoted hmsc hypertrophy and matrix calcification. |
2015-05-12 |
2023-08-12 |
human |
| Chenyu Huang, Rei Ogaw. The link between hypertension and pathological scarring: does hypertension cause or promote keloid and hypertrophic scar pathogenesis? Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 22. issue 4. 2015-05-12. PMID:24899409. |
pathological scars, namely, keloids and hypertrophic scars (hss), are caused by excessive cutaneous wound healing that is characterized by histological extracellular matrix (ecm) accumulation, clinically relevant irritating symptoms, and frequent recurrence after surgical excision. |
2015-05-12 |
2023-08-13 |
Not clear |
| Laura C O'Brien, Eleonora Mezzaroma, Benjamin W Van Tassell, Carlo Marchetti, Salvatore Carbone, Antonio Abbate, Stefano Told. Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure. Molecular medicine (Cambridge, Mass.). vol 20. 2015-05-11. PMID:24804827. |
in animal models of acute myocardial infarction (ami), pressure overload, and lps-induced dysfunction, il-18 regulates cardiomyocyte hypertrophy and induces cardiac contractile dysfunction and extracellular matrix remodeling. |
2015-05-11 |
2023-08-13 |
human |
| Elen Rizzi, Danielle A Guimaraes, Carla S Ceron, Cibele M Prado, Lucas C Pinheiro, Alisson Martins-Oliveira, Raquel F Gerlach, Jose E Tanus-Santo. β1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. Free radical biology & medicine. vol 73. 2015-05-11. PMID:24933619. |
β1-adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. |
2015-05-11 |
2023-08-13 |
rat |
| Elen Rizzi, Danielle A Guimaraes, Carla S Ceron, Cibele M Prado, Lucas C Pinheiro, Alisson Martins-Oliveira, Raquel F Gerlach, Jose E Tanus-Santo. β1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. Free radical biology & medicine. vol 73. 2015-05-11. PMID:24933619. |
hypertension induces left-ventricular hypertrophy (lvh) by mechanisms involving oxidative stress and unbalanced cardiac matrix metalloproteinase (mmp) activity. |
2015-05-11 |
2023-08-13 |
rat |
| Meenalakshmi M Mariappan, Sanjay Prasad, Kristin D'Silva, Esteban Cedillo, Kavithalakshmi Sataranatarajan, Jeffrey L Barnes, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Activation of glycogen synthase kinase 3β ameliorates diabetes-induced kidney injury. The Journal of biological chemistry. vol 289. issue 51. 2015-04-21. PMID:25339176. |
increase in protein synthesis contributes to kidney hypertrophy and matrix protein accumulation in diabetes. |
2015-04-21 |
2023-08-13 |
mouse |
| Meenalakshmi M Mariappan, Sanjay Prasad, Kristin D'Silva, Esteban Cedillo, Kavithalakshmi Sataranatarajan, Jeffrey L Barnes, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Activation of glycogen synthase kinase 3β ameliorates diabetes-induced kidney injury. The Journal of biological chemistry. vol 289. issue 51. 2015-04-21. PMID:25339176. |
snp administered for 3 weeks to mice with streptozotocin-induced type 1 diabetes ameliorated kidney hypertrophy, accumulation of matrix proteins, and albuminuria without changing blood glucose levels. |
2015-04-21 |
2023-08-13 |
mouse |
| Tetsuya Enishi, Kiminori Yukata, Mitsuhiko Takahashi, Ryosuke Sato, Koichi Sairyo, Natsuo Yasu. Hypertrophic chondrocytes in the rabbit growth plate can proliferate and differentiate into osteogenic cells when capillary invasion is interposed by a membrane filter. PloS one. vol 9. issue 8. 2015-04-17. PMID:25121501. |
at the terminal end of the growth plate, hypertrophic chondrocytes extruded from their territorial matrix into the open cavity on the surface of the membrane filter. |
2015-04-17 |
2023-08-13 |
rabbit |
| Guido Tarone, Jean-Luc Balligand, Johann Bauersachs, Angela Clerk, Leon De Windt, Stephane Heymans, Denise Hilfiker-Kleiner, Emilio Hirsch, Guido Iaccarino, Ralph Knöll, Adelino F Leite-Moreira, André P Lourenço, Manuel Mayr, Thomas Thum, Carlo G Tocchett. Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. European journal of heart failure. vol 16. issue 5. 2015-04-10. PMID:24639064. |
these include potentiating cardiomyocyte contractility, increasing cardiomyocyte survival and adaptive hypertrophy, increasing oxygen and nutrition supply by sustaining vessel formation, and reducing ventricular stiffness by favourable extracellular matrix remodelling. |
2015-04-10 |
2023-08-12 |
Not clear |
| Chao Li, Hua-Yu Zhu, Wen-Dong Bai, Lin-Lin Su, Jia-Qi Liu, Wei-Xia Cai, Bin Zhao, Jian-Xin Gao, Shi-Chao Han, Jun Li, Da-Hai H. MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars by targeting PAI-1 and uPA. FEBS letters. vol 589. issue 3. 2015-04-10. PMID:25554417. |
urokinase type plasminogen activator (upa) and plasminogen activator inhibitor-1 (pai-1) have been proposed to play key roles in extracellular matrix (ecm) deposition in hypertrophic scars (hs). |
2015-04-10 |
2023-08-13 |
Not clear |
| Sebastian Winocour, Joshua Vorstenbosch, Alissa Trzeciak, Lucie Lessard, Anie Phili. CD109, a novel TGF-β antagonist, decreases fibrotic responses in a hypoxic wound model. Experimental dermatology. vol 23. issue 7. 2015-04-07. PMID:24815824. |
excessive extracellular matrix deposition that occurs in many fibrotic skin disorders such as hypertrophic scarring and scleroderma is often associated with hypoxia. |
2015-04-07 |
2023-08-13 |
mouse |
| M Mathieu, S Vigier, M N Labour, C Jorgensen, E Belamie, D Noë. Induction of mesenchymal stem cell differentiation and cartilage formation by cross-linker-free collagen microspheres. European cells & materials. vol 28. 2015-04-02. PMID:25179212. |
human msc rapidly adhered to tgf-β3-loaded microspheres and, after 21 d of culture, exhibited typical chondrocyte morphology and produced an uncalcified matrix made of the predominant cartilage components, aggrecan and type ii collagen, but devoid of the hypertrophic marker type x collagen. |
2015-04-02 |
2023-08-13 |
mouse |
| Jian-Yu Chen, Lei Zhang, Hong Zhang, Li Su, Lu-Ping Qi. Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts. Phytotherapy research : PTR. vol 28. issue 10. 2015-03-31. PMID:24706573. |
hypertrophic scarring is characterized by collagen overproduction and excessive deposition of extracellular matrix. |
2015-03-31 |
2023-08-13 |
Not clear |