| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Adele Alberelli, Erica De Candi. Functional role of protease activated receptors in vascular biology. Vascular pharmacology. vol 62. issue 2. 2015-03-31. PMID:24924409. |
however, in conditions associated with endothelial dysfunction, pars mediate contraction, proliferation, migration, hypertrophy of vsmcs and their production of extracellular matrix, thereby contributing to the pathophysiology of atherosclerosis and hypertension. |
2015-03-31 |
2023-08-13 |
Not clear |
| Qia Zhang, Sunil K Joshi, David H Lovett, Bryon Zhang, Sue Bodine, Hubert T Kim, Xuhui Li. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles, ligaments and tendons journal. vol 4. issue 4. 2015-03-13. PMID:25767782. |
matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. |
2015-03-13 |
2023-08-13 |
Not clear |
| Moses B Ekong, Mine D Peter, Aniekan I Peter, Mokutima A Eluwa, Idorenyin U Umoh, Anozeng O Igiri, Theresa B Ekane. Cerebellar neurohistology and behavioural effects of gongronema latifolium and Rauwolfia vomitoria in mice. Metabolic brain disease. vol 29. issue 2. 2015-03-05. PMID:24254993. |
neurohistology of the cerebellum showed slight hypertrophy of purkinje cells, with brain matrix loss in treatment groups 2 and 3, but group 4 showed no apparent histopathology. |
2015-03-05 |
2023-08-12 |
mouse |
| Peihua Zhang, Jin Li, Xudong Tang, Junlei Zhang, Jie Liang, Guofang Zen. Dracorhodin perchlorate induces apoptosis in primary fibroblasts from human skin hypertrophic scars via participation of caspase-3. European journal of pharmacology. vol 728. 2015-03-02. PMID:24525335. |
hypertrophic scar (hs) is an abnormally proliferative disorder characterized by excessive proliferation of fibroblasts and redundant deposition of extracellular matrix. |
2015-03-02 |
2023-08-12 |
human |
| M Fuers. [Chondrocalcinosis. Clinical impact of intra-articular calcium phosphate crystals]. Zeitschrift fur Rheumatologie. vol 73. issue 5. 2015-02-23. PMID:24924727. |
in the process of endochondral ossification, the link between hypertrophy and matrix mineralization is particularly well described. |
2015-02-23 |
2023-08-13 |
Not clear |
| M Fuers. [Chondrocalcinosis. Clinical impact of intra-articular calcium phosphate crystals]. Zeitschrift fur Rheumatologie. vol 73. issue 5. 2015-02-23. PMID:24924727. |
hypertrophic chondrocytes in oa cartilage and at the growth line share certain features, not only hypertrophy but also a capability to mineralize the matrix. |
2015-02-23 |
2023-08-13 |
Not clear |
| Waldemar Hoffmann, Sandra Feliciano, Ivan Martin, Michael de Wild, David Wend. Novel Perfused Compression Bioreactor System as an in vitro Model to Investigate Fracture Healing. Frontiers in bioengineering and biotechnology. vol 3. 2015-02-20. PMID:25699254. |
our findings provide a proof-of-principle that dynamic mechanical loading applied by the pcb can enhance the maturation process of mesenchymal stromal cells toward late hypertrophic chondrocytes and the mineralization of the deposited extracellular matrix. |
2015-02-20 |
2023-08-13 |
human |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 289. issue 47. 2015-02-12. PMID:25288788. |
high glucose forces a positive feedback loop connecting akt kinase and foxo1 transcription factor to activate mtorc1 kinase for mesangial cell hypertrophy and matrix protein expression. |
2015-02-12 |
2023-08-13 |
mouse |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 289. issue 47. 2015-02-12. PMID:25288788. |
high glucose-induced akt acts as a signaling hub for mesangial cell hypertrophy and matrix expansion, which are recognized as cardinal signatures for the development of diabetic nephropathy. |
2015-02-12 |
2023-08-13 |
mouse |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 289. issue 47. 2015-02-12. PMID:25288788. |
together, our results provide the first evidence for the presence of a positive feedback loop for the sustained activation of akt involving inactivated foxo1 and a decrease in catalase expression, leading to increased ros and mesangial cell hypertrophy and matrix protein expression. |
2015-02-12 |
2023-08-13 |
mouse |
| Xu Yang, Samir K Trehan, Yingjie Guan, Changqi Sun, Douglas C Moore, Chathuraka T Jayasuriya, Qian Che. Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist. The Journal of biological chemistry. vol 289. issue 50. 2015-02-12. PMID:25331953. |
hence, as a novel bmp-2-binding protein and antagonist in the cartilage extracellular matrix, matn3 may have the inherent ability to inhibit premature chondrocyte hypertrophy by suppressing bmp-2/smad1 activity. |
2015-02-12 |
2023-08-13 |
mouse |
| Kristen L Lauing, Mauricio Cortes, Miriam S Domowicz, Judith G Henry, Alexis T Baria, Nancy B Schwart. Aggrecan is required for growth plate cytoarchitecture and differentiation. Developmental biology. vol 396. issue 2. 2015-02-05. PMID:25446537. |
aggrecan-null growth plates were devoid of matrix and lacked chondrocyte organization and differentiation, while those of the rescue embryos exhibited matrix production concomitant with partial zonation of chondrocytes having proliferative and hypertrophic morphologies. |
2015-02-05 |
2023-08-13 |
mouse |
| Katsuhiko Amano, Michael Densmore, Riko Nishimura, Beate Lansk. Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2/Smads interactions. The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:25028519. |
independent of this function, we and others recently reported independent ihh functions to promote chondrocyte hypertrophy and matrix mineralization in vivo and in vitro. |
2015-01-28 |
2023-08-13 |
Not clear |
| Tarek Hamdy Abd-Elhamid, Marianne L Conway, Allan R Sinnin. The hLAMP-1-positive particulate matrix involved in cardiac mesenchyme formation in the chick does not include BMP-2. Cells, tissues, organs. vol 198. issue 5. 2015-01-22. PMID:24503594. |
the particulate matrix causes a subset of endocardial cells to hypertrophy, lose their cell-cell contacts, form migratory processes, transform into mesenchymal cells, and migrate into the underlying endocardial cushions. |
2015-01-22 |
2023-08-12 |
chicken |
| Malihe-Sadat Poormasjedi-Meibod, Ryan Hartwell, Ruhangiz Taghi Kilani, Aziz Ghahar. Anti-scarring properties of different tryptophan derivatives. PloS one. vol 9. issue 3. 2015-01-13. PMID:24637853. |
hypertrophic scars are associated with prolonged extracellular matrix (ecm) production, aberrant ecm degradation and high tissue cellularity. |
2015-01-13 |
2023-08-12 |
rabbit |
| Trevi A Ramirez, Rugmani Padmanabhan Iyer, Omid Ghasemi, Elizabeth F Lopez, Daniel B Levin, Jianhua Zhang, Rogelio Zamilpa, Youn-Min Chou, Yu-Fang Jin, Merry L Lindse. Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects. Journal of molecular and cellular cardiology. vol 72. 2015-01-13. PMID:24768766. |
the treatments influenced systolic function and hypertrophy index, as well as extracellular matrix (ecm) and inflammatory genes in the remote region, indicating that primary effects were on the viable myocardium. |
2015-01-13 |
2023-08-13 |
mouse |
| Ana M Briones, Rosa Aras-López, María J Alonso, Mercedes Salaice. Small artery remodeling in obesity and insulin resistance. Current vascular pharmacology. vol 12. issue 3. 2015-01-05. PMID:24846232. |
in general, vascular remodeling of small arteries associated to cardiometabolic diseases seems to be hypertrophic and it is associated to increased extracellular matrix deposition, although specific vascular beds might show different structural patterns. |
2015-01-05 |
2023-08-13 |
Not clear |
| Zhenyu Zhang, Yan Wang, Mingchao Li, Jiaping Li, Jian W. Fibroblast growth factor 18 increases the trophic effects of bone marrow mesenchymal stem cells on chondrocytes isolated from late stage osteoarthritic patients. Stem cells international. vol 2014. 2014-12-29. PMID:25544847. |
results from transwell coculture study showed that expression of matrix producing genes in oa chondrocytes increased when cocultured with mscs with fgf18 in culture medium, while hypertrophic genes were not changed by coculture. |
2014-12-29 |
2023-08-13 |
Not clear |
| Nancy E Castro, Mitsuo Kato, Jung Tak Park, Rama Nataraja. Transforming growth factor β1 (TGF-β1) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells. The Journal of biological chemistry. vol 289. issue 42. 2014-12-22. PMID:25204661. |
increased expression of transforming growth factor-β1 (tgf-β1) in glomerular mesangial cells (mc) augments extracellular matrix accumulation and hypertrophy during the progression of diabetic nephropathy (dn), a debilitating renal complication of diabetes. |
2014-12-22 |
2023-08-13 |
mouse |
| Qia Zhang, Sunil K Joshi, David H Lovett, Bryon Zhang, Sue Bodine, Hubert Kim, Xuhui Li. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles, ligaments and tendons journal. vol 4. issue 3. 2014-12-09. PMID:25489556. |
matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. |
2014-12-09 |
2023-08-13 |
Not clear |