| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ewelyne Miranda Lima, Andrews Marques Nascimento, Girlandia Alexandre Brasil, Ieda Carneiro Kalil, Dominik Lenz, Denise Coutinho Endringer, Tadeu Uggere Andrade, Nazaré Souza Bissol. Cardiopulmonary reflex, cardiac cytokines, and nandrolone decanoate: response to resistance training in rats. Canadian journal of physiology and pharmacology. vol 93. issue 11. 2016-08-18. PMID:26335603. |
myocyte hypertrophy and matrix collagen deposition were determined by morphometric analysis of h&e and picrosirius red-stained samples, respectively. |
2016-08-18 |
2023-08-13 |
rat |
| Ewelyne Miranda Lima, Andrews Marques Nascimento, Girlandia Alexandre Brasil, Ieda Carneiro Kalil, Dominik Lenz, Denise Coutinho Endringer, Tadeu Uggere Andrade, Nazaré Souza Bissol. Cardiopulmonary reflex, cardiac cytokines, and nandrolone decanoate: response to resistance training in rats. Canadian journal of physiology and pharmacology. vol 93. issue 11. 2016-08-18. PMID:26335603. |
the association of nd with rt increased myocyte hypertrophy, deposition of matrix type i collagen, tnf-α and acea; decreased il-10, and impairment in the bjr were observed in nd+exerc compared with cont and exerc. |
2016-08-18 |
2023-08-13 |
rat |
| Neethu Mohan, Jijo Wilson, Dexy Joseph, Dhanesh Vaikkath, Prabha D Nai. Biomimetic fiber assembled gradient hydrogel to engineer glycosaminoglycan enriched and mineralized cartilage: An in vitro study. Journal of biomedical materials research. Part A. vol 103. issue 12. 2016-08-11. PMID:26014103. |
chondrocytes cultured on these fibers secreted a mineralized matrix that consisted of sgag, hypertrophic proteins, collagen type x, and osteocalcin. |
2016-08-11 |
2023-08-13 |
Not clear |
| Xinying Zhang, Tiemin Zhang, Jichao Wu, Xiangjing Yu, Dan Zheng, Fan Yang, Ting Li, Lina Wang, Yajun Zhao, Shiyun Dong, Xin Zhong, Songbin Fu, Chang-qing Xu, Fanghao Lu, Wei-hua Zhan. Calcium sensing receptor promotes cardiac fibroblast proliferation and extracellular matrix secretion. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 33. issue 3. 2016-08-01. PMID:24603056. |
the present study investigated whether car played a role in cardiac fibroblast proliferation and extracellular matrix (ecm) secretion, both in cultured rat neonatal cardiac fibroblasts and in a model of cardiac hypertrophy induced by isoproterenol (iso). |
2016-08-01 |
2023-08-12 |
rat |
| Sejin Han, Yuk Yin Li, Barbara Pui Cha. Extracellular Protease Inhibition Alters the Phenotype of Chondrogenically Differentiating Human Mesenchymal Stem Cells (MSCs) in 3D Collagen Microspheres. PloS one. vol 11. issue 1. 2016-07-08. PMID:26760956. |
results showed that inhibition of matrix proteases particularly the extracellular ones favors the phenotype of fibrocartilage rather than hyaline cartilage in chondrogenically differentiating hmscs by upregulating type i collagen protein deposition and type ii collagen gene expression without significantly altering the hypertrophic markers at gene level. |
2016-07-08 |
2023-08-13 |
human |
| Samina Hyder Ha. 5-Aza-2'-deoxycytidine acts as a modulator of chondrocyte hypertrophy and maturation in chick caudal region chondrocytes in culture. Anatomy & cell biology. vol 49. issue 2. 2016-07-06. PMID:27382512. |
scanning electron microscopy at day 7 showed chondrocytes to have increased in cell volume and at day 14 in culture the extracellular matrix of the pretreated cultures showed regular fibrillar structure heavily embedded with matrix vesicles, which is the characteristic feature of chondrocyte hypertrophy. |
2016-07-06 |
2023-08-13 |
chicken |
| Oliver Dörr, Christoph Liebetrau, Helge Möllmann, Luise Gaede, Christian Troidl, Kareen Morczeck, Jens Wiebe, Jedrzej Hoffmann, Sandra Voss, Timm Bauer, Christian Hamm, Holger Ne. Influence of Renal Sympathetic Denervation on Cardiac Extracellular Matrix Turnover and Cardiac Fibrosis. American journal of hypertension. vol 28. issue 10. 2016-06-23. PMID:25767136. |
extracellular matrix (ecm) turnover and deposition are essential processes in ht-related cardiovascular remodeling, fibrosis, and cardiac hypertrophy and contribute to hypertensive heart disease. |
2016-06-23 |
2023-08-13 |
Not clear |
| Clare L Thompson, Anna Wiles, C Anthony Poole, Martin M Knigh. Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 2. 2016-06-17. PMID:26499268. |
hedgehog signaling is activated in osteoarthritis, where it promotes chondrocyte hypertrophy and cartilage matrix catabolism. |
2016-06-17 |
2023-08-13 |
human |
| Stefany B A Cau, Danielle A Guimaraes, Elen Rizzi, Carla S Ceron, Raquel F Gerlach, Jose E Tanus-Santo. The Nuclear Factor kappaB Inhibitor Pyrrolidine Dithiocarbamate Prevents Cardiac Remodelling and Matrix Metalloproteinase-2 Up-Regulation in Renovascular Hypertension. Basic & clinical pharmacology & toxicology. vol 117. issue 4. 2016-06-14. PMID:25816715. |
imbalanced matrix metalloproteinase (mmp) activity is involved in hypertensive cardiac hypertrophy. |
2016-06-14 |
2023-08-13 |
rat |
| Porfyrios Korompelis, Christina Piperi, Christos Adamopoulos, Georgia Dalagiorgou, Penelope Korkolopoulou, Athanasia Sepsa, Aris Antsaklis, Athanasios G Papavassilio. Expression of vascular endothelial factor-A, gelatinases (MMP-2, MMP-9) and TIMP-1 in uterine leiomyomas. Clinical chemistry and laboratory medicine. vol 53. issue 9. 2016-06-07. PMID:25470608. |
leiomyomas growth involves cellular hypertrophy, modulation of mitotic activity and upregulation of extracellular matrix (ecm). |
2016-06-07 |
2023-08-13 |
Not clear |
| Young-Hyun You, Tammy Quach, Rintaro Saito, Jessica Pham, Kumar Sharm. Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease. Journal of the American Society of Nephrology : JASN. vol 27. issue 2. 2016-06-07. PMID:26203118. |
we report that podocyte-specific induction of nox4 in vivo was sufficient to recapitulate the characteristic glomerular changes noted with dkd, including glomerular hypertrophy, mesangial matrix accumulation, glomerular basement membrane thickening, albuminuria, and podocyte dropout. |
2016-06-07 |
2023-08-13 |
mouse |
| Young-Hyun You, Tammy Quach, Rintaro Saito, Jessica Pham, Kumar Sharm. Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease. Journal of the American Society of Nephrology : JASN. vol 27. issue 2. 2016-06-07. PMID:26203118. |
intervention with a nox1/nox4 inhibitor reduced albuminuria, glomerular hypertrophy, and mesangial matrix accumulation in the f1 akita model of dkd. |
2016-06-07 |
2023-08-13 |
mouse |
| Hamid El Azzouzi, Stefanos Leptidis, Pieter A Doevendans, Leon J De Wind. HypoxamiRs: regulators of cardiac hypoxia and energy metabolism. Trends in endocrinology and metabolism: TEM. vol 26. issue 9. 2016-06-03. PMID:26197955. |
hypoxia is the driving force behind the regulation of the characteristic metabolic switch from predominant fatty acid oxidation in the healthy heart to glucose utilization in the failing myocardium, but also instigates reactivation of the fetal gene program, induces the cardiac hypertrophy response, alters extracellular matrix composition, influences mitochondrial biogenesis, and impacts upon myocardial contractility. |
2016-06-03 |
2023-08-13 |
Not clear |
| Emmet M Thompson, Amos Matsiko, Eric Farrell, Daniel J Kelly, Fergal J O'Brie. Recapitulating endochondral ossification: a promising route to in vivo bone regeneration. Journal of tissue engineering and regenerative medicine. vol 9. issue 8. 2016-05-31. PMID:24916192. |
this is driven by the hypothesis that hypertrophic chondrocytes can secrete angiogenic and osteogenic factors, which play pivotal roles in both the vascularization of constructs in vivo and the deposition of a mineralized extracellular matrix, with resulting bone deposition. |
2016-05-31 |
2023-08-13 |
Not clear |
| Estelle Ayme-Dietrich, Halim Marzak, Roland Lawson, Walid Mokni, Olivia Wendling, Roy Combe, Julien Becker, Lahcen El Fertak, Marie-France Champy, Rachel Matz, Ramaroson Andriantsitohaina, Stéphane Doly, Katia Boutourlinsky, Luc Maroteaux, Laurent Monassie. Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats. Journal of hypertension. vol 33. issue 11. 2016-05-26. PMID:26259125. |
blockade of the serotonin 5-ht2b receptor (5-ht2br) has been shown to reduce cardiac hypertrophy, oxidative stress, and extracellular cell matrix activation. |
2016-05-26 |
2023-08-13 |
rat |
| Renpeng Zhou, Qi Zhang, Yun Zhang, Shibo Fu, Chen Wan. Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars. Experimental cell research. vol 339. issue 2. 2016-05-24. PMID:26500110. |
the post-traumatic hypertrophic scar (hs) is a fibrotic disease with excessive extracellular matrix (ecm) production by fibroblasts in response to tissue injury. |
2016-05-24 |
2023-08-13 |
Not clear |
| Shaohong Cheng, Weirong Xing, Sheila Pourteymoor, Jan Schulte, Subburaman Moha. Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation. Endocrinology. vol 157. issue 1. 2016-05-17. PMID:26562260. |
dynamic histomorphometric analyses revealed increased longitudinal length and osteoid surface per bone surface in the primary spongiosa of the cko mice, suggesting elevated conversion rate from hypertrophic chondrocytes to mineralized bone matrix as well as increased bone formation in the primary spongiosa. |
2016-05-17 |
2023-08-13 |
mouse |
| Andrea Linz, Yvonne Knieper, Tobias Gronau, Uwe Hansen, Attila Aszodi, Natalio Garbi, Günter J Hämmerling, Thomas Pap, Peter Bruckner, Rita Dreie. ER Stress During the Pubertal Growth Spurt Results in Impaired Long-Bone Growth in Chondrocyte-Specific ERp57 Knockout Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 30. issue 8. 2016-05-16. PMID:25704664. |
long-bone growth by endochondral ossification is cooperatively accomplished by chondrocyte proliferation, hypertrophic differentiation, and appropriate secretion of collagens, glycoproteins, and proteoglycans into the extracellular matrix (ecm). |
2016-05-16 |
2023-08-13 |
mouse |
| Andrea Linz, Yvonne Knieper, Tobias Gronau, Uwe Hansen, Attila Aszodi, Natalio Garbi, Günter J Hämmerling, Thomas Pap, Peter Bruckner, Rita Dreie. ER Stress During the Pubertal Growth Spurt Results in Impaired Long-Bone Growth in Chondrocyte-Specific ERp57 Knockout Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 30. issue 8. 2016-05-16. PMID:25704664. |
together this results in a delay of long-bone growth with the following characteristics: (1) enlarged growth plates; (2) expanded hypertrophic zones; (3) retarded osteoclast recruitment; (4) delayed remodeling of the proteoglycan-rich matrix; and (5) reduced numbers of bone trabeculae. |
2016-05-16 |
2023-08-13 |
mouse |
| Yvonne Peck, Ling Yen Ng, Jie Yi Lois Goh, Changyou Gao, Dong-An Wan. A three-dimensionally engineered biomimetic cartilaginous tissue model for osteoarthritic drug evaluation. Molecular pharmaceutics. vol 11. issue 7. 2016-05-04. PMID:24579704. |
up-regulation of matrix metalloproteinase-1 (mmp-1) and mmp-3 genes suggested increased degradative activity, while chondrocytic hypertrophic differentiation was observed. |
2016-05-04 |
2023-08-12 |
Not clear |