| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weishen Chen, Puyi Sheng, Zhiyu Huang, Fangang Meng, Yan Kang, Guangxin Huang, Zhiqi Zhang, Weiming Liao, Ziji Zhan. MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression. International journal of molecular sciences. vol 17. issue 9. 2017-05-01. PMID:27563877. |
chondrocyte hypertrophy, regulated by runt-related transcription factor 2 (runx2) and matrix metalloproteinase 13 (mmp13), is a crucial step in cartilage degeneration and osteoarthritis (oa) pathogenesis. |
2017-05-01 |
2023-08-13 |
mouse |
| Koh Terauchi, Hajime Kobayashi, Kanaka Yatabe, Naoko Yui, Hiroto Fujiya, Hisateru Niki, Haruki Musha, Kazuo Yudo. The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis. International journal of molecular sciences. vol 17. issue 7. 2017-03-21. PMID:27367673. |
we postulated that sirt1 regulates a hypertrophic chondrocyte lineage and degeneration of articular cartilage through the activation of osteogenic transcriptional activator runx2 and matrix metalloproteinase (mmp)-13 in oa chondrocytes. |
2017-03-21 |
2023-08-13 |
mouse |
| Nadja Zöller, Anke König, Manuel Butting, Roland Kaufmann, August Bernd, Eva Valesky, Stefan Kippenberge. Water-filtered near-infrared influences collagen synthesis of keloid-fibroblasts in contrast to normal foreskin fibroblasts. Journal of photochemistry and photobiology. B, Biology. vol 163. 2017-03-17. PMID:27588716. |
hypertrophic scar development is associated to impaired wound healing, imbalanced fibroblast proliferation and extracellular matrix synthesis. |
2017-03-17 |
2023-08-13 |
Not clear |
| Leilei Yang, Wenlong Li, Bing Liu, Shaoxia Wang, Lin Zeng, Cuiping Zhang, Yang L. iRhom2 (Uncv) mutation blocks bulge stem cells assuming the fate of hair follicle. Archives of dermatological research. vol 308. issue 7. 2017-02-17. PMID:27393687. |
in this study, we found irhom2 mutation decreased hair matrix proliferation, however, irhom2 (uncv/uncv) mice displayed hyperproliferation and hyperkeratosis in the interfollicular epidermis along with hypertrophy in the sebaceous glands. |
2017-02-17 |
2023-08-13 |
mouse |
| Miaomiao Lu, Nanchang Yin, Wei Liu, Xiangfei Cui, Shuo Chen, Ermin Wan. Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling. BioMed research international. vol 2017. 2017-02-16. PMID:28194406. |
in comparison to mock-treated db/db mice, curcumin-treated mice showed diminished renal hypertrophy, reduced mesangial matrix expansion, and a lower level of albuminuria. |
2017-02-16 |
2023-08-13 |
mouse |
| Shengzhi Mu, Bei Kang, Weihui Zeng, Yaowen Sun, Fan Yan. MicroRNA-143-3p inhibits hyperplastic scar formation by targeting connective tissue growth factor CTGF/CCN2 via the Akt/mTOR pathway. Molecular and cellular biochemistry. vol 416. issue 1-2. 2017-02-06. PMID:27075467. |
post-traumatic hypertrophic scar (hs) is a fibrotic disease with excessive extracellular matrix (ecm) production, which is a response to tissue injury by fibroblasts. |
2017-02-06 |
2023-08-13 |
human |
| Manjunatha S Muttigi, Inbo Han, Hun-Kuk Park, Hansoo Park, Soo-Hong Le. Matrilin-3 Role in Cartilage Development and Osteoarthritis. International journal of molecular sciences. vol 17. issue 4. 2017-02-06. PMID:27104523. |
matrilin-3 downregulates the expression of matrix-degrading enzymes, such as a disintegrin metalloproteinase with thrombospondin motifs 4 (adamts4) and adamts5, matrix metalloproteinase 13 (mmp13), and collagen x, a hypertrophy marker during development and inflammatory conditions. |
2017-02-06 |
2023-08-13 |
Not clear |
| Naqi Lian, Taiping L. Growth factor pathways in hypertrophic scars: Molecular pathogenesis and therapeutic implications. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-02. PMID:27636511. |
hypertrophic scars represent the most common complication of skin injury and are caused by excessive cutaneous wound healing characterized by hypervascularity and pathological deposition of extracellular matrix (ecm) components. |
2017-02-02 |
2023-08-13 |
Not clear |
| Peng Zhao, Liping Yang, Jiansheng Li, Ya Li, Yange Tian, Suyun L. Combining systems pharmacology, transcriptomics, proteomics, and metabolomics to dissect the therapeutic mechanism of Chinese herbal Bufei Jianpi formula for application to COPD. International journal of chronic obstructive pulmonary disease. vol 11. 2017-01-12. PMID:27042044. |
additionally, bjf was previously shown to effectively prevent copd and its comorbidities, such as ventricular hypertrophy, by inhibition of inflammatory cytokine production, matrix metalloproteinases expression, and other cytokine production, in vivo. |
2017-01-12 |
2023-08-13 |
rat |
| Bing Li, Chao Gao, Jian-Sheng Diao, Da-Lei Wang, Fei-Fei Chu, Yang Li, Gang Wang, Shu-Zhong Guo, Wei Xi. Aberrant Notch signalling contributes to hypertrophic scar formation by modulating the phenotype of keratinocytes. Experimental dermatology. vol 25. issue 2. 2017-01-10. PMID:26566963. |
hypertrophic scar (hs) is characterized by fibroblast hyperproliferation and excessive matrix deposition. |
2017-01-10 |
2023-08-13 |
rabbit |
| Rik Osinga, Nunzia Di Maggio, Atanas Todorov, Nima Allafi, Andrea Barbero, Frédéric Laurent, Dirk Johannes Schaefer, Ivan Martin, Arnaud Scherberic. Generation of a Bone Organ by Human Adipose-Derived Stromal Cells Through Endochondral Ossification. Stem cells translational medicine. vol 5. issue 8. 2016-12-28. PMID:27334490. |
hypertrophic maturation induced upregulation of type x collagen, bone sialoprotein, and matrix metalloproteinase13 (mmp13). |
2016-12-28 |
2023-08-13 |
human |
| Kelei Chen, Kian Siang Ng, Sujata Ravi, James C H Goh, Siew Lok To. In vitro generation of whole osteochondral constructs using rabbit bone marrow stromal cells, employing a two-chambered co-culture well design. Journal of tissue engineering and regenerative medicine. vol 10. issue 4. 2016-12-26. PMID:23495238. |
the cells in the intermediate region were found to be hypertrophic chondrocytes, embedded in a calcified extracellular matrix containing glycosaminoglycans and collagen types i, ii and x. |
2016-12-26 |
2023-08-12 |
rabbit |
| Toshina Ishiguro-Oonuma, Masako Suemoto, Muneyoshi Okada, Kazuki Yoshioka, Yukio Hara, Kazuyoshi Hashizume, Keiichiro Kizak. Aberrant gene expression of heparanase in ventricular hypertrophy induced by monocrotaline in rats. The Journal of veterinary medical science. vol 78. issue 3. 2016-12-26. PMID:26638897. |
the gene expression levels of heparanase, matrix metalloproteinase 2 (mmp2) and mmp9 were examined in ventricles after treatment with monocrotaline (mct) to induce cardiac hypertrophy in rats. |
2016-12-26 |
2023-08-13 |
rat |
| Hung-Wen Liu, Chu-Chun Wei, Sue-Joan Chan. Low-molecular-weight polyphenols protect kidney damage through suppressing NF-κB and modulating mitochondrial biogenesis in diabetic db/db mice. Food & function. vol 7. issue 4. 2016-12-22. PMID:26960417. |
oligonol attenuated serum resistin and il-6 levels and reduced glomerular hypertrophy and mesangial matrix expansion caused by diabetes. |
2016-12-22 |
2023-08-13 |
mouse |
| Alessia Arcaro, Flora Pirozzi, Annalisa Angelini, Cristina Chimenti, Lia Crotti, Carla Giordano, Daniele Mancardi, Daniele Torella, Carlo G Tocchett. Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions-A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology. Oxidative medicine and cellular longevity. vol 2016. 2016-12-14. PMID:26881035. |
myocardial redox imbalance is a hallmark of this syndrome, since excessive reactive oxygen and nitrogen species can behave as signaling molecules in the pathogenesis of hypertrophy and heart failure, leading to dysregulation of cellular calcium handling, of the contractile machinery, of myocardial energetics and metabolism, and of extracellular matrix deposition. |
2016-12-14 |
2023-08-13 |
human |
| H D Amin, C R Ethie. Differential effects of tyrosine-rich amelogenin peptide on chondrogenic and osteogenic differentiation of adult chondrocytes. Cell and tissue research. vol 364. issue 1. 2016-12-13. PMID:26404401. |
thus, a long-term aci strategy should ideally incorporate methods to 'prime' autologous chondrocytes to form a cartilage-specific matrix and suppress hypertrophic mineralization. |
2016-12-13 |
2023-08-13 |
human |
| Carina Prein, Niklas Warmbold, Zsuzsanna Farkas, Matthias Schieker, Attila Aszodi, Hauke Clausen-Schauman. Structural and mechanical properties of the proliferative zone of the developing murine growth plate cartilage assessed by atomic force microscopy. Matrix biology : journal of the International Society for Matrix Biology. vol 50. 2016-12-13. PMID:26454027. |
the growth plate (gp) is a dynamic tissue driving bone elongation through chondrocyte proliferation, hypertrophy and matrix production. |
2016-12-13 |
2023-08-13 |
Not clear |
| G Zaman, K A Staines, C Farquharson, P T Newton, J Dudhia, C Chenu, A A Pitsillides, G K Dhoo. Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing. Histochemistry and cell biology. vol 145. issue 1. 2016-12-13. PMID:26464246. |
sulf2 expression unlike sulf1 also spread to the calcifying matrix around the hypertrophic chondrocytes indicating its possible ligand inhibiting role through hspg desulphation. |
2016-12-13 |
2023-08-13 |
rat |
| Traci L Parry, Gopal Desai, Jonathan C Schisler, Luge Li, Megan T Quintana, Natalie Stanley, Pamela Lockyer, Cam Patterson, Monte S Willi. Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 25. issue 2. 2016-12-13. PMID:26764147. |
in addition to pathological hypertrophy, murf1-/- mice had an unexpected differential expression in genes associated with the pleiotropic effects of fenofibrate involved in the extracellular matrix, protease inhibition, hemostasis, and the sarcomere. |
2016-12-13 |
2023-08-13 |
mouse |
| Maria-Teresa Piccoli, Christian Bär, Thomas Thu. Non-coding RNAs as modulators of the cardiac fibroblast phenotype. Journal of molecular and cellular cardiology. vol 92. 2016-12-13. PMID:26764220. |
cardiac fibroblasts are the principal orchestrators of matrix formation and degradation and indirectly regulate cardiac hypertrophy and inflammation. |
2016-12-13 |
2023-08-13 |
Not clear |